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BOD Lent > Cardiovascular disease > Flashcards

Cardiovascular disease Flashcards

1
Q

Function of Thrombin

A

Multifunctional protease that is activated in the penultimate step of the coagulation cascade. 4 functions:

  1. Cleaves soluble fibrinogen into insoluble fibrin monomers
  2. Activation of factor 12, which cross-links the fibrin monomers to form polymers
  3. Activates other coagulation factors, 11/5/8 - thereby producing a positive feedback loop
  4. Thrombin also binds to various receptors leading to the activation of platelet/ endothelial cells/ leukocytes (neutrophils + monocytes)
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2
Q

Most important stimuli of coagulation cascade in vivo?

A

Initiation of the extrinsic pathway by TISSUE FACTOR derived from damaged tissues

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3
Q

Predisposing factors for thrombosis/ Virchow’s triangle

A
  1. Changes in vessel wall
  2. Changes in blood flow
  3. Changes in constituents of blood
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BOD Lent (4 decks)

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