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Anti-neoplastic drugs > Categories > Flashcards

Categories Flashcards

1
Q

Alkylating Agents

A 
Nitrogen Mustards
Methylhydrazine derivative
Alkyl sulfonate
nitrosoureas
Triazenes
Platinum coordination complexes
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2
Q

Nitrogen Mustards

A 
Cyclophosphamid
ifosfamide
mechlorethamine
melphalan
chlorambucil
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3
Q

Methylhydrazine derivative

A

procarbazine

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4
Q

Alkyl Sulfonate

A

busulfan

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5
Q

Ntrosoureas

A

carmustine
streptozocin
bendamustine

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6
Q

Triazines

A

dacarbazine

temozolomide

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7
Q

Platinum Coordination complexes

A

cisplatin
carboplatin
oxaliplatin

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8
Q

Antimetabolites

A

Folic acid analogs
pyrimidine analogs
purine analogs

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9
Q

Folic acid analogs

A

methotrexate

pemetrexed

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10
Q

Pyrimidine analogs

A 
Flourouracil
capecitabine
cytarabine
gemcitabine
5-aza-cytidine
deoxy-5-aza-cytidine
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11
Q

Purine analogs

A 
mercaptopurine
pentostatin
fludarabine
clofarabine
nelarabine
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12
Q

Natural products

A 
vinca alkaloids
taxanes
epipodophyllotoxins
camptothecins
antibiotics
echinocandins
anthracenedione
enzymes
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13
Q

vinca alkaloids

A

vinblastine
vinorelbine
vincristine

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14
Q

taxanes

A

paclitaxel

docetaxel

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15
Q

epipodophyllotoxins

A

etoposide

teniposide

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16
Q

camptothecins

A

topotecan

irinotecan

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17
Q

antibiotics

A

doxorubicin
dactinomycin
daunorubicin

18
Q

echinocandins

19
Q

anthracenedione

A

bleomycin
mitoxantrone
mitomycin C

20
Q

Enzymes

A

l-asparaginase

pegaspargase

21
Q

Hormones and antagonists

A

steroid hormones

progestins, antiestrogens, antiandrogens

22
Q

Monoclonal Antibodies

A 
Rituximab
alemtuzumab
gemtuzumab
trastuzumab
cetuximab
bevacizumab
ibritumomab
tositumomab
23
Q

Vaccines

A

Hep B vaccine

Gardasil (HPV vaccine)

24
Q

Agents to min adverse effects

A 
Sargramostim
filgrastim and pegfilgrastin
oprelvekin
EPO/darbepoetin
serotonin antagonists (ondansetron)
25
Q

Misc agents

A 
substituted urea
differentiating agents
biological response modifiers
immunomodulators
protein TK inhbitors
proteasome inhibitor
mTOR inhibitors
26
Q

mTOR inhibitors

A

temsirolimus

everolimus

27
Q

proteasome inhibitor

A

bortezomib

28
Q

substituted urea

A

hydroxyurea

29
Q

differentiating agents

A

tretinoin
arsenic trioxide
histone deacetylase inhibitor

30
Q

biological response modifiers

A

interferon-alfa

interleukin-2

31
Q

immunomodulators

A

thalidomide

lenalidomide

32
Q

Protein TK inhib

A 
imatinib
dasatinib
nilotinib
gefitinib
erlotinib
sorafenib
sunitinib
lapatinib
33
Q

Alkylating MOA

A

electrophiles-form covalent linkages with DNA
cross-linkng (prevents tumor from unwiding DNA for mRNA prod)
miscoding tru abn base pairing with T or excision of G (strand breakage)
CCNS

34
Q

Alkylating SE

A

acute-N/V 30-60 min of IV, tissue damage at injection site
delayed-BM dep (leukopenia, thrombocytopen)
nephrotoxicity
alopecia
mucosal ulceration
intestinal denudation
Inc risk of 2 malig (AML)

35
Q

Alkylating SE (cyclophosphamide)

A

hemorrhagic cystitis-accumulation acreolin

IV mesna to prevent

36
Q

Alkylating SE (cisplatin)

A

renal tubular damage-hydration
ototoxicity-worse in kids, UL BL
NV

37
Q

Alkylating SE (busulfan)

A

hyperpigmentation, pulmonary fibrosis, adrenal insuff

38
Q

Antimetabolites MOA (foli acid analogs)

A

inhib dihydrofolate reductase, blocks conversion of folic acid to tetrahydrofolic acid
CCS (s-phase)
can give leucovorin to allow thymidine synthesis to proceed (sparing severe GI, BM tox)

39
Q

Antimetabolites SE (folic acid)

A

mucositis, diarrhea, myelosuppresso with neutropenia/thrombocytopenia, N/V immunosuppression, hepatotox, fatigue

40
Q

Antimetab MOA (pyrimidine, Fluorouracil)

A

prodrug, FdUMP covalently binds thymidylate synthetase blocks synth of thymidylate
interferes with DNA synth/fx, RNA processing, mRNA translation
CCS (s-phase)

41
Q

Antimetab SE/USE (pyrimidine, 5-FU)

A

mostly used in colorectal cancer

anorexia, N/D, stomatitis

Anti-neoplastic drugs (1 decks)

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