Causes of Cell Injury and Death

Question 1

What is lethal injury?

Answer 1

Injury that causes death.

Question 2

What is sublethal injury?

Answer 2

Injury not amounting to cell death and may be reversible. It can, however, progress to cell death.

Question 3

Why don’t cardiac cells die from the increased pressure they are under?

Answer 3

They have adapted. The adaptation is hypertrophy, making them thicker.

Question 4

What are the 8 main causes of cell injury?

Answer 4

Infectious agents.
Chemical agents.
Oxygen deprivation.
Aging.
Physical agents.
Immunological reactions.
Nutritional imbalances.
Genetic defects.

I COAPING

Question 5

What does the response to injury depend on?

Answer 5

Type of injury, the duration and its severity.

Question 6

What four main intracellular systems are vulnerable?

Answer 6

Cell membrane integrity
ATP generation
Protein synthesis
Integrity of the genetic apparatus.