Case 2 - Asthma Flashcards
What are the 3 most important questions to ask at an asthma annual review?
Have you had difficultly sleeping due to your asthma?
Have you had your usual asthma symptoms during the day?
Has your asthma interfered with your usual daily activities?
What features indicate an acute severe asthma attack?
PEF 33-50% best or predicted
Respiratory rate: >25 min
Heart rate > 110/min
Inability to complete sentences in one breath
What features indicate a life threatening asthma attack?
PEF <33% best of predicted SpO2 <92% PaO2 <8kPa Silent Chet Poor respiratory effort Arrthythmia Exhaustion / Altered conscious level Hypotension
What is difference in FEV1/FVC ratios for obstructive and restrictive lung disease?
Obstructive - ratio less than 0.7
Restrictive - ratio is either normal or high
What is the difference between obstructive and restrictive lung disease?
Obstructive - narrowing of the airways, so exhaled air comes out more slowly. Less time to breathe out all the air before next inhalation
Restrictive - lungs are damaged and stiff so cannot fully expand. Less air can enter and exit
What conditions can cause restrictive lung disease?
Interstitial lung disease / pulmonary fibrosis Sarcoidosis Obesity Scoliosis Muscular dystrophy
What is the treatment for an acute asthma attack?
Oxygen - aim for 94-98% sats Oral or IV Steroids Beta agonist (salbutamol) nebulised Ibatropium bromide nebulised Magnum sulphate - where PEF <50% and no response to bronchodilator therapy
Which drugs are contraindicated in patients with asthma?
NSAIDS
Beta blockers
Adenosine
What is the stepwise management of asthma in children (aged 5-16)?
1) SABA
2) SABA + low dose ICS
3) SABA + low dose ICS + leukotriene receptor antagonist
4) SABA + low dose ICS + LABA
5) SABA + maintenance reliever therapy (MART) includes low does ICS
6) SABA + moderate dose ICS MART
7) ICS high dose MART or trial additional drug e.g, theophylline, also refer to asthma specialist
What is the stepwise management of asthma in children (under the age of 5)?
1) SABA
2) SABA + 8 week trial of moderate dose ICS
3) SABA + low dose ICS + leukotriene receptor antagonist
4) Refer to paediatric asthma specialist
What is a maintenance and reliever therapy (MART)for asthma?
A form of combined ICS and LABA treatment in a single inhaler, used for both daily maintenance therapy and the relief of symptoms as required
MART is only available in which the LABA has a fast acting component (e.g, formoterol)
What are the low, moderate and high dose ICS dosages for children?
Low dose: <200 micrograms budesonide or equivalent
Moderate dose: 200-400 micrograms budesonide or equivalent
High dose: >400 micrograms budesonide or equivalent
What is the FeNO test for asthma?
Fractional exhaled nitric oxide
Levels of NO rise in response to inflammation which can occur in asthma
How is asthma diagnosed in adults?
Spirometry - FVC1/FVC ratio less than 70% Bronchodilator reversibility (BDR) - improvement of FEV1 by 12% FeNO test
What is the stepwise treatment of asthma in adults?
1) SABA
2) SABA + low dose ICS
3) SABA + low dose ICS + leukotriene receptor antagonist (LTRA)
4) SABA + low dose ICS + LABA, continue LTRA depending on patients response
5) SABA +/- LTRA, switch ICS for maintenance reliever therapy (MART) includes low does ICS
6) SABA+/- LTRA, medium dose ICS MART
7) SABA+/- lTRA, high dose MART or additional drug e.g, theophylline, refer to asthma specialist