Cardiovascular Flashcards
What are the 4 classes of anti-arrhythmic drugs?
Class 1 - Membrane stabilising drugs (Na+ blockers) - Rhythm Control
Class 2 - Beta-blockers - Rate Control
Class 3 - K+ channel blockers - Rhythm Control
Class 4 - calcium-channel blockers (rate-limiting) - Rate Control
Give examples of Class 1 anti-arrhythmic drugs.
Rhythm Control
- Disopyramide
- Lidocaine
- Flecainide / Propafenone (CI in asthma / severe COPD, avoid in structural / ischaemic heart disease)
Give examples of Class 2 anti-arrhythmic drugs.
Rate Control
- Bisoprolol
- Propranolol
- Esmolol
Give examples of Class 3 anti-arrhythmic drugs.
Rhythm Control
- Amiodarone - 4 weeks before and 12 months after electrical cardioversion to increase success.
- Sotalol
- Dronedarone
Give examples of Class 4 anti-arrhythmic drugs.
Rate-Control
- Verapamil
- Diltiazem
Give examples of other anti-arrhythmic drugs.
- Adenosine
- Digoxin - effective in sedentary patients with non-paroxysmal AF and in patients with associative CHF.
What is AF?
Abnormal, disorganised electrical signals fired causing the atria to fibrilate (quiver) resulting in a rapid and irregular heartbeat.
What are the symptoms of AF?
- Heart palpitations
- Dizziness
- SOB
- Tiredness
What are the complications of AF?
- Stroke
- HF
What are the types of AF?
- Paroxysmal - episodes stop within 48 hours without treatment.
- Persistent - episodes last >7 days.
- Permanent - present all the time.
What is cardioversion?
Cardioversion is procedure which restores sinus rhythm. It uses a defibrillator device.
How is acute, new onset AF managed?
If the patient has life-threatening haemodynamic instability:
- Use electrical cardioversion.
If the patient does NOT have life-threatening haemodynamic stability:
- <48 hours of symptoms - rate or rhythm control (cardioversion OR amiodarone / flecainide).
- > 48 hours of symptoms - rate control (verapamil / beta-blocker).
Outline the pharmacological management of AF.
- 1st-Line: Beta-blockers (not sotalol) / rate-limiting CCB / digoxin for rate control.1
Use monotherapy, then dual therapy, then consider rhythm control.
- 2nd-Line: Rhythm control using Class 1/3 anti-arrhythmic.
What needs to be assessed in patients who have AF?
Risk of thromboembolic stroke and the risk of bleeding.
How is risk of thromboembolic stroke assessed for patients with AF?
CHA2DS2VASc Score
C = CHF / LVSD (Yes = 1) H = HTN (Yes = 1) A2 = Age 75+ (2) D = Diabetes Mellitus (Yes = 1) S2 = Stroke / TIA / VTE Hx (Yes = 2) V = Vascular Disease (Yes = 1) A = Age 65-74 (1) Sc = Sex category (female = 1, male = 0)
Anticoagulation is indicated if score = 2+.
How is bleeding risk assessed for patients with AF?
HAS-BLED Score
H = HTN, >160mmHg systolic (1) A = Abnormal liver / renal function (1) S = Stroke Hx (1) B = Bleeding Hx / predisposition (1) L = Labile INR (1) E = Elderly >65 (1) D = Drugs, antiplatelet or NSAID use (1)
When should anticoagulation be given in patients with AF?
If the risk of thromboembolic stroke > risk of bleeding.
AND
CHA2DS2VASc score = 2+.
What is the choice of anticoagulant for AF?
New-onset AF = parenteral anticoagulant
Diagnosed AF = Warfarin / DOAC
What is ventricular tachycardia (VT)?
Quick, abnormal HR.
How is ventricular tachycardia managed?
- Pulseless = immediate defibrilation and CPR
- Unstable sustained VT = direct current cardioversion. If failed, IV amiodarone and repeat cardioversion.
- Stable sustained VT = IV anti-arrhythmic (preferably amiodarone)
- Non-sustained VT = beta-blocker
How is Torsades de pointes managed?
Magnesium sulfate.
What causes Torsades de pointes?
- Drugs that cause QT interval prolongation..
- HypOkalaemia.
- Bradycardia.
What is paroxysmal supraventricular tachycardia?
A type of supraventricular tachycardia, named for its intermittent episodes of abrupt onset and termination. Often people have no symptoms but may include palpitations, feeling lightheaded, sweating, shortness of breath, and chest pain.
How is paroxysmal supraventricular tachycardia managed?
- Reflex vagal nerve stimulation.
- IV adenosine (CI in COPD / asthma).
- IV verapamil.
If the patient is haemodynamically unstable, cardioversion is required.
If there are recurrent episodes, catheter ablation or other anti-arrhythmics may be used.
What is the initial loading dose of amiodarone?
200mg TDS for 7/7 THEN 200mg BD for 7/7 THEN 200mg OD maintenance
Side-effects of amiodarone.
Eyes:
- Corneal micro-deposits - advise patients it may cause night-time glares when driving.
- Blindness - advise patient to stop taking if vision becomes impaired.
Skin:
- Phototoxicity - burning and erythema
- Slate-grey skin on light-exposed areas.
Advise patient to shield skin from light and use a high SPF for months after stopping.
What monitoring is required with amiodarone use?
- Annual eye test
- Chest x-ray before treatment
- LFTs every 6 months
- TFTs before treatment and every 6 months
- BP and ECG (causes hypotension and bradycardia)
- U&E’s (causes hypOkalaemia)
What is the half-life of amiodarone?
50 days.
Interactions of amiodarone.
Increased plasma amiodarone concentration
- Grapefruit juice (enzyme inhibitor)
Amiodarone is an enzyme inhibitor - increases plasma concentration of
- Warfarin
- Phenytoin
- Digoxin (half dose)
Increased risk of myopathy
- Statins
Bradycardia, AV block and myocardial depression
- Anti-arrhythmics
QT prolongations
- Quinolones
- Macrolides
- TCA’s
- SSRI’s
- Lithium
- Quinine
- Hydroxychloroquine
- Anti-malarials
- Antipsychotics
Due to half-life, there’s a danger of interactions for nearly 2 months after stopping.
What is the target plasma concentration of digoxin?
When should blood be taken to test levels?
1-2 mcg/L
Samples should be taken 6 hours following the previous dose of digoxin.
How does digoxin work?
Increases the force of myocardial contraction (positive inotrope).
Reduces conductivity in the AV node (negative chronotrope).
What monitoring is required for digoxin use?
Regular monitoring is not required during maintenance unless toxicity is suspected OR in renal impairment.
True or False - Digoxin does not require a loading dose.
False - loading doses are required due to long half-life of digoxin.
What is the maintenance dose of digoxin?
AF = 125-250mcg OD
Worsening / Severe HF (sinus) = 62.5-125mcg OD
What is the difference between bioavailability in different preparations of digoxin?
Elixir = 75%
Tablet = 90%
IV = 100%
What are the signs of digoxin toxicity?
SLOW & SICK
- Bradycardia / heart block
- N&V, diarrhoea and abdominal pain
- Blurred or yellow vision
- Confusion or delirium
- Rash
When are patients at risk of developing digoxin toxicity?
- HypOkalaemia
- HypOmagnaesaemia
- HypERcalcaemia
- Hypoxia
- Renal impairment
How is digoxin toxicity managed?
- Withdraw digoxin use.
- Correct electrolyte imbalances.
- Digoxin-specific antibody (used in life-threatening ventricular arrhythmias unresponsive to atropine).
Digoxin interactions.
HypOkalaemia predisposes to toxicity:
- Diuretics
- Beta-2 agonists
- Steroids
- Theophylline
Increased plasma digoxin concentration = toxicity - Amiodarone (half digoxin dose) - Rate-limiting CCB -Macrolides - Ciclosporin These drugs are enzyme inhibitors.
Decreased plasma digoxin concentration = subtherapeutic
- St. John’s Wort
- Rifampacin
These drugs are enzyme inducers.
Reduced renal excretion = toxicity
- NSAIDs
- ACE-i / ARB’s
Pneumonic to remember digoxin interactions?
CRASED
C = CCB R = Rifampicin A = Amiodarone S = St. John's Wort E = Erythromycin D = Diuretics`
What are the 2 types of VTE?
1) Deep Vein Thrombosis - a blood clot occurring within a deep vein, usually in calf.
2) Pulmonary Embolism - detachment of a blood clot which travels to the lungs and blocks the pulmonary artery.
What are the risk factors for developing VTE?
- Immobility
- Obesity
- Malignant disease
- Age >60
- Personal Hx of VTE
- HRT / COC use
- Pregnancy
What do you have to compare to VTE risk to assess whether VTE prophylaxis is required?
Bleeding risk:
- Thrombocytopenia
- Acute stroke
- Bleeding disorders (acquired or inherited)
- Anticoagulant use
- Systolic HTN
What types of VTE prophylaxis are available?
1) Mechanical, e.g. compression stockings. FLOWTRONS.
2) Pharmacological - for high VTE risk. This may be using parenteral anticoagulants or DOACs.
How long is VTE prophylaxis required?
Depending on the indication:
- General surgery = 5-7 days, or until sufficiently mobile.
- Major cancer surgery in abdomen/pelvis - 28 days
- Knee/Hip surgery - extended duration
What comprises VTE treatment?
- LMBH / unfractioned heparin for at least 5 days and until INR >2 for at least 24 hours.
- Start oral anticoagulant at the same time (usually warfarin).
What treatment should be used for VTE in pregnancy?
Why?
LMWH preferred due to lower risk of osteoporosis and heparin-induced thrombocytopenia. Stopped at labor.
How does heparin work?
Unfractioned heparin activates antithrombin.
LMWH inactivate factor Xa.
What LMWH are available?
- Tinzaparin
- Enoxaparin
- Dalteparin
When would unfractioned heparin be preferred to LMWH’s?
- High risk of bleeding
- Renal impairment
What needs to be monitored with heparin use?
APTT
What are the side-effects of heparin & LMWH’s?
- Hemorrhage - withdraw use and if rapid reversal required, give protamine.
- HypERkalaemia - inhibits aldosterone secretion. Monitor.
- Osteoporosis.
- Heparin-induced thrombocytopenia - occurs after 5-10 days. Shows as 30% reduction in platelets, skin allergy and thrombosis.
What other parenteral anticoagulants are available?
- Heparinoid - used in thrombophlebitis, bruising and haematoma.
- Argatroban - use for anticoagulation in patients with heparin-induced thrombocytopenia.
- Hirudin
- Heparin flushes - used to maintain patency of peripheral and central catheters.
- Epoprostenol
- Fondaparinux - used for patients unable to use animal products.
What is the mechanism of action of warfarin?
Antagonises the action of Vitamin K in blood clotting.
How long does it take for warfarin to work?
48-72 hours.
What is the initiation dose of warfarin?
5mg initially and monitored every 1-2 days.
What is the usual maintenance dose of warfarin?
3-9mg OD taken at the same time each day.
What monitoring is required with warfarin treatment?
INR every 3 months once stable.
What should the target INR be?
Depends on indication:
- 5 - VTE, AF, MI, Cardioversion, Bioprosthetic mitral valve
- 5 - Recurrent VTE
Important warfarin interactions.
Changes in INR:
- Direct-acting antivirals for chronic hepatitis C treatment
Increased risk of bleeding:
- Miconazole. Closely monitor if miconazole prescribed.
Warfarin side-effects.
- Bleeding, e.g. node bleeds <10mins, bleeding gums, bruising.
- Calciphylaxis (painful skin rash). Consider stopping if diagnosed. Increased risk in end-stage renal disease.
What is used to reverse the effects of warfarin in a major bleed?
Vitamin K (phytomenadione)
+
Dried prothrombin complex / Fresh Frozen Plasma
What should you do if a patient’s INR is 5.0-8.0 with no bleeding?
- Withhold 1-2 doses.
- Reduce maintenance dose.
- Measure INR after 2-3 days.
What should you do if a patient’s INR is 5.0-8.0 with minor bleeding?
- Omit warfarin.
- IV Vitamin K.
- Repeat if INR still high after 24 hours.
- Restart warfarin when INR<5.0.
What should you do if a patient’s INR is >8.0 with no bleeding?
- Omit warfarin.
- IV Vitamin K.
- Repeat if INR still high after 24 hours.
- Restart warfarin when INR<5.0.
What should you do if a patient’s INR is >8.0 with minor bleeding?
- Omit warfarin.
- IV Vitamin K.
- Repeat if INR still high after 24 hours.
- Restart warfarin when INR<5.0.
When should warfarin be held before surgery?
Elective:
- Stop 5 days before surgery.
- Give oral Vitamin K for 1 day if INR>1.5.
- Restart warfarin on evening or next day.
Emergency:
- Delay surgery for 16-12 hours.
- Delay not possible, give IV Vitamin K and dried prothrombin complex.
If high risk of VTE:
- If VTE in last 3 months, AF with previous stroke/TIA or mechanical valve, bridge therapy with LMWH (treatment dose) and stop 24 hours before surgery.
High risk of bleeding:
- Start LMWH 48 hours after surgery.
Which DOAC works by directly inhibiting thrombin?
Dabigatran.
Which DOAC’s work by directly inhibiting factor Xa?
- Apixaban
- Edoxaban
- Rivaroxaban
What are the 2 types of stroke?
1) Ischaemic - blood clot obstructs blood supply to the brain.
2) Haemorrhagic - weak blood vessel in the brain bursts.
What is the long-term management of a TIA?
MR dipyridamole & aspirin & statin (irrespective of serum cholesterol)
Treat any HTN
What is the long-term management of an ischaemic stoke?
Clopidogrel & statin (irrespective of serum cholesterol)
In an AF-related stroke, review for an anticoagulant.
Treat any HTN.
How do antiplatelet drugs work?
Decrease platelet aggregation and inhibit thrombus formation in the arterial circulation.
Name the antiplatelet drugs.
- Low-dose aspirin
- Clopidogrel
- Dipyridamole
- Cangrelor
- Prasugrel
- Ticagrelor
The following are glycoprotein IIa/b inhibitors:
- Abciximab
- Eptifibatide
- Tirofiban