Cardiovascular Flashcards
Hypertension
Stages 3
Rx 4
Normal targets 2
Lifestyle advice
Def…
Stage 1: ≥140/90, then ABPM/HBPM of ≥135/85
Stage 2: ≥160/100, then ABPM/HBPM of ≥150/95
SEVERE: sys≥180, dias≥110
Rx…
1. A or C
2. A + C
3. A + C + D
4. Add spiro if K ≤4.5, or (stronger thiazide diuretic if greater)
If further diuretic contraindicated/ineffective then + B (alpha or beta blocker)
If no response then - RESISTANT HYPERTENSION therefore refer
Normal…
Less than 80 yo: <140/90 (clinic), <135/85 (ambulatory/home)
Over 80 yo: <150/90, <145/85
Lifestyle…
- Reduce salt (<6mg/d, ideally 3mg/d) and caffeine
- Lower weight and regular exercise
- Stop smoking and lower alcohol intake
- Balanced diet (rich in fruit and veg)
Risk factors for CVD
Non-mod 4; Mod 7
Non-mod:
- Age
- FH
- Male
- Ethnicity
Mod:
- BP
- Lipids
- Smoking
- Alcohol
- Exercise
- Weight
- Diet
QRISK every 5 years, except with…
5
- Hx of CVD
- Familial hypercholesterolaemia
- Age ≥85
- T1DM (sometimes QRISK3 helpful)
- CKD (sometimes QRISK3 helpful)
If 10% 10-year CVD risk…
3
- Discuss pros and cons of statin (atorvastatin 20mg)
- Lifestyle discussion
- Treat co-morbidities, e.g. BP
Offer statins in over 10% QRISK2 score and…
2
- T1DM if >40, DM for 10 years, nephropathy
- Over 85 - consider(!) offering statin
[T2DM - carry out QRISK2 as normal]
Chest pain causes
Causes by system - 6
- Cardiac
- Resp
- GI
- Msk
- Psych
- Non-specific
Chest pain causes
Features - subcategories - 4
- Tight, pressure, central, radiation to shoulder/jaw/arm/neck —> ISCHAEMIC
- Pleuritic —> think PE
- Tearing, between shoulder blades —> think DISSECTING AORTIC ANEURYSM
- Relieved by sitting forward —> think PERICARDITIS
?ACS
Referral (3)
999
Pain right now
ECG new changes
Rx: GTN (&/or opioid, e.g. IV diamorphine), O2 if sats <94%, Aspirin 300mg (unless CI)
- SAME-DAY ASSESSMENT* - currently pain-free
- Pain in last 12h, normal ECG, no complications
- Pain 12-72h, no complications
WITHIN 2 WKS - currently pain free
- Pain >72h, no complications
(Can consider assessment for ACS in 1º care - ECG, trop - & consider aspirin 75mg, GTN stat —> 5 mins —> 999)
ACS Severity Heirarchy
3
Unstable angina —> NSTEMI —> STEMI
Unstable angina & NSTEMI Mx
Initial; High risk; If insufficient; Long-term
INITIAL
- Oxygen
- Nitrates
- Morphine
- Aspirin + Clopidogrel / Prasrugrel (if undergoing PCI)
- also: LMWH, B-blockers indefinitely (if CI, then diltiazem or verapamil)
Secondary prevention (+ statins)
Offer ____ (1)
If history of ____ (5 eg)
Offer ATORVASTATIN 80mg (seek specialist advice if contraindicated)
If history of CVD
- eg MI, angina, stroke, TIA, PVD
Statin side-effects
3
Headache
GI disturbance
Myalgia
(N.B. Remember link with grapefruit juice - may increase statin concentration)
Monitoring of statins
3
- Lipids - at 3/12, aim for 40% drop in non-HDL cholesterol
- LFTs - at 3/12 and 12/12
- CK - if unexplained muscle symptoms
Angina…
…caused by myocardial ischaemia (5)
- CAD (atheroma)
- Aortic stenosis
- HOCM
- Htn
- Coronary artery spasm (Prinzmetal’s)
Angina…
…Ix (3)
- Resting ECG may be normal
- Exercise ECG may show ST depression
- Exercise myocardial perfusion scans may be useful
Angina…
…symptom control
3
- Acute —> GTN
- Prevention 1 —> B blocker OR Ca channel blocker
- Prevention 2 —> monotherapy: Long-acting nitrate (ISMN) / Nicorandil / Ivabradine / Ranolazine
Angina…
…Interventions (2)
- PTCA
= percutaneous transluminal coronary angioplasty - inflating a balloon to correct atheromatous obstructions - CABG
= coronary artery bypass grafting - multivessel disease, failed PTCA, etc (a vessel, e.g. internal mammary artery, is used to bypass the blocked areas)
Angina…
…2º prevention
3
- Consider antiplatelet - usually aspirin 75mg OD (may already be on clopidogrel)
- Consider ACEi if diabetes (other conditions as per NICE guidance)
- Statin/Hypertension treatment as per NICE guidance
MI definition
= myocardial infarction
= death of heart muscles due to ischaemia, usually due to ruptured plaque
MI diagnosis
3
Overall: symptoms + ECG + troponin
- Features: pale, sweaty, cardiac pain, unwell
- ECG: STE, T wave inversion, tall T waves, STD, Q waves
- Troponin, CK, AST, LDH
MI types
2
STEMI (usually full blockage)
NSTEMI (usually partial blockage)
MI treatment
2
Reperfusion by PCI (PTCA) preferred
OR
Fibrinolysis (if PCI not possible within 120 minutes)
E.g. with streptokinase/alteplase
Post-MI Mx
3
- Lifestyle (eg smoking, diet)
- Cardiac rehab programme & exercise
- Medication (4A’s)
ACEi or ARB (A) - indefinite
Beta-blocker (A - atenolol) - at least 12/12
Statin (A - atorvastatin) - indefinite
Antiplatelets (A)
Post-MI Antiplatelets
2
- If medially managed (NSTEMI or STEMI):
Aspirin 75mg OD + Ticagrelor 90mg BD - 12/12
(If high risk of bleeding, continue for at least one month)
(If high ischaemic risk can consider continuing for up to 36/12 - w ticagrelor dose of 60mg BD)
- ACS + PCI:
Aspirin 75-100mg BD + one of following for UP TO 12/12
- Prasrugrel 10mg OD (5mg if <60kg / >75yo)
- Ticagrelor 90mg BD
- Clopidogrel 75mg OD (if above two are not suitable)
Then aspirin alone
Lifestyle modification (Lipids modification)
4
- Stop smoking
- Alcohol (14 units male/female)
- 150 mins per week of moderate intensity exercise
- Diet
Diet modification (lipids modification)
7
- Fat intake <30% total energy intake (saturated <7%)
- Olive oil/rapeseed oil instead of butter
- 5 portions fruit/veg per day
- 2 portions fish per week (1 oily)
- 4-5 portions unsalted mixed nuts/seeds per week (1 portion approx 30g)
- Whole grain cereals/breads, etc
- Salt low (<6g/day), sugar low
BONOFFS
Heart failure definition
Cardiac output / BP inadequate for body’s needs
Poor prognosis - 50% 5y mortality
Types of heart failure
2
- LEFT - ischaemia, hypertension, valve disease, etc
2. RIGHT - 2º to left, cor pulmonale (lung disease)
Heart failure signs/symptoms
Sx 5; signs 6; CXR 4
Sx
- Orthopnoea
- PND
- SOBOE
- Fatigue
- Pink frothy sputum
Signs
- Bibasal creps
- Raised JVP
- Tachycardia
- Displaced apex
- 3rd HS
- Oedema
CXR
- CARDIOMEGALY!
- Kerly B lines
- Upper lobe diversion
- Pleural effusions
Heart failure:
Acute Mx
- FBC, U&E, BNP, CXR, ECG, echo
- IV diuretic
(No routine use of opioids, nitrates, inotropes, vasopressors)