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Therapeutics 3 > CCD and ACS/HF Drug Formulary 2024 > Flashcards

CCD and ACS/HF Drug Formulary 2024 Flashcards

Top 300 Drugs from Sowinski

1
Q

Amlodipine (Norvasc) Dosing:

A

5-10mg daily
Starting dose: 2.5mg daily

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2
Q

Amlodipine (Norvasc) AE:

A

-Hypotension, flushing, headache, peripheral edema, dizziness, reflex tachycardia

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3
Q

Amlodipine (Norvasc) Monitoring Parameters:

A
  • BP (bc hypotension risk)
  • DI: grapefruit juice, CYP3A inducers/inhibitors
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4
Q

Aspirin (Ecotrin, Valazore) Dosing:

A

for CCD: 81mg daily

for ACS: 325mg chewable ASA loading dose

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5
Q

Aspirin (Ecotrin, Valazore) AE:

A
  • GI/Brain bleed
  • Hypersensitivity
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6
Q

Aspirin (Ecotrin, Valazore) Monitoring Parameters:

A
  • Bleeding
  • Drug interactions: take 12h apart from ticagrelor
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7
Q

Atenolol (Tenormin) Dosing:

A

50-100mg daily
Starting dose: 25-20mg daily

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8
Q

Atenolol (Tenormin) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
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9
Q

Atenolol (Tenormin) Monitoring Parameters:

A
  • HR
  • CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome
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10
Q

Atorvastatin (Lipitor) Dosing:

A

40-80mg daily (high)

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11
Q

Atorvastatin (Lipitor) AE:

A
  • Muscle pain, darkened urine
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12
Q

Atorvastatin (Lipitor) Monitoring Parameter:

A
  • Get lipid panel
  • Muscle pain, darkened urine
  • Liver function tests
  • Grapefruit juice (1 quart)
  • CI: pregnancy
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13
Q

Benazepril (Lotensin) Dosing:

A

40mg daily/20mg BID
Starting dose: 10mg daily/BID

N/A for HF

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14
Q

Benazepril (Lotensin) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
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15
Q

Benazepril (Lotensin) Monitoring Parameters:

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
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16
Q

Bisoprolol (Monocor, Zebeta) Dosing:

A

5-10mg daily

For HF:
10mg daily
Initial: 1.25mg daily

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17
Q

Bisoprolol (Monocor, Zebeta) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
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18
Q

Bisoprolol (Monocor, Zebeta) Monitoring Parameters:

A

-HR
- CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome

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19
Q

Bumetanide (Bumex) Dosing:

A

2mg daily
Starting dose: 0.5mg daily/BID

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20
Q

Bumetanide (Bumex) AE:

A
  • Hypokalemia
  • Hypomagnesemia
  • Hypocalcemia
  • Hyperuricemia
  • Ototoxicity
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21
Q

Bumetanide (Bumex) Monitoring Parameters:

A
  • CI: Sulfa allergy
  • Better in pts w/ CrCl<30ml/min
  • Check K, Mg, Ca levels
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22
Q

Candesartan (Atacand) Dosing:

A

32mg daily
Starting dose: 8mg daily

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23
Q

Candesartan (Atacand) AE:

A
  • Hypotension
  • Hyperkalemia
  • Angioedema
  • GFR reduction
  • fetal pathologies
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24
Q

Candesartan (Atacand) Monitoring Parameters:

A
  • BUN/Scr, K, renal function
  • CI: Hx of angioedema on an ARB, concomitant use of aliskiren in pts w/ DM, pregnancy/breastfeeding
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25
Q

Carvedilol (Coreg) Dosing:

A

25-50mg BID
Starting dose: 6.25mg BID

For HF:
Coreg - 25-50mg BID
Initial - 3.125 BID

Coreg CR 80mg daily
Initial - 10mg daily

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26
Q

Carvedilol (Coreg) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
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27
Q

Carvedilol (Coreg) Monitoring Parameters:

A
  • CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome
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28
Q

Chlorthalidone (Thalitone, Hygroton) Dosing:

A

100mg daily
Starting dose: 12.5mg daily

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29
Q

Chlorthalidone (Thalitone, Hygroton) AE:

A
  • Hypokalemia
  • Metabolic acidosis
  • Hyperuricemia
  • Hypercalcemia
  • Hyperglycemia
  • Hyperlipidemia
  • Sexual dysfunction
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30
Q

Chlorthalidone (Thalitone, Hygroton) Monitoring Parameters

A
  • K levels, electrolyte levels, glucose levels, lipid/TG/cholesterol levels
  • DI: lithium toxicity with concurrent use
  • CI: sulfa allergy, anuria (can’t pee)
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31
Q

Clopidogrel (Plavix) Dosing:

A

75mg daily
Loading dose: 300-600mg (none if they took a fibrinolytic + they’re above 75 yo)

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32
Q

Clopidogrel (Plavix) AE:

A
  • Bleeding (increased when added to ASA)
  • Diarrhea
  • Rash
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33
Q

Clopidogrel (Plavix) Monitoring Parameters:

A
  • Hold 5 days prior to CABG
  • Bleed risk
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34
Q

Dapagliflozin (Farxiga) Dosing:

A

10mg daily
Starting dose: 5mg daily

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35
Q

Dapagliflozin (Farxiga) AE:

A
  • UTIs
  • Genital fungal infections (gangrene)
  • Hypotension
  • Hyperkalemia
  • Increased cholesterol
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36
Q

Dapagliflozin (Farxiga) Monitoring Parameters:

A
  • Do not use in pts with eGFR of <25, unless already on it, then monitor
  • Do not use if pt is on end-stage renal dysfunction on hemodialysis
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37
Q

Digoxin (Lanoxin) Dosing:

A

0.25mg daily
Starting dose: 0.125mg daily

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38
Q

Digoxin (Lanoxin) AE:

A
  • Seeing halos (hallucinations)
  • Dizziness
  • Headache
  • Stomach pain
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39
Q

Digoxin (Lanoxin) Monitoring Parameters:

A
  • HR, ECGs, BUN/SCr, K, Mg, Ca, serum digoxin levels to watch for toxicity
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40
Q

Diltiazem (Cardizem) Dosing:

A

80-120mg TID

Dilt ER:
Starting dose: 120-180mg daily
Max dose: 360-540mg daily

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41
Q

Diltiazem (Cardizem) AE:

A
  • Red. myocardial contractility, bradycardia, hypotension, flushing, headache, dizziness, constipation
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42
Q

Diltiazem (Cardizem) Monitoring Parameters:

A
  • CI in HFrEF, bradycardia (HR<50); high deg AV block or sick sinus syndrome (no pacemaker)
  • Do not use in pts w/ LV dysfunction, increased risk for cardiogenic shock, PR interval >0.24s
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43
Q

Empagliflozin (Jardiance) Dosing:

A

25mg daily
Starting dose: 10mg daily

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44
Q

Empagliflozin (Jardiance) AE:

A
  • UTIs
  • Genital fungal infections (gangrene)
  • Hypotension
  • Hyperkalemia
  • Increased cholesterol
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45
Q

Empagliflozin (Jardiance) Monitoring Parameters:

A
  • Do not use in pts with eGFR of <30ml/min, unless already on it, then monitor
  • Do not use if pt is on end-stage renal dysfunction on hemodialysis
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46
Q

Enalapril (Vasotec) Dosing:

A

40mg daily
Starting dose: 5mg BID/TID

HF:
10mg BID
Initial: 2.5-5mg BID

20mg enalapril = 20mg lisinopril = 150mg captopril

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47
Q

Enalapril (Vasotec) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
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48
Q

Enalapril (Vasotec) Monitoring Parameters:

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
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49
Q

Felodipine (Plendil) Dosing:

A

5-10mg daily
Max dose: 20mg daily

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50
Q

Felodipine (Plendil) AE:

A

-Hypotension, flushing, headache, peripheral edema, dizziness, reflex tachycardia

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51
Q

Felodipine (Plendil) Monitoring Parameters:

A
  • DI: grapefruit juice, CYP3A inducers/inhibitors
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52
Q

Fosinopril (Monopril) Dosing:

A

40mg daily
Starting dose: 10mg daily

For HF:
40mg daily
Initial: 5-10mg daily

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53
Q

Fosinopril (Monopril) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
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54
Q

Fosinopril (Monopril) Monitoring Parameters

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
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55
Q

Furosemide (Lasix) Dosing:

A

80mg daily
Starting dose: 20mg/dose

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56
Q

Furosemide (Lasix) AE:

A
  • Hypokalemia
  • Hypomagnesemia
  • Hypocalcemia
  • Hyperuricemia
  • Ototoxicity
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57
Q

Furosemide (Lasix) Monitoring Parameters:

A
  • CI: Sulfa allergy
  • Better in pts w/ CrCl<30ml/min
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58
Q

Hydrochlorothiazide (Microzide) Dosing:

A

50mg daily
Starting dose: 12.5mg daily

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59
Q

Hydrochlorothiazide (Microzide) AE:

A
  • Hypokalemia
  • Metabolic acidosis
  • Hyperuricemia
  • Hypercalcemia
  • Hyperglycemia
  • Hyperlipidemia
  • Sexual dysfunction
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60
Q

Hydrochlorothiazide (Microzide) Monitoring Parameters

A
  • K levels, electrolyte levels, glucose levels, lipid/TG/cholesterol levels
  • DI: lithium toxicity with concurrent use
  • CI: sulfa allergy, anuria (can’t pee)
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61
Q

Hydralazine (Apresoline) Dosing:

A

40-300mg 2-4 times daily

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62
Q

Hydralazine (Apresoline) AE:

A
  • Palpitations
  • Tachycardia
  • Chest pain
  • GI SE
  • Lupus-like rash
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63
Q

Hydralazine (Apresoline) Monitoring Parameters:

A
  • Caution with CVA, renal impairment, CAD, liver disease, SLE
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64
Q

Irbesartan (Avapro) Dosing:

A

300mg daily
Starting dose: 150mg daily

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65
Q

Irbesartan (Avapro) AE:

A
  • Hypotension
  • Hyperkalemia
  • Angioedema
  • GFR reduction
  • fetal pathologies
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66
Q

Irbesartan (Avapro) Monitoring Parameters:

A
  • BUN/Scr, K, renal function
  • CI: Hx of angioedema on an ARB, concomitant use of aliskiren in pts w/ DM, pregnancy/breastfeeding
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67
Q

Isosorbide dinitrate (Isordil, ISDN) Dosing:

A

Chewable tab: 5-10mg once daily

SL tab: 2.5-10mg once daily

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68
Q

Isosorbide dinitrate (Isordil, ISDN) AE:

A
  • Headaches
  • Hypotension
  • Bradycardia
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69
Q

Isosorbide dinitrate (Isordil, ISDN) Monitoring Parameters

A
  • Caution with HOCM, severe aortic stenosis, PDI use
70
Q

Isosorbide mononitrate (Monoket, Imdur, ISMO) Dosing:

A

20mg BID

71
Q

Isosorbide mononitrate (Monoket, Imdur, ISMO) AE:

A
  • Headaches
  • Hypotension
  • Bradycardia
72
Q

Isosorbide mononitrate (Monoket, Imdur, ISMO) Monitoring Parameters:

A
  • Caution with HOCM, severe aortic stenosis, PDI use
73
Q

Labetolol (Trandate) Dosing:

A

200-400mg BID

74
Q

Labetolol (Trandate) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
75
Q

Labetolol (Trandate) Monitoring Parameters:

A
  • CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome
76
Q

Lisinopril (Zestril) Dosing:

A

For HF:
20-40mg daily
Starting dose: 2.5-5mg daily

20mg enalapril = 20mg lisinopril = 150mg captopril

77
Q

Lisinopril (Zestril) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
78
Q

Lisinopril (Zestril) Monitoring Parameters:

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
79
Q

Losartan (Cozaar) Dosing:

A

100mg daily
Starting dose: 50mg daily/BID

80
Q

Losartan (Cozaar) AE:

A
  • Hypotension
  • Hyperkalemia
  • Angioedema
  • GFR reduction
  • fetal pathologies
81
Q

Losartan (Cozaar) Monitoring Parameters:

A
  • BUN/Scr, K, renal function
  • CI: Hx of angioedema on an ARB, concomitant use of aliskiren in pts w/ DM, pregnancy/breastfeeding
82
Q

Metoprolol (Lopressor, Toprol XL) Dosing:

A

N/A for HF:
Lopressor (succinate): 50-100mg BID

Toprol XL (tartrate): 100-200mg daily
Starting dose: 25-50mg q6-12h

For HF: Toprol XL ONLY
200mg daily
Initial: 12.5-25mg daily

83
Q

Metoprolol (Lopressor, Toprol XL) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
84
Q

Metoprolol (Lopressor, Toprol XL) Monitoring Parameters:

A
  • CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome
85
Q

Nebivolol (Bystolic) Dosing:

A

40mg daily
Starting dose: 5mg daily

86
Q

Nebivolol (Bystolic) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
87
Q

Nebivolol (Bystolic) Monitoring Parameters:

A
  • CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome
88
Q

Nifedipine (Procardia XL) Dosing:

A

30-60mg daily
Max dose: 120mg daily

89
Q

Nifedipine (Procardia XL) AE:

A

-Hypotension, flushing, headache, peripheral edema, dizziness, reflex tachycardia

90
Q

Nifedipine (Procardia XL) Monitoring Parameters:

A
  • CI in HFrEF
  • DI: grapefruit juice, CYP3A inducers/inhibitors
91
Q

Nitroglycerin (SL, Patches, IV) (Nitrostat, Nitro-Dur, glyceryl trinitrate IV) Dosing:

A

SL Tabs: 0.3-0.6mg PRN, repeat dose up to 3 times every 5 min

SL Spray: 0.4mg/spray, repeat dose up to 3 times every 5 min

IV NTG: 10mcg/min; titrate by 5mcg/min q5min

Patches: 1 patch daily, on 7am, off 7-9pm (not for ACS)

92
Q

Nitroglycerin (SL, Patches, IV) (Nitrostat, Nitro-Dur, glyceryl trinitrate IV) AE:

A
  • Headache (throbbing or pulsating sensation)
  • Hypotension, dizziness, lightheadedness and facial flushing
  • Reflex tachycardia
93
Q

Nitroglycerin (SL, Patches, IV) (Nitrostat, Nitro-Dur, glyceryl trinitrate IV) Monitoring Parameters:

A
  • APAP use
  • Extreme caution with PDEi (potent vasodilators)
  • Caution with HOCM, severe aortic stenosis, PDI use
94
Q

Olmesartan (Benicar) Dosing:

A

40mg daily
Starting dose: 20mg daily

95
Q

Olmesartan (Benicar) AE:

A
  • Hypotension
  • Hyperkalemia
  • Angioedema
  • GFR reduction
  • fetal pathologies
96
Q

Olmesartan (Benicar) Monitoring Parameters:

A
  • BUN/Scr, K, renal function
  • CI: Hx of angioedema on an ARB, concomitant use of aliskiren in pts w/ DM, pregnancy/breastfeeding
97
Q

Omega-3 fatty acid (Lovaza, icosapent ethyl) Dosing:

A

Lovaza: 2-4gms daily or divided BID
Vascepa (icosapent ethyl): 2gm BID w/ food

98
Q

Omega-3 fatty acid (Lovazza, icospent ethyl) AE:

A
  • Fishy breath
  • Increase bleeding risk
99
Q

Omega-3 fatty acid (Lovazza, icospent ethyl) Monitoring Parameters:

A
  • LDL/TG
100
Q

Prasugrel (Effient) Dosing:

A

10mg daily

101
Q

Prasugrel (Effient) AE:

A
  • Bleeding (increases life-threatening bleeding compared to clopidogrel)
  • Diarrhea
  • Rash
102
Q

Prasugrel (Effient) Monitoring Parameters:

A
  • Hold for 7 days prior to CABG
  • Bleed risk
103
Q

Propranolol (Inderal LA, Innopran XL, Inderal XL) Dosing:

A

Inderal: Variable

Inderal LA: 80-160mg daily
Starting dose: 40mg BID-TID

104
Q

Propranolol (Inderal LA, Innopran XL, Inderal XL) AE:

A
  • Sinus bradycardia, sinus arrest, AV block, reduced LVEF
  • bronchoconstriction
  • fatigue, depression, exercise intolerance, sexual dysfunction
105
Q

Propranolol (Inderal LA, Innopran XL, Inderal XL) Monitoring Parameters:

A
  • CI in bradycardia (HR<50); high deg AV block or sick sinus syndrome
106
Q

Quinapril (Accupril) Dosing:

A

80mg daily
Starting dose: 10mg daily/BID

HF:
20-40mg BID
Initial: 5-10 BID

107
Q

Quinapril (Accupril) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
108
Q

Quinapril (Accupril) Monitoring Parameters:

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
109
Q

Potassium Chloride (Klor Con, KDur) Dosing:

A
110
Q

Potassium Chloride (Klor Con, KDur) AE:

A
111
Q

Potassium Chloride (Klor Con, KDur) Monitoring Parameters:

A
112
Q

Pravastatin (Pravachol) Dosing:

A

40-80 mg daily (moderate)

113
Q

Pravastatin (Pravachol) AE:

A
  • Muscle pain
114
Q

Pravastatin (Pravachol) Monitoring Parameters:

A
  • Get lipid panel
  • Muscle pain, darkened urine
  • Liver function tests
  • Grapefruit juice (1 quart)
  • CI: pregnancy
115
Q

Ramipril (Altace) Dosing:

A

10mg daily OR 5mg BID
Starting dose: 2.5mg BID

For HF:
5mg BID or 10mg daily
Initial: 1.25-2.5mg QD

116
Q

Ramipril (Altace) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
117
Q

Ramipril (Altace) Monitoring Parameters:

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
118
Q

Ranolazine (Ranexa) Dosing:

A

500-1000mg BID

119
Q

Ranolazine (Ranexa) AE:

A
  • constipation, nausea, dizziness, headache
120
Q

Ranolazine (Ranexa) Monitoring Parameters:

A
  • Do not use with strong CYP3A inhibitors/inducers; limit dose (500mg) w/ mod inhibitors (Dilt, Ver)
  • Do not use with other drugs that prolong QT interval
121
Q

Rivaroxaban (Xarelto) Dosing:

A

15-20mg daily with food
Also available in 2.5mg BID

122
Q

Rivaroxaban (Xarelto) AE:

A
  • Major hemorrhage
  • Spinal/epidural hematomas
123
Q

Rivaroxaban (Xarelto) Monitoring Parameters:

A
  • Kidney function
124
Q

Rosuvastatin (Crestor) Dosing:

A

20-40mg daily (high)

125
Q

Rosuvastatin (Crestor) AE:

A
  • Muscle pain
126
Q

Rosuvastatin (Crestor) Monitoring Parameters:

A
  • Get lipid panel
  • Muscle pain, darkened urine
  • Liver function tests
  • Grapefruit juice (1 quart)
  • CI: pregnancy
127
Q

Sacubitril/Valsartan (Entresto) Dosing:

A

Initial: 24mg/26mg BID
Max: 97mg/103mg BID daily

128
Q

Sacubitril/Valsartan (Entresto) AE:

A
  • AKI
  • Angioedema
  • Hyperkalemia
  • Hypotension
129
Q

Sacubitril/Valsartan (Entresto) Monitoring Parameters:

A
  • BP
  • Kidney function
  • SCr
130
Q

Simvastatin (Zocor) Dosing:

A

20-40mg daily (moderate)

131
Q

Simvastatin (Zocor) AE:

A
  • Muscle pain
132
Q

Simvastatin (Zocor) Monitoring Parameters:

A
  • Get lipid panel
  • Muscle pain, darkened urine
  • Liver function tests
  • Grapefruit juice (1 quart)
  • CI: pregnancy
133
Q

Spironolactone (Aldactone) Dosing:

A

100mg daily
Starting dose: 12.5mg daily/BID

134
Q

Spironolactone (Aldactone) AE:

A
  • Hyperkalemia
  • Hyponatremia
  • Gynecomastia
135
Q

Spironolactone (Aldactone) Monitoring Parameters:

A
  • Avoid with ACEi/ARBs/Renin inhibitors/ NSAIDS - risk of hyperkalemia
  • CI: Concomitant use with potassium-sparing diuretics
136
Q

Ticagrelor (Brilinta) Dosing:

A

90mg BID
Loading dose: 180mg

137
Q

Ticagrelor (Brilinta) AE:

A
  • Bleeding
  • Bradycardia
  • Heart block
  • Dyspnea
  • Ventricular pauses
138
Q

Ticagrelor (Brilinta) Monitoring Parameters:

A
  • Take about 12h apart w/ ASA
  • Tell Dr. if you experience SOB
  • Hold 3 days prior to CABG
139
Q

Telmisartan (Micardis) Dosing:

A

80mg daily
Starting dose: 20mg daily

140
Q

Telmisartan (Micardis) AE:

A
  • Hypotension
  • Hyperkalemia
  • Angioedema
  • GFR reduction
  • fetal pathologies
141
Q

Telmisartan (Micardis) Monitoring Parameters:

A
  • BUN/Scr, K, renal function
  • CI: Hx of angioedema on an ARB, concomitant use of aliskiren in pts w/ DM, pregnancy/breastfeeding
142
Q

Torsemide (Soaanz) Dosing:

A

10mg daily
Starting dose: 0.5mg daily/BID

143
Q

Torsemide (Soaanz) AE:

A
  • Hypokalemia
  • Hypomagnesemia
  • Hypocalcemia
  • Hyperuricemia
  • Ototoxicity
144
Q

Torsemide (Soaanz) Monitoring Parameters:

A
  • CI: Sulfa allergy
  • Better in pts w/ CrCl<30ml/min
145
Q

Valsartan (Diovan) Dosing:

A

160mg BID
Starting dose: 20mg BID

146
Q

Valsartan (Diovan) AE:

A
  • Hypotension
  • Hyperkalemia
  • Angioedema
  • GFR reduction
  • fetal pathologies
147
Q

Valsartan (Diovan) Monitoring Parameters:

A
  • BUN/Scr, K, renal function
  • CI: Hx of angioedema on an ARB, concomitant use of aliskiren in pts w/ DM, pregnancy/breastfeeding
148
Q

Verapamil (Calan, Isoptin) Dosing:

A

60-90mg TID-QID

Vera ER:
Starting dose: 100-180mg daily
Max dose: 400-480mg daily

149
Q

Verapamil (Calan, Isoptin) AE:

A
  • Red. myocardial contractility, bradycardia, hypotension, flushing, headache, dizziness, constipation
150
Q

Verapamil (Calan, Isoptin) Monitoring Parameters:

A
  • CI in HFrEF, bradycardia (HR<50); high deg AV block or sick sinus syndrome
151
Q

Bivalirudin (Angiomax) Dosing:

A

Bolus: 0.75mg/kg IV
Maintenance 1.75mg/kg/hr infusion

152
Q

Bivalirudin (Angiomax) AE:

A
  • Thrombosis
  • Hemorrhage
153
Q

Bivalirudin (Angiomax) Monitoring Parameters:

A
  • ACR, aPTT, PT/INR, bleeding
154
Q

Captopril (Capoten) Dosing:

A

For HF:
50mg TID
Starting dose: 6.25-12.5mg TID

20mg enalapril = 20mg lisinopril = 150mg captopril

155
Q

Captopril (Capoten) AE:

A
  • Dry cough, angioedema, hyperkalemia
  • DI: NSAIDs
156
Q

Captopril (Capoten) Monitoring Parameters

A
  • Do not use in hypotension/shock, bilateral renal artery stenosis or Hx of worsening of renal function w/ ACE inhibitor/ARB exposure, acute renal failure, or drug allergy/angioedema
  • Check Scr, K, BP, and angioedema
157
Q

Enoxaparin (Lovenox, LMWH) Dosing:

A

Bolus: 30mg IV
Maintenance: 1mg/kg sc q12h (15 min after bolus)

158
Q

Enoxaparin (Lovenox) AE:

A
  • Major bleeding
  • Spinal/epidural hematomas
  • Thrombocytopenia
159
Q

Enoxaparin (Lovenox) Monitoring Parameters:

A
  • Renal impairment
  • Platelet count, HgB, HcT, SCr,
160
Q

Eplerenone (Inspra) Dosing:

A

100mg daily
Starting dose: 50mg daily/BID

161
Q

Eplerenone (Inspra) AE:

A
  • Hyperkalemia
  • Hyponatremia
162
Q

Eplerenone (Inspra) Monitoring Parameters:

A
  • Avoid with ACEi/ARBs/Renin inhibitors/ NSAIDS - risk of hyperkalemia
  • CI: impaired renal function, T2DM & proteinuria, concomitant use with potassium-sparing diuretics
163
Q

Fondaparinux (Arixtra) Dosing:

A

Bolus: 2.5mg IV
Maintenance: 2.5mg sc q24h

164
Q

Fondaparinux (Arixtra) AE:

A
  • Hypotension
  • Insomnia
  • Dizziness
  • Hypokalemia
165
Q

Fondaparinux (Arixtra) Monitoring Parameters:

A
  • Do not use alone for PCI
  • CI for CrCl < 30ml/min
  • CBC, SCr, check stools for bleeding
166
Q

Heparin Dosing:

A

Initial bolus: 60-80 units/kg
Cont. infusion: 12-18 units/kg/hour

167
Q

Heparin AE:

A
  • Major bleeding
  • Osteoporosis
  • Thrombocytopenia
168
Q

Heparin Monitoring Parameters:

A
  • HgB, HcT, platelet count, aPTT, bleeding in the stool
169
Q

Prasugrel (Effient) Dosing:

A

10mg daily
Loading dose: 60mg

170
Q

Prasugrel (Effient) AE:

A
  • High bleeding risk
171
Q

Prasugrel (Effient) Monitoring Parameters:

A
  • CI in pts w/ Hx of TIA/stroke
  • Not recc in pts >75yo <60kg, or a high bleeding risk

Therapeutics 3 (3 decks)

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