Catecholamines

Question 1

Dopamine, Norepinephrine and Epineprhine bio-synthetic pathway

Answer 1

Tyrosine is conerted to L-DOPA by Tyrosine Hydroxylase.
L-DOPA gets converted to Dopamine by Aromatic Amino Acid Decarboxylase (AAAD).
Dopamine get converted to Norepinephrine by Dopamine-B-hydroxylase.
Norepinephrine gets converted to Epinephrine by Phenylethanolamine-N-methyltransferase

Question 2

The rate limiting steps of Dopamine, Norepinephrine and Epinerphine biosynthetic pathway

Answer 2

Tyrosine hydroxylase and Aromatic Amino Acid Decarboxylase(AAAD)

Question 3

Dopamine system components genes

Answer 3

Heteroreceptor - DRD2, DRD4
Autoreceptors - DRD1, DRD5
Transporter - DAT
Proton pump - VMAT2
Enzyme - MAOB, COMT

Question 4

Norepinephrine system components genes

Answer 4

Heteroreceptors - a2
Autoreceptors - a1, B
Transporter - NET
Proton Pump - VMAT2
Enzyme - MAOB, COMT

Question 5

Serotonin system components genes

Answer 5

Heteroreceptors - HTR2A,HTR2B,HTR2C
Autoreceptors - HTR1B,HTR1A,HTR1F
Transporter - SERT, HTT
Proton Pump - VMAT2
Enzyme - MAOA

Question 6

Serotonin Biosynthetic Pathway

Answer 6

Tryptophan gets converted to 5-hydroxytryptophan by Tryptophan Hydroxylase.
5-Hydroxytryptophan gets converted to Serotonin (5-Hydroxytryptamine by Aromatic Amino Acid Decarboxylase (AAAD)