CB32 Neurotransmission 2

Question 1

Describe the possible mechanisms by which transmitter action may be terminated

Answer 1

• Neurotransmitter diffuses out of the cleft
• enzymatic degradation of the signal in the synaptic cleft
• uptake of the transmitter via presynaptic transporters

e.g. ACh is terminated by enzyme degradation
- ACh diffuses out of cleft
- terminated by acetyle