Causes Of Cell Injury Flashcards
What is anything that disrupts cellular homeostasis?
Cell injury
What are the 3 types of responses to injury?
Degeneration
Death
Adaptation
What is when:
-inadequate oxygenation of blood
-reduction of vascular perfusion
-reduced oxygen transport by erythrocytes
Inhibition of respiratory enzymes of the cell
Oxygen deficiency = hypoxia
What are anemia and carbon monoxide poising examples of?
Oxygen deficiency/hypoxia
What is the following cell injury?
Mechanical trauma
Electric shock
Temperature extremes- heat stroke/frostbite
Physical agents
What is the following cell injury?
-bacteria= exotoxins and endotoxins
-viruses
-fungi
-parasites
Infectious microbes
What is the following cell injury?
Deficiencies
Excesses
Imbalances
Nutritional imbalances
What is the following cell injury?
Long-term starvation
Insufficient vitamin D
Grain overload
Nutritional imbalances
What is the following cell injury?
Mutation results in:
-production of abnormal protein and defective enzyme
-lack of necessary enzyme
-neoplasia
Genetic derangement
What is the following cell injury?
Polycystic kidney disease
Medulloblastoma
Genetic derangement
What is the following cell injury?
-overwork or overstimulation
-underwork or lack of stimulation
Workload imbalance
What is the following cell injury?
-hypertrophy of muscle in weightlifters
-myocardial hypertrophy secondary to valvular stenosis
-disuse atrophy
-denervation atrophy
-lack of endocrine stimulation
Workload imbalance
What is the following cell injury?
-snakebite
-mycotoxin
-therapeutic drugs
-various metals
Chemicals, drugs, toxins
What is the following cell injury?
-immunological deficiencies
-allegories or hypersensitivity
-autoimmune diseases
Immunological dysfunction
What is the following cell injury?
-cumulative damage to cell proteins, lipids, nucleic acids
-attired to ROS, DNA mutations
-cumulative damage to DNA predisposes to neoplasia
-penile squamous carcinoma in horses
Aging
