CCFP Flashcards
Secondary causes of HTN ABCDES
Atherosclerotic, coarctation of the aorta
Bad kidneys - Renal parenchymal disease
Catecholamines
Drug, Diet
Endrocrine (Hypothyroid, aldosterone, Cushing), EtOH
Fibromuscular dysplasia
sleep apnea, stress
Medications that raise BP
Steroids, NSAIDs, amphetamines, many psychiatric meds - SSRIs, SNRIs, carbamazepine, estrogen/progesterone/androgens, sympathomimetic (decongestant), licorice
What does a lipid panel include
Chol, HDL, LDL, non-HDL, TG
Risks of HCTZ?
Skin cancer non melanoma, possible 4x risk after 3 years
Avoid long acting Chlorthalidone, indapamine b/c of DM2, renal and electrolyte abnormalities
Lifestyle interventions for HTN
Lower salt, exercise, weight loss, reduce alcohol, DASH diet, relaxation –> CBT
HTN Meds to avoid in HTN
alpha blocker alone
Beta blockers if > 60
ACE if black
Risk factors for uterine perforation
breast feeding grand multiparity history of csection nulliparity inexperienced HCP uterine abnormalities postpartum state in breastfeeding women
when should you start various kinds of birth control when removing an IUD?
POP 2 days before, ocp/depo etc 7 days before
contraindications to IUD
pelvic TB, pregnancy, uterine/cervical malignancy, puerperal sepsis, post-septic abortion, unexplained vaginal bleeding, gestational throphoblastic disease with persistently elevated betahcg (decreasing beta is relative), distorted uterine cavity, current PID/gonochlam
mirena: breast cancer, hx of ischemic heart disease, antiphospholipid antibodies, migraine with aura, severe cirrhosis
copper: severe thrombocytopenia
What does SAD PERSONS stand for
Male sex Age <19, >45 Depression Previous attempt Excess EtOH/substances Loss of rational thinking Social supports lackings organized plan no spouse Sickness
What else should you r/o with depression
mania, anxiety (does worry get in the way of your life?), OCD (thoughts/rituals you cannot stop), delusions (special powers/plot against you), hallucinations
when to consider bipolar?
age <25 >= 5 episodes family hx hypersomnia hyperphagia/increased weight lability of mood/irritability
first line meds/treatments for PTSD
fluoxetine, paroxetine, sertraline
venlafaxine
CBT
group therapy
first line meds/treatments for OCD
escitalopram, fluoxetine, paroxetine, sertraline
CBT
exposure with response prevention
mimics for depression
hypothyroid, adrenal insufficiency, grief/adjustment disorder, drug use, bipolar, tumor, delirium
SPIKES
setting up perception invitation knowledge emotion strategy, also SAFETY.
SNOPQRST
Safety Next visit Offer Prevention Quit Refer Start Teach
Osteoporosis risk factors
Age > 65 Sex - female post menopausal Alcohol Chronic disease i.e. RA Chronic steroid use Previous fragility fracture Malabsorption/eating disorder Hypogonadism low body weight <60kg for <50yo, fragility #, prolonged use of CS, high risk meds, hypogonadism/premature menopause, malabsorption syndrome, primary hyperparathyroidism, other d/o associated with rapid bone loss and/or fracture
Chronic bronchitis criteria
Chronic bronchitis is defined as a cough with sputum expectoration for at least 3 consecutive months for at least
2 consecutive years
Thalassemia regions
Southeast Asia Africa South America Middle East Carribbean Mediterranean
Broad differential? VINDICATE
Vascular Infectious Neoplasm Drugs Idiopathic Congenital Autoimmune Trauma Endocrine
COPDE
cough, purulence, dyspnea, CRP >40
Early warning score i.e. NEWS2
Common ear bugs? what about (complicated) COPD? what about PNA?
Hemophilus influenza
Moraxella catarrhalis
Strep pneumonia
(same as for COPD; if complicated add on klebsiella, gram negatives, pseudomonas; same for pneumonia, if comorbid add on staph aureus, if not comorbid, atypicals - mycoplasma and chlamydophila)
COPD Adjunctive Treatment
Flu/pneumonia shots Action plan to reduce hospital use CPAP? Daily macrolide (azithro, erythro) to decrease exacerbations Exercise Quit smoking Pulmonary rehab Puffers - SABA, LAMA, Respiratory therapy Teach inhaler technique
SNOPQRST
Safety Next visit Offer Prevent Quit Refer Start Teach
Criteria for dx asthma in <6 yo
Wheeze that reverses
it’s not something else
What are the criteria for asthma dx
FEV1/FVC pre <0.75
FEV1 post increases 12%
vs. COPD; post <0.70 and not reversible
Asthma rx pyramid for pre-schoolers
mild - saba
mod - saba + ICS
severe - saba, ICS, oral steroids
Asthma rx pyramid for 6+
mild - LABA + ICS (symbicort) as needed
mod - saba + daily ICS OR as-needed ICS/LABA- formeterol (LTRA as alternative)
mod + - low dose ICS/LABA plus as needed SABA, OR low dose ICS/LABA plus as needed ICS/LABA
mod ++ - med dose ICS/LABA plus as needed SABA, OR low dose ICS/LABA plus as needed ICS/LABA
next! refer for phenotypic investigations + add-on treatment
severe - saba, ICS, LABA, LAMA, LTA, theophylline
**if uncontrolled, saba +/- ICS/LABA on demand
Good asthma control
<1 night time symptoms
<4 use of prn puffer
no activity restrictions, no missed school/work
Risk factors for asthma exacerbations
ICS not prescribed, poor adherence,
GERD, obesity, previous ICU/intubation for asthma, irritants - smoking/allergen/pollution, allergic rhinitis, food allergy, depression, anxiety, pregnancy, FEV1<60%
NSAIDs, betablockers
Frequency of asthma f/up? in pregnancy?
1-3 months after starting treatment then 3-12 months after that; in pregnancy, every 4-6 weeks
Testicular cancer BALLS CFP
Bhcg
Alpha fetoprotein
Lop it off
Cryptorchidism
Family hx
Personal hx
Lung cancer screening
age 55-74, 30pk/yr smoke, current or quit <15 years ago. CT annually up to 3 times
Cervical cancer screening
25-69 every 3 years unless - never sexually active - weakened immune system - symptoms of cervical ca - previous abnormal results - those who do not have a cervix - immunosuppressed CAN stop at age 70 if 3 normal in last 10 years
Skin cancer risk factors
Nevi > 15 older white skin, red hair hx of skin cancer, sun exposure family history multiple sunburns actinic skin damage --> refer if hi risk, skin checks q6 months
skin cancer ABCDE
Asymmetry
Border - gradual, indistinct vs. sharp cut off
Colour variation
Different dermatoscopic structures - pigment network, homogeneous areas, streaks, dots, globules
Evolving size/shape/colour
Colorectal screening
50-74
flex sig q10 or FIT q2 years
Breast Ca screening (5)
1. Screen with mammography every 2-3 y if aged 50-74 y 2. Do not routinely screen those aged 40-49 y 3. Do not screen with magnetic resonance imaging 4. Do not perform clinical breast examination 5. Advise patients not to perform self breast examination
Management for Feb neut?
early antibiotic treatment, look for source and consider fungal
stabilize and assess
severe sepsis –> ICU
H Pylori quad therapy
PPI
Bismuth salicylate
Metronidazole
Tetracycline
what is Barrett’s esophagus? prevention,
columnar cells replace squamous;
prevention - high dose PPI and ASA
long term risks of PPIs
fractures
b12 deficiency
dementia
c diff
gallstone RF
female
forty
fat
fertile – on OCP
pancreatitis RF
septra, flagyl HCTZ, ACE progesterone atorva estrogen gall stones ETOH
I = idiopathic (also known as the fancy medical way of saying, “I dunno.”)
G = gallstones (one of the two most common causes of acute pancreatitis)
E = EtOH (the other common cause of acute pancreatitis)
T = trauma
S = steroids
M = mumps/malignancy
A = autoimmune
S = scorpion stings … though this probably shouldn’t be your first guess for why your patient has pancreatitis
H = hypertriglyceridemia/hypercalcemia
E = (post) ERCP
D = drugs. Most commonly: thiazides, sulfa drugs, and didanosine
admission criteria - UN
uncontrolled symptoms
unstable
undiagnosed pain esp in elderly, immunocompromised
undischargable i.e. poor social support
fluid for peds
20 mg/kg maintenance 4/2/1 - 4 ml/kg for the first 10kg - 2ml/kg for 11-20 - 1 ml/kg 20+
measures to monitor for severe dehydration
weight gfr/creatinine na, k glucose urea
c diff risks
abx esp fluoroquinolones previous infxn recent hospitalization older age immunocompromised
c diff pitfalls, who not to test? and rx
not just hospital acquired
don’t test kids <1
rx: vanco po
Crohn’s medications
start with sulfasalazine if mild, otherwise steroids
thiopurines - not for induction
methotrexate
biologics
celiac testing
TTG/IGA plus total IGA +/- upper endoscopy, small intestine biopsy
OR endomysial IGA (but this is +++expensive)
if IGa deficiency, DGP IgA and IgG
IBS rx
r/o celiac psyllium probiotics, peppermint oil FODMAP CBT colonoscopy if >50/alarm features antispasmodics anti depressants eluxadoline - diarrhea predominant lubiprostone - constipation predominant linaclotide - "
Restless legs rx, rx and non rx
non rx iron, mg stretch calves avoid caffeine massage, heat exercise rx non ergot dopamine agonists - pramipexole, ropinirole alpha-2-delta calcium channel ligand - gabapentin, pregabalin
restless legs dx
sensation or urge to move legs
worse with rest, improves with activity
worse in evening
restless legs risk factors
▪ Highly heritable – often family history (↑young age onset)
▪ Pregnancy
▪ Low ferritin (can be with or without anemia)
▪ Medication induced –Caffeine, Alcohol, Antihistamines, Dopamine agonists, Antidepressants, Lithium
▪ Associated diseases –ADHD, Parkinsons disease, Anxiety, Depression, Anemia with iron deficiency, Obesity, Diabetes, Renal disease
Dx hyperthyroid
Radioactive iodine uptake (NOT for ladies who are preggers), unless 100% sure it’s graves
B block for symptoms
nodule? >1cm = FNA
don’t treat subclinical hyperthyroid
suspicious features of thyroid nodule
> 1cm
Taller than wide
irregular surface
calcifications within
Treating thyroid storm - BLOCK x 5
Beta blocker - propanalol
Block synthesis - methimazole, propylthiouracil
Block conversion T4 –> T3 propylthiouracil
Block release - iodine
Block Bile - cholestyramine
Treating graves, 3 Rs
Rx - First 4 Blocks - beta blocker, block synthesis, block conversion, block release
Radiation
Removal
Meds to stop when sick/at risk of dehydration
SADMANS
SFU ACE Diuretics Metformin ARBs NSAIDs SGLT2
Three reasons people develop DKA
- acute illness,
- drugs: clozapine, terbutaline, cocaine, lithium, SGLT2
- non compliance
Diabetes complications, micro/macro
micro - retinopathy, neuropathy, nephropathy
macro - atherosclerosis –> CVD, CVA, PVD
Biguanide
metformin
SGLT2 inhibitors
flozins - empagliflozin, canagliflozin
GLP-1R agonists
glutide - semaglutide, liraglutide
DPP4 inhibitors
saxagliptin
sulfonylureas
gliclazide, glyburide
driving 2-4-6 rule
test BS every 2 hours - if hypoglycemia unawareness
test BS every 4 hours - treat and wait 40 min
keep 6 lifesaver candies in the car for lows
risk factors for hep B
IVDU sex with partner with hep B child born to mother with hep B tattoos blood transfusions living in crowded conditions unimmunized multiple sexual partners MSM occupation prison hx of STIs breastfeeding OK if skin is in intact
medications to treat chronic gout
allopurinol
prboenecid
febuxostat
how to test for Hep C?
anti - HCV (unless known previous hep C)
HCV RNA serum
genotype and subtype
–> spontaneous clearance in 20-45%
how to test for Hep b?
HbsAg Anti HBS Anti HBC --> IgM, total if +ve HBeAg HBV DNA Anti HBe
Mgmt and monitoring hep B
Refer to hepatology Anti virals if severe, cirrhosis U/S q6-12 months for HCC scope every 1-3 years for varices Cirrhosis/fibrosis - fibroscan, Child Pugh
The current approved treatments for HBV are interferon injections (standard or pegylated interferon) or oral nucleoside/nucleotide analogues (entecavir, lamivudine, tenofovir). As oral antivirals are excreted by the kidney, dose adjustments are required in renal failure.
Not all patients with chronic HBV infection need to be treated. The decision to treat depends on several factors including age, serial ALT and HBV DNA levels, and severity of liver disease. Co-infection, particularly with HIV and HCV, needs to be considered when deciding on which medications to use.
HBsAg (surface antigen) indicates infection. Persistence of HBsAg for 6 months or more indicates chronic infection. However, up to 50% of people with extended chronic infection will eventually clear HBsAg. By contrast, those with resolving acute HBV will clear HBsAg several months after initial infection.
Anti-HBs (surface antibody) is a protective antibody produced with recovery from infection or in response to immunization. Over time, titre may decline to undetectable levels. Note: There is a gap of several weeks to months between the disappearance of HBsAg and the appearance of anti-HBs; during this period, anti-HBc total is detectable as a marker of HBV infection.
Anti-HBc IgM (core antibody - IgM) appears early in acute HBV infection and persists for about 6 months. It may also be seen in chronic infection during flares of activity, so clinical/epidemiological correlation is required for interpretation.
Anti-HBc total (total core antibody - IgM and IgG) is a marker of past exposure or current infection. IgG usually persists for life. In low prevalence populations, a finding of isolated anti-HBc may signify a false positive result.
HBeAg (e-antigen) is a marker of viral replication; its presence indicates high infectivity. Implications for liver injury vary with stage of infection (see Module 7 for significance).
Anti-HBe (e-antibody) appears with recovery from acute infection. In chronic infection, the presence of anti-HBe is generally a marker of reduced viral replication, indicating a less infectious state. The implications for liver injury vary with stage of infection (see Module 7 for significance)
Mgmt and monitoring hep C
Refer to hepatology Treat: interferon or new regimens U/S q6-12 months for HCC scope every 1-3 years for varices Cirrhosis/fibrosis - fibroscan, Child Pugh
NAFL vs NASH, and treatment?
NASH = NAFL + hepatitis (increased ALT/AST)
= signs of inflammation
NAFL - no inflammation or fibrosis = STEATOSIS
Rx - stop EtOh, weight loss, lipid control, DM control, if fibrosis >2 consider vitamin E
Ankylosing Spondylitis features
low back/SI pain stiffness
worse w/ rest, improves w/ movement
worse at night
30 minutes + for morning stiffness to recede
weight loss, fatigue
chest pain – from insertion into sternum
enthesis i.e. plantar fasciitis, achilles tendonitis
anemia
uveitis
aortitis
heart block
what is Schober’s test
find L5, measure 10cm above and 5cm below = 15cm
if <20cm when bending forward = restrictive
investigations for Ankylosing Spondylitis
ESR, CRP
HLA b27
spine xray or MRI for early changes
mgmt AS
nsaids steroids for flares - oral, IM, into joint anti TNF monoclonal antibody physio no smoking bisphosphonates if osteoporosis
Back pain physical exam
ALWAYS: numbness, weakness, pedal pulses, neuro exam
Lower limb Myotomes memory aid
L1/L2 buckle my shoe - hip flexion
L3/L4 kick the door - knee extension
C5/6 pick up sticks - biceps
C7/8 - shut the gates
Dermatomes memory aid
L4 down on all 4s - knees to first toe
L5 middle toes
S1 pinky toe
joint red flags
hot boggy AM stiffness PM night pain extra-articular symptoms? think genital infection, vasculitis, systemic illness
ADHD medication classes
Stimulants - methylphenidate (concerta, biphentin, ritalin), amphetamine (vyvanse, adderall)
SNRI - Atomoxetine
Alpha receptor antagonist - Guanfacine
ADHD meds – Consider DATER before changing medication to 2nd/3rd line
Dosage
All - trial of all 1st line
Time - enough time given for response/side effects to resolve
Examine - what are the targets? what standardized measures
Review - comorbidity, lifestyle
ADHD non rx management
patient and family education
psychological treatment
education accommodations
driving – restrict cell phone use, recommend manual transmission
ODD vs conduct disorder
ODD children do not show aggressions towards peope/animals; destroy property; pattern of theft and deceit
Bedwetting management
make toilet accessible pee before bed including in morning cleanup training pants avoid fluids/caffeine/chocolate before bed do not punish, introduced diapers enuresis alarms desmopressin for short-term
Well baby care counselling HONEY ‘n’ guns
No honey Choking hazards Vitamin D Breast/fed is best button battery ingestion No guns Carbon monoxide detector Cover electric plugs Hot water heater car seats Storage and poison control
Milestones
2 months - two = coo, smiles 4 months - hold object - four fingers and hold head, laughs 6 - sit at six with support 8 - pincer grasp 1 year - walk, 1 word; responds to name 15 months- stranger danger 2 - run, 2 word sentence, 1-2 step directions 3 - 3 step instructions 5 - adult like sentences
Breastfeeding guideline
> =2 years
400IU daily vitamin D
circumcision, pros and cons
pros
- decreased infection - phimosis (rx with topical steroids), uti, hpv, cancer
cons
- pain, stenosis, damage to surrounding tissues
undescended testes cause
torsion trauma tumor inguinal hernia infertility
torsion TWIST score
absent cremasteric reflex nausea/vomiting testicle swelling testicle hard high riding testicle
4 nots for nuts
refer if
- not descended at 6 months
- not there anymore
- not there
- not positioned properly
AIDS defining illnesses
Kaposi’s sarcoma Pneumocystis jirovecii pneumonia (PCP) Cytomegalovirus Candidiasis (oesophageal or bronchial) Lymphomas (excluding Hodgkins) Tuberculosis
when to give Tdap to pregnant ladies
> 13, ideally 27-32 weeks
which vaccines can you NOT give if someone is breastfeeding?
BCG, yellow fever, japanese encephalitis
which vaccines do you need to delay if someone is ill?
lots of congestion – don’t give nasal flu
acute GI – defer cholera, dukoral
mod to severe – defer rotavirus
who gets flu vaccine?
kids > 6 months
everyone, but esp adults with neurologic/developmental conditions, work in health care, work with poultry
> 65 yo
vaccines in person with egg allergy
flu, MMR ok
do not give yellow fever, tick-borne encephalitis or rabies
make vaccine less painful?
breastfeed skin to skin most painful last sugar tylenol after, otherwise blunts immune response topical anesthetic don't aspirate
what are the two shingles vaccines?
what kind, how often, how $$$, how effective?
zostavax = live attenuated
1 dose, $170, >60 yo
shingrix = non live recombivant, adjuvanted
2 doses, 2(-6) months apart
2x as effective, 2x as much
>50yo
HPV vaccine - # of doses, #-valent
2 doses, 9-valent, all genders
who do you give meningitis C to? (5)
all travellers to Hajj meningitis belt of africa military recruits asplenia and sickle cell all canada adolescents
vaccines for the immunocompromised? keep 3 things in mind
- no polio, varicella, MMR
- close contacts: avoid giving or avoid contact for 2 weeks
- consult public health/ID
vaccines contra-indicated in…
pregnancy? TB? severe asthma/medical wheeze in last 7 days? uncorrected GI malformation? HIV?
pregnancy: live vaccines (polio, varicella, MMR), BCG –> flu ok
active TB: MMR, varicella, herpes zoster, BCG
asthma: live attenuated influenza
GI malformation: rotavirus (risk of intussception)
HIV: all live vaccines
Common cold treatment? (5)
NSAIDs, honey (> 1 year), intranasal ipratropium, nasal decongestant/anti-histamine (>5 year), zinc (not intranasal)
sinusitis risk factors? (4) which bugs?
allergic rhinitis asthma anatomy smoking ear bugs
red flags on sinusitis? (9)
fever > 39 periorbital edema cranial nerve palsies abnormal EOM proptosis vision changes severe headache altered mental status meningeal signs
what are the meningeal tests?
Brudzinski - flexed neck –> flexed extremities
Kernig - with hips flexed cannot extend knee
PODS acute sinusitis
pressure/pain obstruction (nasal) dischage - thick, purulent smell, loss of 2 or more -- persists for >7-10 days
mgmt of acute sinusitis
ct/xr only if red flags amox 500 TID 5-10 days nasal steroids! nasal rinse decongestants analgesics anti-inflammatories mucolytics
why give abx for GAS? what does it NOT prevent?
prevent... AOM rheumatic heart disease sinusitis decrease illness <1 day peritonsillar abscess does NOT prevent glomerulonephritis
mono - how does it spread? symptoms? labs? recommendations re: spleen?
saliva
lymphadenopathy, fatigue, sore throat, splenomegaly, headache
lymphocyte count, serume AST/ALT, monospot
NO abx
no contact sports min. 3 weeks, can last up to 8 weeks
Jaundice beyond two weeks, order:
hemoglobin serum conjugated bili coomb's test group and screen peripheral smear
Symptoms of down syndrome - rule of 1s
1st toe web space
1 palmar crease
1% recurrence
Hip dysplasia risks, ffff
first born feet -- breech family history fluid -- oligo female
full septic workup in kids
CBC
LP
CXR
urine/blood cx
pediatric LIMPSS cannot miss
Legg calves perthe Infectious Malignancy - ewing's sarcoma, osteosarcoma Pain from a fracture - abuse? Slipped capital femoral epiphysis Something else above/below
Classes and examples of constipation meds
Stool softeners – docusate (colace)
Osmotic laxatives – lactulose, Mg salts, sorbitol, PEG
Bowel stimulants (motility agents) – senna, bisacodyl, cascara, prune juice
Bulking agents – psyllium, bran (Metamucil ok)
Bowel lubricants – mineral oil, castor oil, glycerine
Enemas – tap water, saline, sodium phosphate (fleet), oil
Counselling pts for HCV - 4
Discussion of avoidance of alcohol
Monitoring of progression (ALT/AST, annual AFP)
Counsel on risk of transmission
Screening sexual partners
HCV treatments
Pegylated Interferon Ribavirin Telaprevir Simeprevir Sofosbrevir Harvoni (ledipasvir/sofosbuvir) Holkira Pak (dasabuvir, ombitasvir, paritaprevir, ritonavir) velpatasvir daclatasvir
Mechanism of scaphoid #
Extreme dorsiflexion of the wrist with compressive force to the radial side of the palm
Fall on outstretched hand/arm
Forceful radial deviation and dorsiflexion of wrist
Direct axial compression or hyperextension of the wrist
Physical exam for snuffbox tenderness
Anatomic snuffbox tenderness
Scaphoid tubercle tenderness (extend the patient’s wrist with one hand and apply pressure to the tuberosity at the proximal wrist crease with the opposite hand)
Positive results on the scaphoid compression test (axially/longitudinally compressing a patient’s thumb along the line of the first metacarpal)
Swelling on the dorsoradial side of wrist or over the anatomical snuffbox
Pain in the snuffbox with pronation of the wrist followed by ulnar deviation
Reproduction of pain when patient pinches tips of their thumb and index finger together
Scapholunate disruption on xray
A gap of more than 3 mm between the scaphoid and lunate bones (the Terry Thomas sign)
Scaphoid #, reasons to refer to ortho
open fractures neurovascular compromise displacement of 1 mm or more angulated fractures associated tilt of the lunate bone associated carpal instability evidence of nonunion or displacement during follow up osteonecrosis possible scapholunate dissociation proximal pole fractures oblique fractures unwillingness or inability of the patient to wear a cast for up to 3 months
Why does scaphoid have higher rates of fracture complications?
The scaphoid bone has a tenuous blood supply running from distal to proximal.
RATIONALE: The blood supply comes from the radial artery, feeding the bone on the dorsal surface near the tubercle and scaphoid waist with no direct blood supply to the proximal portion. Thus, there is an increased possibility of nonunion or osteonecrosis with fractures, particularly those of the proximal pole.
Symptoms of hypercalcemia
mental status change confusion poor concentration abdominal groans (e.g. abdominal pain) nausea vomiting anorexia fatigue/lethargy renal colic dehydration polyuria polydipsia constipation bone pain muscle weakness anxiety depression
Rx for hypercalcemia
Hydration with normal saline
Calcitonin
Bisphosphonates
Medications that cause hypercalcemia
ationale: Thiazide diuretics (class or specific drug name of any thiazide acceptable) Lithium Teriparatide Abaloparatide Theophylline Excessive vitamin A Excessive vitamin D
1st blood test to order with dx of hypercalcemia
PTH
Risk factors for neonatal jaundice
Prematurity
Vacuum delivery leading to cephalohematoma
Asian background
Possible dehydration (poor weight gain)
Blood tests in neonatal jaundice
Blood type (ABO and Rh status) of infant Direct antiglobulin test (direct Coomb’s test)
Inherited disorder that cause hyperbilirubinemia
Glucose-6-Phosphate Dehydrogenase Deficiency
Pyruvate Kinase deficiency
Crigler-Najjar syndrome
Hereditary spherocytosis or elliptocytosis
Hemoglobinopathies (sickle cell, thalassemia, Hemoglobin H disease)
Side effects from phototherapy?
Dehydration
Bronze baby syndrome / bronze discolouration of the skin
skin rash
over or under heating of infant / temperature instability
loose stools/diarrhea
electrolyte disturbance (hyponatremia or hypokalemia)
interference with maternal –infant interactions
Ocular damage
Causes of hyperbilirubinemia in babies <24 hrs
hemolytic disease of the newborn (Rh or ABO incompatibility, spherocytosis, G-6PD deficiency, Kell Congential hemolytic states)
Maternal autoimmune hemolytic anemia (e.g. lupus) Type 1 – usually by day 3
Concealed hemorrhage/hematoma
Vitamin K deficiency
Treatment for ABRS
amox, nasal steroids
Classic sites for infantile eczema
Cheeks
Face
Scalp
Extensor surfaces (elbows and knees would count as 2 answers)
1/2 point for Flexor surfaces (flexor surfaces can be found in any age, however, extensor surface involvement is more classic for infantile eczema)
Trunk
Risk factors for infantile eczema
Positive family history of atopy (give ½ point for either “allergy” or “asthma”) Weather changes (cold, dry) Chemical irritants (scented soaps, detergents)
strategies to prevent/treat eczema
Reducing frequency of baths Unscented products (soap, detergents) Minimize soaps Emollients Barrier creams Use luke warm water for baths Avoiding triggers or irritants Exclusive breastfeeding (although some small studies are refuting this) Parental education Topical steroids Antibiotics in severe cases
when to treat asymptomatic BV?
Pregnant women with history of a high-risk pregnancy (previous preterm delivery)
Prior to IUD insertion
Second trimester even if asymptomatic (check this)
Prior to gynecologic surgery/therapeutic abortion/genitourinary instrumentation
Immunocompromised patient
abx to treat trich? what else can be used for BV?
metronidazole
clinda, doxy
Pediatric Limps LIMPSS
Leg Calve Perthes Syndrome - boys, age 4-10, white Infection/inflammation Malignancy - Ewing's Sarcoma (small round blue cells - pelvis, thigh, lower leg, upper arm, and rib), Osteosarcoma (Osteosarcoma usually develops at the edges of the long bones, in the “metaphysis” esp. the knee) Pain from a fracture - abuse? Slipped Capital Femoral Epiphysis - obese, adolescent, black/latino Something above or below?
HEADSS
Home environment - smokers, smoke alarms Education - bullying Activities - helmets Drugs - prescription drugs Sexuality/sex Suicide
Kawasaki’s CRASH
Conjunctivitis Rash Adenopathy Strawberry tongue Hands and feet swollen/rash/peeling if you CRASH call the CAA --> coronary artery aneurysm treat with ASA and IVIG kawASAkI
Violent/aggressive patient? Think of other causes
DIM FACES
Drugs/dehydration
Infection
Metabolic/medication change
Failure Anemia/alcohol Cardiac/stroke/bleed Electrolytes Structural/seizure disorder/psychiatric
Which vaccines should you consider for travel?
General - Hep A and B, rabies
Country specific - typhoid, meningitis, yellow fever, encephalitis
routine - flu, shingrix, pneumococcal, tetanus, pertussis
Anti malarial medications and their pros/cons?
Malarone - only for 7 days after exposure daily, expensive
Doxy - cheap but photosensitivity rash. daily dose, need for 30 days after exposure
Mefloquine - frequent side effects, vivid dreams. once weekly
primaquine - only for 7 days after exposure; daily dose need test for G6Pd
chloroquine - cheap, safe, widespread resistance so check first, skin and corneal side effects
Rx for traveller’s diarrhea and how to prevent
Azithro oral rehydration solution loperamide bismuth subsalicylate boil, peel; avoid ice cubes, salads, uncooked veggies use bottle water, wash hands often
medications for altitude sickness?
acetazolamide - carbonic anhydrase inhibitor dexamethasone nifedipine sildenafil/tadalafil prophylactic salmeterol
AAA screening
men 65-80 one time ultrasound
calculate sensitivity
specificity
ppv
npv
sens = true pos / true pos + fals neg spec = true neg / true neg + fals pos ppv = true pos / true pos + false pos npv = true neg / false neg + true neg
DM screening
- Screen every 1-5 y depending on risk
determined using a calculator, other risk
factors, or age ≥40 y - HbA1c level is the preferred screening test
(FPG level or OGTT are acceptable
alternatives) - HbA1c level of ≥6.5%, FPG level of
≥7 mmol/L, or 2-h plasma glucose level
in an OGTT of ≥11.1 mmol/L are diagnostic
DLP screening
- Screen fasting lipid profile in men aged ≥40 y,
women aged ≥50 y (or postmenopausal), or
earlier if at increased risk - Screen with Framingham risk assessment
every 3-5 y if 10-y risk is <5%, or every y
if 10-y risk is ≥5%, until age 75 y - Framingham risk should be doubled if
positive family history for premature
cardiovascular disease - Discuss “cardiovascular age”
Colon Ca screening
- Screen with FIT or FOBT every 1-2 y, or
flexible sigmoidoscopy every 10 y, if aged
50-75 y - Consider individualized opportunistic
screening with FIT or FOBT, flexible
sigmoidoscopy, or colonoscopy up to age
85 y
HPV recommendations
1. Recommended for women up to age 45 y even if already sexually active and regardless of past infection 2. Recommended for men up to age 26 y 3. Recommended for men who have sex with men
Immigrant health, four areas - infection
HIV, Hep C, TB
mantoux skin test is intradermal
TB rx, RIPE
Rifampin
Isoniazid
Pyrazinamide
Ethambutol
Common parasitic infections? Ss
strongyloides
Schistosomiasis
Unconscious patient? DONT
dextrose
oxygen
Narcan
Thiamine
Rx for new psychosis?
start med 1st gen = 2nd gen maintain for 18 months oral = depo if depression, treat that too.
neuroleptic malignant syndrome FARM and treatment (5) and meds (3)
Fever
Autonomic - BP, HR, sweating
Rigidity
Mental status changes
stop the rx; IV NS; cooling blankets; ice packs; DVT prophylaxis
benzos if agitation; bromocriptine; dantrolene for muscle relaxation
qSOFA
resp rate >22
aMS
SBP < 100
STI abx
cefixime + azithro or doxy OR
ceftriaxone + doxy if PID
sinusitis abx
amox or amox-clav
bronchitis abx
none
diverticulitis abx
none if CT confirmed with no abscess/free air
cipro + flagyl or amox clav
sepsis abx
ceftriaxone or pip tazo +/- vanco
yeast vaginitis rx
fluconazole oral
pneumonia abx
macrolide or fluoroquinolone
meningitis bugs and abx
TB, LEGS - listeria, e coli, GBS, meningococcus = neisseria meningitis
< 1mo - amp + gent
Group B Streptococci
E. coli
Listeria spp
1-3 mo amp + cefotaxime Group B Streptococci E. coli Listeria spp S. pneumoniae N. meningitidis H. influenzae
> 3 months cef + vanco S. pneumoniae N. meningitidis H. influenzae
Adult > 50 years or Immunocompromised (including AIDS), Alcohol abuse, Debilitating illness, Pregnancy cef + amp + vanco S. pneumoniae Listeria monocytogenes N. meningitidis Enterobacterales
REMEMBER… contact public health! contact prophylaxis! vaccinate!
cellulitis abx? MRSA?
with pus = ?mrsa = doxy, septra, clinda
w/o = strep = amox clav, cephalexin
uti abx? what if complicated? severely ill? peds?
nitrofurantoin, septra, cephalexin, fosfomycin
if complicated… fluoroquinolone, 3rd gen cephalosporins, broad spectrum, of severely ill i.e. pip-tazo, ertapenem
peds - cefixime 7-10 days and image if febrile <2 yrs, recurrent or complicated (sepsis, obstruction, retention, impacted stone, pyelo)
pyelo abx
ceftriaxone
then cefixime or septra or cipro or amox-clav
remember your TOCC hx
travel
occupation
contacts
critters
4 strategies to minimize statin effects on muscles
lower dose
rink lots of fluids
stop interacting medications
alternative day dosing
rx for molluscum contagiosum
cantharidin topical
Describe arterial ulcer
Punched out full thickness ulcer with smooth wound edges often on lateral ankle or distal digits
Describe karposi sarcoma
Red-purple lesions/patches/nodules
Describe scabies
intensely pruritic and pimple like rash at the wrists and Intertriginous areas
describe herpes labialis
small grouped blisters/sores on lips that can coalesce into an ulcer that heals with 2-3 weeks
describe hand foot and mouth
lesions on oral mucosa, tongue, palms, soles and buttocks, grey-white vesiculo pustules
describe venous ulcers? risk factors?
shallow and superficial ulcers with irregular margins usually on the lower leg and ankle
rf: obesity, immobility, pregnancy, DVT, CHF, varicose veins, conditions with poor musculature
describe herpes zoster
grouped, unilateral vessicles in dermatomal distribution +/- pain and prodromal symptoms. anti virals with in 48-72 hours
–> do not confuse with eczema herpeticum
indications for shingrix vaccine
over 50 years, diabetes, heart disease, renal disease, immunosuppresion
describe BCC, treatment options
shiny, pearly nodule located on sun exposed area of skin with telangectasia
rx: excision, cryotherapy, topical chemo
describe roseola infantum
high fever then rash on chest that turns into a pink maculopapular eruption lasting 1-2 days. 6th disease, HHV 6/7, supportive care
describe erythema infectiosum
macular erythema on face on day 1, then erythematous maculopapular eruption for up to 7 days on proximal extremities, then a reticulated or lacy erythema on extensor extremities up to 3 weeks. parvovirus/5th disease
Dx of HTN, work-up
AOBP > 135/85 or non-AOBP >140/90
Lipid panel (HDL, LDL, chol, trig, non-HDL)
Na, K, Creat, urinalysis, HbA1C, EKG
CPAP does not decrease morbidity/mortaliity
Recommendations for HTN lifestyle
reduce salt - diet - DASH <1800mg reduce weight reduce stress - CBT increase exercise 30-45 min, 3x/week reduce alcohol <2.7 drinks/day
Fever? keep the ddx broad (11) and don’t forget the most dangerous things
sepsis meningitis steven's johnston syndrome PE GCA medication cancer/feb neut serotonin syndrome neurleptic malignant syndrome endocarditis rheum -- still's disease unclear? back to basics, serial exams/ekgs/imaging
DLP screening. When should it be fasting?
> 40 and <75 consider earlier in at risk groups: South/East asians and First Nations, gestational HTN
Fasting if TG > 4.5
no evidence of mortality benefit of statins if >75
DLP management - who to start on statin?
what other things can you do?
Statin based on Framingham > 10 OR if CHD, CAD, PAD, AAA, DM2, CKD
Optimize renal, HTN, and CVD rx
dietician (med diet), counselling, stop smoking, kinesiology, cardiology, endocrinology (if familial)
Vertigo Exam (4)
Orthostatic BP
Gait
Hints
Dix-Hallpike
Vertigo ddx
BPPV orthostatic meniere's migraine neuritis stroke
HINTS exam
Pt looks at nose; head impulse to one size
continues looking at you = normal (central vertigo)
corrective saccades = abnormal (peripheral vertigo)
Acute situatuation - ABC MOVIES and cereal
monitors oxygen vitals IV large bore x 2 ECG sugars serial ekgABCs/vitals
GI Bleed rx
PPI infusion
Erythromycin prior to scope because it increases GI motility
Hgb only if <70
IF varices, give ceftriazone + octeotride (somatostatin)
what’s the reversal agent for…
warfarin?
heparin?
dabigatran?
vit K
protamine, fresh frozen plasma
praxbind
what are the drug classes for anxiety?
benzodiazepines buspirone selective serotonin reuptake inhibitors selective norepinephrine reuptake inhibitors tricyclic antidepressants monoamine oxidase inhibitor atypical anti-psychotics
after SIGECAPS, r/o other conditions by asking about
- excessive worry, panic, PTSD
- hallucinations?
- rituals/compulsions that you cannot stop?
- mania – feel better than good?
- delusions - do you have special powers? is there a plot against you?
Bipolar II, criteria and dx
Bipolar meds
- hypomania, no psychosis
quetiapine is first line
Acute: abilify, paliperiodone, risperidone
Maintenance: quetiapine, lamotrigine, lithium, divalproe
1st gen antipsychotics - D2 antagonism, higher risk of neurological side effects
haldol
chlorpromazine
2nd gen antipsychotics “atypicals” 5HT2A/D2 antagonism
higher risk of metabolic side effects
abilify olanzapine paliperidone quetiapine risperidone clozapine
Tourette syndrome rx
Tetrabenazine or Risperidone (dopamine blockers)
Botox - neuromuscular blocade
Habit reversal training
PICA rx
methylphenidate - CNS stimulant
olanzapine
Treat the complications – radiography for a bezoar
Scabies rx
permethrin, invermectin
Mastitis rx
continue BF
NSAIDs, abx (cloxacillin, cephalexin)
usually staph
warm/cold compresses
Melanoma dx
Asymmetry Border irregularity Color not uniform Diameter > 6mm Evolving shape/size/colour
Measles description, symptoms
purplish red, maculopapular rash starting on the scalp/face/neck and spreading downwards
Four Cs: cough, coryza, photophobia, conjunctivitis, koplik spots on buccal mucosa
describe Alopecia areata? what conditions is it associated with?
what is the treatment?
circular lesion on scalp/body with no hair, may have characteristic exclamation mark hairs. Focal, non scarring
ddx: trichotillomania
associated with SLE, thyroid, family hx
<50% hair loss - steroids either topically or injected, minoxidil
>50% hair loss - oral steroids 8 week taper while minoxidil while awaiting referral
Marjolin ulcer
non healing ulcer or growth on the edge of a chronic wound - type of SCC
Pityrasis rosea
single lesion followed by all over body rash. Oval, dull pink colour involving the trunk and upper arms and legs. Christmas tree distribution
Head lice rx
permethrin or pyrethrin, repeat in 7-10 days
Rx for androgenic alopecia
stop offending meds
minoxidil
finasteride
hair transplant
Rosacea
superficial, dilated blood vessels and papules/pustules/swelling on the face
stevens-johnson syndrome
painful red or purplish rash involving the skin and mucous membranes stop med/avoid drug class in future
Koebner’s phenomenon
formation of psoriasis in areas of trauma
Rx for post herpetic neuralgia
topical capsaicin NSAIDs gabapentin TCAs glucocorticoids paracetamol topical lidocaine
investigations to order for dx osteoporsis (7)
hgb TSH ionized Ca Alk Phos Creatinine SPEP if vertebral # Vit D --> after 3 months of Vit D supplementation
Osteoporosis rx - 3 options + 2 for high risk
When can you stop it?
Bisphosphonates
- jaw osteonecrosis
- esophageal ulcers
- atypical fractures
Raloxifene –> selective estrogen receptor modulator
- VTE/PE
HRT
for high risk
Teriparatide - PTH analogy
- hypercalciuria, hypercalcemia - usually transient
- angioedema
Denosumab - monoclonal ab vs. RANKL
- joint muscle pain
- jaw osteo
- CI in pregnancy
Stop after 3-5 years if low risk take holiday
HIV med complications
DLP
hyperglycemia
BMD loss
Renal disease
HIV meds to know
Truvada for PREP
Zidovudine - peripartum and neonate
PEP - truvada, raltegravir
Opioid guidelines
maxmimum 50mg MED start
taper down to 90mg MED if they are above that
only use if no other options - TCAs, nabilone, NSAIDs, CBT, exercise, physio
ADL - DEATH
Dressing Eating Ambulating Toileting Hygiene
IADLS - SHAFT
Shopping Housework Accounting Food and meds Telephone, transportation
Frail elderly checklist
vision hearing skin - ulcers mobility cognition pain medications rx monitoring abuse driving incontinence falls teeth
Post phlebitic syndrom
horse chestnut seed extract for venoconstriction
DVT w/up and treatment
if low Pre test prob/Wells < 2 – D-dimer. if +ve, proximal leg compression ultrasound or CTPA if you suspect PE
if high Pre test prob/Wells >2 – ultrasound. if -ve, d dimer
if suspicion is high and testing will be delayed, treat first!
1 dose of oral Xa inhibitor or 1 dose of LMWH/IV heparin
Bell’s palsy, dx and treatment
Stroke spares forehead
lubricant eye drops
steroids eg prednisone
add antivirals if severe
Ramsay Hunt Triad
aka Herpes Zoster reactivation
- ipsilateral facial paralysis
- ear pain
- vesicles in the auditory canal
Ischemic vs hemorrhagic findings
ischemic 80% - early, focal
Hemorrhagic 20% - late focal deficits, compression effects (headache, vomiting)
Acute stroke management
- ABCs, MOVIEs
- Stroke scale
- Labs: Na, K, Hgb, INR, aPTT, creatinine, troponin, glucose
- Head CT non contrast –> if 4.5-6 hours adter symptoms add CT angiogram from vertex to arch OR CT perfusion. If 6-24 hours after symptoms add CT angiogram AND CT perfusion
- Treat fever and severe hypertension >220/120
Acute stroke treatment options
- Bust clot - alteplase, tenecteplase
- treatment within 3-4.5 hours, >18 yo - Yank clot 6-24 hrs- endovascular thrombectomy, aspiration/vacuum/removal stent
- acute ischemic stroke, anterior circulation, large vessel
Stroke w/up (cause - 4)
- Holter monitor
- Carotid doppler/duplex ultrasound
- manage A fib if found
- ECHO
Stroke prevention ABCDEs
A Fib BP CVD DM2 Ethanol
cephalosporins
1st gen - cephalexin (keflex) PO, cefazolin (ancef) IM/IV
2nd gen - cefuroxime IM/IV
3rd gen - cefixime PO, ceftriaxone IV
no activity against LAME = listeria, atypicals, MRSA, enterococci
Good against gram +ves, increasing gram -ves as you progress at expense of gram +
Macule
flat lesion less than 1 cm, without elevation or depression
Patch
flat lesion greater than 1 cm, without elevation or depression
Plaque
flat, elevated lesion, usually greater than 1 cm
Papule
elevated, solid lesion less than 1 cm
Nodule
elevated, solid lesion greater than 1 cm
Vesicle
elevated, fluid-filled lesion, usually less than 1 cm
Pustule
elevated, pus-filled lesion, usually less than 1 cm
3 indications for using cannabinoids ? which product for which indications?
Muscle spasm 2/2 SCI, MS - nabiximol
Neuropathic pain refractory to standard therapies- nabilone or nabiximol
N/V from chemo - nabilone
4-6-8 rule for driving after cannabinoid
don’t drive less than 4 hours
less than 6 hours for oral ingestions
and less than 8 if you experience euphoria
managing opioid withdrawal
treat type of pain - neuropathic vs other
clonidine if BP >150/90, HR >50; for nausea/vomiting/sweating/tremor
diarrhea - start loperamide, stop stool softeners
abdo cramping - buscopan (hyoscine), pinaverium
muscle cramping - quinine
sweating - oxybutynin (anti-cholinergic)
what are the domains for major neurocognitive disorder? 5 W’s
WHO you are, WHAT you say, WHERE you go, WHY you do things, WHEN you remember
learning and memory complex attention executive function language, perceptual motor social cognition Alzheimer's is any one PLUS memory affected mild = 1 domain major = 2 or more plus impair function/decline
how to assess competency?
explain your treatment options? WHAT
reasoning? WHY
choice? WHAT ELSE
investigations for MNCI d/o?
TSH Hgb/ferritin B12 Na, Ca, glucose
Do a CT Head if last done less than 2 years ago/looking for something else
Management for MNCI
- cholinesterase inhibitors –> donepezil
- glutamatergic –> memantine
exercise
cognitive stimulation
avoid antipsychotics
Parkinson’s symptoms TRAP SSSS
Tremor Rigidity Akinesia Postural instability Shaky Stiff Slow Steps
DDx for Parkinson’s
tremor improves with EtOH? better at rest? –> Essential tremor
On an antipsychotic? - extrapyrimidal side effects
falls, slow vertical gaze - progressive supranuclear palsy
no L-dopa improvement, symmetric - Multi-systems atrophy
Parkinson treatment, things to avoid (5), treat other features
first line - carbidopa/levidopa
30% don’t respond, 20% who do have another dx
second line -
1. Dopamine agonists, non ergot - pramipexole, warn about impulse control d/o i.e. gambling, binge eating
avoid ergot derived i.e. bromocriptine
- MAO inhibitors - selegiline, rasagiline
Avoid… anti psychotics (except quetiapine, clozapine); abruptly stopping meds; amantadine early on; genetic testing/PET scanning; vit E/coenzyme q10
Also look for/treat: constipation, drooling, ED, hypotension
Rx for postural hypotension
quit - large meals, EtOH, warmth, medications
start - compression stockings, increase salt intake, bed tilt, elastic stockings, midodrine (alpha 1 agonist) or corticosteroid
headache – serious causes to r/o
GCA SAH Stroke meningitis Tumour
red flags for headache SNOOP
systemic features neuro symptoms older pt/onset other red flags pattern change
ottawa SAH tool
r/o tool must meet criteria (4), C/I (5)
Rule: if any of the following 6…
alert patients >15 years old new severe atraumatic headache maximum intensity in 1 hr do NOT USE if: neuro deficits, prior aneurysm, prior SAH, known brain tumour, chronic recurrent headache require investigations if: 1. neck pain or stiffness 2. => 40 yo 3. witnessed LOC 4. peak during exertion 5. thunderclap headache -- immediate peak intensity 6. limited neck flexion on exam
Migraine Rx - acute, chronic, lifestyle management
Migraine medications: A) Acute migraine medications. B) Prophylactic migraine medications.
A)
Type ACUTE MEdications
First line Ibuprofen 400 mg, ASA 1000 mg, naproxen sodium 500-550 mg, acetaminophen 1000 mg
Second line Triptans (oral wafer/nasal spray/IM)
Antiemetics: domperidone 10 mg or metoclopramide 10 mg for nausea
Third line Naproxen sodium 500-550 mg in combination with a triptan
Fourth line Fixed-dose combination analgesics (with codeine if necessary; not recommended for routine use)
also consider – sphenopalatine ganglion block
B)
Prophylactic Medications
First line
• propranolol/metoprolol - avoid in asthma
• ami/nottriptyline - Consider if patient has depression,
anxiety, insomnia, or tension-type
headache
Second line • topiramate • candesartan • gabapentin Few drug interactions Botox for chronic
Lifestyle management:
- decrease caffeine, improve sleep, increase exercise, relaxation, CBT
ABCs of fractures
Antibiotics? Analgesia Brace/splint Consult ortho? Compartment syndrome? Stick them with Tetanus -- Tetanus immunoglobulin if dirty wound/not vaccinated or immunocompromised
Fractures of abuse (8)
multiple multiple, many healing non ambulatory femur <12-18 months humerus <18 months skull metaphyseal - bucket handle rib posterior
Salter-Harris
Slipped Type I Above Type II Lower Type III Through or transverse Type IV Rammed Type V
causes of Afib (6)
ischemic valvular alcohol hyperthyroid HTN pulmonary - COPD, pulmonary embolism
Afib rx, anticoagulate?
convert IF unstable, symptomatic/poor QOL, cardiomyopathy
otherwise bblockers or ccb
if unstable/low clot risk – anticoagulate now and cardiovert now
if hi clot risk, OAC for 3 weeks or TEE
rate control if old, longstanding, asymptomatic, other disease
rhythm control if young, new dx, symptomatic, no other disease
CHADS2
CHF HTN Age >65 DM2 Stroke/TIA/embolism
Bleed risk management HAS BLED
HTN SBP>160
Abnormal liver/kidney fxn
Stroke
Bleeding
Labile INR
Elderly >65
Drugs/EtOH
Which anticoagulant for – CKD? pregnancy? cancer? valvular afib?
UFH - renal disease CKD
LMWH - pregnant, cancer
Warfarin.- valvular
Systemic Exertional Intolerance
Functional impairment > 6 months Non exertional new fatigue Post exertion malaise Rest does not refresh At least 1 of cognitive impairment or orthostatic intolerance
Panic attack symptoms
Students Fear CCCs Sweating Trembling Unsteadiness Dyspnea Excessive sweating Nervousness Tachycardia/tachypnea Sensation weird Fear of death Choking Chills Chest pain
Lupus
MD SOAP BRAIN
Mallar rash
Discoid Rash
Serositis - pericarditis, pleuritis
Oral ulcers
ANA +ve
Photosensitivity
Blood - thrombocytopenia, hemolytic anemia
Renal - GN
Arthritis
Immune - anti phospholipid, anti dsDNA, anti rho, C3/C4, anti smith
Neurological disorders, including psychiatric disorders - psychosis, seizures
Symptoms/presentation of Thyroid Storm?
Altered mental status Tachy Fever Dyspnea/orthopnea Chest pain Hypertension Profuse sweating
IBD systemic features APIESAC
Apthous ulcers Primary sclerosis cholangitis, pyoderma gangrenous Iritis/uveitis Erythema nodosum Sacroilitis Arthritis Clubbing
Pro-thrombotic states
Protein c and s deficiency - like renal disease because you lose protein Nephrotic syndrome Hormonal meds Pregnancy Cancer IBD, CHF Factor V leiden Anti phospholipid syndrome
Upper Arm DVT
CONSTANS score — upper arm DVT
1 point each, -1 if other dx more likely
Unilateral pain
Edema
Hx of central line/pacemaker placement “trauma”
Risk factors for AOM
maternal smoking
pacifiers
day care
bottle feeding
Ear bugs? 5
strep pneumo moraxella catarrhalis hemophilus influenza staph aureus group a strep
rx for AOM? if failure?
amoxicillin - high is BID, low if TID 40-90mg/kg
if failure? clavulin or ceftriaxone
tylenol 10mg/kg
advil 15 mg/kg
what are the indications for ear ventilation tubes? (3)
>6/yr or 4 per 6 months or Chronic OM with effusion, "glue ear" > 3 months with hearing loss or retracted TM
CATCH2 for pediatric head injury, AVPU?
Minor head injury and any one of the following
GCS <15 (can also use AVPU for younger children –> Awake - Verbal - Responds to Pain - Unresponsive)
worsening headache
Suspected open/depressed skull fracture
irritability
Sign of basal skull fracture
Large, boggy scalp hematoma
Dangerous mechanism
>4 episodes of vomiting (common pain response in kiddos)
types of SHOCK
septic hypovolemic obstructive cardiac AnaphylacticK
Burns - formulas? special sites?
> 10% resuscitate - Brooke formula: 2mls x body surface areas burned (BSAB) x weight
Rule of 9s
adult - legs 18% x 2, arms 9% x 2, head 9%, chest 18%/back 18%, groin 1%
infant - legs 14% x 2, arms 9% x 2, head 18%, chest 18%/back 18%, groin 1%
special sites: face, hand, foot, genital, perineum, joint
Frostbite rx - 5 steps
rapid rewarming - water bath possible thombolysis and heparin and iloprost sterile wound care consult surgery tetanus
MAPLE hx
medications allergies past medical history last meal events leading up to
GCS
4 - eye response; 4 spontaneous - 3 sound - 2 pressure
5 - verbal; 5 oriented - 4 confused - 3 words - 2 sounds
6 - motor; 6 obeys - 5 localizes pain - 4 withdraws from pain 3 - flexion to pain 2 - extension to pain 1 - no movement
ATLS updates
give blood early! after 1L crystalloids
smaller chest tubes 28-32 french
needle decompression 4th/5th intercostal space laterally
use massive transfusion protocols
tranexamic acid 1g for 10 min and 1g for 8 hours
e-fast for pneumothorax
Trauma in pregnancy
Mom then fetus Chest tube 1-2 spaces higher NG tube Left lateral decubitus No vag exam until previa ruled out Anti D immune globulin if Rh negative Tetanus vaccine is safe Document domestic violence
Treatments for acute seizure in adult? pregant? pediatric? 1st and 2nd line.
Adult - 1st benzo 2nd phenytoin, valproate
Pregnant - 1st Mag Sulf 2nd benzo
Peds - 1st benzo 2nd phenytoin, phenobarb
Reversible causes of LOC
Hyperopioidemia Seizure Hypovolemia HyperCa Hyperthermia Hypoglycemia Hypoxia Hyponatremia
Red eye red flags (5)
Pain Decrease visual acuity Aniscoria Photophobia Metal work
Clinical ft of acute angle closure glaucoma (5), physical exam (6), and treatment?
Headache N/v Halos around lights Eye pain Decreased vision
Physical Exam:
Visual acuity, Evaluation of the pupils, Intraocular pressure (IOP), Slit-lamp examination of the anterior segments, Visual field testing, Undilated fundus examination
Rx:
- pressure lowering eye drops
- IV acetazolamide
repeat eye pressures 30-60 minutes after meds administration
What to do before prescribing eye steroids?
measure eye pressure!
Management for premature rupture?
steroids and antibiotics
Management for preterm labour?
fetal fibronectin
steroids
tocolysis
magnesium sulfate <32 weeks
active labour? labour dystocia? abnormal FHR?
active = >4 cm dilation
dystocia = <2cm in 4 hours
abnormal fhr = <110 or >160
post partum Bs (11)
breasts bottom belly baby breast feeding bowels bladder bleeding blues birth control boinking
Approach to medical abortion
- confirm GA
- exclude ectopic
- assess for CI: uncontrolled asthma, chronic adrenal failure, chronic corticosteroid use, hematologic disorders
- remove IUD
Ordering lab tests:
bHCG if using for monitoring completion
GC/CT testing
Rh status
Hgb if reason to suspect anemia
Advise of risks. Surgical evacuation may be required in the event of retained products of
conception or heavy bleeding (5%) or ongoing pregnancy (<1%). Heavy bleeding requiring
transfusion is rare (0.1%). Infection is rare (1%) and severe infection/sepsis extremely rare
(.01%).
Management for STEMI
CODE STATUS!
- PCI < 120 minutes
- Morphine - only if severe pain, increases mortality in NSTEMI
- O2 only if O2 <90% otherwise increases free radicals
- Nitrates – use for analgesia, no mortality benefit
- ASA - 27% mortality benefit
- B blocker
- antiplatelet therapy
- ACE
- statin 80
DDx for chest pain
lung - pneumothorax, PE, infection, blood
heart - valves, endocarditis, pericarditis/Dressler’s syndrome (post MI)
esophagus - inflammation, acid, spasm, foreign body, rupture, tear
aorta - dissection, aneurysm, infection
chest wall - costochondritis, muscle, contusion, fracture, zoster
psychiatric
abdomen
Management for PE
Do WELLS first; if low risk, do PERC to rule out. YEARS for pregnant women
Rx for HFrEF
mineralocorticoid receptor antagonist i.e. spironolactone ACE beta blocker lasix \+ SGLT2 inhibitor even if no DM2
Breast Cancer risk factors
Estrogen exposure Early menarche Late menopause Nulliparity Postmenopausal HRT, obesity Radiation exposure Alcohol Sedentary lifestyle
Non modifiable
Age > 50
sex
past hx, family hx
Red flags in breast lump and when to monitor (4 each(
Peau d’orange
Firm fixed lymph nodes
Inverted nipple
Risk factors
Monitor if:
smooth, rubbery, mobile, cyclic
BMI formula and ranges
kg/m^2 <18.5 underweight 18.5-25 normal 25-30 overweight 30-35 class I obesity 35-40 class II >40 class III
treatments for obesity?
bupropion-naltrexone (Contrave) orlistat - lipase inhibitor GLP-1 receptor agonist (Victoza) rx underlying factors or illness surgery: gastric bypass, sleeve gastrectomy, adjustable gastric band
Smoking Cessation medications and CI
Bupropion
- avoid if seizure d/o, eating d/o, EtOH w/d, MAOI use, allergy
Varenicline (partial nicotine agonist)
- now ok in psychiatric conditions
AUD rx
1st line naltrexone (not in liver disease, OUD)
others: acamprosate, gabapentin
refer to counselling, set goals, eat when drinking
OUD rx
OAT! side effects = constipation, amenorrhea, decreased testosterone
treatment agreements
UDS
harm reduction - lock box, naloxone, don’t use alone
avoid cannabinoids, benzos, EtOH/sedatives
Nexus C-spine rule
Exclusions (6)
Exclusions: acute paralysis, known vertebral disease, previous C-spine surgery, non trauma patients GCS <15, unstable vital signs, <16
NO neuro deficit spinal tenderness midline alertness intoxication distracting injury
Test for cervical radiculopathy
Spurling test - The Spurling test is a medical maneuver used to assess nerve root pain (also known as radicular pain). The examiner turns the patient’s head to the affected side while extending and applying downward pressure to the top of the patient’s head.
Causes of unconjugated hyperbilirubinemia
ABC BILI ABO hemolysis Breast milk Conjugation defect - Gilbert’s syndrome Breastfeeding (dehydration) Infection Loss of blood Idiopathic (physiologic)
Causes of conjugated hyperbilirubinemia?
BAD-C
Biliary atresia
Ductal stenosis
Cystic fibrosis
Modified CENTOR criteria
Cough absent Tonsils red or exudative Cervical lymph nodes Fever <14 +1 14-45 0 45+ -
Causes of abnormal uterine bleeding
PPALMCOEIN Pregnancy ruled out Polyp Adenomyosis Légion Yona Malignancy and hyperplasia Coagulopathy Ovulatory dysfunction Endometrial Iatrogenic
Features of renal artery stenosis
New HTN <30 or >55 Abdominal bruit Creatinine increases more than 30% with ACE or ARB HTN resistant to 3 or more meds Récurrent pulmonary derm with HTN surges
Bipolar medications in pregnancy advice
Lowest effective dose Avoid valproate Monotherapy Psychosocial preferred over meds in 1st trimester Restart medications after childbirth
Classes of pharmacological treatment for endometriosis
GNRH antagonists (CI: postmenopausal or <18)
Aromatase inhibitors
NSAIDS
hormonal contraception
The Menopause 5
Quit: smoking, alcohol, caffeine
Start: exercise, weight loss
Fan, layers, cool environment, no hot drinks, optimize sleep
Menopause - 4 medication classes
SSRIs HRT -- safe for 5 yrs w/in 10 years of LMP, transdermal is best. No uterus? No progesterone OCP Progestin TCAs Anticonvulsants
C/I to estrogen
migraine with aura smoker >35 CVD/valvular disease liver disease diabetes w/ end organ damage malignancy uncontrolled HTN
Cat bite!
Amox-Clav
if pen allergy - doxy or septra/flagyl
don’t close the wound
dog bite less risk but consider in immunocompromised
Rabies Rx
Dog/cat/ferret - observe for 10 days, at first sign of rabid, give Rabig and four doses of HDCV or PDECV and test animal
Dog/cat/ferret/skunk/bat/fox/coyote/raccoon/carnivores that is suspected rabid - Rabig + fours doses of HDCV or PCECV, immediately test animal
sedation of peds lac repair?
intranasal midazolam
IV/IM ketamine
sutures # of days
face - 5
joint, scalp 10-14
everything else -7
Toxidromes for... Stimulant Anticholinergic Cholinergic Opioids Sedative-Hypnotics Benzos
Stimulant – BIG pupils, use benzos
Anticholinergic: TCAs, tegretol, anti-Parkinson’s, antipsychotics, jimson weed – use physostigmine. NO sweating
Mad as a hatter, dry as a bone, red as a beet, hot as a hare, blind as a bat, full as a flask
Cholinergic: mushrooms, organophosphates/insectiticides, nerve agents / sarin gas – atropine, pralidoxime. Tiny pupils, increased sweating.
SLUDGE = salivation, lacrimation, urinary incontinence, diarrhea, GI upset, emesis, miosis
Opioids
Sedative-Hypnotics: anti-epileptics, barbiturates, muscle relaxants. Depressed vitals.
Benzos - give flumazenil (seizure risk)
Antidotes for …
beta blockers?
iron?
Aceminophen?
BB - glucagon & CABs
iron - deferoxamine & ABCs
acetaminophen - N-acetylcysteine & ABCs
If UTI 1st line abx fail…
reinfection vs. relapse
treat 7-14 days
reconsider dx/refer - upper tract imaging, cystoscopy, urodynamics
causes and mgmt for epistaxis… mild? severe? Posterior?
90% are anterior causes TIME to stop BLEED Trauma/tumor Infection Meds - nasal steroids Exogenous - foreign body BLEEDing disorders
Mgmt - mild:
- blow nose
- 2 sprays oxymetazoline
- pinch x 10 minutes
Severe:
- ABCs, MOVIES, labs
- tranexamic acid
- freeze and cauterize or freeze and pack. Don’t cauterize both sides! (Septal perforation)
Posterior - identify by packing; if still bleeding, call ENT. Nasal baloon/foley.
Prophylaxis for those in close contact to bacterial meningitis?
Rifampin or ceftriaxone or ciprofloxacin
Croup management
steroid dose?
ddx?
fup instructions for parents?
Mild - ABCs, treat fever, PO fluids, reassure parents
Dexamethasone 0.15 (mild)-0.6mg/kg
If severe, inhaled racemic epinephrine (if receives this, fup <24 hours post discharge)
if given dex, should get better! If not, consider ddx: influenza, RSV, adenovirus, metapneumovirus, foreign body, tracheomalacia
fever persistiting past 24-48 hours
fluid intake or output not adequate
fatigued/listless
decreased LOC, respiratory distress
Meningitis management, CSF findings
Start IV abx right away! They are a resuscitation drug.
Steroids only if H flu and <2 hours from antibiotics
Normal
CSF findings:
Bacterial: WBC >500 - neutrophils, low in glucose, protein >100
Aseptic, often viral i.e. syphillis: WBC 10-1000 - lymphocytes, normal glucose, protein <200
SAH: xanthochromia, normal glucose, elevated protein
Fungal: WBC 10-500, cloudy, low glucose, elevated protein
TB: 50-500 clear to opaque, low glucose, elevated
Contraindications to LP
- blood pressure - shock
- brain herniation
- bleeding - coagulopathy
- blisters - rash at site
Anaphylaxis treatment
0.01 mg/kg 1:1000 IM
ABC MOVIES SUPINE (unless seizure, pregnant, decreased LOC) EPI Allergy alphabet, rule of 5
Adrenaline 0.5mg
Breathing - O2 5L nasal or 15L non rebreather
Corticosteroid - methylprenisolone 125mg
Diphenhydramine 50mg
Epi again?
Fluids - treat hypotension 2/2 vasodilation 500c
Glucagon if on B-blocker
H2 blocker - ranitidine 150mg
Inhaled salbutamol - if wheezy
observe for at least 4-8 hours, can have rebound in 23%; steroids don’t help reduce this
Eating d/o - SCOFF screening tool
Made yourself SICK because you felt uncomfortably full?
Lost CONTROL over how much you eat?
Recently lost more than ONE stone (14 lbs) in a 3 month period?
Do you believe yourself to be FAT when others say you are too thin?
Would you say that FOOD dominates your life?
BMI in eating disorders
> 17 mild
16+ moderate
15+ severe
<15 extreme
The new Female Athlete Triad
Relative Energy Deficiency in Sport RED-S
Signs on exam of eating disorder
Bradycardia Slow cap refill Postural tachycardia Postural hypotension Decreased core temperature Pressure sores
Emergency Contraception (4)
OCP
Ullipristal
Levonorgestrel
Copper IUD
Counselling after sexual assault, pregnancy, when to retest?
HIV post-exposure prophylaxis Hep B immune globulin, vaccinate within 8 hours Retest at 6, 12 weeks Azithro + cefixime/ceftriaxone Preg test in 4 weeks Reporting = voluntary unless <18
1st trimester bleeding
missed abortion? expectant vs. D&C vs. misoprostol
Always remember your WinRHO
if threatened, serial ultrasound/serial beta
ectopic - pain, <7 weeks, tubal risk factors - expectant, medical or surgical
Tests and managemnet for AUB
tests: Endometrial biopsy, colposcopy, Pap
Management: Levonorgestrel IUS, OCP, progestin, NSAIDs(??), TXA
Surgical - ablation, hysterectomy, polypectomy, myomectomy
Test for vaginitis
Swabs/culture KOH Wet mount PH Biopsy
To PSA or not to PSA
And how to interpret
RFs for prostate cancer
Discuss it if life expectancy >10 years
Start at 50, or 45 if high risk
PSA < 10 low risk, routine
PSA 10-20 semiurgent
PSA > 20 high risk, urgent
PSA > 10 and abnormal prostate = urgent
RFs: age, high risk race, family hx, smoking, obesity
Physical exam/investigations for suspected BPH?
ABDO and rectal exam
Midstream urine culture + sensitivity and analysis, GC/CT screening
PSA if >10 year life expectancy
BPH management
Stop (7)
Start (2)
- Stop antihistamines, decongestants, NSAIDs, saw palmetto, excess fluid, caffeine, alcohol
- Start 5-Alpha reductase inhibitor - Finasteride
Alpha blocker - Tamsulosin (or both)
Phosphodiesterase type 5 inhibitors - tadalafil
Anti-muscarinics
Risk factors for tubal dysfunction
Endometriosis, ectopic, surgery, Crohn’s, PID, chlamydia, ruptured appendix
Causes of infertility / workup
bloodwork to r/o hyperangronism
Anovulation
Tubal dysfunction
Uterine abnormalities - adhesions (surgery), septate/arcuate uterus, intracavitary fibroids
Ovulation –> Day 3 FSH (ovarian reserve), Estrogen (ensure FSH not being suppressed), TSH, prolactin, midluteral progesterone
Anti Mullerian hormone for women > 35 or with risk factors for low ovarian reserve: single ovary, ovarian surgery, poor response to FSH, chemo/radiation, unexplained infertility
Hyperandrogenism –> DHEA-S, 17-OH progesterone, total testosterone
Structural, tubal –> ultrasound, hysterosalpingogram
Partner –> semen analysis
Male
Testicles - trauma, torsion, surgery, infection
Sperm - tobacco, marijuana, hypogonadism
When to refer for ?infertility
12 months if no risk factors
6months if risk factors or <35
immediately if >40
start exercise!
PID symptoms, counselling
cervical motion tenderness, purulent discharge, fever
treat partner
contact tracing
abstinence x 7 days
Ages for abuse
16 if non exploitative 18 if exploitative consenting youth 12-13 -- up to 2 years older 14-15 -- up to 5 years older`
PreP recommended for :
MSM
trans people having condomless anal sex with HIV+/unknown status partners
might benefit:
- IVDU
- hetero people with HIV+ partners with detectable viral loads
How to start PREP, counselling?
Truvada one pill per day or on demand
Doesn’t protect from other STIs, use condoms
Baseline labs: STI screen CBC/Hgb Creat HCG urinalysis - q3 montly lab fup
Priapasm management
Doppler ultrasound, cavernosal blood gas
Non ischemic?
watch and wait
- finasteride
- gonadotropic-releasing hormone agonists - Leuprolide
Ischemic
- needle drainage
- intracavernosal phenylephrine
- surgical shunt if >48 hours
Bloodwork for ED
Serum glucose
Chol HDL LDL Trig non-HDL
Testosterone Prolactin TSH LH FSH
Semen analysis
Most important results are CONCENTRATION (>15 million/ml) and MOTILITY (>40%)
morphology less important
Heart failure treatment
ACE/ARB Betablocker Mineralocorticoid Lasix AND if HFrEF (EF <40%), add SGLT2 even if no DM2
If HFpEF, add SGLT2 if DM2/CVD, >30yo w/ DM2/CKD, >50yo w/ DM2 and risk of CVD
If ongoing symptoms despite triple therapy, add entresto for NYHA II to IV
If Heart rate > 70, also add Ivrabradine
When to suspect cardiac amyloid and what to order
“Frequent” and “underlooked” Occurs in 1 in 4 over 80 yrs old If HF unexplained, or associated with neuropathy or carpal tunnel (bilateral): Order SPEP, UPEP & serum free light chains Monoclonal protein: Absent: Tc-99m-PYP SPECT scan Present: Refer to hematology for biopsy
Microcytic anemia
Thalassemia Anemia of chronic disease Iron deficiency Lead poisoning Sideroblastic anemia
Macrocytic anemia
M FAT RBC
Myelodysplasia Fetal hgb/folate deficiency Alcohol Thyroid Reticulocytosis B12 deficiency Chronic disease
Normocytic anemia
HARPS normocytic Hemolytic anemia Anemia of chronic disease Renal failure Pregnancy/pernicious anemia/pyridoxine deficiency Spherocytosis
Anemia workup
Hemoglobin Mean cell volume Serum Ferritin Peripheral Blood Smear Serum Iron Total Iron Binding Capacity Colonoscopy HCG
Elevated RDW = iron deficiency
Low/normal RDW = thalassemia - hgb electrophoresis
B12 DEFICIENCY
Risk Factors
1. Gastric surgery Gastric parietal cells make intrinsic factor 2. Strict vegans 3. Breastfed children of #2 4. Elderly 5. Psychiatric
Iron for peds?
FERROUS SULFATE FOR SMALL ONES
Causes of recurrent UTI in peds:
VUR
Uretrocele
Posterior urethral valves
Causes of unconjugated hyperbilirubinemia?
ABC Bili - unconjugated
ABO hemolysis
Breastmilk
Conjugation deficiency
Breastfeed, lack of - dehydration
Infection
Loss of blood, vit K deficiency
Idiopathic
Causes of conjugated hyperbili?
Bad C Bili - conjugated
Biliary atresia
Biliary duct stenosis
Cystic fibrosis
C diff test
Stool PCR For c diff toxin A and B
Ottawa Ankle Rule
An ankle X-Ray series is only required if there is any pain in the malleolar zone and…
Bone tenderness at the posterior edge or tip of the lateral malleolus (A)
OR
Bone tenderness at the posterior edge or tip of the medial malleolus (B)
OR
An inability to bear weight both immediately and in the emergency department for four steps
Ottawa Foot Rule
A foot X-Ray series is only required if there is any pain the midfoot zone and…
Bone tenderness at the base of the fifth metatarsal (C)
OR
Bone tenderness at the navicular (D)
OR
And inability to bear weight both immediately and in the emergency department for four steps
Ottawa Knee Rule
knee X-Ray series is only required for knee injury patients with any of these findings:
Age 55 or older
OR
Isolated tenderness of the patella
No bone tenderness of knee other than patella
OR
Tenderness of the head of the fibula
OR
Cannot flex to 90 degrees
OR
Unable to bear weight both immediately and in the emergency room department for 4 steps
Unable to transfer weight twice onto each lower limb regardless of limping
Wells Criteria for DVT
Active cancer
Treatment or palliation within 6 months
Bedridden recently >3 days or major surgery within 12 weeks
Calf swelling >3 cm compared to the other leg
Measured 10 cm below tibial tuberosity
Collateral (nonvaricose) superficial veins present
Entire leg swollen
Localized tenderness along the deep venous system
Pitting edema, confined to symptomatic leg
Paralysis, paresis, or recent plaster immobilization of the lower extremity
Previously documented DVT
Alternative diagnosis to DVT as likely or more likely
Zika counselling
- do not get pregnant if travelling to Zika-risk country
- mosquito precaustions
If traveler is female: Consider using condoms or not having sex for at least 2 months after travel to an area with risk of Zika (if she doesn’t have symptoms), or for at least 2 months from the start of her symptoms (or Zika diagnosis) if she develops Zika.
If traveler is male: Consider using condoms or not having sex for at least 3 months after travel to an area with risk of Zika (if he doesn’t have symptoms), or for at least 3 months from the start of his symptoms (or Zika diagnosis) if he develops Zika.
Schizophrenia symptoms
Positive (i.e. hallucinations, delusions, racing thoughts), negative (i.e. apathy, lack of emotion, poor or nonexistant social functioning), and cognitive (disorganized thoughts, difficulty concentrating and/or following instructions, difficulty completing tasks, memory problems)
SADMAN drugs
Sulfonylureas ACE Diuretics - spironolactone Metformin ARBs NSAIDs SGLT2
PE Wells Criteria
Clinical signs and symptoms of DVT
PE is #1 diagnosis OR equally likely
Heart rate > 100
Immobilization at least 3 days OR surgery in the previous 4 weeks
Previous, objectively diagnosed PE or DVT
Hemoptysis
Malignancy w/ treatment within 6 months or palliative
PERC score
Age ≥50
HR ≥100
O₂ sat on room air <95%
Unilateral leg swelling
Hemoptysis
Recent surgery or trauma
Surgery or trauma ≤4 weeks ago requiring treatment with general anesthesia
Prior PE or DVT
Hormone use
Oral contraceptives, hormone replacement or estrogenic hormones use in males or female patients
Murmur for hypertrophy cardiomyopathy
Significant LVOT obstruction, often due to a combination of LV upper septal hypertrophy and systolic anterior motion (SAM) of the mitral valve, results in a harsh crescendo-decrescendo systolic murmur that begins slightly after S1 and is heard best at the apex and lower left sternal border.
An increase in intensity, due to enhancement of obstruction, is seen with the assumption of an upright posture from a squatting, sitting, or supine position; the Valsalva maneuver; during the more forceful contraction that follows the compensatory pause after a PVC; and following the administration of nitroglycerin.
●A decrease in intensity, due to attenuation of obstruction, is heard after going from a standing to a sitting or squatting position, with handgrip, and following passive elevation of the legs.
Stevens Johnsons syndrome, presentation and management
- Risk limited to the first eight weeks of treatment.
- typical exposure period before reaction four days to four weeks of first continuous use of the drug.
- Fever, often exceeding 39°C and influenza-like symptoms precede by one to three days the development of mucocutaneous lesions
- Photophobia, conjunctival itching or burning, and pain on swallowing may be early symptoms of mucosal involvement. Malaise, myalgia, and arthralgia are present in most patients.
- Signs and symptoms that should alert the clinician to the possibility of SJS/TEN include fever >38°C (100.4°F), mucositis, skin tenderness, and blistering
- Nikolsky sign
- labs: Complete blood count with differential, metabolic panel (ie, glucose, electrolytes, blood urea nitrogen, creatinine, calcium, total protein, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase), erythrocyte sedimentation rate, and C-reactive protein –> chest xray due to high risk of pneumonia
●Bacterial and fungal cultures should be performed from blood, wounds, and mucosal lesions. Because of the high risk of bacterial superinfection and sepsis in these patients, cultures should be repeated throughout the acute phase of the disease.
Management:
referral to the most appropriate health care setting (eg, intensive care unit, burn unit, specialized dermatology unit, where present), and initiation of supportive treatment.
- wound care, fluid and electrolyte management, prompt withdrawal of offending agent, pain control, prevention/treatment of infections
what is sarcoidosis?
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs. It typically affects young adults and initially presents with one or more of the following abnormalities:
●Bilateral hilar adenopathy
●Pulmonary reticular opacities
●Skin, joint, and/or eye lesions
what is acute aortic syndrome?
It is a clinical spectrum of diagnoses including aortic dissection, intramural hematoma and penetrating atherosclerotic ulcer at any location along the aorta
Meniere’s disease
Tinnitus, vertigo, hearing loss, nausea/vomiting (clinical dx; rarely may do MRI)
From build up of fluid in the ears, occurs in episodes
Treatment:
symptoms - anti-emetic: promethazine, prochloperazine
treat of fluid build up - diuretics (HCTZ, acetazolamide), low salt diet
Toxic labyrinthitis – related to EtOH
Signs of advanced HF
2 or more hospitalization or ED for HF visits in the past year
progressive deterioration of renal function
weight loss without other cause = cardiac cachexia
stop ACE due to hypotension or worsening renal failure
intolerance of bblockers because of worsening HF or hypotension
SBP < 90
NYHA class III or IV
need to escalate diuretics to maintain volume status, often reaching furosemide > 160 or supplemental metolazone rx
progressive decline in serum sodium
frequent implantable cardioverter debrillator shocks
Who do you give pneumococcal vaccine to, and which one?
It is recommended that immunosuppressed adults of all ages receive the 13-valent pneumococcal conjugate vaccine (PCV13)
all adults aged 65 years and older receive PCV13 on an individual basis, followed by the 23-valent pneumococcal polysaccharide vaccine
One dose of Pneu-P-23 vaccine should be administered to all individuals 24 months of age and older who are at high risk of IPD due to an underlying medical condition or who are residents of long-term care facilities. People at highest risk of IPD should also receive 1 booster dose of Pneu-P-23 vaccine.
One dose of Pneu-P-23 vaccine is recommended for adults:
65 years of age and older, regardless of risk factors or previous pneumococcal vaccination.
at high risk of IPD due to lifestyle factors: smokers, persons with alcoholism, persons who are homeless. Adults who use illicit drugs should be considered for Pneu-P-23 vaccination.
Why
S. pneumoniae is a common cause of invasive disease, such as bacteremia and meningitis.
The case fatality rate of bacteremic pneumococcal pneumonia is 5% to 7% and is higher among elderly persons.
What is degenerative cervical myelopathy and how do you treat it?
Degenerative cervical myelopathy occurs when age-related osteoarthritic changes cause narrowing of the cervical spinal canal, leading to chronic spinal cord compression and resultant neurologic disability.
The natural course of DCM presents as a stepwise decline, with symptoms ranging from muscle weakness to complete paralysis. All individuals with signs and symptoms should be referred to a spine surgeon for consideration of surgery.
Asymptomatic patients with evidence of cord compression on magnetic resonance imaging might need to be referred for assessment; however, surgery is not advised. It is critical to closely monitor asymptomatic individuals or those with mild DCM for neurologic deterioration.
Patient presentation can vary broadly, with symptoms ranging from mild dysfunction, such as numbness or dexterity problems, to severe dysfunction, such as quadraparesis and incontinence, as later findings. It is important to note that paresthesia in the extremities is often the first sign, and because it might be mild, it can be easily overlooked by patients and providers.
What is a tool that uses lab values to predict cirrhosis?
AST to Platelet Ratio Index (APRI)
APRI score greater than 1.0 had a sensitivity of 76% and specificity of 72% for predicting cirrhosis. In addition, they concluded that an APRI score greater than 0.7 had a sensitivity of 77% and specificity of 72% for predicting significant hepatic fibrosis.
Similarly, the FIB-4 score uses the AST/ALT, age and platelet levels to predict the level of fibrosis using a different equation.
Treatment for rosacea
Topical - metronidazole azelaic acid invermectin minocycline
Oral -
doxycycline
minocycline
tetracycline
persistent erythema -
brimonidine gel
oxymetazoline
persistent erythema/telangectasia - laser
Questions from the Cannabis Abuse Screening Test?
Have you smoked cannabis before midday?
Have you smoked cannabis when you were alone?
Have you had memory problems when you smoked cannabis?
Have friends or members of your family told you that you ought to reduce your cannabis use?
Have you tried to reduce or stop your cannabis use without succeeding?
Have you had problems because of your use of cannabis (argument, fight, accident, bad result at school, etc)?
Which ones?
What is POMI?
Prescription Opioid Misuse Index
1. Do you ever use more of your medication, that is, take a higher dose, than is prescribed for you?
- Do you ever use your medication more often, that is, shorten the time between doses, than is prescribed for you?
- Do you ever need early refills for your pain medication?
- Do you ever feel high or get a buzz after using your pain medication?
- Do you ever take your pain medication because you are upset, using the medication to relieve or cope with problems other than pain?
- Have you ever gone to multiple physicians, including emergency room doctors, seeking more of your pain
medication?
Breastfeeding safe medications
Allergic rhinitis
Beclomethasone (Beconase)
Fluticasone (Flonase)
Cromolyn (Nasalcrom)
Cardiovascular
Hydrochlorothiazide (Esidrix)
Metoprolol tartrate (Lopressor)
Propranolol (Inderal)
Labetalol (Normodyne)
Nifedipine (Procardia XL) Verapamil (Calan SR) Hydralazine (Apresoline) Captopril (Capoten) Enalapril (Vasotec)
Use with caution: Atenolol (Tenormin) Nadolol (Corgard) Sotalol (Betapace) Diltiazem (Cardizem CD)
Depression
Sertraline (Zoloft)
Paroxetine (Paxil)
Nortriptyline (Pamelor)
Desipramine (Norpramin)
Use with caution: Fluoxetine (Prozac)
Diabetes
Insulin
Glyburide (Micronase)
Glipizide (Glucotrol)
Tolbutamide (Orinase)
Acarbose (Precose)
Use with caution:
Metformin (Glucophage)
Thiazolinediones
Epilepsy
Phenytoin (Dilantin)
Carbamazepine (Tegretol)
Ethosuximide (Zarontin) Valproic sodium (Depakote)
Use with caution:
Phenobarbital
Pain
Ibuprofen (Motrin)
Morphine
Acetaminophen (Tylenol)
Use with caution:
Naproxen (Naprosyn)
Meperidine (Demerol)
Asthma
Cromolyn (Intal)
Nedocromil (Tilade)
Fluticasone (Flovent)
Beclomethasone (Beclovent)
Contraception
Barrier methods
Progestin-only agents
Risks of opthalmic steroids
- PERFORATION: In the event of herpetic keratitis, steroids can facilitate progression resulting in corneal perforation
- GLAUCOMA: Ophthalmic steroids can cause chronic open-angle glaucoma if used for a prolonged period of time (i.e. > 2 weeks)
- CATARACTS: Ophthalmic steroids can cause cataracts if used for a prolonged period of time
- CORNEAL ULCERS: Ophthalmic steroids have been associated with development of corneal ulcers of a fungal origin.
What are the ABCDEF of red eye?
A = ache, B = blob, C = constriction, D = document acuity, E = erythema pattern, F = flourescin
Iritis
Remember anatomically what the IRIS is (coloured part of the eye), what the IRIS does (constricts in response to light), and what it surrounds (pupil):
It makes sense that if the iris is inflamed…
- it will be red around the iris (PERILIMBAL HAZE)
- it hurts when the iris constricts (PHOTOPHOBIA)
- it can become warped (DISTORTED PUPIL)
A • Pain - Photophobia
B • Yes, watery
C •Miosis / reacts poorly on
affected side / distorted pupil (anisocoria)
D • Blurred vision
E • Perilimbal Haze
F •Normal
•Not necessary unless FB
sensation
- Refer for Steroids
- R/O systemic cause (i.e. SpA, Behcet’s , IBD, Kawasaki’s, TINU, JIA, Sjögren’s, Polychondritis, Granulomatous Tx)
angiitis…)
DDx – Unlike Iritis…
Conjunctivitis has morning crusting, no pain
Sclerits has SEVERE pain & tenderness to palpation
Episcleritis is NOT painful
Keratitis has corneal opacity, discharge, fluoresces
Glaucoma has hazy, nonreactive pupil & headache
Scleritis
Remember the sandwich, from superficial to deep:
CONJUNCTIVA
EPISCLERA
SCLERA
As the deepest part of the eye, the eye will be will be VERY VERY PAINFUL if the inflammation gets all the way down to the sclera.
A
• SEVERE CONSTANT BORING PAIN -
++ night, pain w/palpation, + photophobia
B • Tears
C • PERL
D • Decreased - DOCUMENT
E • No erythema…but deep red / blue / purple hue
F •Normal •Not necessary unless FB sensation
•REFER for Steroids
•R/O systemic cause (RA, IBD, microscopic polyangiitis, Churg-Strauss, Sjogren’s, Polychondritis, Granulomatous angiitis, Tx
SLE, infectious)
Episcleritis
Remember the sandwich, from superficial to deep:
CONJUNCTIVA
EPISCLERA
SCLERA
The episclera is not the deepest part, so there’s no
pain & normal acuity. As well, it’s sealed in by
conjunctiva so there’s no significant discharge &
no A.M. crusting. Focal redness-think Episcleritis.
A •Irritation (pain is rare) B •Tears - NO pus, NO a.m. crusting C •PERL D • Normal- DOCUMENT E •FOCAL redness F •Normal •Not necessary unless FB sensation Tx •Artificial Tears
Keratitis
Keratitis is inflammation of the cornea. Think
about how painful a corneal abrasion is and you’ll remember keratitis. These patients are miserable.
Also, if the CORNEA is inflamed, ACUITY will
obviously be decreased as light passes through the
cornea.
Don’t forget FLOURESCIN staining as this will give away the diagnosis of keratitis!
A •Difficulty keeping eye open •VIRAL - Watery B •BACTERIAL - Possibly Purulent C •PERL but you may notice a haze or branching pattern on the cornea D •Blurred vision •Halos around lights E •Diffuse (maybe perilimbal) •Corneal haze F •+ HSV - Branching pattern •+ Bacterial - Corneal Ulceration
Tx •REFER URGENTLY •Ophtho will target instigating bug
Conjunctivitis
A No pain just irritation! If it’s painful, it’s not conjunctivitis
B •Viral/Allergic: Watery esp. in AM
•Bacterial: PUS esp. in AM
C •PERLA. (If abnormal, it’s not conjunctivitis)
D •Normal -DOCUMENT
E •Diffuse
•Normal
F •Not necessary unless FB sensation
•SWABS = USELESS (exceptions: contact lens
wearer, painful, failed Tx, immunocompromised)
Tx •ABx for Bacterial (cover for Pseudo if contacts)
Glacuoma
Remember the rule of thumb: REFER all patients with any PAINFUL EYE. And – look for red eye if your patient has serious headache. If you do this you won’t miss a rare, but serious, glaucoma.
A good analogy is the eye is like an overinflated balloon, ready to pop… imagine how PAINFUL that would be. These patients are often IN DISTRESS.
As well an overinflated eyeball won’t function normally – pupil FIXED and DECREASED acuity.
•Acute, SEVERE Pain, Tender, & firm - these patients are in distress B •Minimal Watery C •Fixed, Hazy, Dilated •Anisocoria D • Decreased - DOCUMENT • Halos around lights E •Ciliary Flush F •Normal •Not necessary unless FB sensation
Tx •LOWER PRESSURE within HOURS
•IMMEDIATE REFERRAL to ED
Acute Angle-Closure Glaucoma
Emergent Treatment
Consult Ophthalmology Emergently
Initiate treatment WITHIN 60 MINUTES as recommended by ophthalmology
A sample regimen may include:
0.5% timolol maleate
1% apraclonidine, and 1 gtt each, to affected eye, 1min apart
2% pilocarpine
Oral medications may include acetazolamide, two x 250mg tablets in the office
IV medications may include acetazolamide or mannitol
Approach to vertigo
Classifying vertigo or dizziness by timing (episodic or continuous) and trigger (positional or not), rather than type (vertigo vs lightheadedness vs unsteadiness, etc) allows for effective clinical identification of both high-risk-for-stroke and low-risk-for-stroke populations.”
Consider POSTERIOR STROKE in ANY patient with dizziness, nausea, vomiting.
Symptoms can also include swallowing difficulties, facial pain with vertigo or numbness, or gait disturbance
Vertigo red flags
Red flags: hearing loss, new, unilateral focal neuro headache, new head impulse that suggests central cause (no corrective saccade)
Pitfall: Don’t use the Dix-Hallpike Maneuver on patients with continuous vertigo symptoms
Only perform this maneuver on patients whose episodes of vertigo last less than 2min, and have no nystagmus at rest.
Note that most types of vertigo will be exacerbated by head movements. Even with episodic vertigo, the feeling of nausea can persist, which can be confusing. The key is that BPPV has provoked brief episodes that resolve, and there are no nystagmus present at rest.
Peripheral
Head Impulse - Catch-up saccade (“abnormal”)
Nystagmus - unidirectional
Test of Skew - No vertical skew
Hearing loss absent
Central Head Impulse - Normal gaze tracking Nystagmus - bidirectional Test of Skew - Vertical skew present Hearing loss present
Pitfall: Don’t use the HINTS Plus exam on patients with BPPV (episodic vertigo without nystagmus at rest)
This is only indicated for patients with ongoing, constant vertigo and nystagmus at rest. The results are meaningless and confusing when performed on patients with suspected BPPV.
Validated score for Autism?
M CHAT RF
How is long QT defined? Risk factors (6) and medications to avoid for TdeP (4)?
MEN QTc > 450, WOMEN QtC > 460
congenital long QT syndrome older age previous TdeP electrolyte abnormalities: low K, low Mg, low Ca bradycardia female
Meds: domperidone citalopram macrolides quinolones
How to reduce recurrent UTIs in premenopausal women
increase daily water consumption by 1.5L/day
Reasons to prescribe abx when doing an I+D?
extensive tissue damage, risk of poor healing/complications, immunocompromised, prosthetic device
–> if MRSA, add clinda or septra
Tool for suspected concussions in sport?
questions to ask before someone can consider return to sport?
SCAT-5
sport concussion assessment tool
to return to sport:
are all symptoms resolved?
unrestricted return to normal cognitive activity achieved?
endurance and physical activities performed without symptoms?
normal exam of cervical spine and neurologic status?
any other health condition/previous concussion/context to justify an additional delay?
criteria for admission for anorexia nervosa
weight <75% of ideal body weight temp < 35.5 HR 45 SBP <80 orthostatic change in pulse >20 orthostatic change in BP >10
Rourke Baby nutritional recommendations
avoid hard/small/round foods until 3 years. Remain seated while eating/drinking
Promote family meals with self-feeding
avoid all sweetened beverages
Vit D supplementation 400IU and 800IU in high risk infants while breastfed
early introduction starting at 6 months and repeated ingestion of allergenic foods like egg, fish, peanut
Child safety advice
Rear facing car seat until 2 years of age and then booster seat for 40-80 pounds
Sleep in crib/cradle/bassinet without soft objects/loose bedding in parents room for 6 months
after umbilical stump detaches, should have supervised tummy time
vary the direction of the infants head while supine
Swaddling not recommended after 2 months