Case 5 - Autism and Personality Disorders Flashcards

1
Q

How would you define Autism?

A

It is a lifelong (chronic), developmental disability that affects how a person communicates with and relates to other people + the world around them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Autism disorder is a social disability - what is the triad of autism in regard to this social disability?

A

Social communication:

  • ​late to start talking or remain non-verbal
  • difficulty initiating or sustaining conversation
  • unusual / repetitive language
  • not responding to name
  • difficulty understanding non-verbal comms

Social interaction:

  • ​difficulty recognising emotion in self + others
  • ↓ eye contact
  • unaware of appropriate social behaviour (share toys, take turns talking)

Social imagination: rigidity of thought, behaviour and play

  • limited range of interests
  • favour one specific toy (heavily)
  • repetitive patterns of play / gestures
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Autism is associated with ↑ occurrence of several mental health conditions - name some.

A
  • Anxiety
  • Depression / low mood (may be worse in adolescence)
  • OCD (up to 30% of persons with autism)
  • Sleep disturbance
  • Gender dysmorphia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are some known risk factors for autism?

A
  • Males (~4x more likely)
  • 1st degree relatives with ASD (high heritability)
  • ↑ parental age (father > 50 and mother > 40)
  • Exposure to specific chemicals / medications or infections during pregnancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Review other side of card for Autism history taking / questions.

A

Language + communication:

  • Can they hold a conversation?
  • Voice: pitch? monotone? content of speech?
  • Gestures when communicating?
  • Meaningless repetition of speech?

Social + emotional interaction:
- Making + keeping friends?
0 Understand emotions of others + themselves?
- How is their eye contact?
- Ignoring social cues / behaviour appropriate for age?
- Narrowed interests? Unable to talk about other topics?

Flexibility / rigidity of thought?

  • Repetitive play?
  • How do they cope with change?
  • Any obsessions? Routines Rituals?

Behaviour:

  • Temper? Meltdowns?
  • Obsessions, fears, phobias?

Sensory features:

  • Problems with loud noises? textures? water?
  • Sensory seeking? Sensory avoiding?

Birth History:

  • Antenantal - Hx of alcohol, drugs, smoking, illness?
  • Perinatal - delivery problems, ↓ birth weight?
  • Postnatal issues

Developmental Hx:

  • Motor development progressing?
  • Hearing, speech and language progression? - speech regression = RED FLAG
  • Development of social interaction and play?

Family Hx:

  • Learning disabilities?
  • Epilepsy / fits?
  • Alcohol / drug abuse?
  • Domestic violence or care leavers?
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What tools can be used to screen for autism spectrum disorder (ASD)?

A
  1. CAST (childhood autism spectrum test)
    • screen children 4-11yrs
    • 39 yes/no questions
  2. ADOS-2 (autism diagnostic observation schedule)
    • for diagnosing and assessing autism
    • series of tasks involving
    • interaction between examiner + patient
    • observations of behaviour converted into quantitative score
  3. ADI-R (autism diagnostic interview-revised):
    • structured interview with parents of individual (about the patient)
    • examines; language / communication, social interaction, restricted, repetitive behaviours and interests
    • min mental age of 24 months (2yrs)
  4. DISCO (diagnostic interview for social and communication disorders):
    • semi-structured interview with parent/care giver
    • 300 questions
    • children + adults of any age
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What medical conditions is ASD associated with?

progress test info

A
  1. Fragile X syndrome - trinucleotide repeat disorder
    • male (females far less affected)
    • autism is more common
    • learning difficulties
    • large low set ears, long thin face, high arched palate
    • macroorchidism (large testes)
    • hypotonia
    • mitral valve prolapse
  2. Rett’s syndrome - non genetic, new mutation
    • MECP2 gene
    • female (males die after birth)
    • autism like features: language, repetitive movements
    • slower growth
    • walking impairment
    • smaller head size
    • Complications: seizures, scoliosis, sleep disorders
  3. Congenital rubella (especially exposure during 1st trimester)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Is ADHD more common on males or females?

A

Males

~4x more than females

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the 2 categories of features associated with ADHD?

A

1) Inattention and/or

2) Hyperactivity / Impulsivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What features fall into the diagnostic categories 1) inattention 2) hyperactivity/impulsivity for ADHD?

A

INATTENTION:

  • Doesn’t follow through on instructions
  • Reluctant to engage in mentally-intense tasks
  • Distracted
  • Can’t sustain tasks
  • Poor organisation of tasks/activities
  • Forgets daily activities
  • Often loses things necessary for tasks/activities
  • Doesn’t listen when spoken to

HYPERACTIVITY / IMPULSIVITY:

  • Unable to play quietly
  • Talks excessively
  • Doesn’t wait turn
  • Spontaneously leave seat when expected to sit
  • Often ‘on the go’
  • Interruptive or intrusive to others
  • Answer prematurely, before a question has been finished
  • Run and climb in situations where it is not appropriate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the diagnostic criteria for ADHD?

A

Features from inattention and/or hyperactivity/impulsivity lists:

  • If < 16yrs then 6 features
  • If > 17yrs then 5 features

Symptoms cause significant functional impairment; socially, psychologically, educationally etc.

Pervasive - symptoms occur in 2 or more settings; social, home, school etc.

Onset < 7 yrs (DSM-V) < 6 yrs (ICD-10)

Persists for > 6/12 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How is ADHD managed?

A

CONSERVATIVE:

  • Education on ADHD impact
  • Parenting strategies - involvement from both parents
  • Liaison for school, college, university
  • Behaviour management strategies

PHARMACOLOGICAL: - stimulants!!

5+ and young people
- 1st line = methylphenidate
- Low starting dose
- Titrate dose against behaviour + school work
- 2nd line = lisdexamfetamine
​ - If 6-week trial of methylphenidate at therapeutic dose did’t work
- Consider dexamfetamine IF responding to lisdexamfetamine but don’t tolerate long effect profile

Adults:

  • 1st line = methylphenidate or lisdexamfetamine ​
    • Try the other if the 1st didn’t work
  • Consider dexamfetamine IF responding to lisdexamfetamine but don’t tolerate long effect profile
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is autism managed?

A

CONSERVATIVE:

Psychotherapy - both parents + patients:

  • CBT
  • Behaviour management programmes
  • Applied behavioural analysis program - intense program (40hr a week for 3yrs) based on operant conditioning, imitation and reinforcement

Social - led by functional assessment:

  • Carers
  • Respite care
  • Education of peers in school
  • Learning support / special schools

PHARMACOLOGICAL:

2nd gen anti-psychotics = 1st line for children + adolescents with ASD
- Risperidone (only one liscenced in UK) - for aggressive, challenging behaviour in autistic children

SSRIs - low dose, used for restricted repetitive behaviours (evidence limited)

Melatonin - ↓ sleep latency (time taken to fall alseep)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is ‘Conduct Disorder’?

A

DEFINITION:

  • A repetitive and persistent pattern of behaviour in which either the basic rights of others or major age appropriate societal norms or rules are violated
  • Lasting > 6/12
  • Can occur in infancy, childhood or adolescence

FEATURES:

  • aggressive / cruel behaviour; towards other people or animals
  • frequent + severe temper tantrums for age
  • deceitfulness / lies frequently
  • thievery / breaking + entering
  • frequent physical fights
  • carrying / use of a weapon
  • destruction of property
  • violation of rules that is persistent and repetitive
  • bullying

RISKS:

  • risk of developing mental disorder
  • retaliation from others due to behaviour
  • substance misuse
  • risk of harm to others (aggressive behaviour)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What would the management plan for a conduct disorder involve?

A

Multi-systemic therapy (MST)

  • Identify problematic behaviours
  • Interventions for each behaviour (tackle one at a time) and how to monitor progress

Work on any substance misuse

Continued assessment of mental state to monitor for development of mental health disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What one of the following is not a common comorbidity in young people with conduct disorder?

  • ADHD
  • Psychosis
  • Learning difficulties
  • Depression
  • Autism spectrum disorder
A

Psychosis

46% of boys / 36% of girls who have conduct disorder, have at least 1 coexisting mental health problem:

  • ADHD (>40%)
  • Learning difficulties
  • Autistic Spectrum
  • Disorder
  • Depression
  • Anxiety
17
Q

Which one of the following is recommended first line for the treatment of conduct disorder?

  • Interpersonal therapy
  • Psychodynamic psychotherapy
  • Multi systemic therapy
  • Fluoxetine
  • Diazepam
A

-

18
Q

Which of the following risk factors are not associated with conduct disorder?

  • Substance misuse
  • ADHD
  • Physical or sexual abuse
  • Parental family history
  • Low IQ
  • Being female
A

-

19
Q

Which of the following would point towards a diagnosis of Oppositional Defiant Disorder instead of Conduct Disorder?

  • Negative and oppositional behaviour present at home with well known adults or peers, but not at school
  • Negative and oppositional behaviour in all areas of life, both at school and home
  • A 16 year old who severely bullies primary school children
  • Extreme levels of aggressive behaviour that is pervasive, across all areas of life.
  • Aggressive behaviour that goes beyond mere defiance, disobedience or disruptiveness
A

-

20
Q

Emotionally unstable personality disorder (EUPD) is split into 2 types,

what are they?

A

-

21
Q

What are some features of EUPD?

A

-

22
Q

What is a personality disorder?

A

-

23
Q

What causes personality disorders?

A

-

24
Q

How are personality disorders managed?

A

-

25
Q

What is dialectical behaviour therapy (DBT)?

A

-