CC Flashcards
Measurement of analytes in biochemistry may either use:
Conventional unit or System unit
Seven independent base units of SI unit. Give measure and unit
Meter-length kilogram-mass seconds-time mole-quantity of substance ampere-electric current kelvin-thermodynamic temperature candela-luminous intensity
SI unit is used because (a) and (b) in such terms allows for:
a. compound react on a molar basis
b. expression of amounts of substances
for: better understanding of relative proportion of compounds
3 classes of SI unit
Base, Derived, Supplemental units
In SI unit, analytes be reported using:
moles of solute/ volume of solution (mmol/l)
enzymatic activity is measured utilizing the?
International unit per liter (IU/L) or (U/L) or Katal unit (KU/L)
Quality control is a system of ensuring (a) and (b) in the laboratory by including quality control reagents in every series of measurements
accuracy and precision
Quality control involves the process of: (3)
- monitoring the characteristics of analytical processes
- detects analytical errors during testing
- prevent the reporting of inaccurate patient test results
Parameters of QC: measure the smallest concentration
Sensitivity
Parameters of QC: measure only the analyte of interest
specificity
Parameters of QC: nearness or closeness
Estimated using 3 types of studies: (1), (2), (3)
Accuracy
- recovery
- interference
- patient sample comparison
Parameters of QC: give repeated results on the same sample that agree with one another
Precision or reproducibility
Parameters of QC: method is easily repeated
practicability
Parameters of QC: maintain accuracy and precision over an extended period of time
reliability
Parameters of QC: detect the proportion of individuals with the disease. More true-positive and few false-negative
Give the formula
Diagnostic sensitivity
Sensitivity (%) = 100 X the number of diseased individuals with a positive test/ total number of diseased individuals tested
