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Semester 4 > Case 4 > Flashcards

Case 4 Flashcards

1
Q

Grade of cancer

A

How closely tumours resemble their tissue of origin

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2
Q

Stage of cancer

A

How far a tumour has spread at the time of presentation

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3
Q

Examples of oncogenes

A

B-catenin and K-RAS

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4
Q

Examples of tumour suppressor genes

A

p53 and APC

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5
Q

Wnt signalling mutation in colorectal cancer

A

Wnt signal attaches to the receptor, GSK-3B is not activated, B-catenin is not phosphorylated, so doesn’t degrade, enters cell nucleus, transcription occurs, alters gene expression of cyclin D and Myc

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6
Q

MSH2 and MLH1 genes were mutated in HNPCC Pts

A

…

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7
Q

W/o anti proliferative effect of TGF-B pathway

A

colon sensitised to inflammation

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8
Q

Inflammatory bowel disease and type 2 diabetes

A

risk factors for colorectal cancer

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9
Q

Inflammatory bowel disease includes

A

Ulcerative colitis and crohn’s disease

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Semester 4 (5 decks)

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