Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharm > Cardiovascular Drugs: Antidysrhythmics > Flashcards

Cardiovascular Drugs: Antidysrhythmics Flashcards

(57 cards)

Start Studying
1
Q

What is happening during the P wave

A

atrial depolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is happening during the PR interval

A

impulse pauses at AV node

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is happening during the QRS complex?

A

ventricles depolarize

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is happening during ST interval?

A

ventricles pause before repolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is happening during T wave?

A

ventricles repolarize

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where in the EKG do the atria repolarize?

A

Hidden within the QRS complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What ions are involved with electrophysiology of myocyte?

A

Na+, K+, Cl-, Ca++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which ion rushes into the myocyte to elicit contraction?

A

Na+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which ion leaves the myocyte to allow for repolarization?

A

K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which ion prolongs repolarization in the myocyte?

A

Ca++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which ion initiates depolarization of the SA node?

A

Na+ (funny current)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which ion rushes in and elicits depolarization of SA node?

A

Ca++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Efflux of which ion results in SA node repolarization?

A

K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

List supraventricular arrhythmias

A

atrial fibrillation
atrial flutter
atrial tachycardia (like SVT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

List ventricular arrhythmias

A

ventricular fibrillation (vfib)
ventricular tachycardia (vtach)
PVCs
torsades

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Two bradycardic arrhythmias

A

heart block
sick sinus syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What ion do Class I antidysrhythmics inhibit?

A

Na+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What do class II antidysrhythmics inhibit?

A

B1 receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What ion do class III antidysrhythmics inhibit?

A

K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What ion do class IV antidysrhythmics inhibit?

A

Ca++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

List some class I antidysrhythmics

A

quinidine
procainamide
lidocaine
flecainide
propafenone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How do the class subtypes of class I antidysrhythmics differ?

A

IA = increase AP, ERP, QT interval
IB = decrease AP, ERP
IC = increase ERP in AV node only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Uses & AEs - Class IA

Study These Flashcards
A
  • uses = atrial & ventricular arrhythmias (SVTs & VTs)
  • AE = anticholinergic
24
Q

Uses & AEs: Class IB

Study These Flashcards
A
  • uses = post MI & other ventricular arrhythmias (affects ischemic tissues)
  • AEs: toxicity at high doses
25
Uses & AEs: Class IC
- uses: SVTs & afib - AE: can induce life threatening VT
26
Potency of Na channel blockade (Class I)
1C > IA > 1B
27
Increase in ERP: Class I
1A > 1C > 1B - 1B decreases
28
which subtype of beta blockers are used as class II antidysrhythmics?
cardioselective usually 9atenolol, metoprolol, esmolol)
29
results of beta 1 antagonism
decreased HR decreased contractility decreased conduction through AV node
30
Uses for Class II
SVTs & VTs & post MI (improved O2 supply demand & decreased cardiac remodeling)
31
adverse effects of beta antagonism
bradycardia hypotension
32
name a class III antidysrhythmic
amiodarone
33
What is amiodarone used for
ventricular tachycardias (vfib, vtach) - off label for afib/flutter
34
Amiodarone MOA
- block K+ exit - delayed repolarization, increased AP duration, increases ERP - prolongs QT
35
how long is amiodarone's half life?
25-60 days
36
adverse effects of amiodarone
pulmonary fibrosis hypothyroidism corneal microdeposits skin discoloration hepatotoxicity *pro-dysrhythmic: torsades, bradycardia, AV block
37
What is a dihydropyridine
ca++ channel blocker that only impacts the vasculature (results in arteriole vasodilation)
38
What is a nondihydropyridine
ca++ channel blocker that works on the arteries (arterial vasodilation) AND on the heart (decreased contractility, HR, AV node conduction)
39
Which type of Ca++ blocker is used in treatment of dysrhythmias
nondihydropyridines
40
List some dihydropyridines
amlodipine nifedipine nicardipine
41
list some nondihydropyridines
diltiazem verapamil
42
Class IV MOA
- blocks Ca influx - decreases HR, decreased contractility, decreased conduction through AV node
43
Uses & AEs for class IV
- uses = SVTs - AEs: bradycardia, AV block, hypotension
44
Which two classes of antidysrhythmics are contraindicated together?
Class II & Class IV (beta blockers and Ca++ channel blockers)
45
What does adenosine do?
hyperpolarize cardiac membranes = no AP can occur (kinda stops the heart for a sec!) - K channel opening, hyperpolrization, inhibition of pacemaker cells & decreased HR
46
half life of adenosine
10 seconds
47
How to administer adenosine
rapid IV push followed immediately by rapid saline flush
48
adverse effects of adenosine
flushing transient hypotension transient flat line transient chest pain
49
mechanism of action of digoxin
Na+/K+ ATPase inhibition = increased Na+ and therefore increased Ca++ = increased contractility - longer phase 4 & 0 AP --> bradycardia
50
drug class of digoxin
cardiac glycoside
51
does digoxin cause tachycardia or bradycardia?
bradycardia potentially
52
adverse effect of digoxin
arrhythmias AV block toxicity
53
contraindications of digoxin
heart block hypokalemia (can lead to drug toxicity) WPW advanced CKD
54
What class of medication is atropine
anticholinergic (or muscarinic antagonist)
55
Cardiac effects of atropine
increased HR
56
uses for atropine as an antidysrhythmic
symptomatic bradycardia (1mg Q3-5mins)
57
adverse effects of atropine
decreased GI/GU dry mouth mydriasis

Pharm (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions