Cartilage Flashcards
1
Q
Composition of cartilage
A
95% ECM - 70% water, 30% organic (collagen type II, proteoglycans)
5% Cells
2
Q
Types of cartilage
A
Hyaline - Skeletal: articular, Non-skeletal: trachea
Fibrocartilage - IV discs
Elastic - epiglottis
3
Q
Enzymes involves in cartilage synthesis and degradation
A
Degradation:
- Collagenases, aggrecanses
- IL-1, TNF-a
Synthesis:
- Collagen, proteoglycans
- TGF-b, IGF-1
4
Q
Characteristics of cartilage
A
Avascular, aneural
Only heals if injury penetrates subchondral bone
