Cases Flashcards
Factors associated with increased breast cancer risk (11 things)
Family history, menarche before 12 or menopause after 45, BRCA 1 or 2, advanced age, female, increased breast density, advanced age at first pregnancy, exposure to diethylstilbestrol, hormone therapy, therapeutic radiation, obesity
Four factors associated with decreased breast cancer rates
pregnancy at early age, late menarch/early menopause, high parity, medications like SERMs and NSAIDS and Aspirin
Does the practice of regular breast self-exam by trained women reduce breast cancer mortality?
no
Does the USPTSF recommend breast self exams?
NO
Does the American Cancer society recommend breast exams?
women should know how their breasts normally feel and report any changes. Breast self exam is an option of women starting in their 20s
American cancer society recommendations for clinical breast exams?
part of periodic health exam every three years for women in 20s and 30s, every year for 40 and over.
5 factors associated with increased risk of cervical cancer
early onset of intercourse, greater # of sexual partners, DES exposure, cigarette smoking, immunosuppresion
difference between gardasil and cervarix
gardasil: types 6, 11, 16, 18 approved for ages 9-26. Cervarix: types 16, 18, 31, and 45 for ages 10-25.
average age of menopause
51
smoking affect on menopause
smokers go through menopause a few years earlier than nonsmokers
hallmark of perimenopause
menstrual irregularity
8 risk factors for osteoporosis
low estrogen, lack of physical activity, inadequate calcium intake, family history, history of previous osteoporotic fractures, dementia, cigarette smoking, white
USPSTF osteoperosis screening in postmenopausal women younger than 60
insufficient evidence
USPSTF DEXA recommendations
recommends screening DEXA in all women 65 years and older and 60-64 who have increased fracture risk.
How often to get Td and when to replace with Tdap
Td every ten years. Tdap should replace a single dose of Td for adults 19-64 if they’ve never had a Tdap
Which type of Pap allows for later HPV testing if pap is abnormal?
the liquid based system
how much earlier can mammography detect cancer than self exam
1 or 2 years earlier
does mammography decrease breast cancer mortality?
yes
sensitivity of mammography
60-90%
is there a radiation risk with mammography
negligible
Mammography in women younger than 40
not indicated unless they fall into high risk category such as known BRCA mutation
women btwn 40 and 50 of average risk mammogram suggestions
individualized
upper age at which mammography screening should be discontinued
no specific- as long as woman is in good health and would be candidate for breast cancer treatment she should be screened.
when should pap smears be performed
cerivcal cancer screening starts at 21 every 2 years btwn 21 and 29 and every 3 years btwn 30 and 65. HIV positive and compromised immunity or history of CIN 2, 3, or cancer or DES need more frequent screening. women btwn 65 and 70 who have had 3+ normal paps within ten years may stop screening.
what makes a pap smear ‘adequate’
must contain over 5,000 squamous cells and have sufficient endocervical cells in order to be a sample of the transformation zone
Categories of epithelial abnormalities in PAPs
Atypical squamous cells (ASC): some abnormal cells. may be infection, irritation, precancerous.
Low grade squamous intraepithelial lesion (LSIL)- may progress to high grade lesion but most regress.
High grade squamous intraepithelial lesion (HSIL)- significant precancerous lesion.
Squamous cell carcinoma
Factors of a breast lump that increase likelihood of malignancy
presence of a single, hard, immobile lesion of approximately 2 cm or larger with irregular borders
breast lump-> suspected cystic lesion- what are next steps?
aspiration can be attempted and fluid sent of cytology.
breast lump-> solid lesion- what are next steps?
mammography.
What diagnostic test is helpful for distinguishing a solid mass from a cystic lesion in the breast?
ultrasound
Physiological causes of nipple discharge
pregnancy, excessive breast stimulation
Pathologic causes of nipple discharge
prolactinoma, breast cancer
work up of nipple discharge
imaging studies like mammogram, ultrasound, ductogram, and/or biopsy. consider hormonal testing to exclude endocrinological reasons. review and d/c any meds that may be the cause.
Osteoporosis prevention
postmenopausal women need to take between 1200 and 1500 mg of calcium and 800 IU of Vitamin D a day. Calcium tablets can be combined with Vitamin D in the form of cholecalciferol. Calcium in more than 500mg doses should be divided for absorption
losing 5-10% of body weight, patients can significantly reduce risk of what three diseases
diabetes, HTN, and Cardiovascular disease
The key aspects of the preventive exam
RISE: Identifying risk factors for serious medical conditions, updating Immunizations, ordering appropriate screening tests, Educating patients about living a healthy lifestyle and reducing risk of disease
Screening should be considered for conditions that are ___ and ____
important and treatable
Major modifiable risk factors for heart disease
Sedentary lifestyle, tobacco use, excess alcohol. high stress, poor diet, obesity,
Three known cardiovascular risk factors
older age, male gender, family history
Tobacco addiction characterized by the 3 Cs
compulsion to use, lack of control, and continued use despite adverse consequences.
four stages of behavior change
pre contemplative (not aware of need to change or not interested in changing), contemplative- currently interested in changing behavior. active- currently making change, relapse- attempted but no longer
possible protection from moderate alcohol consumption
cardiovascular protection- small increase in HDL, may contain other chemicals that act as anti oxidants or inhibit platelet aggregation
The CAGE questions
felt you needed to Cut down? felt Annoyed by criticism? had Guilty feelings? taken a morning Eye opener?
A brief nutritional history should include:
number of meal and snacks eaten in a 24 hour period, dining-out habits, frequency of consumption of fruits, vegetables, meats, poultry, fish, dairy, desserts.
WAVE pocket card tool
dialogue about Weight, Activity, Variety, and Excess. eating appropriate number of servings of each food group and whether he or she is eating too much fat/sugar etc
Food frequency questionnaire
covers food intake over period of a month. often used in combination with 24 hour recall, it is the quickest way to determine nutritional deficiencies and excesses.
Rapid eating and activity assessment for patients (REAP)
brief validated questionnaire that assesses diet related to the food guide pyramid. questions about patient shopping and preparing their own food, trouble shopping/cooking, diet, limits foods, how willing they are to change.
BMI calculation
weight in kg/height in meters squared
Normal BMI range
18-25
Overweight BMI range
25-30
Obese BMI range
> 30
Very Obese BMI range
35-40
Morbidly Obese range
> 40
What measurements can you use to further determine risk and need for weight loss
body fat distribution, waist circumference, and waist-hip ratio
Three clinical findings associated with dyslipidemia and atherosclerosis
arcus corneus, acanthosis nigricans, xanthelasmas
ABCDE of skin lesions
Asymmetry, border irregularity, color non uniform, diameter >6mm, evolution or change over time
USPSTF on PSA
recommends against it.
ACS and AUA on PSA
recommend testing be offered to men starting at age 50 but that physician should discuss with patient the harm and benefit of screening
Potential benefits of PSA
prolonged life from early detection and tx of prostate cancer, psychological reassurance of a negative screen or detecting at treatable stage
Potential harms of PSA
pain and discomfort associated with prostate biopsy, psychological effects of false-positive test results, complications (including erectile dysfunction, urinary incontinence, bowel dysfunction, even death) from treatment of prostate cancer they may have never caused symptoms
Available methods of colon cancer screening
Colonoscopy (preferred), annual testing of three stools for blood and a flexible sigmoidoscopy test every five years, double contrast enemas every five years, CT colography (virtual colonoscopy) is experimental
Lung cancer screening (USPSTF)
screening with CT, CXR, or sputum cytology can detect lung cancer at an earlier stage than lung cancer would be detected in an unscreened population. However- poor evidence that any screening strategy for lung cancer decreases mortality. invasive and high false positive risk-> significant harms
4 steps of assessing an ECG
- look at rate, PR, QRS, and QT interval
- look for abnormalities in P waves
- assess axis, R wave progression, presence of Q waves, levels of voltage.
- look for ST depression or elevation and inverted T waves
Labs to assess risk for diabetes and CVD
draw glucose and a lipid panel. drawn in fasting state at least 8 hours after last food
5 As when counseling for behavior change
- Ask or Address behavior needing change
- Assess for interest in behavior change
- Advise on methods to change
- Assist with motivation
- Arrange for follow up
are oral meds successful for smoking cessation
oral meds somewhat effective (12 month quit rates 1.5-3 times the placebo)
Annual quit rate for smokers without any medical interventions
2-3% a year
Three things to do when a patient is ready to quit smoking
set a quit date, have patient call 1-800-QUIT-NOW or www.smokefree.gov, instruct pt to start bupropion one week before quit date
Bupropion dosing schedule
start with one pill a day for first three days, then increase to one pill twice a day, after four days, stop smoking and continue on pills twice a day. may add nicotine gum for bad cravings, if needed. after about two months on the pills- gradually stop
initial management of obesity, hyperlipidemia, elevated blood pressure, and glucose (6 things)
- educate pt about increased CVD and cerebrovascular risk
- obtain stress test
- initiate 81 mg aspirin daily
- f/u in one month
- repeat fasting lipid panel in 3 months, initiate meds if necessary
- counsel to reduce calories consumed and increase exercise
Exercise prescriptions should include what specific recommendations
type of exercise, precautions, specific workloads, duration and frequency, intensity guidelines
Calculation of target heart rate
(220-age) x 0.7
Borg rating of perceived exertion scale
6- no exertion, 9- very light, 11- light, 13- somewhat hard, 15- hard, 17- very strenuous/fatigued, 19- extremely hard
follow up of tubular adenoma with low grade dysplasia
repeat colonoscopy in 5-10 years
What percentage of population has hypothyroidism
5%
medical conditions associated with depression (3)
hypothyroidism, parkinsons, dementia
what percentage of parkinson’s patients experience depressive symptoms
60%
which is more sensitive- mini cog or MMSE?
mini-cog (99%) . the MMSE is only 91%
Diagnostic criteria for major depressive disorder
depressed mood or anhedonia and at least five of the following 8: sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicidal ideation.
Major depressive disorder vs. bereavement
MDD only if symptoms are present two months after the loss. Guilt about other things, thoughts of death, morbid preoccupation with worthlessness, marked psychomotor retardation, prolonged funtional impairment, hallucinatory experiences other than hearing deceased person.
In what ethnic group is depression identified less frequently?
hispanics
how do hispanic patients tend to present with depression?
somatic complaints like myalgias or fatigue
which group has a lower rate of depression- US born hispanics or immigrants?
immigrants have up to 50% lower rate of depression
Factors that increase a patient’s likelihood of completing a suicide attempt
white male, previous attempt, suicide in elderly
most common means of suicide in elderly
drug overdose
SSRI examples
citalpram (celexa), fluoxetine (prozac), fluvoxamine (luvox), paroxetine (paxil), sertraline (zoloft), escitalopram (lexapro)
Venlafaxine (effexor)
serotonin and NE reuptake inhibitor
Bupropion (wellbutrin)
NE and dopamine reuptake inhibitor
nefazodone (serzone) and trazodone (desyrel)
serotonin antagonist and reuptake inhibitors
mirtazapine (remeron)
NE and serotonin antagonist, antihistaminic effects
duloxatine (cymbalta)
serotonin and NE reuptake inhibitor
TCA antidepressants
nortriptyline (pamelor), amitriptyline clomipramine, doxepin (sinequan). block reuptake of NE, 5HT
MOA-Is
Phenelzine (nardil), tranylcypromine (parnate). block pre-synaptic catabolism of NE and 5HT
SSRI/SNRI side effects
headaches, sleep disturbances, GI problems, hyponatremia due SIADH, serotonin syndrome, increased GI bleeding, elderly- increased risk for falls, possible adverse effects on bone density.
TCA side effects
cardiac arrhythmias
common causes of insomnia in elderly
environmental (noise or bedding), drugs/alcohol/caffeine, sleep apnea, parasomnias (restless leg syndrome, period leg movement and rapid eye movement sleep behavior disorder), disturbances in cycle (shift work), psychiatric disorders (Depression and anxiety), cardiorespiratory disorders, pain or pruritis, GERD, hyperthyroidism.
risk factors for elder abuse
dementia, shared living situation of elder and abuser (except $ abuse), caregiver substance abuse or mental illness, heavy dependence of caregiver on elder, social isolation of elder from people other than abuser
Geriatric depression scale- short form (GDS-SF)
over the past week: are you satisfied with your life? have you dropped many of your activities and interests? do you feel that your life is empty? bored easily? good spirits? afraid something bad will happen? happy? helpless? stay at home or go out and do things? memory problems?
screen for common causes of insomnia, fatigue, depression
comprehensive metabolic panel- electrolyte, renal, hepatic problems. TSH, CBC (anemia and vitamin def.), ESR (rheumatologic disease), EKG (if on TCAs etc)
What two behavioral treatments for insomnia have met evidence based criteria for efficacy?
sleep restriction-sleep compression therapy and multi component cognitive behavioral therapy for insomnia.
pharmacologic treatment of insomnia
side effects are prolonged sedation and dizziness. non benzodiazepines (i.e. zolpidem (ambien) and melatonin receptor agonists) are safest.
first line pharm approach to major depress. disorder
SSRI or SNRI
fluoxetine (prozac)
long half life. can cause agitation, restlessness, decreased libido in women, insomnia
sertraline (zoloft)
used in pregnancy. approved for OCD, panic, and PTSD. more GI side effets
paroxetine (paxil)
strong anti anxiety effects, best studied SSRIs in children, side effects include significant weight gain, impotence, sedation, and constipation. due to short half life, paroxetine is most likely of all ssris to cause antidepressant discontinuation syndrome
fluvoxamine (luvox)
particularly useful in OCD, greater frequency of emesis compared to other SSRIs
citalopram (celexa)
most common side effects include nausea, dry mouth, and somnolence
escitalopram (lexapro)
approved specifically for generalized anxiety disorder, fewer side effects than citalopra
for first episode of major depressive disorder- tx duration
9-12 months of meds, stopping sooner is high risk for recurrence.
recurrent episodes of depression are treated for how long
2-3 years
allow how long for depression meds to be fully effective, but follow up in how long?
4-6 weeks to be effective, but f/u in 2 weeks to monitor side effects
for patient who is seriously considering suicide, a tool to assess severity of the situation is the ___ scale (acronym)
SAD PERSONS: sex (male), age (under 19 or over 45), depression, previous attempts, ethanol or other substance abuse, rational thinking impaired, social supports lacking, organized plan, no significant other, sickness (7 out of 10 suggests hospitalization)
differential diagnosis for ankle pain
sprain, fracture of distal fibular, fracture of talus, peroneal tendon, subtalar injury
what percent of ankle injuries are clinically significant fractures?
less than 15%
compartment syndrome
serious life and limb-threatening complication of extremity trauma. rising pressure in a muscle compartment impairs perfusion to that same muscle compartment.
causes of compartment syndrome
fractures, crush injuries, burns, arterial injuries
signs and symptoms of compartment syndrome
Pain, Pallor, Pulselessness, paresthesias (burning, itching, prickling, or tingling), poikilothermia (can’t regulate body temp), paralysis
what is the most reliable sign of compartment syndrome
paresthesias
most common mechanism of injury for ankle sprain
plantarflexion and inversion
Medial ankle sprain mechanism of action
forced eversion and dorsiflexion.
why are medial ankle sprains less common than lateral?
bony articulation btwn the medial malleolus and the talus
history of a snap or tear is diagnostically significant in what injury
knee injury
is a history o fa snap or tear diagnostically significant in ankle injuries?
no
which ligaments are most often damaged in ankle injuries caused by plantarflexion and inversion
lateral stabilizing ligaments- anterior talofibular, calcaneofibular, posterior talofibular).
Anterior drawer test
assesses integrity of the anterior talofibular ligament (most easily injured). knee flexed 90 degrees. one hand holds tibia and exerts a slight posterior force while the other brings calcaneus and talus forward on tibia.
inversion test
when ankle i inverted it does not appear lax, indicating calcaneofibular ligament is intact
what ligament is the strongest of the lateral complex
posterior talofibular
crossed-leg test
detects high ankle tibiofubular syndesmotic sprain. while patient is sitting with one leg crossed over the other, pressure is applied to the medial side of the knee. high ankle sprain will produce pain in the syndesmosis area.
Grade I ankle sprain
stretching and/or small tear of a ligament. slight/no functional loss. mild tenderness, mild swelling. usually no ecchymosis. no mechanical instability: no streatching or opening of the joint with stress.
Grade II ankle sprain
incomplete tear. moderate functional impairment, loss of some motor function. difficulty bearing weight. tenderness and pain. mild to moderate swelling. ecchymosis common. moderate instability, stretching of the joint with stress, but a definite stopping point.
Grade III ankle sprain
complete tear and loss of integrity of ligament. inability to bear weight. severe swelling, ecchymosis. mechanical instability. significant stretching of the joint with stress, without stopping point.
most common acute ankle injury
lateral ankle inversion sprain
Medial ankle stability is provided by
the strong deltoid ligament, the anterior tibiofibular ligament, and bony mortise.
Peroneal tendon tear
usually due to an inversion injury or reptitive trauma. may occur in conjunction w/ankle sprain. persistent pain posterior to the lateral malleolus.
Talar dome fracture
may occur in conjunction with an ankle sprain, and initial x rays may miss a talar dome fracture.
ankle tendonitis
inflammatory condition, usually involving the posterior tibialis tendon. swelling/warmth may be present in the affected area. worsens initially with aggravating activity only. may then progress to discomfort at any time. chronic. worse during the day and after exercise.
subtalar injury
often due to a high-energy injury. a dislocation involves the talocalcaneal and talnavicular joints. pain, swelling, deformity, are present.
tarsal tunnel syndrome
entrapment of the tibial nerve. pain, tingling, and burning sensations along the sole of the foot. pain along the inside of the ankle and/or bottom of the feet and shooting pain.
syndesmotic injury
generally involves the interosseus membrane and the anterior inferior tibiofibular ligament. pain and disability are often out of proportion to the injury. one would expect a positive ankle squeeze test.
infection of the ankle joint
less common. appropriate history and physical exam neede. symptoms include painful range of active and passive motion, edema, erythema, warmth, and fever.
arthritis of ankle
less common than in some other joints. chronic process, more commonly seen in older people. the tibiotalar joint is generally involved and condition may occur as result of prior injury, obesity, or history of rheumatoid disease.
ottawa rules
decision tool designed to help in evaluation of adults w/acute ankle and midfoot injuries. 97-100% sensitive. also used to exclude fractures in children under 5.
according to ottawa rules, radiographs of ankle needed if:
pain in malleolar zone AND either bony tenderness along distal 6cm of posterior edge of either malleolus OR inability to bear weight both immediately and in the emergency department
according to ottawa rules, radiographs of foot needed if:
there is pain in the midfoot region AND bony tenderness at either the navicular bone or base of fifth metatarsal OR inability to bear weight both immediately and in emergency department.
management of ankle sprain
RICE: (rest for first 72 hours only, Ice several times throughout the day for ten minutes at a time, Compression with tape, elastic wrap, or semi rigid ankle support, Elevation.) Ibuprofen TID PRN. Daily ankle exercises- inversion, eversion, plantar and dorsi flexion, calf stretching, single leg balancing. proprioceptive exercises help prevent and reduce the likelihood of re-injury.
dysuria Rx
if pt has no hx of allergy to sulfa, trimethoprim-sulfamethoxazole may be used for empirical tx for uncomplicated lower UTIs. a quinolone like cipro may be used if high uropathogen resistence to trimethoprim-sulfamethoxazole.
DDx of heart palpatations
cardiac dysrhthmias, anxiety/panic disorder, anemia, hyperthyroidism, drug/caffeine abuse
hyperthyroidism causes increased heart rate and cardiac output due to
increased peripheral oxygen needs, and increased cardiac contractility
weight loss in hyperthyroidism is due to
increased calorigenesis (heat produced by consumption of food), and increased gut motility and the associated hyperdefecation and malabsorption
exercise intolerance and fatigue in hyperthryoidism is caused by
oxygen consumption and CO2 production, respiratory muscle weakness
60-80% of hyperthyroidism is caused by
toxic diffuse goiter (graves’)
hypervascularity of thyroid may result in a bruit or thrill upon auscultation in what disease
graves’
worldwide most common cause of goiter
lack of iodine.
ankle clonus
elicited by rapidly dorsiflexing the foot, causing alternate contraction and relaxation of the gastrocnemius and soleus muscles.
lid lag
elicited by hasving pt follow with his eyes your finger moving slowly from their upper to lower field of vision. if lid lag- upper eyelid lags behind the upper edge of the iris as teh eye moves downward.
how to differentiate btwn hyperthyroidism and anxiety
in anxiety, peripheral manifestations of excess thyroid hormones are absent- the skin is cold and clammy. panic attacks. ask about brief periods of overwhelming terror
why does anemia cause palpaitations?
tachycardia from hypovolemia. heart responds to low blood volume by speeding up to increase the exposure of blood to oxygenation in the lungs. anemia can cause dyspnea on exertion bc of the lack of oxygen carrying capacity of the blood. A common source of anemia in menstruating women is heavy periods.
tests to order on a patient with palpitations
TSH, T4, ECG, CBC (anemia), Radioactive iodine uptake test and scan (RAIU)
thyroid ultrasound
evaluation of thyroid nodules and thyroid enlargement. US characteristics of a nodule can be used to stratify risk of malignancy and US can guide the fine needle aspiration of nodules that are not easily palpated.
Management of hyperthyroidism
propranolol can be used for symptomatic relief of adrenergic symptoms (tachycardia, tremor, heat intolerance)
management of hypothyroidism
easier to manage than hyperthyroidism. can be managed with one or two blood tests a year.
levothyroxine
increase dose slowly, especially in elderly. aim for dose of 1.5-1.8mcg per kg. check TSH one month after starting. in primary- once a stable TSH level is achieved, blood work can be checked annually.
At risk populations for DM
Native Americans, African, and Asian Americans, Latin Americans, Pacific Islanders.
how many people in US have undiagnosed diabetes
7 million
preferred method for diagnosing diabetes
HbA1c (>6.5%)
American Diabetes Association screening recommendations
overweight or obese (BMI over 25) pts who have 1+ :sedentary lifestyle, race, 1st degree relative w/DM, previously impaired fasting glu, HTN, HDL 250, history of gestational DM or baby >9lbs, PCOS, CVD. If none of those risks- screening begins at 45 yo. If results normal, testing repeated at 3 year intervals- more frequent if risk factors or borderline results.
USPSTF screening recommendations for DM
screen for type 2 DM in asymp adults w/sustained BP greater than 135/80.
leading cause of death in DM patients
cardiovascular disease (i.e. coronary heart disease and stroke)
most common cause of new cases of blindness among adults of working age
diabetes
do diabetics on insulin or oral hypoglycemics have greater chance of retinopathy
40% in insulin, 24% w/oral hypoglycemic agents
how likely is glaucoma in diabetics
40%
prevalence of neuropathy in DM
7% at one year, increasing 50% at 25 years for type 1 and 2
what % of DM patients have nephropathy
20-40%
Fatalismo
holding to a belief that control over one’s DM is external to self.
utility of EMR
templates increase likelihood the pt will receive the recommended care. Assists in evaluating how the physician is caring for specific patient populations. helps the physician improve reimbursement by creating reports of pt care data for specific measures of care, such as HbA1c or blood pressure control for medicare and medicaid
why is examining the thyroid in diabetics important?
thyroid disease can lead to diabetes and hyperlipidemia
Diabetic foot exam should include:
testing for loss of protective sensation: sensory testing can be conducted with a 10g monofilament, tuning fork, pinprick, ankle reflexes. Assessment of pedal pulses: evaluate for peripheral vascular disease, strongest risk factor for delayed ulcer healing and amputation in diabetes patients. Inspection- inspect of breaks in skin.
what is the strongest risk factor for delayed ulcer healing and amputation in diabetes patients
peripheral vascular disease (test pedal pulse)
four reasons for ordering lab tests in DM patients
monitoring diabetic control, assessing end organ damage, monitoring side effects of treatment, uncovering management complications
recommended lab tests for DM patient
HbA1c (4-12 week period. measure at dx and at least 2x a year in pts who are stable and meeting goal. quarterly when therapy is changing or goal not being met), electrocardiogram (die from CVD. test at baseline), Sport urine albumin:creatinine ratio (screening for microalbuminuria. many rx like metformin are renally excreted. annual monitoring is required to identify renal insuff and avoid drug tox). Serum B12 (metformin can cause asymp subnormal b12), TSH, fasting lipids, fingerstick blood sugar
how often to test spot urine albumin:creatinine ratio in DM?
annually
when to test B12 in DM?
if patient exhibits signs of neuropathy
ADA and USPSTF recommendations for TSH testing in DM
do not recommend for or against ordering TSH.
how often to do fasting lipid profile in DM
at diagnosis, every three months until control is achieved, annually once lipids are well controlled.
when to do a fingerstick blood sugar in DM
only if pt is experiencing acute symptoms of hyperglycemia or hypoglycemia at time of visit
ADA/European Association for the Study of Diabetes (EASD) Consensus Algorithm for Management of DM II [FIRST TIER]
Step 1: Diagnosis. If HbA1c > 6.5%. lifestyle change + metformin.
Step 2: Assessment: If HbA1c >8%, continue lifestyle and metformin and add sulfonylurea (glyburide, glipizide, or glimepiride) or basal insulin (glargine, detemir, or protamine hagedorn NPH).
Step 3: Reassessment: If HbA1c >8, continue lifestyle and metformin, add basal insulin or (if already on insulin) intensify insulin regimen, consider discontinuing sulfonylurea to avoid hypoglycemia.
ADA/European Association for the Study of Diabetes (EASD) Consensus Algorithm for Management of DM II [SECOND TIER]
Explore other Tx options: adding rapid acting insulin with meals, thiazolidinediones: pioglitazone (actos) or rosiglitazone (avandia) may be useful for those who cannot tolerate the GI effects of metformin or have hypoglycemia with sulfonylureas. Can increase risk of heart failure, edema, and bone fractures. Meglitinides, GLP 1 analogs, DPP4 inhibitors, amylin analog, alpha glucosidase inhibitors
in the diabetes prevention program (DPP) what was the most successful method to prevent diabetes?
lifestyle alteration
what improves cardiovascular risk improvement more- BP and lipid control or glycemic control?
BP and lipid
barriers to insulin tx
pts opposed to injecting (need education), drawing up insulin if visually impaired or poor dexterity (insulin pens), misconception that it causes complications, physicians reluctant to rx insulin cause don’t have time to teach pts how to use it.
first line therapy for CHF in DM patients
ARBs.
when should a statin be used regardless of lipid level?
for patients with known CVD or over 40 with one risk factor for CVD
NCEP ATP III guidelines for dyslipidemia
target non HDL cholesterol as a second goal after lowering LDL. Non HDL cholesterol may be a stronger predictor of CVD bc it represents the atherogenic VLDL remnants as well as the LDL.
when to use aspirin therapy
secondary prevention in diabetes patients with history of CVD or in those deemed at moderate or high risk of CVD. primary prevention in DM pts with increased CV risk (over 40 who have HTN, smoking, dyslipidemia, fam history, or albuminuria).
what can be used instead of aspirin for CVD if pt has aspirin allergy
clopidogrel (75mg)
what is the most important modifiable cause of premature death in DM
smoking
DM I patients should have their first eye exam when
five years after dx
immunizations in DM pts
annual vaccination for influenza, pneumococcal polysaccharide vaccine for all diabetes patients over two years old. one time revaccination is recommended for pts over 64 if first received greater than 5 years ago or have nephrotic syndrome, CKD or immunocomp.
DDx for leg swelling
cellulitis, DVT, venous insufficiency, lymphangitis, peripheral arterial disease
single greatest contributor to mortality in US
smoking
three leading specific causes of smoking attributable death
lung cancer, ischemic heart disease, COPD
known health risks of obesity
HTN, dyslipidemia, DM, coronary heart disease, stroke, gall bladder disease, osteoarthritis, sleep apnea, respiratory problems, endometrial cancer, breast cancer, colon cancer,
Wagner Ulcer grading system
Grade 1: superficial ulcer, involves full skin thicnkess. outpatinet management.
Grade 2: deep ulcer. penetrating down to ligaments and muscle, no bone involvement or abscess formation.
Grade 3: deep ulcer, cellulitis or abscess formation, often osteomyelitis (evaluate for myelitis. may need hospitalization(
Grade 4: localized gangrene. surgery/amputation.
Grade 5: extensive gangrene/whole foot.
organism in small skin break cellulitis vs. large skin break.
small = strep, large = staph.
homan’s sign
classic sign of DVT. pain on passive dorsiflexion of the foot
most robust risk factors in development of DVT
smoking and obesity
ankle brachial index
ABI. can be done to determine the presence of PAD. an ABI <0.9 is consistent with the disease.
doppler ultrasound of lower extremity
confirms w/good sensitivity and specificity if DVT is present. Best predictive value for a DVT. can be overused.
D dimer
small protein fragment present in blood after a clot is degraded by fibrinolysis, sensitive but not specific.
Well’s Criteria For Dx of DVT
active cancer =1pt, paralysis/paresis/immobilization cast=1pt, bedridden 3+ days or surg=1pt, localized tenderness=1pt, entire leg swollen=1pt, calf swelling more than 3cm compared to asymp leg= 1pt, pitting edema= 1pt, collateral superficial veins=1pt, alt dx as likely = -2pts. 3points is high probability, 1-2 is moderate,
management of DVT- criteria to treat on an outpatient basis
hemodynamically stable, good kidney function, low risk for bleeding, stable and supportive home environment, daily access to international normalized ratio (INR) monitoring
warfarin tx duration for DVTs
isolated calf thrombophelbitis: 6-12 weeks. first time event from surg or trauma - 3 months, first episode of idiopathic thromboembolic disease= 6 months. recurrent= 12 months to indefinitely
titration of warfarin
half life is 40 hours, so 5-7 days to reach stable state. check INR three days after warfarin initiation to make sure its not too high. if INR is >5 and 9, hold warfarin and give an oral dose of vit k
screening for inherited thrombophilia
no absolute indications. initial thrombosis occurring prior to age 50 w/out immediate risk factor. family history. recurrent, starting in unusual vascular beds- portal, hepatic, mesenteric, cerebral.
definition of high blood pressure
systolic > 140, diastolic > 90
official diagnosis of HTN
must be at least two elevated measurements- at least 5 minutes apart, one in each arm, on two or more visits- in order to accurately diagnose a patient with HTN. a patient cannot be diagnosed with HTN if patient is acutely ill or in acute pain.
USPSTF HTN screening recommendations
screen for high BP in pts without known HTN starting at age 18.
JNC guidelines- evaluation of pt w/possible new dx of HTN has three goals
- assess presence or absence of target end organ disease (heart, brain, kidneys, PVD, eyes), 2. assess lifestyle and identify other CV risk factors or concomitant disorders that may affect prognosis and guide tx. (metabolic synd, fam history of CVD, smoking, etoh, cocaine, age, sedentary, microalbuminuria) 3. reveal identifiable causes of high BP (apnea, CKD, hyperaldosteronism, pheochrom, coarctation, rx, OTC, herbals, cocaine,)
studies recommended for a new dx of HTN
ECG, urinalysis, H/H (low hematocrit can mean anemia in HTN and makes major CV event more likely), serum potassium, serum creatinine or corresponding GFR, fasting serum cholesterol panel, urinary albumin excretion or albumin/creatinine ratio (optional except for those with DM or kidney disease), serum Ca
Tx for stage 1 HTN without compelling indications
Thiazide. may consider ACEI, ARB, BB, CCB or combo
Tx for stage 2 HTN without compelling indication
2 drug combo (thiazide and ACE, ARB, BB, or CCB)
Tx for HTN + heart failure
thiazides, BB, ACEI, ARB, aldosterone antagonists
Tx for HTN + post MI
BB, ACEI, Aldo antagonist
Tx for HTN + CAD risk
thiazides, BBs, ACEIs, ARBs, CCBs
Tx for HTN + DM
Thiazides, BBs, ACEIs, ARBs, CCBs
Tx for HTN + CKD
ACEIs, ARBs
Tx for recurrent stroke prevention
thiazides, ACEIs
most cost effective antiHTN drug on market
Hydrochlorothiazide (4.30 for a month)
possible problems with hydrochlorothiazide
may cause hyponatremia, avoid in gout pts, problem if urine incontinent
what 2 ethnic groups have lowest rates of BP control
mexican americans and native americans
causes of resistant HTN
improper BP measurement, excess sodium intake, inadequate diuretic therapy, medication issues (inadequate doses, drug interactions, excess alcohol, secondary HTN
ATP III dyslipidemia therapy recommendations
- CHD pts (or w/ CAD, PAD, AAA, DM) should start lifestyle modifications and an LDL lowering drug simultaneously
- determine major risk factors (cigarette smoking, HTN, low HDL (under 40), fam history of premature CHD, age)
- If 2+ risk factors present w/out CHD, assess 10 year CHD risk. take LDL drug after 3 months of lifestyle changes if LDL is still above 130.
- almost all ppl with 0-1 risk factor have 10 year risk of less than 10%
palpatations ddx (5)
dysrhthmia, CHD, valvular heart disease, anxiety/panic, vasomotor symptoms of menopause.
Framingham risk score Risk Factors for CHD
total cholesterol, DM, smoking, Age, HTN, elevated LDL, male gender
NCEP ATP III Risk factors for CHD
smoking, age, HTN, elevated LDL, fam history of CHD
USPSTF screening recommendations for CHD
screen adults over 18 for high BP, routinely screen men over 35 and women over 45 for lipid disorders adn treat abnormal lipids in people who are at increased risk for coronary heart disease. recommends AGAINST routine screening with resting ECG, treadmill test, or EBCT in adults at low risk.
Typical CHD chest pain
radiates to one or both shoulders or arms. precipitated by exertion. more likely ACS or ischemic.
The three Ps of pain- characteristics that decrease the likelihood of ACS
Pleuritic- worsened by respiration, exacerbated when lying down. causes of pleuritic chest pain include pulm embolism, pneumothorax, viral or idiopathic pleurisy, pneumo, and pleuropericarditis.
Positional pain
Reproduced by Palpation
Characterizing chest symptoms using PQRST
Provocation/palliation, Quality, region/radiation, severity, temporal elements, associated symptoms