CCS Flashcards
Initial orders (4) on a 40 year old woman at clinic with weakness, fatigue, depression, orthostatic hypotension, skin hyperpigmentation, weight loss, anorexia x 8 months?
Follow-up, diagnostic orders (2.)?
- think Addison disease aka chronic adrenal insufficiency*
1) orthostatic vital signs
2) ECG
3) CBC
4) BMP (should show hyperkalemia)
- Early morning cortisol level (IF LOW/undetectable, diagnostic of Addison. If Intermediate, go to step 2)
- ACTH (cosyntropin) stimulation test (ACTH given, cortisol measured at 0, 30, & 60 min. If cortisol remains low, diagnostic of Addison. If cortisol increases at 30/60min, it’s pituitary or hypothalamic dysfxn/secondary hypoadrenalism
Treatment (3) for Addison disease?
1) fluid replacement (b/c usually orthostatic hypotension)
2) hydrocortisone
3) fludrocortisone
Initial orders (3) on a 36 year old year old woman at clinic with dysmenorrhea, loss of peripheral vision/increased car accidents, nipple discharge?
Follow-up/treatment (2.)?
- think prolactinoma/pituitary adenoma > pregnancy > primary brain tumor*
1) urine pregnancy test
2) prolactin level
3) brain MRI
- bromocriptine or cabergoline (dopamine agonist)
- consult neurosurgery re: possible surgery (not always done)
Differential diagnosis for person with altered mental status brought to ED (mnemonic)?
AEIOU TIPS: Acidosis Electrolytes, Encephalopathy, Endocrine (DKA, HOHC) Insulin(-->hypoglycemia) Opiates/OD Uremia Trauma, Thermia (hypo/hyper), Toxemia Infections PE, Psychogenic Space-occupying lesions, Shock, Seizure
Initial orders (9) on a patient brought to ED with AMS?
1) CBC
2) BMP
3) serum ketones
4) U/A
5) VBG or ABG
6) ECG
7) Portable CXR
8) Urine Toxicology
9) IVF
Patient comes to ED with hyperglycemia, urine ketones, +anion gap: what are your first steps in management(3)?
While monitoring, what are the (2.) steps to remember to add/change things during management?
- think DKA*
1) rapid IVF + potassium (only if K+ <5.5)
2) regular insulin IV drip (only start if/when K+ >3.3)
3) admit to ICU
- when glucose (via repeating fingerstick glucose) falls < 250, add glucose to IVF
- when acidosis (via repeating VBG, BMP) and ketosis (via repeating serum ketones) resolves, STOP insulin drip and transition to SC insulin
Initial orders (3) on a 28 year old woman coming to clinic with fatigue, dry skin, weight gain, constipation, hair loss x 4 months?
Follow-up orders (2.) for diagnosis?
- think hypothyroidism ie. Hashimoto, deQuervain, Reidel > depression >anemia*
1) CBC
2) BMP
3) TSH (should be increased)
- free T4 (should be decreased)
- T3
Initial orders (2) on a 25 year old woman coming to clinic with tremor, weight loss, palpitations, diaphoresis, decrease in appetite x 3 months?
If one of the above orders is low, what are follow-up orders (2.)?
If one of the above orders is normal, what are the follow-up orders (#2)?
- think hyperthyroidism (Graves, toxic mult goiter, toxic adenoma, deQuervain, Hashitoxicosis-early in dz, exogenous, etc), anxiety/panic, pheochromocytoma, stimulant abuse*
1) ECG
2) TSH
If TSH low/undetectable: 1. free T4 2) T3
If TSH normal: #1) 24 hr urine metanephrines #2) urine toxicology screen
Management (2 +/- 3) for diagnosis of hyperthyroidism?
1) Propanolol (symptomatic relief)
2) methimazole or propylthiouracil
+/- 3) anti-TPO Antibodies
+/- 4) thyroid uptake scan (diffuse in Graves, mult nodules in tox mult goiter, no update with thyroiditis/exogenous)
+/- 5) endocrinology referral for radioactive iodine ablation
Initial orders (6) on a 41 year old woman with HTN + DM on HCTZ, metformin, amlopidine, glipizide coming to clinic with fatigue, insomnia, hirsutism, central abdominal weight gain, stretch marks, dysmenorrhea, HTN x 2 months?
- hypercortisolism (exogenous, ACTH-producing, or adrenal) > depression, metabolic syndrome*
1) CBC
2) BMP
3) urine b-HCG
4) CK
5) urinalysis
6) 24 hour urine free cortisol (should be increased) OR salivary cortisol (should be increased) OR dexamethasone suppression test
If low dose dexamethasone suppression test shows no suppression and high dose shows suppression, what does this mean and what are the follow-up actions(3) to diagnosis & management?
- suspect ACTH-producing pituitary tumor (Cushing disease)– dexa at high doses will do negative feedback on ACTH in pituitary, but NO effect on ectopic ACTH tumor or adrenal adenoma)*
1) ACTH (should be increased only in pituitary tumor & ectopic ACTH tumor, & with high dose dexa supression you know it’s pituitary)
2) brain CT/MRI (should show pituitary mass)
3) neurosurgery consult for transsphenoidal surgery
Initial orders (6) on 51 year old obese man with no PMHx presenting to clinic, fasting, after getting blood glucose of 290 measured at health fair?
- suspect T2DM*
1) fingerstick blood glucose
2) BMP
3) CBC
4) HgA1c
5) U/A
6) fasting lipid panel (if LDL <100, start statin // <70 when concurrent +CVD)
Follow up actions (5) on 51 year old obese man with no prior MHx, at clinic with mild nonproliferative diabetic retinopathy on fundoscopic exam and new findings of fingerstick blood glucose 200, HgA1c 7.9%, LDL 65, U/A with moderate glucose and trace protein?
1) Diabetes counseling (i.e. check feet daily for ulcers)
2) Lifestyle modification - diet and exercise
3) Metformin (& f/u in 3 months, remeasure A1c)
4) urinary microalbumin (*if increased, start ACE-i EVEN if no HTN!!)
5) Ophthalmology referral for retinal photography
Initial orders and management (8) on 52 year old white woman, smoker, with no PMHx who comes to clinic with 3rd measurement of elevated BP despite changing diet & exercise?
- suspect essential HTN > hyper/hypothyroidism > pheochromocytoma, RAS*
1) CBC
2) BMP
3) U/A
4) TSH
5) lipid panel
6) ECG
7) thiazide diuretic (& f/u in 1 month. If unresolved, add 2nd agent: ACE-i/ARB/CCB/BB)
8) counseling smoking cessation, diet, exercise
Initial orders (7) on 60 year old woman presenting to ED after being referred by PCP for constipation, nausea, memory deficits x 5 months, and hypercalcemia on labs?
- suspect hypercaclemia d/t PTH or malignancy > hyperthyroid, meds, milk alkali syndrome, immobilization
1) CBC
2) CMP
3) ECG
4) PTH (can get as initial order b/c already had hypercalcemia on labs)
5) ionized Ca+2
6) albumin
7) ECG