Catecholamines Flashcards
T/F catecholamines pass the blood brain barrier very poorly.
True
Describe the epinephrine.
Direct acting
Catecholamine
Adrenergic agonist
Describe NE
Direct acting
Catecholamine
Works on a1,a2 and b adrenergic receptors
Describe isoproterenol.
Direct acting
Catecholamine
Describe dopamine.
Precursor to NE.
Describe GABA.
Inhibitory neurotransmitter
Describe glutamate and aspartate
CNS amino acids
Excitatory effects on cns
List the catecholamines.
Epi, NE, isoproterenol, dopamine, dobutamine.
What sympathomimetic has clinical applications for anaphylaxis, glaucoma, asthma and vasoconstriction?
Epi
What sympathomimetic causes vasoconstriction during HYPOtension?
NE
What is the clinical application of isoproterenol?
Asthma
Dopamine and dobutamine have clinical application for what emergencies?
Shock and hear failure
Amphetamine, phenmetrazine are used to treat?
Narcolepsy, obesity and ADHD.
Ephedrine is used to treat?
Incontinence an vasoconstriction during HYPOtension.
Phenylephrine causes?
Mydrasis, vasoconstriction, decongestion.
Analeptics are cns stimulants that treat?
Drug induced respiratory depression and hypnosis.
What is the action of xanthines?
Improve mental alertness, reduce the urge to sleep and elevate mood.
Theophylline is what type of stimulant and what is it used to treat?
Xanthine, used to treat asthma.
What is considered the toxic range for caffeine?
> 1000mg a day
What part of the cns does caffeine stimulate the most?
Cortex
Liberation of ach after threshold stimulus does what to the cell?
Alters cell membrane permeability.
