Catecholamines

Question 1

What NT is this?

Answer 1

Dopamine

Question 2

What NT is this?

Answer 2

Norepinephrine

Question 3

What NT is this?

Answer 3

Epinephrine

Question 4

Fill in the blanks

Question 5

Reserpine

Answer 5

• inhibits VMAT
• depletes DA and NE
• treatment causes
  
  • sedation:animals
  • depression:humans

Question 6

Cocaine

Answer 6

• inhibits DAT
• leads to synaptic accumulation of DA

Question 7

Amphetamine

Answer 7

• Enters cell through DAT
• Releases DA from vessicles
• Reverses flow of DA through DAT
• Increases DA in the synapse

Question 8

Dopamine Receptors

D1 and D2

Answer 8

Both are G-protein coupled

D1 signals through G_salpha to increase cAMP (excitatory)

D2 signals through G_ialpha to decrease cAMP (inhibitory)

Question 9

State and describe the dopaminergic pathways

Answer 9

1. Nigrostriatal System: projects from the substantia nigra and VTMA to striatum
2. Tuberoinfundibular System: projects from the medial eminence to the pituitary
3. Mesolimbic/Mesocortical system: projects from the VMTA to the limbic system, nucleus accumbens,

Question 10

6-OHDA (6-hydroxydopamine)

Answer 10

• neurotoxin
• BBB permeable
• used for sterotaxic surgeries
• Bilateral Lesion: sensory neglect, motivational deficits, motor impairment
• Unilateral lesion: nigrostriatal pathway results in postural assymmetry and turning