CBD

Question 1

What dose of “hemp rich” CBC has been shown to be an adjunct therapy for CAD?

Answer 1

2mg/kg BID

Question 2

Does CBC affect pruritus or lesions?

Answer 2

Decreased pruritus at 14 days

Question 3

T/F CBC has a narrow range of serum concentration

Answer 3

False, wide range

Question 4

What are the concerns for cytotoxicity with CBD?

Answer 4

Liver, upregulation of cytochrome p450

Question 5

What is the precursor for CBD?

Answer 5

Cannabidiolic acid (CBDA) is precursor carboxylic acid form of cannabidiol (CBD)

Question 6

T/F cannabinoids have been shown to have immunomodulatory and anti-inflammatory effects in mammals

Answer 6

True, effective at reducing OA pain and seizures

Question 7

What are the cannabinoid receptors? What is their significance?

Answer 7

CB1 and CB2 G-protein coupled receptors both expressed in keratinocytes; immunoreactivity heightened in atopic dogs compared to healthy dogs

Question 8

CBD alters endogenous levels of naturally derived endocannabinoids such as anandamide but does it interact with CB1 and CB2 directly?

Answer 8

No, but CBD may also interact with other receptor systems in inflammatory cells or neurons such as TRPV (transient receptor activation channels), adenosine reuptake inhibitor, and PARR (peroxisome proliferation and activation receptors)