CCFP Flashcards

1
Q

Secondary causes of HTN ABCDES

A

Atherosclerotic, coarctation of the aorta
Bad kidneys - Renal parenchymal disease
Catecholamines
Drug, Diet
Endrocrine (Hypothyroid, aldosterone, Cushing), EtOH
Fibromuscular dysplasia
sleep apnea, stress

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2
Q

Medications that raise BP

A

Steroids, NSAIDs, amphetamines, many psychiatric meds - SSRIs, SNRIs, carbamazepine, estrogen/progesterone/androgens, sympathomimetic (decongestant), licorice

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3
Q

What does a lipid panel include

A

Chol, HDL, LDL, non-HDL, TG

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4
Q

Risks of HCTZ?

A

Skin cancer non melanoma, possible 4x risk after 3 years

Avoid long acting Chlorthalidone, indapamine b/c of DM2, renal and electrolyte abnormalities

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5
Q

Lifestyle interventions for HTN

A

Lower salt, exercise, weight loss, reduce alcohol, DASH diet, relaxation –> CBT

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6
Q

HTN Meds to avoid in HTN

A

alpha blocker alone
Beta blockers if > 60
ACE if black

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7
Q

Risk factors for uterine perforation

A
breast feeding
grand multiparity
history of csection
nulliparity
inexperienced HCP
uterine abnormalities 
postpartum state in breastfeeding women
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8
Q

when should you start various kinds of birth control when removing an IUD?

A

POP 2 days before, ocp/depo etc 7 days before

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9
Q

contraindications to IUD

A

pelvic TB, pregnancy, uterine/cervical malignancy, puerperal sepsis, post-septic abortion, unexplained vaginal bleeding, gestational throphoblastic disease with persistently elevated betahcg (decreasing beta is relative), distorted uterine cavity, current PID/gonochlam

mirena: breast cancer, hx of ischemic heart disease, antiphospholipid antibodies, migraine with aura, severe cirrhosis
copper: severe thrombocytopenia

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10
Q

What does SAD PERSONS stand for

A
Male sex
Age <19, >45
Depression
Previous attempt
Excess EtOH/substances
Loss of rational thinking
Social supports lackings
organized plan
no spouse
Sickness
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11
Q

What else should you r/o with depression

A

mania, anxiety (does worry get in the way of your life?), OCD (thoughts/rituals you cannot stop), delusions (special powers/plot against you), hallucinations

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12
Q

When to consider bipolar in absence of mania

A
age <25
>= 5 episodes
family hx
hypersomnia
hyperphagia/increased weight
lability of mood/irritability
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13
Q

first line meds/treatments for PTSD

A

fluoxetine, paroxetine, sertraline
venlafaxine
CBT
group therapy

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14
Q

first line meds/treatments for OCD

A

escitalopram, fluoxetine, paroxetine, sertraline
CBT
exposure with response prevention

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15
Q

mimics for depression

A

hypothyroid, adrenal insufficiency, grief/adjustment disorder, drug use, bipolar, tumor, delirium

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16
Q

SPIKES

A
setting up
perception
invitation
knowledge
emotion
strategy, also SAFETY.
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17
Q

SNOPQRST

A
Safety
Next visit
Offer
Prevention
Quit 
Refer
Start
Teach
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18
Q

Osteoporosis risk factors

A
Age > 65
Sex - female
post menopausal
Alcohol 
Chronic disease i.e. RA
Chronic steroid use
Previous fragility fracture
Malabsorption/eating disorder
Hypogonadism
low body weight <60kg
for <50yo, fragility #, prolonged use of CS, high risk meds, hypogonadism/premature menopause, malabsorption syndrome, primary hyperparathyroidism, other d/o associated with rapid bone loss and/or fracture
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19
Q

Chronic bronchitis criteria

A

Chronic bronchitis is defined as a cough with sputum expectoration for at least 3 consecutive months for at least
2 consecutive years

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20
Q

Thalassemia regions

A
Southeast Asia
Africa
South America
Middle East
Carribbean 
Mediterranean
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21
Q

Broad differential? VINDICATE

A
Vascular
Infectious
Neoplasm
Drugs
Idiopathic
Congenital
Autoimmune
Trauma
Endocrine
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22
Q

COPDE sx

A

cough, purulence, dyspnea, CRP >40

Early warning score i.e. NEWS2

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23
Q

Common ear bugs? what about (complicated) COPD? what about PNA?

A

Hemophilus,
Moraxella,
Strep pneumonia
(same as for COPD; if complicated add on klebsiella, gram negatives, pseudomonas; same for pneumonia, if comorbid add on staph aureus, if not comorbid, atypicals - mycoplasma and chlamydophila)

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24
Q

COPD tx to prevent exacerbations

A
Flu/pneumonia shots
Action plan to reduce hospital use
CPAP?
Daily macrolide (azithro, erythro) to decrease exacerbations
Exercise
Quit smoking
Pulmonary rehab
Puffers - SABA, LAMA, 
Respiratory therapy
Teach inhaler technique
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25
Q

SNOPQRST

A
Safety
Next visit
Offer
Prevent
Quit
Refer
Start
Teach
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26
Q

Criteria for dx asthma in <6 yo

A

Wheeze that reverses

it’s not something else

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27
Q

What are the criteria for asthma dx

A

FEV1/FVC pre <0.75
FEV1 post increases 12%

vs. COPD; post <0.70 and not reversible

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28
Q

Asthma rx pyramid for pre-schoolers

A

mild - saba
mod - saba + ICS
severe - saba, ICS, oral steroids

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29
Q

Asthma rx pyramid for 6+

A

mild - LABA + ICS (symbicort) as needed
mod - saba + daily ICS OR as-needed ICS/LABA- formeterol (LTRA as alternative)
mod + - low dose ICS/LABA plus as needed SABA, OR low dose ICS/LABA plus as needed ICS/LABA
mod ++ - med dose ICS/LABA plus as needed SABA, OR low dose ICS/LABA plus as needed ICS/LABA
next! refer for phenotypic investigations + add-on treatment
severe - saba, ICS, LABA, LAMA, LTA, theophylline

**if uncontrolled, saba +/- ICS/LABA on demand

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30
Q

Good asthma control

A

<1 night time symptoms
<4 use of prn puffer
no activity restrictions, no missed school/work

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31
Q

Risk factors for asthma exacerbations

A

ICS not prescribed, poor adherence,
GERD, obesity, previous ICU/intubation for asthma, irritants - smoking/allergen/pollution, allergic rhinitis, food allergy, depression, anxiety, pregnancy, FEV1<60%
NSAIDs, betablockers

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32
Q

Frequency of asthma f/up? in pregnancy?

A

1-3 months after starting treatment then 3-12 months after that; in pregnancy, every 4-6 weeks

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33
Q

Testicular cancer workup and risk facrors BALLS CFP

A

Bhcg
Alpha fetoprotein
Lop it off

Cryptorchidism
Family hx
Personal hx

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34
Q

Lung cancer screening

A

age 55-74, 30pk/yr smoke, current or quit <15 years ago. CT annually up to 3 times

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35
Q

Cervical cancer screening indications and nor indications

A
25-69 every 3 years unless
- never sexually active
- weakened immune system
- symptoms of cervical ca
- previous abnormal results
- those who do not have a cervix
- immunosuppressed
CAN stop at age 70 if 3 normal in last 10 years
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36
Q

Skin cancer risk factors

A
Nevi > 15
older
white skin, red hair
hx of skin cancer, sun exposure
family history
multiple sunburns
actinic skin damage
--> refer if hi risk, skin checks q6 months
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37
Q

skin cancer ABCDE

A

Asymmetry
Border - gradual, indistinct vs. sharp cut off
Colour variation
Different dermatoscopic structures - pigment network, homogeneous areas, streaks, dots, globules

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38
Q

Colorectal screening

A

50-74

flex sig q10 or FIT q2 years

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39
Q

Breast Ca screening (5)

A
1. Screen with mammography every 2-3 y
 if aged 50-74 y
2. Do not routinely screen those aged
 40-49 y
3. Do not screen with magnetic resonance
 imaging
4. Do not perform clinical breast
 examination
5. Advise patients not to perform self breast
 examination
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40
Q

Feb neut

A

early antibiotic treatment, look for source and consider fungal
stabilize and assess
severe sepsis –> ICU

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41
Q

H Pylori quad therapy

A

PPI
Bismuth salicylate
Metronidazole
Tetracycline

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42
Q

what is Barrett’s esophagus? prevention,

A

columnar cells replace squamous;

prevention - high dose PPI and ASA

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43
Q

long term risks of PPIs

A

fractures
b12 deficiency
dementia
c diff

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44
Q

gallstone RF

A

female
forty
fat
fertile – on OCP

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45
Q

pancreatitis RF

A
septra, flagyl
HCTZ, ACE
progesterone
atorva
estrogen
gall stones
ETOH

I = idiopathic

G = gallstones

E = EtOH

T = trauma

S = steroids

M = mumps/malignancy

A = autoimmune

S = scorpion stings … though this probably shouldn’t be your first guess for why your patient has pancreatitis

H = hypertriglyceridemia/hypercalcemia

E = (post) ERCP

D = drugs. Most commonly: thiazides, sulfa drugs, and didanosine

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46
Q

admission criteria - UN

A

uncontrolled symptoms
unstable
undiagnosed pain esp in elderly, immunocompromised
undischargable i.e. poor social support

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47
Q

fluid for peds

A

20 mg/kg bolus

maintenance 4/2/1

  • 4 ml/kg for the first 10kg
  • 2ml/kg for 11-20
  • 1 ml/kg 20+
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48
Q

measures to monitor for severe dehydration

A
weight
gfr/creatinine
na, k 
glucose
urea
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49
Q

c diff risk factors

A
abx esp fluoroquinolones
previous infxn
recent hospitalization
older age
immunocompromised
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50
Q

c diff pitfalls and rx

A

don’t test kids <1
rx: vanco po

Can be community acquired

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51
Q

Crohn’s medications

A

Immune system suppressors:
Azathioprine, nethotrexate, remicade

Anti-inflammatory: steroids (5 asa no longer used)

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52
Q

celiac testing

A

Anti tissue trans glutaminase + IGA
+/- upper endoscopy, small intestine biopsy
OR endomysial IGA (but this is +++expensive)
if IGa deficiency, DGP IgA and IgG

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53
Q

IBS treatment and medications

A

Lifestyle: Fluid, fibre, avoid fructose/sugar alcohols
Natural: peppermint oil, laxatives

Rx

  1. ) Antidepressants (SSRI/TCA)
  2. ) Anti-spasmodics (hyoscamine)
  3. ) Anti-cholinergics (bentyl)
  4. ) Linaclotide - for constipation type
  5. ) Lotronex - for diarrhea
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54
Q

Restless legs treatment and medications

A
Lifestyle: 
iron, mg
stretch calves
avoid caffeine
massage, heat
exercise

rx
non ergot dopamine agonists - pramipexole, ropinirole

gabapentin, pregabalin

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55
Q

restless legs dx

A

sensation or urge to move legs
worse with rest, improves with activity
worse in evening

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56
Q

restless legs risk factors

A

Etiology

  1. Primary- genetics, young onset
  2. Secondary
    - fe/mg deficiency
    - uremia
    - neuropathy
    - pregnancy
    - varicose veins
    - rx (dopamine agonists, lithium, antihistamines, antidepressants)

Associated diseases –ADHD, Parkinsons, DM, renal disease, depression

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57
Q

Tx hyperthyroid

A

Radioactive iodine uptake (NOT for ladies who are preggers), unless 100% sure it’s graves
B block for symptoms
nodule? >1cm = FNA
don’t treat subclinical hyperthyroid

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58
Q

suspicious features of thyroid nodule

A

> 1cm
Taller than wide
irregular surface
calcifications within

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59
Q

Treating thyroid storm - BLOCK x 5

A

Beta blocker - propanalol
Block synthesis - methimazole, propylthiouracil
Block conversion T4 –> T3 propylthiouracil
Block release - iodine
Block Bile - cholestyramine

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60
Q

Treating graves, 3 Rs

A

Rx - First 4 Blocks - beta blocker, block synthesis, block conversion, block release
Radiation
Removal

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61
Q

Meds to stop when sick/at risk of dehydration

SADMANS

A
SFU
ACE
Diuretics
Metformin
ARBs
NSAIDs
SGLT2
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62
Q

Three reasons people develop DKA

A
  • acute illness,
  • drugs: clozapine, terbutaline, cocaine, lithium, SGLT2
  • non compliance
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63
Q

Diabetes complications, micro/macro

A

micro - retinopathy, neuropathy, nephropathy

macro - atherosclerosis –> CVD, CVA, PVD

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64
Q

Biguanide

A

metformin

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65
Q

SGLT2 inhibitors

A

flozins - empagliflozin, canagliflozin

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66
Q

GLP-1R agonists

A

glutide - semaglutide, liraglutide

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67
Q

DPP4 inhibitors

A

saxagliptin

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68
Q

sulfonylureas

A

gliclazide, glyburide

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69
Q

driving 2-4-6 rule diabetes

A

test BS every 2 hours - if hypoglycemia unawareness
test BS every 4 hours - treat and wait 40 min
keep 6 lifesaver candies in the car for lows

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70
Q

risk factors for hep B

A
IVDU
sex with partner with hep B
child born to mother with hep B
tattoos
blood transfusions
living in crowded conditions
unimmunized
multiple sexual partners
MSM
occupation
prison
hx of STIs
breastfeeding OK if skin is in intact
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71
Q

medications to treat chronic gout

A

allopurinol
prboenecid
febuxostat

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72
Q

how to test for Hep C?

A

anti - HCV (unless known previous hep C)
HCV RNA serum
genotype and subtype
–> spontaneous clearance in 20-45%

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73
Q

how to test for Hep b?

A
HbsAg - infxn
Anti HBS - vaccine
Anti HBC --> IgM, total
if +ve
HBeAg
HBV DNA
Anti HBe
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74
Q

Mgmt and monitoring hep B

A
Refer to hepatology
Anti virals if severe, cirrhosis
U/S q6-12 months for HCC
scope every 1-3 years for varices
Cirrhosis/fibrosis - fibroscan, Child Pugh

The current approved treatments for HBV are interferon injections (standard or pegylated interferon) or oral nucleoside/nucleotide analogues (entecavir, lamivudine, tenofovir). As oral antivirals are excreted by the kidney, dose adjustments are required in renal failure.

Not all patients with chronic HBV infection need to be treated. The decision to treat depends on several factors including age, serial ALT and HBV DNA levels, and severity of liver disease. Co-infection, particularly with HIV and HCV, needs to be considered when deciding on which medications to use.

HBsAg (surface antigen) indicates infection. Persistence of HBsAg for 6 months or more indicates chronic infection. However, up to 50% of people with extended chronic infection will eventually clear HBsAg. By contrast, those with resolving acute HBV will clear HBsAg several months after initial infection.

Anti-HBs (surface antibody) is a protective antibody produced with recovery from infection or in response to immunization. Over time, titre may decline to undetectable levels. Note: There is a gap of several weeks to months between the disappearance of HBsAg and the appearance of anti-HBs; during this period, anti-HBc total is detectable as a marker of HBV infection.

Anti-HBc IgM (core antibody - IgM) appears early in acute HBV infection and persists for about 6 months. It may also be seen in chronic infection during flares of activity, so clinical/epidemiological correlation is required for interpretation.

Anti-HBc total (total core antibody - IgM and IgG) is a marker of past exposure or current infection. IgG usually persists for life. In low prevalence populations, a finding of isolated anti-HBc may signify a false positive result.

HBeAg (e-antigen) is a marker of viral replication; its presence indicates high infectivity. Implications for liver injury vary with stage of infection (see Module 7 for significance).

Anti-HBe (e-antibody) appears with recovery from acute infection. In chronic infection, the presence of anti-HBe is generally a marker of reduced viral replication, indicating a less infectious state. The implications for liver injury vary with stage of infection (see Module 7 for significance)

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75
Q

Mgmt and monitoring hep C

A

Refer to hepatology
Treat: interferon or new regimens (harvoni, epclusa)
U/S q6-12 months for HCC
scope every 1-3 years for varices
Cirrhosis/fibrosis - fibroscan, Child Pugh

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76
Q

NAFL vs NASH, and treatment?

A

NASH = NAFL + hepatitis (increased ALT/AST)
= signs of inflammation
NAFL - no inflammation or fibrosis = STEATOSIS
Rx - stop EtOh, weight loss, lipid control, DM control, if fibrosis >2 consider vitamin E

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77
Q

Ankylosing Spondylitis features

A

low back/SI pain stiffness
worse w/ rest, improves w/ movement
worse at night
30 minutes + for morning stiffness to recede
weight loss, fatigue
chest pain – from insertion into sternum
enthesis i.e. plantar fasciitis, achilles tendonitis
anemia
uveitis
aortitis
heart block

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78
Q

what is Schober’s test

A

find L5, measure 10cm above and 5cm below = 15cm

if <20cm when bending forward = restrictive

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79
Q

investigations for Ankylosing Spondylitis

A

ESR, CRP
HLA b27
spine xray or MRI for early changes

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80
Q

mgmt Ank spond

A
nsaids
steroids for flares - oral, IM, into joint
anti TNF
monoclonal antibody
physio
no smoking
bisphosphonates if osteoporosis
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81
Q

Back pain physical exam

A

ALWAYS: numbness, weakness, pedal pulses, neuro exam

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82
Q

Lower limb Myotomes memory aid

A

L1/L2 buckle my shoe - hip flexion
L3/L4 kick the door - knee extension
C5/6 pick up sticks - biceps
C7/8 - shut the gates

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83
Q

Dermatomes memory aid

A

L4 down on all 4s - knees to first toe
L5 middle toes
S1 pinky toe

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84
Q

joint red flags

A
hot
boggy
AM stiffness
PM night pain 
extra-articular symptoms? think genital infection, vasculitis, systemic illness
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85
Q

ADHD medication classes

A

Stimulants - methylphenidate (concerta, biphentin, ritalin), amphetamine (vyvanse, adderall)
SNRI - Atomoxetine
Alpha receptor antagonist - Guanfacine

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86
Q

ADHD meds – Consider DATER before changing medication to 2nd/3rd line

A

Dosage
All - trial of all 1st line
Time - enough time given for response/side effects to resolve
Examine - what are the targets? what standardized measures
Review - comorbidity, lifestyle

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87
Q

ADHD non rx management

A

patient and family education
psychological treatment
education accommodations
driving – restrict cell phone use, recommend manual transmission

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88
Q

ODD vs conduct disorder

A

ODD children do not show aggressions towards peope/animals; destroy property; pattern of theft and deceit

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89
Q

Bedwetting management

A
make toilet accessible
pee before bed
including in morning cleanup
training pants
avoid fluids/caffeine/chocolate before bed
do not punish, introduced diapers
enuresis alarms
desmopressin for short-term
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90
Q

Well baby care counselling safety

A
No honey
Choking hazards
Vitamin D
Breast/fed is best
button battery ingestion
No guns
Carbon monoxide detector
Cover electric plugs
Hot water heater
car seats
Storage and poison control
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91
Q

Milestones

A
2 months - two = coo, smiles
4 months - hold object - four fingers and hold head, laughs
6 - sit at six with support
8 - pincer grasp 
1 year - walk, 1 word; responds to name
15 months- stranger danger
2 - run, 2 word sentence, 1-2 step directions
3 - 3 step instructions
5 - adult like sentences
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92
Q

Breastfeeding guideline

A

> =2 years

400IU daily vitamin D

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93
Q

circumcision, pros and cons

A

pros
- decreased infection - phimosis (rx with topical steroids), uti, hpv, cancer

cons
- pain, stenosis, damage to surrounding tissues

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94
Q

undescended testes sequelae

A
torsion
trauma
tumor
inguinal hernia
infertility
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95
Q

torsion TWIST score

A
absent cremasteric reflex
nausea/vomiting
testicle swelling
testicle hard
high riding testicle
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96
Q

When to refer for testicles in children

A

refer if

  • not descended at 6 months
  • not there anymore
  • not there
  • not positioned properly
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97
Q

AIDS defining illnesses

A
Kaposi’s sarcoma
Pneumocystis jirovecii pneumonia (PCP)
Cytomegalovirus
Candidiasis (oesophageal or bronchial)
Lymphomas (excluding Hodgkins)
Tuberculosis
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98
Q

when to give Tdap to pregnant ladies

A

> 13, ideally 27-32 weeks

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99
Q

which vaccines can you NOT give if someone is breastfeeding?

A

BCG, yellow fever, japanese encephalitis

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100
Q

Under what circumstances do we have to delay vaccines if someone is ill?

A

lots of congestion – don’t give nasal flu
acute GI – defer cholera, dukoral
mod to severe – defer rotavirus

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101
Q

who gets flu vaccine?

A

kids > 6 months
everyone, but esp adults with neurologic/developmental conditions, work in health care, work with poultry
> 65 yo

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102
Q

vaccines in person with egg allergy

A

flu, MMR ok

do not give yellow fever, tick-borne encephalitis or rabies

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103
Q

make vaccine less painful?

A
breastfeed
skin to skin
most painful last
sugar
tylenol after, otherwise blunts immune response
topical anesthetic
don't aspirate
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104
Q

what are the two shingles vaccines?

what kind, how often, how $$$, how effective?

A

zostavax = live attenuated
1 dose, $170, >60 yo

shingrix = non live recombivant, adjuvanted
2 doses, 2(-6) months apart
2x as effective, 2x as much
>50yo

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105
Q

HPV vaccine - # of doses, #-valent

A

2 doses, 9-valent, all genders

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106
Q

who do you give meningitis C to? (5)

A
all travellers to Hajj
meningitis belt of africa
military recruits
asplenia and sickle cell
all canada adolescents
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107
Q

vaccine cautions for the immunocompromised? keep 3 things in mind

A
  • no polio, varicella, MMR
  • close contacts: avoid giving or avoid contact for 2 weeks
  • consult public health/ID
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108
Q

vaccines contra-indicated in…

pregnancy? TB? severe asthma/medical wheeze in last 7 days? uncorrected GI malformation? HIV?

A

pregnancy: live vaccines (polio, varicella, MMR), BCG –> flu ok
active TB: MMR, varicella, herpes zoster, BCG
asthma: live attenuated influenza
GI malformation: rotavirus (risk of intussception)
HIV: all live vaccines

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109
Q

Common cold treatment? (5)

A

NSAIDs, honey (> 1 year), intranasal ipratropium, nasal decongestant/anti-histamine (>5 year), zinc (not intranasal)

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110
Q

sinusitis risk factors? (4) which bugs?

A
allergic rhinitis
asthma
anatomy
smoking
ear bugs
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111
Q

Sinusitis complications and red flags? (9)

A
Osteomyelitis, intracranial abscess, epidural abscess, meningitis, periorbital/orbital cellulitis. 
fever > 39
periorbital edema
cranial nerve palsies
abnormal EOM
proptosis
vision changes
severe headache
altered mental status
meningeal signs
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112
Q

what are the meningeal tests?

A

Brudzinski - flexed neck –> flexed extremities

Kernig - with hips flexed cannot extend knee

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113
Q

PODS acute sinusitis

A
pressure/pain
obstruction (nasal)
dischage - thick, purulent
smell, loss of
2 or more -- persists for >7-10 days
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114
Q

mgmt of acute sinusitis

A
ct/xr only if red flags
amox 500 TID 5-10 days
nasal steroids!
nasal rinse
decongestants
analgesics
anti-inflammatories
mucolytics
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115
Q

why give abx for GAS? what does it NOT prevent?

A
prevent...
AOM
rheumatic heart disease
sinusitis
decrease illness <1 day
peritonsillar abscess 
does NOT prevent glomerulonephritis
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116
Q

mono - how does it spread? symptoms? labs? recommendations re: spleen?

A

saliva
lymphadenopathy, fatigue, sore throat, splenomegaly, headache
lymphocyte count, serume AST/ALT, monospot
NO abx
no contact sports min. 3 weeks, can last up to 8 weeks

117
Q

Jaundice beyond two weeks, order:

A
hemoglobin
serum conjugated bili
coomb's test
group and screen
peripheral smear
118
Q

Symptoms of down syndrome - rule of 1s

A

1st toe web space
1 palmar crease
1% recurrence

119
Q

Hip dysplasia risks, ffff

A
first born
feet -- breech
family history
fluid -- oligo
female
120
Q

full septic workup in kids

A

CBC
LP
CXR
urine/blood cx

121
Q

pediatric LIMPSS cannot miss

A
Legg calves perthe
Infectious
Malignancy - ewing's sarcoma, osteosarcoma
Pain from a fracture - abuse?
Slipped capital femoral epiphysis
Something else above/below
122
Q

Classes and examples of constipation meds

A

Stool softeners – docusate (colace)

Osmotic laxatives – lactulose, Mg salts, sorbitol, PEG

Bowel stimulants (motility agents) – senna, bisacodyl, cascara, prune juice

Bulking agents – psyllium, bran (Metamucil ok)

Bowel lubricants – mineral oil, castor oil, glycerine

Enemas – tap water, saline, sodium phosphate (fleet), oil

123
Q

Counselling pts for HCV - 4

A

Discussion of avoidance of alcohol
Monitoring of progression (ALT/AST, annual AFP)
Counsel on risk of transmission
Screening sexual partners

124
Q

HCV treatments

A
Pegylated Interferon
Ribavirin
Telaprevir
Simeprevir
Sofosbrevir
Harvoni (ledipasvir/sofosbuvir)
Holkira Pak (dasabuvir, ombitasvir, paritaprevir, ritonavir)
velpatasvir
daclatasvir
125
Q

Mechanism of scaphoid #

A

Extreme dorsiflexion of the wrist with compressive force to the radial side of the palm
Fall on outstretched hand/arm
Forceful radial deviation and dorsiflexion of wrist
Direct axial compression or hyperextension of the wrist

126
Q

Physical exam for scaphoid fracture

A

Anatomic snuffbox tenderness
Scaphoid tubercle tenderness (extend the patient’s wrist with one hand and apply pressure to the tuberosity at the proximal wrist crease with the opposite hand)
Positive results on the scaphoid compression test (axially/longitudinally compressing a patient’s thumb along the line of the first metacarpal)
Swelling on the dorsoradial side of wrist or over the anatomical snuffbox
Pain in the snuffbox with pronation of the wrist followed by ulnar deviation
Reproduction of pain when patient pinches tips of their thumb and index finger together

127
Q

Scapholunate disruption on xray

A

A gap of more than 3 mm between the scaphoid and lunate bones (the Terry Thomas sign)

128
Q

Scaphoid #, reasons to refer to ortho

A
open fractures
neurovascular compromise
displacement of 1 mm or more
angulated fractures
associated tilt of the lunate bone
associated carpal instability
evidence of nonunion or displacement during follow up
osteonecrosis
possible scapholunate dissociation
proximal pole fractures
oblique fractures
unwillingness or inability of the patient to wear a cast for up to 3 months
129
Q

Why does scaphoid have higher rates of fracture complications?

A

The scaphoid bone has a tenuous blood supply running from distal to proximal.

RATIONALE: The blood supply comes from the radial artery, feeding the bone on the dorsal surface near the tubercle and scaphoid waist with no direct blood supply to the proximal portion. Thus, there is an increased possibility of nonunion or osteonecrosis with fractures, particularly those of the proximal pole.

130
Q

Symptoms of hypercalcemia

A
mental status change
confusion
poor concentration
abdominal groans (e.g. abdominal pain)
nausea
vomiting
anorexia
fatigue/lethargy
renal colic
dehydration
polyuria
polydipsia
constipation
bone pain
muscle weakness
anxiety
depression
131
Q

Rx for hypercalcemia

A

Hydration with normal saline
Calcitonin
Bisphosphonates

132
Q

Medications that cause hypercalcemia

A
ationale:
Thiazide diuretics (class or specific drug name of any thiazide acceptable)
Lithium
Teriparatide
Abaloparatide
Theophylline
Excessive vitamin A
Excessive vitamin D
133
Q

1st blood test to order with dx of hypercalcemia

134
Q

Risk factors for neonatal jaundice

A

Prematurity
Vacuum delivery leading to cephalohematoma
Asian background
Possible dehydration (poor weight gain)

135
Q

Blood tests in neonatal jaundice

A
Blood type (ABO and Rh status) of infant
Direct antiglobulin test (direct Coomb’s test)
136
Q

Inherited disorders that cause hyperbilirubinemia in infants

A

Glucose-6-Phosphate Dehydrogenase Deficiency
Pyruvate Kinase deficiency
Crigler-Najjar syndrome
Hereditary spherocytosis or elliptocytosis
Hemoglobinopathies (sickle cell, thalassemia, Hemoglobin H disease)

137
Q

Side effects from phototherapy?

A

Dehydration
Bronze baby syndrome / bronze discolouration of the skin
skin rash
over or under heating of infant / temperature instability
loose stools/diarrhea
electrolyte disturbance (hyponatremia or hypokalemia)
interference with maternal –infant interactions
Ocular damage

138
Q

Causes of hyperbilirubinemia in babies <24 hrs

A

hemolytic disease of the newborn (Rh or ABO incompatibility, spherocytosis, G-6PD deficiency, Kell Congential hemolytic states)
Maternal autoimmune hemolytic anemia (e.g. lupus) Type 1 – usually by day 3
Concealed hemorrhage/hematoma
Vitamin K deficiency

139
Q

Treatment for ABRS

A

amox, nasal steroids

140
Q

Classic sites for infantile eczema

A

Cheeks
Face
Scalp
Extensor surfaces (elbows and knees would count as 2 answers)
1/2 point for Flexor surfaces (flexor surfaces can be found in any age, however, extensor surface involvement is more classic for infantile eczema)
Trunk

141
Q

Risk factors for infantile eczema

A
Positive family history of atopy (give ½ point for either “allergy” or “asthma”)
Weather changes (cold, dry)
Chemical irritants (scented soaps, detergents)
142
Q

strategies to prevent/treat eczema

A
Reducing frequency of baths
Unscented products (soap, detergents)
Minimize soaps
Emollients
Barrier creams
Use luke warm water for baths
Avoiding triggers or irritants
Exclusive breastfeeding (although some small studies are refuting this)
Parental education
Topical steroids
Antibiotics in severe cases
143
Q

when to treat asymptomatic BV?

A

Pregnant women with history of a high-risk pregnancy (previous preterm delivery)
Prior to IUD insertion
Second trimester even if asymptomatic (check this)
Prior to gynecologic surgery/therapeutic abortion/genitourinary instrumentation
Immunocompromised patient

144
Q

abx to treat trich? what else can be used for BV?

A

metronidazole

clinda, doxy

145
Q

Pediatric Limps LIMPSS

A
Leg Calve Perthes Syndrome 
- boys, age 4-10, white
Infection/inflammation
Malignancy - Ewing's Sarcoma (small round blue cells - pelvis, thigh, lower leg, upper arm, and rib), Osteosarcoma (Osteosarcoma usually develops at the edges of the long bones, in the “metaphysis” esp. the knee)
Pain from a fracture - abuse?
Slipped Capital Femoral Epiphysis
- obese, adolescent, black/latino
Something above or below?
146
Q

HEADSS

A
Home environment - smokers, smoke alarms
Education - bullying
Activities - helmets
Drugs - prescription drugs
Sexuality/sex 
Suicide
147
Q

Kawasaki’s CRASH

A
Conjunctivitis
Rash
Adenopathy
Strawberry tongue
Hands and feet swollen/rash/peeling
if you CRASH call the CAA --> coronary artery aneurysm
treat with ASA and IVIG kawASAkI
148
Q

Violent/aggressive patient? Think of other causes

DIM FACES

A

Drugs/dehydration
Infection
Metabolic/medication change

Failure
Anemia/alcohol
Cardiac/stroke/bleed
Electrolytes
Structural/seizure disorder/psychiatric
149
Q

Which vaccines should you consider for travel?

A

General - Hep A and B, rabies
Country specific - typhoid, meningitis, yellow fever, encephalitis
routine - flu, shingrix, pneumococcal, tetanus, pertussis

150
Q

Anti malarial medications and their pros/cons?

A

Malarone - only for 7 days after exposure daily, expensive
Doxy - cheap but photosensitivity rash. daily dose, need for 30 days after exposure
Mefloquine - frequent side effects, vivid dreams. once weekly
primaquine - only for 7 days after exposure; daily dose need test for G6Pd
chloroquine - cheap, safe, widespread resistance so check first, skin and corneal side effects

151
Q

Rx for traveller’s diarrhea and how to prevent

A
Azithro
oral rehydration solution
loperamide
bismuth subsalicylate
boil, peel; avoid ice cubes, salads, uncooked veggies use bottle water, wash hands often
152
Q

medications for altitude sickness?

A
acetazolamide - carbonic anhydrase inhibitor
dexamethasone 
nifedipine
sildenafil/tadalafil 
prophylactic salmeterol
153
Q

AAA screening

A

men 65-80 one time ultrasound

154
Q

calculate sensitivity
specificity
ppv
npv

A
sens = true pos / true pos + fals neg
spec = true neg / true neg + fals pos 
ppv = true pos / true pos + false pos
npv = true neg / false neg + true neg
155
Q

DM screening

A
  1. Screen every 1-5 y depending on risk
    determined using a calculator, other risk
    factors, or age ≥40 y
  2. HbA1c level is the preferred screening test
    (FPG level or OGTT are acceptable
    alternatives)
  3. HbA1c level of ≥6.5%, FPG level of
    ≥7 mmol/L, or 2-h plasma glucose level
    in an OGTT of ≥11.1 mmol/L are diagnostic
156
Q

DLP screening

A
  1. Screen fasting lipid profile in men aged ≥40 y,
    women aged ≥50 y (or postmenopausal), or
    earlier if at increased risk
  2. Screen with Framingham risk assessment
    every 3-5 y if 10-y risk is <5%, or every y
    if 10-y risk is ≥5%, until age 75 y
  3. Framingham risk should be doubled if
    positive family history for premature
    cardiovascular disease
  4. Discuss “cardiovascular age”
157
Q

Colon Ca screening

A
  1. Screen with FIT or FOBT every 1-2 y, or
    flexible sigmoidoscopy every 10 y, if aged
    50-75 y
  2. Consider individualized opportunistic
    screening with FIT or FOBT, flexible
    sigmoidoscopy, or colonoscopy up to age
    85 y
158
Q

HPV recommendations

A
1. Recommended for women up to age 45 y
 even if already sexually active and
 regardless of past infection
2. Recommended for men up to age 26 y
3. Recommended for men who have sex
 with men
159
Q

Immigrant health, four areas - infection

A

HIV, Hep C, TB

mantoux skin test is intradermal

160
Q

TB rx, RIPE

A

Rifampin
Isoniazid
Pyrazinamide
Ethambutol

161
Q

Common parasitic infections? Ss

A

strongyloides

Schistosomiasis

162
Q

Unconscious patient? DONT

A

dextrose
oxygen
Narcan
Thiamine

163
Q

Rx for new psychosis?

A
start med 
1st gen = 2nd gen 
maintain for 18 months
oral = depo 
if depression, treat that too.
164
Q

neuroleptic malignant syndrome FARM and treatment (5) and meds (3)

A

Fever
Autonomic - BP, HR, sweating
Rigidity
Mental status changes
stop the rx; IV NS; cooling blankets; ice packs; DVT prophylaxis
benzos if agitation; bromocriptine; dantrolene for muscle relaxation

165
Q

qSOFA

A

resp rate >22
aMS
SBP < 100

166
Q

STI abx

A

cefixime + azithro or doxy OR

ceftriaxone + doxy if PID

167
Q

sinusitis abx

A

amox or amox-clav

168
Q

bronchitis abx

169
Q

diverticulitis abx

A

none if CT confirmed with no abscess/free air

cipro + flagyl or amox clav

170
Q

sepsis abx

A

ceftriaxone or pip tazo +/- vanco

171
Q

yeast vaginitis rx

A

fluconazole oral

172
Q

pneumonia abx

A

macrolide or fluoroquinolone

173
Q

meningitis abx

A

< 1mo - amp + gent
Group B Streptococci
E. coli
Listeria spp

1-3 mo
amp + cefotaxime
Group B Streptococci
E. coli
Listeria spp
S. pneumoniae
N. meningitidis
H. influenzae
> 3 months
cef + vanco
S. pneumoniae
N. meningitidis
H. influenzae
Adult > 50 years or Immunocompromised (including AIDS), Alcohol abuse, Debilitating illness, Pregnancy
cef + amp + vanco
S. pneumoniae
Listeria monocytogenes
N. meningitidis
Enterobacterales
174
Q

cellulitis abx? MRSA?

A

with pus = ?mrsa = doxy, septra, clinda

w/o = strep = amox clav, cephalexin

175
Q

uti abx

A

nitrofurantoin, septra, cephalexin, fosfomycin

176
Q

pyelo abx

A

ceftriaxone

then cefixime or septra or cipro or amox-clav

177
Q

remember your TOCC hx

A

travel
occupation
contacts
critters

178
Q

4 strategies to minimize statin effects on muscles

A

lower dose
rink lots of fluids
stop interacting medications
alternative day dosing

179
Q

rx for molluscum contagiosum

A

cantharidin topical

180
Q

Describe arterial ulcer

A

Punched out full thickness ulcer with smooth wound edges often on lateral ankle or distal digits

181
Q

Describe karposi sarcoma

A

Red-purple lesions/patches/nodules

182
Q

Describe scabies

A

intensely pruritic and pimple like rash at the wrists and Intertriginous areas

183
Q

describe herpes labialis

A

small grouped blisters/sores on lips that can coalesce into an ulcer that heals with 2-3 weeks

184
Q

describe hand foot and mouth

A

lesions on oral mucosa, tongue, palms, soles and buttocks, grey-white vesiculo pustules

185
Q

describe venous ulcers

A

shallow and superficial ulcers with irregular margins usually on the lower leg and ankle
rf: obesity, immobility, pregnancy, DVT, CHF, varicose veins, conditions with poor musculature

186
Q

describe herpes zoster

A

grouped, unilateral vessicles in dermatomal distribution +/- pain and prodromal symptoms. anti virals with in 48-72 hours
–> do not confuse with eczema herpeticum

187
Q

indications for shingrix vaccine

A

over 50 years, diabetes, heart disease, renal disease, immunosuppresion

188
Q

describe BCC

A

shiny, pearly nodule located on sun exposed area of skin with telangectasia
rx: excision, cryotherapy, topical chemo

189
Q

describe roseola infantum

A

high fever then rash on chest that turns into a pink maculopapular eruption lasting 1-2 days. 6th disease, HHV 6/7, supportive care

190
Q

describe erythema infectiosum

A

macular erythema on face on day 1, then erythematous maculopapular eruption for up to 7 days on proximal extremities, then a reticulated or lacy erythema on extensor extremities up to 3 weeks. parvovirus/5th disease

191
Q

Dx of HTN, work-up

A

AOBP > 135/85 or non-AOBP >140/90
Lipid panel (HDL, LDL, chol, trig, non-HDL)
Na, K, Creat, urinalysis, HbA1C, EKG
CPAP does not decrease morbidity/mortaliity

192
Q

Recommendations for HTN lifestyle

A
reduce salt - 
diet - DASH <1800mg
reduce weight
reduce stress - CBT
increase exercise 30-45 min, 3x/week
reduce alcohol <2.7 drinks/day
193
Q

Fever? keep the ddx broad (11) and don’t forget the most dangerous things

A
sepsis
meningitis
steven's johnston syndrome
PE
GCA
medication
cancer/feb neut
serotonin syndrome
neurleptic malignant syndrome
endocarditis 
rheum -- still's disease
unclear? back to basics, serial exams/ekgs/imaging
194
Q

DLP screening. When should it be fasting?

A

> 40 and <75 consider earlier in at risk groups: South/East asians and First Nations, gestational HTN
Fasting if TG > 4.5
no evidence of mortality benefit of statins if >75

195
Q

DLP management

A

Statin based on Framingham > 10 OR if CHD, CAD, PAD, AAA, DM2, CKD
Optimize renal, HTN, and CVD rx
dietician (med diet), counselling, stop smoking, kinesiology, cardiology, endocrinology (if familial)

196
Q

Vertigo Exam (4)

A

Orthostatic BP
Gait
Hints
Dix-Hallpike

197
Q

Vertigo ddx

A
BPPV 
orthostatic
meniere's
migraine
neuritis
stroke
198
Q

HINTS exam

A

Pt looks at nose; head impulse to one size
continues looking at you = normal (central vertigo)
corrective saccades = abnormal (peripheral vertigo)

199
Q

Acute situatuation - ABC MOVIES and cereal

A
monitors
oxygen
vitals
IV large bore x 2 
ECG
sugars
serial ekgABCs/vitals
200
Q

GI Bleed rx

A

PPI infusion
Erythromycin prior to scope because it increases GI motility
Hgb only if <70
IF varices, give ceftriazone and somatostatin (octeotride)

201
Q

what’s the reversal agent for…
warfarin?
heparin?
dabigatran?

A

vit K
protamine, fresh frozen plasma
praxbind

202
Q

what are the drug classes for anxiety?

A
benzodiazepines
buspirone 
selective serotonin reuptake inhibitors
selective norepinephrine reuptake inhibitors
tricyclic antidepressants
monoamine oxidase inhibitor 
atypical anti-psychotics
203
Q

after SIGECAPS, r/o other conditions by asking about

A
  • excessive worry, panic, PTSD
  • hallucinations?
  • rituals/compulsions that you cannot stop?
  • mania – feel better than good?
  • delusions - do you have special powers? is there a plot against you?
204
Q

Bipolar II, criteria and dx

Bipolar meds

A
  • hypomania, no psychosis
    quetiapine is first line
    Acute: abilify, paliperiodone, risperidone
    Maintenance: quetiapine, lamotrigine, lithium, divalproe
205
Q

1st gen antipsychotics - D2 antagonism, higher risk of neurological side effects

A

haldol

chlorpromazine

206
Q

2nd gen antipsychotics “atypicals” 5HT2A/D2 antagonism

higher risk of metabolic side effects

A
abilify
olanzapine
paliperidone
quetiapine
risperidone
clozapine
207
Q

Tourette syndrome rx

A

Tetrabenazine or Risperidone (dopamine blockers)
Botox - neuromuscular blocade
Habit reversal training

208
Q

PICA rx

A

methylphenidate - CNS stimulant
olanzapine
Treat the complications – radiography for a bezoar

209
Q

Scabies rx

A

permethrin, invermectin

210
Q

Mastitis rx

A

continue BF
NSAIDs, abx
usually staph
warm/cold compresses

211
Q

Melanoma dx

A
Asymmetry
Border irregularity
Color not uniform
Diameter > 6mm
Evolving shape/size/colour
212
Q

Measles description, symptoms

A

purplish red, maculopapular rash starting on the scalp/face/neck and spreading downwards
Four Cs: cough, coryza, photophobia, conjunctivitis, koplik spots on buccal mucosa

213
Q

Alopecia areata

A

circular lesion on scalp/body with no hair, may have characteristic exclamation mark hairs. Focal, non scarring
ddx: trichotillomania
associated with SLE, thyroid, family hx

214
Q

Marjolin ulcer

A

non healing ulcer or growth on the edge of a hronic wound - type of SCC

215
Q

Pityrasis rosea

A

single lesion followed by all over body rash. Oval, dull pink colour involving the trunk and upper arms and legs. Christmas tree distribution

216
Q

Head lice rx

A

permethrin or pyrethrin, repeat in 7-10 days

217
Q

Rx for alopecia

A

stop offending meds
minoxidil
finasteride
hair transplant

218
Q

Rosacea

A

superficial, dilated blood vessels and papules/pustules/swelling on the face

219
Q

stevens-johnson syndrome

A
painful red or purplish rash involving the skin and mucous membranes
stop med/avoid drug class in future
220
Q

Koebner’s phenomenon

A

formation of psoriasis in areas of trauma

221
Q

Rx for post herpetic neuralgia

A
topical capsaicin
NSAIDs
gabapentin
TCAs
glucocorticoids
paracetamol
topical lidocaine
222
Q

investigations to order for dx osteoporsis

A
hgb
TSH
ionized Ca
Alk Phos
Creatinine
SPEP if vertebral #
Vit D --> after 3 months of Vit D supplementation
223
Q

Osteoporosis rx - 3 options + 2 for high risk

When can you stop it?

A

Bisphosphonates

  • jaw osteonecrosis
  • esophageal ulcers
  • atypical fractures

Raloxifene –> selective estrogen receptor modulator
- VTE/PE

HRT

for high risk
Teriparatide - PTH analogy
- hypercalciuria, hypercalcemia - usually transient
- angioedema

Denosumab - monoclonal ab vs. RANKL

  • joint muscle pain
  • jaw osteo
  • CI in pregnancy

Stop after 3-5 years if low risk take holiday

224
Q

HIV med complications

A

DLP
hyperglycemia
BMD loss
Renal disease

225
Q

HIV meds to know

A

Truvada for PREP
Zidovudine - peripartum and neonate
PEP - truvada, raltegravir

226
Q

Opioid guidelines

A

maxmimum 50mg MED start
taper down to 90mg MED if they are above that
only use if no other options - TCAs, nabilone, NSAIDs, CBT, exercise, physio

227
Q

ADL - DEATH

A
Dressing
Eating
Ambulating
Toileting
Hygiene
228
Q

IADLS - SHAFT

A
Shopping
Housework
Accounting
Food and meds
Telephone, transportation
229
Q

Frail elderly checklist

A
vision
hearing 
skin - ulcers
mobility
cognition
pain
medications
rx monitoring
abuse
driving
incontinence
falls
teeth
230
Q

Post phlebitic syndrom

A

horse chestnut seed extract for venoconstriction

231
Q

DVT w/up and treatment

A

if low Pre test prob/Wells < 2 – D-dimer. if +ve, proximal leg compression ultrasound or CTPA if you suspect PE
if high Pre test prob/Wells >2 – ultrasound. if -ve, d dimer
if suspicion is high and testing will be delayed, treat first!
1 dose of oral Xa inhibitor or 1 dose of LMWH/IV heparin

232
Q

Bell’s palsy, dx and treatment

A

Stroke spares forehead
lubricant eye drops
steroids eg prednisone
add antivirals if severe

233
Q

Ramsay Hunt Triad

A

aka Herpes Zoster reactivation

  • ipsilateral facial paralysis
  • ear pain
  • vesicles in the auditory canal
234
Q

Ischemic vs hemorrhagic findings

A

ischemic 80% - early, focal

Hemorrhagic 20% - late focal deficits, compression effects (headache, vomiting)

235
Q

Acute stroke management

A
  1. ABCs, MOVIEs
  2. Stroke scale
  3. Labs: Na, K, Hgb, INR, aPTT, creatinine, troponin, glucose
  4. Head CT non contrast –> if 4.5-6 hours adter symptoms add CT angiogram from vertex to arch OR CT perfusion. If 6-24 hours after symptoms add CT angiogram AND CT perfusion
  5. Treat fever and severe hypertension >220/120
236
Q

Acute stroke treatment options

A
  1. Bust clot - alteplase, tenecteplase
    - treatment within 3-4.5 hours, >18 yo
  2. Yank clot 6-24 hrs- endovascular thrombectomy, aspiration/vacuum/removal stent
    - acute ischemic stroke, anterior circulation, large vessel
237
Q

Stroke w/up (cause - 4)

A
  • Holter monitor
  • Carotid doppler/duplex ultrasound
  • manage A fib if found
  • ECHO
238
Q

Stroke prevention ABCDEs

A
A Fib
BP
CVD
DM2
Ethanol
239
Q

cephalosporins

A

1st gen - cephalexin (keflex) PO, cefazolin (ancef) IM/IV
2nd gen - cefuroxime IM/IV
3rd gen - cefixime PO, ceftriaxone IV
no activity against LAME = listeria, atypicals, MRSA, enterococci
Good against gram +ves, increasing gram -ves as you progress at expense of gram +

240
Q

Macule

A

flat lesion less than 1 cm, without elevation or depression

241
Q

Patch

A

flat lesion greater than 1 cm, without elevation or depression

242
Q

Plaque

A

flat, elevated lesion, usually greater than 1 cm

243
Q

Papule

A

elevated, solid lesion less than 1 cm

244
Q

Nodule

A

elevated, solid lesion greater than 1 cm

245
Q

Vesicle

A

elevated, fluid-filled lesion, usually less than 1 cm

246
Q

Pustule

A

elevated, pus-filled lesion, usually less than 1 cm

247
Q

3 indications for using cannabinoids ? which product for which indications?

A

Muscle spasm 2/2 SCI, MS - nabiximol
Neuropathic pain refractory to standard therapies- nabilone or nabiximol
N/V from chemo - nabilone

248
Q

4-6-8 rule for driving after cannabinoid

A

don’t drive less than 4 hours
less than 6 hours for oral ingestions
and less than 8 if you experience euphoria

249
Q

managing opioid withdrawal

A

treat type of pain - neuropathic vs other
clonidine if BP >150/90, HR >50; for nausea/vomiting/sweating/tremor
diarrhea - start loperamide, stop stool softeners
abdo cramping - buscopan (hyoscine), pinaverium
muscle cramping - quinine
sweating - oxybutynin (anti-cholinergic)

250
Q

what are the domains for major neurocognitive disorder? 5 W’s

A

WHO you are, WHAT you say, WHERE you go, WHY you do things, WHEN you remember

learning and memory
complex attention
executive function
language,
perceptual motor
social cognition
Alzheimer's is any one PLUS memory affected 
mild = 1 domain
major = 2 or more plus impair function/decline
251
Q

how to assess competency?

A

explain your treatment options? WHAT
reasoning? WHY
choice? WHAT ELSE

252
Q

investigations for MNCI d/o?

A

TSH Hgb/ferritin B12 Na, Ca, glucose

if less than 2 years ago/looking for something else

253
Q

Management for MNCI

A
  • cholinesterase inhibitors –> donepezil
  • glutamatergic –> memantine
    exercise
    cognitive stimulation
    avoid antipsychotics
254
Q

Parkinson’s symptoms TRAP SSSS

A
Tremor
Rigidity
Akinesia
Postural instability
Shaky
Stiff
Slow
Steps
255
Q

DDx for Parkinson’s

A

Essential - improves with EtOH?
Antipsychotic? - extrapyrimidal side effects
Parkinson’s - at rest?

falls, slow vertical gaze - progressive supranuclear palsy
no L-dopa improvement, symmetric - MSA

256
Q

Parkinson treatment, things to avoid (5), treat other features

A

first line - carbidopa/levidopa
30% don’t respond, 20% who do have another dx
second line -
1. Dopamine agonists, non ergot - pramipexole, warn about impulse control d/o i.e. gambling, binge eating
avoid ergot derived i.e. bromocriptine

  1. MAO inhibitors - selegiline, rasagiline

Avoid… anti psychotics (except quetiapine, clozapine); abruptly stopping meds; amantadine early on; genetic testing/PET scanning; vit E/coenzyme q10

constipation, drooling, ED, hypotension

257
Q

Rx for postural hypotension

A

quit - large meals, EtOH, warmth, medications
start - compression stockings, increase salt intake, bed tilt, elastic stockings, midodrine (alpha 1 agonist) or corticosteroid

258
Q

headache – serious causes to r/o

A
GCA
SAH
Stroke
meningitis
Tumour
259
Q

red flags for headache SNOOP

A
systemic features
neuro symptoms
older pt/onset
other red flags 
pattern change
260
Q

ottawa SAH tool

r/o tool for 4 criteria, C/I (5),

A
alert patients
>15 years old
new severe atraumatic headache
maximum intensity in 1 hr
do NOT USE if: neuro deficits, prior aneurysm, prior SAH, known brain tumour, chronic recurrent headache
require investigations if: 
1. neck pain or stiffness
2. => 40 yo
3. witnessed LOC
4. peak during exertion
5. thunderclap headache -- immediate peak intensity
6. limited neck flexion on exam
261
Q

Migraine Rx - acute, chronic, lifestyle management

A

Migraine medications: A) Acute migraine medications. B) Prophylactic migraine medications.
A)
Type ACUTE MEdications
First line Ibuprofen 400 mg, ASA 1000 mg, naproxen sodium 500-550 mg, acetaminophen 1000 mg
Second line Triptans (oral wafer/nasal spray/IM)

Antiemetics: domperidone 10 mg or metoclopramide 10 mg for nausea
Third line Naproxen sodium 500-550 mg in combination with a triptan
Fourth line Fixed-dose combination analgesics (with codeine if necessary; not recommended for routine use)

also consider – sphenopalatine ganglion block
B)
Prophylactic Medications
First line
• propranolol/metoprolol - avoid in asthma
• ami/nottriptyline - Consider if patient has depression,
anxiety, insomnia, or tension-type
headache

Second line
• topiramate 
• candesartan 
• gabapentin 
Few drug interactions
Botox for chronic 

Lifestyle management:
- decrease caffeine, improve sleep, increase exercise, relaxation, CBT

262
Q

ABCDs of fractures

A
Antibiotics? Analgesia
Brace/splint
Consult ortho? Compartment syndrome?
Stick them with Tetanus
-- Tetanus immunoglobulin if dirty wound/not vaccinated or immunocompromised
263
Q

Fractures of abuse (8)

A
multiple
multiple, many healing 
non ambulatory
femur <12-18 months
humerus <18 months
skull
metaphyseal - bucket handle
rib posterior
264
Q

Salter-Harris

A
Slipped Type I
Above Type II
Lower Type III
Through or transverse Type IV
Rammed Type V
265
Q

causes of Afib (6)

A
ischemic
valvular
alcohol
hyperthyroid
HTN
pulmonary - COPD, pulmonary embolism
266
Q

Afib rx, anticoagulate?

A

convert IF unstable, symptomatic/poor QOL, cardiomyopathy
otherwise bblockers or ccb

if unstable/low clot risk – anticoagulate now and cardiovert now

if hi clot risk, OAC for 3 weeks or TEE

rate control if old, longstanding, asymptomatic, other disease

rhythm control if young, new dx, symptomatic, no other disease

267
Q

CHADS2

A
CHF
HTN
Age >65
DM2
Stroke/TIA/embolism
268
Q

Bleed risk management HAS BLED

A

HTN SBP>160
Abnormal liver/kidney fxn
Stroke

Bleeding
Labile INR
Elderly >65
Drugs/EtOH

269
Q

Which anticoagulant for – CKD? pregnancy? cancer? valvular afib?

A

UFH - renal disease CKD
LMWH - pregnant, cancer
Warfarin.- valvular

270
Q

Systemic Exertional Intolerance

A
Functional impairment > 6 months
Non exertional new fatigue 
Post exertion malaise
Rest does not refresh
At least 1 of cognitive impairment or orthostatic intolerance
271
Q

Panic attack symptoms

A
Students Fear CCCs
Sweating
Trembling
Unsteadiness
Dyspnea
Excessive sweating
Nervousness
Tachycardia/tachypnea
Sensation weird
Fear of death
Choking
Chills
Chest pain
272
Q

Lupus

MD SOAP BRAIN

A

Mallar rash
Discoid Rash
Serositis - pericarditis, pleuritis
Oral ulcers
ANA +ve
Photosensitivity
Blood - thrombocytopenia, hemolytic anemia
Renal - GN
Arthritis
Immune - anti phospholipid, anti dsDNA, anti rho, C3/C4, anti smith
Neurological disorders, including psychiatric disorders - psychosis, seizures

273
Q

Thyroid Storm

A
Altered mental status
Tachy
Fever 
Dyspnea/orthopnea
Chest pain
Hypertension
Profuse sweating
274
Q

IBD systemic features APIESAC

A
Apthous ulcers
Primary sclerosis cholangitis, pyoderma gangrenous
Iritis/uveitis
Erythema nodosum
Sacroilitis 
Arthritis 
Clubbing
275
Q

Pro-thrombotic states

A
Protein c and s deficiency - like renal disease because you lose protein 
Nephrotic syndrome 
Hormonal meds
Pregnancy
Cancer
IBD, CHF
Factor V leiden
Anti phospholipid syndrome
276
Q

Upper Arm DVT

A

CONSTANS score — upper arm DVT
1 point each, -1 if other dx more likely

Unilateral pain
Edema
Hx of central line/pacemaker placement “trauma”

277
Q

Risk factors for AOM

A

maternal smoking
pacifiers
day care
bottle feeding

278
Q

Ear bugs? 5

A
strep pneumo
moraxella catarrhalis
hemophilus influenza
staph aureus
group a strep
279
Q

rx for AOM? if failure?

A

amoxicillin - high is BID, low if TID 40-90mg/kg
if failure? clavulin or ceftriaxone
tylenol 10mg/kg
advil 15 mg/kg

280
Q

what are the indications for ear ventilation tubes?

A
>6/yr or 4 per 6 months
or
Chronic OM with effusion, "glue ear" > 3 months with hearing loss
or
retracted TM
281
Q

CATCH2 for pediatric head injury, AVPU?

A

Minor head injury and any one of the following
GCS <15; Awake - Verbal - Responds to Pain - Unresponsive
worsening headache
Suspected open/depressed skull fracture
irritability
Sign of basal skull fracture
Large, boggy scalp hematoma
Dangerous mechanism
>4 episodes of vomiting (common pain response in kiddos)

282
Q

types of SHOCK

A
septic
hypovolemic
obstructive
cardiac
AnaphylacticK
283
Q

Burns - formulas? special sites?

A

> 10% resuscitate - Brooke formula: 2mls x body surface areas burned (BSAB) x weight
Rule of 9s
adult - legs 18% x 2, arms 9% x 2, head 9%, chest 18%/back 18%, groin 1%
infant - legs 14% x 2, arms 9% x 2, head 18%, chest 18%/back 18%, groin 1%
special sites: face, hand, foot, genital, perineum, joint

284
Q

Frostbite rx - 5 steps

A
rapid rewarming - water bath
possible thombolysis and heparin and iloprost
sterile wound care
consult surgery
tetanus
285
Q

MAPLE hx

A
medications
allergies
past medical history
last meal
events leading up to
286
Q

GCS

A

4 - eye response; 4 spontaneous - 3 sound - 2 pressure
5 - verbal; 5 oriented - 4 confused - 3 words - 2 sounds
6 - motor; 6 obeys - 5 localizes pain - 4 withdraws from pain 3 - flexion to pain 2 - extension to pain 1 - no movement

287
Q

ATLS updates

A

give blood early! after 1L crystalloids
smaller chest tubes 28-32 french
needle decompression 4th/5th intercostal space laterally
use massive transfusion protocols
tranexamic acid 1g for 10 min and 1g for 8 hours
e-fast for pneumothorax

288
Q

Trauma in pregnancy

A
Mom then fetus
Chest tube 1-2 spaces higher
NG tube
Left lateral decubitus 
No vag exam until previa ruled out
Anti D immune globulin if Rh negative
Tetanus vaccine is safe
Document domestic violence