Cardiovascular Disorders Flashcards
What are the main types of cardiovascular disorders?
Cardiac muscle disorders:
heart failure
Electrical transmission disorders:
Atrial arrhythmias
Conduction block
Vasculature disorders:
Hypertension
Acute coronary syndromes
What is the definition of heart failure?
Heart unable to maintain adequate circulation for metabolic requirements of body
Types:
- Preserved ejection fraction - EF > 50%, decreased diastolic function
- Reduced EF - EF<50%, decreased systolic function
What is the pathophysiology of heart failure?
Secondary to cardiac damage (ischaemia, myopathy) , hypertension, valve disease
What are the investigations related to heart failure?
Signs and symptoms: exertional dyspnoea
Tests: blood tests (elevated brain natriuretic peptide/BNP), chest X ray (cardiomegaly)
ECG: may be an enlarged QRS complex
What are some treatment options for heart failure?
Drugs that reduce the exertional pressure on the heart
What is the definition of atrial arrhythmias?
Atrial fibrillation: disorganised electrical activity and contraction
Wolff-Parkinson-white: syndrome causing tachycardia and abnormal cardiac electrical conductance
What is the pathophysiology of atrial arrhythmias?
AF: spontaneously active cells throughout the atria
WPW: additional accessory conduction pathway (bundle of kent) between the atria and ventricles
What are the investigations related to atrial arrhythmias?
Signs and symptoms: both: palpitations and chest pain
ECG:
AF - absent P waves and irregularly irregular rhythm
WPW - QRS pre excitation and biphasic/inverted T wave
What are some treatment options relating to atrial arrhythmias?
AF: strategies to maintain sinus (cardioversion, anti-arrhythmetics, catheter ablation)
WPW: benign, no treatment required
What is the definition of conduction block?
First degree: slowing down conduction through AV node
Second degree: reduced transmission of signal from atria to ventricles
Third degree: complete block of current from atria to ventricles
What is the pathophysiology of conduction block?
Damage (fibrosis, calcification, necrosis) to the conduction system (AV node or His pyrkinje system)
What are the investigations relating to conduction block?
ECG:
First degree - increased P-R interval
Second - increased P-R interval or missing QRS complexes, depending on type
Third - p waves not followed by QRS complexes
What are the treatment options for conduction block?
Discontinuation of AV blocking drugs (beta blockers, calcium channel blockers)
Pacemaker implantation in severe cases
What is the definition of hypertension?
Clinical BP > 140/90 mmHg
Ambulatory BP daytime average > 135/85 mmHg
What is the pathophysiology of hypertension?
Primary: unknown
Secondary: resulting from another medical condition (kidney disease, adrenal disease)