Cardiovascular System Flashcards
Present at erythrocyte-plasma junction
Buffy coat
The Buffy coat contains
leukocytes and platelets
what percentage of the total volume of blood do erythrocytes make up?
45%
This 45% is also termed
the hematocrit
What percentage of blood volume is made up of plasma?
55%(remaining)
Blood accounts for approx ___ of body weight
8%
average healthy volume in adult males; adult females
5-6 L; 4-5 L
List some functions of blood
Distribution, Regulation, Protection
Most plasma proteins are produced by
the liver
maintaining normal pH in body tissues
a regulatory function of blood
maintaining adequate fluid volume of blood
a regulatory function of blood
preventing blood loss/clotting formation action
a protective function of blood
preventing infection
a protective function of blood
a straw-colored, sticky fluid that is 90% water and contains over 100 different solutes, including electrolytes and proteins
blood plasma
accounts for 60% of plasma protein
albumin(major blood protein contributing to osmotic pressure)
formed elements of blood
erythrocytes, leukocytes, platelets
Only ____ are complete cells with nuclei
leukocytes
“bags” of Hb
RBC/erythrocytes
How do erythrocytes generate ATP?
anaerobic mechanisms. they do not consume any of the oxygen they carry, which makes them highly efficient oxygen transporters.
Hemoglobin contains
2 alpha and 2 beta polypeptide chains and 4 heme groups
the heme pigment is bound to the protein; each heme group bears an iron atom in its
globin; center
what male hormone enhances EPO
testosterone
the average daily loss of iron in women in mg is roughly
1.7 mg
List two other necessary micronutrients(vitamins)linked to potential erythrocyte deficits
B12 and Folic Acid
the “red blood cell” graveyard
spleen
when blood oxygen carrying capacity is too low to support normal metabolism
anemia
anemia is a _____ rather than a disease itself.
sign of some disorder
anemia caused by blood loss
hemorrhagic anemia
results in large, pale cells called microcytes
pernicious anemia
results from destruction or inhibition of of red marrow by certain drugs and chemicals, ionizing radiation, or viruses
aplastic anemia
erythrocytes rupture or lyse prematurely
hemolytic anemia(s)
Thalassemias
Typically occur in Mediterranean ancestry. One of the globin chains is absent or fault, erythrocytes are thin, delicate and deficient in hemoglobin.
Sickled erythrocyte results from a single amino acid change in the __________.
Beta chain of hemoglobin
polycythemia
increases erythrocyte count so blood becomes more viscous and sluggish
polycythemia vera
bone marrow cancer. High RBC count and extreme dizziness.
artificially induced polycythemia
Blood Doping
accounts for less than 1% of total blood volume
WBCs (leukocytes)
diapedesis
WBCs ability to slip out of capillary blood vessels and use the circulatory system to transport to areas of the body where they mount inflammatory and immune responses
rarest white blood cells
Basophils
histamine is an inflammatory chemical that acts as a
vasodilator
Accounts for 25% or more of the leukocyte population
Lymphocytes
Account for 3-8% of WBCs
Monocytes
replacing blood volume generally consists of
an isotonic salt solution.
Group O is the
universal donor blood type
three steps in homeostasis after a blood vessel rupture
- vascular spasm
- platelet plug formation
- coagulation (blood clotting)
factors that inhibit clogging are
anticoagulants
removes unneeded clots when healing has occurred
fibrinolysis
describe a lymphocyte
large, spherical nucleus, thin rim of pale blue cytoplasm
describe a monocyte
kidney-shaped nucleus, abundant pale blue cytoplasm
what network of proteins on the face of RBCs allows for fluidity of their structure?
Spectrin
when oxygen combines with iron, it is called
oxyhemoglobin
when oxygen detaches from iron, hemoglobin becomes
deoxyhemoglobin
blood cell formation
hematopoiesis
blood cell forming stem cell
hemocytoblast
erythropoiesis
formation of red blood cells
first step in erythropoiesis
myeloid stem cells transforms into a proerythroblast
_______ arise and produce a large number of ribosomes
pro erythroblast