Cards Test 2 Medications Flashcards
Drugs most effective for HTN in younger white patients
ACE-I, CCB, BB
Drugs most effective for HTN in older white patients
CCB, diuretics
Drugs most effective for HTN in younger black patients
CCB
Drugs that are ineffective for HTN in younger black patients
ACE-I, BB
Drugs most effective for HTN in older black patients
CCB, diuretics
Drugs most effective for isolated systolic HTN
CCB, diuretics
Hydrochlorothiazide (type of drug)
Thiazide diuretic
Metazolone (type of drug)
Thiazide diuretic
Indapamide (type of drug)
Thiazide diuretic
HTN drug that causes ototoxicity
Loop Diuretic
Furosemide (type of drug)
Loop diuretic
Bumetanide (type of drug)
Loop diuretic)
Torsemide (type of drug)
Loop diuretic
Triameterene (type of drug)
Na+/K+ antagonist K+ sparing diuretic
Most common alpha2-agonist AE
dry mouth
HTN drug safe in pregnancy
Methyldopa
HTN drug that can also alleviate symptoms of BPH
Alpha-blockers
Clonidine (type of drug)
alpha2-agonist for HTN
The “-sin” drugs (type of drug)
Alpha-blockers for HTN
Difference between DHP and non-DHP calcium channel blockers
Non-DHPs focus have greatest effect in heart (reduce contractility and AV conduction).
DHPs are potent vasodilators and have little effect on heart
Verapamil (type of drug)
Non-DHP CCB
Diltiazem (type of drug)
Non-DHP CCB
Nifedipine (type of drug)
DHP CCB
Hydralazine (type of drug)
Direct vasodilator
Minoxidil (type of drug)
direct vasodilator
Sodium Nitroprusside (type of drug)
Potent arteriolar and venous dilator
DOC for hypertensive emergency
Sodium nitroprusside
“Renal protective” HTN drug
ACE-I and ARBs
Drug type to use when patient can’t be on ACE-I
ARB
Initial agent for diabetic HTN
ACE-I
Initial agent for CAD or recent MI hypertension
BB
Initial agent for HTN patient with overactive thyroid
BB
Initial agent for HTN patient with tachyarrhythmia
BB
initial agent for HTN in HF patient
ACE-I
initial agent for HTN in chronic renal failure patient
ACE-I or CCB
Drug that raises standing blood pressure levels
Midodrine
Statins’ effect on lipid profile
- reduces LDL 20-55%
- reduces TG 7-30%
- raises HDL 5-15%
Statins’ AE
- myopathy
- increased liver enzymes (hepatic toxicity)
Absolute contraindications for statins
-liver disease
Statins’ effect on atherosclerotic plaque
Causes plaque regression, but also increases the hard fibrous cap (increasing stability)
Fibrates MOA
Increase FA oxidation in the muscle and liver
Drug most effective at reducing VLDL
Fibrates
Fibrates’ effect on lipid profile
- reduces VLDL
- reduces TG 20-50%
- reduces LDL 5-15%
- raises HDL 10-20%
Drugs most effective at lowering LDL
Statins
Drug most effective at raising HDL
Nicotinic acid (niacin)
Only safe hyperlipidemic drugs for pregnancy
Bile acid sequestrants
Cholestyramine (type of drug)
bile acid sequestrant
Colestipol (type of drug)
bile acid sequestrant
Ezetimibe MOA
cholesterol absorption inhibitor
Effect of Ezetimibe + Statins
Decreases LDL by 60%
Drugs best at decreasing TG
Fibrates and Niacin
Drugs used to illustrate the “steal” phenomenon in pharmacologic/nuclear medicine stress testing
IV Dipyridamole or Adenosine
Drug that increases HR and contractile force for pharmacologic stress testing
Dobutamine
Pre-hospital management of STEMI
- ASA
- Continuous cardiac monitoring
- oxygen
- sublingual NTG
Emergency department management of STEMI
- ASA (if not already given)
- cardiac monitoring
- MONA (morphine, oxygen, NTG, ASA)
- Beta blockers
- Heparin
Time deadline for reperfusion therapy
< 12 hrs from onset of symptoms
Time deadline for fibrinolytic therapy
< 30 minutes from hospital arrival
Drugs to give for aortic dissection?
IV NTG
sodium nitroprusside
BBs (reduces LV contractile force)
vasodilators (lowers SBP)