Caries Etiology Flashcards
Biofilms EARLIEST colonizers
MOS
S.mitis
S. Salivarius
S. Oralis
Make environment favorable to others or unfavorable to themselves, replacement sp that better suited for environment
Aquired Pellicle
Acellular, proteinaceous, forms minutes after cleaning teeth
Made of: Salivary glycoproteins
Phosphoproteins
Lipids
Gingival crevicular fluid
Mutants streptococci is a grouping
Initial biofilm colonizers?
Once teeth erupt what can be detected?
Mutans streptococci include: S mutans and S sobrinus
Initial colonizer: S.sanguine, S.oralis, S. Mitis biovar 1, Actinomyces species
Cariogenic bacteria
Conversion sugars to acids
Maintain metabolism in extreme environment (low ph)
Produce extra cellular polysaccharides: glucans/fructans > contribute to biofilm
Cariogenic bacteria
Cariogenic bacteria in SECC
1) Acid producing gram + cocci (non mutans and mutans streptococci)
2) Gram + rods (Actinomyces, lactobaccilli)
Cariogenic bacteria SECC
1) S. Mutans
2) Scardovia wiggsiae
3) S. Cristatus
4) Actinomyces gerencseriae
Bacteria In caries INITIATION
Bacteria in advanced lesions
Actinomyces species - CARIES INITIATION
Bifidobacterium species - role in advanced lesions
Window infectivity
1st window Starts : 19-30 months
Closes after all primary teeth erupt
2nd window starts: 6 yo when 6s erupt
HA
In enamel,
-ve inside and + outer layer
Negative macromolecule in saliva attracted to HA absorbed onto enamel
Critical PH for HA and FA and enamel
HA - ph 5.5
FA - ph 4.5
Enamel - ph 5.5
Critical PH - ph where saliva and plaque stop being saturated with calcium and phosphate and HA in enamel dissolved
It is the highest ph where there is net loss of enamel from teeth
Critical PH varies depending on total calcium and phosphate in spit
Remin
FAP has 2 advantages that make it better than HA
1) fluoride acts as a catalyst (assist remin of enamel with phosphate Ions from saliva)
2) displace hydroxide in HA with fluoride (removes weakness in HA to lactic acid)
what’s needed to form FAP?
2 Fluoride ions
10 calcium
6 phosphate
If not enough calcium or phosphate limit remin
Ready to feed infant formula PPM
Milk: 0.15 ppm Soy: 0.21 ppm 1 ppm = 1mg/L 1L = 4.16 cups = 0.24 mg/cup Baby drinks 2.5 oz/lb/day, 10 lb baby drinks 25 oz which is 3 cups per day = .72 mg F-
Fluorosis - what age are perm max incisors most susceptible to fluorosis?
First 3 years - and that’s why pea sized amount after age 3
MAKES sense! Crown finishes at 4 yo
New Level water fluoridation ppm - and what is the goal?
0.7 ppm
Goal: maintain anti cavity but reduce risk of fluorosis (old range was .7 to 1.2 ppm higher rate of fluorosis)
Main effect of fluoride?
ENHANCES REMIN of early lesions and DECREASES DEMIN of intact structure
Main effect is topical! low evidence for systemic
water is constant topical application
Fluoride in Juices? Fluoride toothpaste? Fluoride mouth rinse? Professionally applied fluoride GEL? Professionally applied fluoride VARNISH? Dietary Fluoride Supplement?
Juices: 0.2-0.8 ppm
White grape juice - highest ( fluoridated or non fluoridated
Fluoride toothpaste: 1000 mg/L
Fluoride mouth rinse: 226 mg/L (OTC)
Professionally applied fluoride GEL: 12,300 mg/L (HIGH Dose) 1-2 x per year
Professionally applied fluoride VARNISH: 22,600 mg/L NaFl-
Dietary Fluoride Supplement: .25-1 mg easy if you think of chart .25 to 1 max (MODERATE) designed to take place of FL water
Halo effect?
Ppl in non fluoridated areas - eat and drink food processed in fluoridated areas
Acute toxicity Fluoride?
Lethal dose Fluoride?
TOXIC: 5MG/KG (5 letters in toxic!)
LETHAL: 15 MG/KG
MG FL in pea vs smear fluoridated toothpaste?
Smear/ r1ce (under 3 yo) : 0.125 mg
Pea (over 3 yo) : 0.25 mg
Recommended DAILY
systemic dose for kids between 6 months and 3 years
Remember : 6 months because 1st tooth till 3 years (when you can start using .25 mg toothpaste pea sized)
Fluorosis is extrinsic of intrinsic stain?
Fluorosis is INTRINSIC (excessive fluoride ingestion DURING tooth development )
Severe fluorosis –> Enamel damage
Stain color: usually white, can be dark brown, orange
Can occur in both primary OR permanent teeth
What is the goal of fluoride therapy?
Goal: Caries prevention in infants and young kids while minimizing risk of ingested fluoride, acute toxicity, and fluorosis
Dietary Fluoride supplementation chart
Age UNDER .3 .3-.6 ppm OVER .6ppm
0-6 mo
6mo - 3 yrs .25 mg (IMP: system. daily for 6m-3y=.25 mg!)
3 yrs - 6 yrs 0.5 mg .25 mg
6yrs PLUS 1.0 mg .50 mg
Note only .25, .5, and 1 in this chart!
Total systemic daily dose for 6 month to 3 year old is .25 mg that’s why you give rice size amount to under 3 yo because its .125 mg and with other halo sources (like water) you dont wanna go over! but with this they dont have those sources
Fluoride supplements for moderate or high risk?
only for VERY HIGH RISK of developing caries with deficient water fluoride. Determine fluoride exposure remember halo effect