Case roundup Flashcards
1
Q
what does gene therapy involve
A
modification of T cells
2
Q
what does immunotherapy involve
A
checkpoint inhibitors block proteins that stop the immune system from attacking cancer cells
- MAbs
3
Q
what is the gene therapy Kymriah used for and how does it work
A
- licensed for relapse cases
- B cell acute lymphoblastic leukaemia in children and young adults
- diffuse large B cell lymphoma and follicular lymphoma in adults
- patients T cells are harvested and genetically modified to make chimeric antigen receptor
- CAR is produced on the cancer cells and modified T cells attach to cancer cells
4
Q
what were the results of Kymriah gene therapy
A
- B cell acute lymphoblastic leukaemia in children and young adults- 66% had complete response
- DLBCL- 24% had complete response, 34% had partial response
- FL- 69% had complete response
5
Q
what is nivolumab and what is it used for
A
- IgG4 monoclonal antibody
- binds to the programmed death 1 receptor
- PD1 receptor is a negative regulator of T cell activity that has been shown to be involved in control of T cell immune responses - treatment of advanced melanoma and squamous non small cell lung cancer
6
Q
what is adalimumab used for
A
- tumour necrosis factor alpha inhibitor (TNFa)
- rheumatoid arthritis and ankylosing spondylitis
- reduces inflammation and time to flare up
7
Q
what is semaglutide
A
a glucagon like peptide 1 analogue (GLP1)
