Case files Flashcards
what is the gold standard test for diagnosing subarachnoid hemorrhage? What is it’s main limitation?
- an LP showing Xanthochromia (RBCs)
- may be negative early in the disease course
Recommended screening test for cardiovascular conditions in a 52-y/o male with no medical problems in for physical?
- Blood pressure
- Lipids
Recommended screening test for cancer in a 52-y/o male with no medical problems in for physical?
- Fecal occult blood testing, Flex sig, colonoscopy or double contrast barium enema to screen for colorectal cancer
- There is insufficient evidence to recommend for or against universal prostate cancer screening by PSA testing
Recommended immunizations in a 52-y/o male with no medical problems in for physical?
-Tetanus toxoid, reduce diphtheria toxoid, and acellular pertussis vaccine (Tdap) if he has not had one before and if it has been 10 years or more since he has had a tetanus-diphtheria (Td) vaccine, or if he required booster protection against pertussis, influenza vaccine annually, in the fall or winter months
how often should tetanus vaccine be given
every 10 years
at what age should you screen me and women for lipid disorders?
- men 35 or older
- women 45 or older
- screen adults overs 20 who are at increased risk for cardiovascular disease
at what age are men recommended to take aspirin daily to reduce the risk of MI as long as the benefit outweighs their risk of GI hemorrhage
45-79
describe the screening for AAA?
-US to assess for AAA is recommended in men aged 65 to 75 who have ever smoked
Recommendation for AAA screening for men who have NEVER smoked?
No recommendation
Recommendation for AAA screening for women who have NEVER smoked?
recommended against
Describe the recommendation for screening for AAA in women aged 65-75 who have smoked?
insufficient evidence
Age to start screening both men and women for colorectal cancer
50
recommendation for routine screening for prostate cancer using digital exam or PSA?
recommended against
Who should undergo annual low-dose CT of chest to screen for lung cancer?
- men and women aged 50 to 80 with a 30 or more pack-year history who continue to smoke or who quit less than 15 years ago
- screening for lung cancer with routine chest x-ray is not recommended
recommendation for DM2 screening
- insufficient evidence to recommend screening asymptomatic adults
- screening recommended for adults with HTN (135/89 or more sustained or untreated) or hyperlipidemia
routine screening of thyroid disease in asymptomatic individuals?
-insufficient evidence
age for Pneumococcal polysaccharide and pneumococcal conjugate vaccines?
-all adults 65 and older
in whom is Hep B vaccination recommended
- those at high risk of exposure
- health care
- those exposed to blood or blood products
- dialysis Pts
- IV drug users
- Persons with multiple sex partners or recent STD
- Men who have sex with men
- All patients with diabetes who have not previously been immunized
In whom Is hep A vaccine recommended
- chronic liver disease
- those who use clotting factors
- occupational exposure to hep A
- IV drug users
- Men who have sex with men
- those who travel where hep A is endemic
Who need meningococcal vaccine
- high risk groups
- college dorm residents
- military recruits
- complement deficiencies
- functional or anatomic asplenia
- those who travel where its endemic
what is the appropriate treatment of an acute exacerbation of COPD
- antibiotic
- bronchodilators
- systemic corticosteroids
what vaccine should all smokers and those with chronic pulmonary disease receive
- pneumococcal vaccine
- influenza
When is oxygen therapy needed for COPD
- Stage IV
- FEV1/FVC
What is the only intervention that has been shown to decrease mortality of COPD?
Oxygen therapy and must be worn for at least 15 h/d
What are the most common bacteria implicated in COPD exacerbations
- Pneumococcus
- Haemophilus influenza
- Moraxella catarrhalis
If a man presents with the sudden onset of monoarticular joint pain what is the first diagnosis that needs to be excluded
an infected joint
what are the ages of men and women that most gout attacks occur? Why is there a difference?
- Men 30-50
- Women 50-70 (postmenopausal)
- Pre menopausal women are less likely due to increased level of female sex hormones, which aid in urinary excretion of uric acid
Why may thiazide diuretics induce hyperuricemia
increasing urinary urate reabsorption
Describe the joint aspirate in crystal induced arthritis
-WBC count 2000 to 60,000 with <90% neutrophils
Describe the joint aspirate in a septic joint
-WBC average 100,000 with more than 90% neutrophils
Describe the serum uric acid levels in an acute attack of gout
- may be normal or even low
- likely as a result of the existing deposition of urate crystals
describe X-rays of OA at first
usually normal
what level do you want the uric acid to be in someone with recurrent gout attacks?
below 5
What are the 2 options for maintenance therapy of gout and what is the MOA of each
- Probenecid, increases urinary excretion
- allopurinol, reduces production of uric acid
what are first line agents in treatment of RA
-Disease-modifying antirheumatic drugs (DMARDs) . . sulfasalazine and methotrexate
what are the indications for an ultrasound in pregnancy?
- not mandatory in routine, low-risk prenatal care
- evaluation of uncertain gestational age
- size/date discrepancies, vaginal bleeding
- multiple gestations
- other high risk situations
What Laboratory studies are recommended at the initial prenatal visit
- CBC
- HBsAg
- HIV
- Syphilis RPR
- urinalysis and urine culture
- rubella antibody
- Blood type and Rh status with antibody screen
- Pap smear
- cervical swab for gonorrhea and chlamydia
What is the risk to the pregnancy based on the radiation exposure from dental x-rays
- Risk for the baby is increased once radiation exposure is greater than 5 rad
- The radiation exposure from routine dental x-rays is .00017 rad
The optimal time for the trisomy screen
- first trimester for Nuchal translucency (NT) via US
- combo of NT with serum markers hCG and PAPP-A b/t 10 and 13 weeks
- Second trimester triple (AFP, hCG, estriol) or quadruple (triple + inhibin-A) between 16 and 18 weeks
- Conceerning results from the above tests may warrant more invasive testing to confirm chromosome abnormalities (Chorionic villous sampling at 10 to 13 weeks or amniocentesis at 16 to 18 weeks)
What is Advanced Maternal age
pregnant woman who will be 35 years or beyond at the estimated date of delivery (EDD)
Describe Asymptomatic Bacteriuria
-100,000 cfu/mL or more of a pure pathogen of a mid-stream voided specimen without clinical symptoms. In pregnant women this increases risk for acute pyelonephritis, preterm delivery, and low birth weight; therefore, early detection is paramount and treatment is mandated
For low risk women, how much folic acid daily is recommended to reduce the risk of neural tube defects
400-800 ug
How much folic acid a day is recommended in women with diabetes mellitis or epilepsy
1 mg
How much folic acid should a woman who has had a child with a neural tube defect take?
4 mg daily
Women who will be what age or older at the anticipated time of delivery should be educated about age related risk
35
what is one of the most crucial pieces of information in an initial prenatal visit
-accuracy of dating . . by using LMP
Describe Naegele’s rule in dating a fetus
subtract 3 months and add 7 days to the first day of the LMP
When should fetal heart tones be obtainable
by 10 weeks gestation
Describe how often prenatal visits are typically
- every 4 weeks until 28 week gestation
- every 2 weeks from 28-36 weeks
- every week from 36 wk to delivery
If Prenatal Hb is < 10.5 what are possible ramifications?
- Preterm delivery
- Low fetal iron stores
- Identify thalassemia
If Prenatal Hb is < 10.5 what is the next step?
- Mild: therapeutic trial of iron
- Moderate: ferritin and Hb electrophoresis
If prenatal Rubella test is negative what are ramifications?
Nonimmune to rubella
If prenatal Rubella test is negative what is the next step?
- Stay away from sick individuals
- vaccinate with live attenuated vaccine postpartum
if prenatal HIV ELISA is positive, what antiretroviral is used and when is it started?
- Zidovudine
- 2nd trimester
What weeks of gestation are the triple and quadruple screen best to screen for trisomies?
-weeks 15 to 20 (2nd trimester)
What is the most common cause for a false positive serum screen for trisomies
incorrect gestational dating
What testing can be performed at 10-14 weeks (1st trimester) for trisomies
-Nuchal translucency combined with maternal serum analyte levels (free hCG and PAPP-A)
what are the recommended immunizations for a 6 month well-child visit (in a child who is up to date on routine immunizations)?
- Diphtheria
- Tetanus
- Acellular pertussis (DTap) no. 3
- Hep B no. 3
- Haemophilus influenza type b (Hib) no. 3
- Pneumococcal conjugate vaccine (PCV 13) no. 3
- rotavirus no. 3
- inactivated polio vaccine (IPV) no. 3 can be given between 6 and 18 months
- if encounter is during “flu season”, annual influenza vaccination is recommended beginning at 6 months
At what age should a child be able to say “mama” and “dada”
nonspecifically b/t 6 and 9 months
-becomes specific between 8 and 15 months
When is it recommended that a child can be put in a forward facing car seat
-A child should stay in a rear-facing car seat until the age of 2 or until the child reaches the maximum height and weight limit for the car seat
What is amblyopia?
What is the most common cause?
- monocular childhood vision reduction caused by abnormal vision development
- Strabismus
What is strabismus?
-ocular misalignment
All states require screening testing for what childhood disorders?
- PKU
- congenital hypothyroidism
- as early treatment can prevent the development of profound mental retardation
What is the Mantoux test
-an intradermal injection of PPD tuberculin and is the screening test of choice for newborns
Describe the recommendation for screening of high cholesterol in children
- All children at least one time b/t the ages of 9 and 11 and again b/t 17 and 21
- screening for hyperlipidemia should begin at age 2 in children with a family history of hyperlipidemia, premature cardiovascular disease, or other risk factors
When is it recommended that all children see a dentist
by 12 months
Screen time for children (like TV and games) should be limited to how much daily
1 to 2 hours or less
What is the leading cause of death in children older than 1 year?
-Accidents and injuries
What are the top 3 causes of death in infants younger than 1 year
- congenital abnormalities
- short gestation
- sudden infant death syndrome (SIDS)
At what weight can a child start using a forward facing booster seat in the rear rather than a car seat
40 lbs
A 35 year old asthmatic woman complains of chronic nasal congestion that is worse in the spring and the fall.
Most likely Dx?
-allergic rhinitis
A 35 year old asthmatic woman complains of chronic nasal congestion that is worse in the spring and the fall.
next step in management?
-antihistamines, decongestants, or intranasal steroids
A 35 year old asthmatic woman complains of chronic nasal congestion that is worse in the spring and the fall.
Considerations and possible complications of therapy?
- Recognition and reduction of potential allergen exposure will yield more success in management than pharmacotherapy alone
- Excessive use of topical decongestants can cause rebound congestion
appearance of the mucosa of nasal turbinates in allergic rhinitis
- swollen (boggy)
- has a pale, bluish-gray color
- thin, watery secretions are seen
what medication offers the most consistent symptomatic relief in allergic rhinitis
nasal corticosteroids
At the first suspicion of anaphylaxis, what should be given?
- Aqueous epinephrine 1:1000, in a dose of .2 to .5 mg, injected SQ or IM
- repeated infections can be given every 5 to 15 minutes when necessary
Most likely diagnosis in a 65 y/o women with worsening dyspnea on exertion, fatigue, dizziness, and palpitations. She is found to have conjunctival pallor and guaiac-positive stool.
- Anemia secondary to GI bleeding
- other considerations should include new-onset angina, CHF, and Afib
in a 65 y/o women with worsening dyspnea on exertion, fatigue, dizziness, and palpitations, after the initial workup for cardiac and pulmonary causes is negative and the Hb and Hct are low, what would you evaluate for the cause of the anemia?
- CBC with peripheral smear
- reticulocyte count
- iron studies
- vitamin B12 levels
- Folic acid levels
- A gastroenterology consult for possible EGD and colonoscopy to further investigate the source of GI bleed should be considered
Conjunctival pallor is recommended as a reliable sign of anemia in the elderly and commonly noted in patients with hemoglobin levels of what?
less than 9 g/dL
What are signs suggestive of Vitamin B12 deficiency anemia?
- Glossitis
- decreased vibratory and positional senses
- ataxia
- paresthesia
- confusion
- dementia
- pearly gray hair at an early age
What cause of anemia may produce Koilonychias (spoon nails), glossitis, or dysphagia
profound iron deficiency anemia
Jaundice in anemia can be a clue that what is a contributing factor?
-hemolysis
Splenomegaly in anemia can indicate that what may be present?
-thalassemia or neoplasm
What should the initial workup of anemia include?
- CBC with measurement of RBC indices
- peripheral blood smear
- reticulocyte count
- further laboratory studies would be indicated base on the results of the initial tests and the presence of symptoms or signs suggestive of other diseases
What do iron studies show in iron deficiency anemia?
- Low serum iron
- Low ferritin
- High TIBC
Elevated levels of what can be used to confirm vitamin B12 deficiency
-Methylmalonic acid (MMA)
Elevated levels of what can be used to confirm folate deficiency?
homocysteine
Folate deficiency anemia is usually seen in who
alcoholics
B12 deficiency anemia is usually seen in who
- ppl with pernicious anemia (lack of intrinsic factor)
- Hx of gastrectomy
- diseases of malabsorption (bacterial infx, Crohn, celiac)
What level of Hb is commonly used as a threshold for transfusion?
7 g/dL
What is considered first line therapy in uncomplicated iron deficiency anemia
-ferrous sulfate
A 40 yr old man who recently returned from Mexico with profuse, acute, nonbloody diarrhea, and dry mucous membranes on examination, which are consistent with developing dehydration. An ill family member with identical symptoms suggests an infectious cause of this acute illness. Most likely dx?
Acute gastroenteritis
A 40 yr old man who recently returned from Mexico with profuse, acute, nonbloody diarrhea, and dry mucous membranes on examination, which are consistent with developing dehydration. An ill family member with identical symptoms suggests an infectious cause of this acute illness. Next steps?
- Fecal leukocyte or fecal lactoferrin testing
- Rehydration with oral or IV fluids
A 40 yr old man who recently returned from Mexico with profuse, acute, nonbloody diarrhea, and dry mucous membranes on examination, which are consistent with developing dehydration. An ill family member with identical symptoms suggests an infectious cause of this acute illness. Potential complication?
- Dehydration
- Electrolyte abnormalities
What are the most probable etiologies of diarrhea?
- virus
- E. coli
- Shigella
- Salmonella
- Giardia
- Amabiasis
The presence of blood in the stool of an acute diarrhea patient would suggest what type of infection?
- Invasive bacterial
- such as, EHEC nad EIEC, Yersinia, Shigella, and Entamaeba histolytica
Examining stool for leukocytes is an inexpensive test that helps differentiate b/t types of infectious diarrhea. if present, suspicion is higher for what
- Salmonella
- Shigella
- Yersinia
- EHEC and EIEC
- C. diff
- Campylobacter
- E. histolytica
Describe the role of lactoferrin in a diarrhea workup?
- it is an iron binding protein found in PMNs and bodily secretions such as breast milk
- GI inflammation causes immune activated PMNs to release lactoferrin
- Lactoferrin elevations in stool can be seen with IBS, intestinal bacterial infections, parasitic infections, and others.
- Lactoferrin will be LOW IN VIRAL INFECTIONS, making it a useful test for distinguishing viral from bacterial diarrhea
Describe the role of stool cultures in the evaluation of diarrhea?
- they have limited benefit due to high cost and inefficient results
- should be limited to individuals with blood diarrhea, diarrhea lasting for more than 3 to 7 days, immunocompromised patients, and evidence of systemic disease or severe dehydration
Describe Traveler’s Diarrhea prophylaxis
- best method is to avoid contaminated food and water
- Antibx is not indicated unless pt is at increased risk (IBD, renal disease, or immunocompromised) . . Fluoroquinolones usually used
- antibacterial and antisecretory effects of bismuth subsalicylate decrease the incidence of TD (avoid if allergic to aspirin, pregnant, taking methotrexate, probenecid, or doxy for malaria prophylaxis)
Describe the use of antibiotics in Treatment of TD when indicated?
- Ciprofloxacin (500 mg BID) for 3 days . . cannot be used in children or pregnant women
- Azithromycin, given as a single 1000 mg dose in adults or 10 mg/Kg daily for 3 days in children . . CAN be used in pregnant women
- Rifaximin 200 mg TID for 3 days can be used in TD caused by noninvasive strains of E coli. not effective against infections associated with fever or blood in the stool
USPSTF recommendation for interval for screening mammography in a 55 yr old woman
-Biennial (every 2 years), b/t ages of 50 and 74
Describe the USPSTF recommendation on lipid screening in women?
- Women more than age 45 with risk factors for heart disease, including diabetes, previous Hx of heart disease, family history of CVD, tobacco use, HTN, and obesity should be screened with a lipid panel
- Also, women b/t ages of 20 and 44 who have risk factors should have a one-time screening
Describe the link b/t hormone replacement therapy and risk of cardiovascular disease in post menopausal women
- Increased rates of adverse cardiovascular outcomes in women taking either estrogen alone or combined estrogen and progesterone
- For this reason, the use of hormone replacement therapy for the prevention of chronic conditions (osteoporosis) is not advised
Describe USPSTF recommendation for PAP smear for any women with a cervix
- begin at age 21 and 3 year intervals
- For women more that 30 desiring longer intervals, contesting for HPV can be used in conjunction with cytology once every 5 years
HPV vaccine against high risk subtypes is available as a three series. It is indicated for who?
- females aged 11 through 26
- To date, there is no recommendation to alter the pap smear screening intervals for women who have been vaccinated
USPSTF recommends stopping Pap smears at what age and with what stipulation
-age 65 in women who have had three consecutive negative pap results and 2 consecutive negative HPV results within the last 10 years
What are the risk factors for osteoporosis
- advancing age
- tobacco use
- low body weight
- poor nutrition
- Caucasian or Asian ancestry
- family history
- low calcium intake
- sedentary lifestyle
What are the additions risk factors for osteoporosis in men
- prolonged use of corticosteroids
- presence of diseases that alter hormone levels (such as chronic kidney or lung disease)
- undiagnosed low testosterone levels
Osteoporosis is present if the patient’s T-score from DXA scane is what
at or below -2.5
Osteopenia is present if the T score is what
between -1.0 and -2.5
the USPSTF recommends screening for osteoporosis via DXA in women at what age
over 65 and considering screening in women younger than 64 with higher risk
-there is no current recommendation on repeating screening if the initial test is normal
Describe the recommendation for calcium and vitamin D intake in women to prevent osteoporosis
- women over age of 51 consume 1200 mg of calcium daily
- women over age of 50 consume 800 to 1000 IU of Vitamin D daily
- per NOF **** not USPSTF
at what ages does USPSTF recommend that physicians screen women for domestic violence
b/t 14 and 46
What are the different pneumonics of screening tools for domestic violence
- HITS
- STaT
- HARK