Cardiovascular Flashcards
General cause of dilated cardiomyopathy
malfunction of myocardium
Most common causes of dilated cardiomyopathy (4)
Alcohol abuse (most common)
Idiopathic
Myocarditis
Drugs (doxorubicin)
Sequelae of dilated cardiomyopathy
right and left systolic dysfunction, congestive heart failure
Most common first symptom of dilated cardiomyopathy
exertional intolerance
In addition to exertional intolerance, other s/sx dilated cardiomyopathy (4)
dyspnea
orthopnea
lower extremity edema
chest pain
Physical exam in dilated cardiomyopathy (5)
S3 heart sound
JVD
crackles on lungs
mitral regurgitation
lower extremity edema
EKG in dilated cardiomyopathy (3)
nonspecific ST and T wave changes, LBBB
CXR in dilated cardiomyopathy (2)
cardiomegaly, pulmonary vascular congestion
Echo in dilated cardiomyopathy (4)
dilated chambers
thin left ventricular wall
poor wall movement
decreased ejection fraction (often less than 30%)
Non-druggy treatment of dilated cardiomyopathy (3)
withdraw offending agents like booze
sodium restriction
maybe heart transplant
druggy treatment of dilated cardiomyopathy (4)
Diuretics
maybe digoxin
ACE inhibitors (unless contraindicated)
Beta-blockers in stable heart failure
Most common cause of death in young athletes
Ventricular tachyarrhythmias due to hypertrophic cardiomyopathy
Most common cause of hypertrophic cardiomyopathy
Autosomal dominant genetic cause
Pathogenesis of hypertrophic cardiomyopathy
Hypertrophy of cardiac septum leads to LV outflow obstruction, impaired diastolic filling, this leads to pulmonary congestion.
Most patients with hypertrophic cardiomyopathy have these symptoms:
None. Ha. Got you good.
Most common presenting symptoms in hypertrophic cardiomyopathy (3)
Dyspnea on exertion (most common)
angina
syncope
Physical exam, hypertrophic cardiomyopathy (3)
Mitral regurgitation (increases with valsalva, decreases with handgrip and leg elevation)
S4 sound
Prominent left ventricular impulse
Primary diagnostic test for hypertrophic cardiomyopathy (results)
Echocardiogram (septal wall thickness, ejection fraction usually greater than 60%)
EKG in hypertrophic cardiomyopathy
LVH
Treatment of symptomatic hypertrophic cardiomyopathy (3)
Beta-blockers (propanolol)
Calcium channel blockers (verapamil)
Diuretics for fluid overload
Common causes of restrictive cardiomyopathy (5)
Amyloidosis
Sarcoidosis
Hemochromatosis
Post-radiation
Post open-heart surgery
Restrictive cardiomyopathy pathogenesis
Myocardial changes lead to diastolic noncompliance with elevated filling pressures, this leads to pulmonary congestion
Most common symptoms in restrictive cardiomyopathy (2)
Exertional intolerance
fluid retention
Restrictive cardiomyopathy physical exam
elevated JVD
pronounced S4 sound
mitral regurgitation
tricuspid regurgitation
Echocardiogram in restrictive cardiomyopathy (3)
ejection fraction between 25% and 50%
Normal LV thickness
Increased atrial size
EKG in restrictive cardiomyopathy (3)
Low voltage QRS
Nonspecific ST and T wave changes
Definitive / specific diagnostic test for restrictive cardiomyopathy
tissue biopsy
Treatment for restrictive cardiomyopathy (2)
Treat underlying cause
Diuretics
Name this rhythm

Atrial fibrillation
Most common sustained arrhythmia in adults
Atrial fibrillation
Major risk with atrial fibrillation
Risk of intra atrial clot formation
QRS rhythm in atrial fibrillation
irregularly irregular
3 major goals in a-fib treatment
Rate control
Anticoagulation
Rhythm control
Rate control agents in a-fib (3)
Beta blockers (metoprolol)
Calcium channel blockers (verapamil, diltiazem)
digoxin
Anticoagulation agents in a-fib (2)
heparin acutely
warfarin long term
Rhythm control agents in a-fib (2)
Amiodarone is most effective, but side effects are common
Cardioversion may be attempted if no sign of atrial clots
Name this rhythm

atrial flutter
Atrial flutter symptoms (4)
Dizziness
Palpitations
Chest pain
Dyspnea
Best leads to recognize pattern in a-flutter
sawtooth pattern in II, III, aVF
Common ventricular rate in atrial flutter
75-150
Common atrial rate in atrial flutter
250 to 400
Primary treatment of atrial flutter
cardioversion
Acute medication treatments of atrial flutter (2)
Beta blockers (metoprolol, esmolol)
Calcium channel blockers (verapamil, diltiazem)
Long-term medication treatments for atrial flutter (4)
Amiodarone, sotalol, quinidine or procainamide
Definitive treatment of atrial flutter if reentrant site is known
catheter ablation
What the heck is going on here? (ignore those lame arrows)

multifocal atrial tachycardia
Common patients that get multifocal atrial tachycardia (2)
COPD
severe systemic illness
EKG findings in multifocal atrial tachycardia
polymorphic p waves
differing PR intervals
Treatment of multifocal atrial tachycardia (one druggy, one non-druggy)
Treat underlying cause
Calcium channel blockers
What the fuck, yo?

1st degree AV block
Some people with AV block do this for fun
pass out (ok, maybe not so fun)
Definition of first degree AV block
PR greater than 200 milliseconds
Name that rhythm

Second degree, type 1, Wenckebach
Definition of Wenckebach rhythm
progressive increase in PR interval until a P wave is blocked, then the cycle is repeated
What it is?

Second degree AV block, type 2
Definition of second degree AV block type 2
sudden block of a P wave with no change in PR interval
Whaddaya call this?

3rd degree AV block
Third degree AV block definition
Atria and ventricles are controlled by different pacemakers, they fire independently
Look at this table
because I say so

Three non-druggy considerations for treatment of AV block
Asymptomatic patients do not require treatment
Correct any reversible causes
Permanent pacing may be needed
Druggy treatment for symptomatic AV blocks (2)
Atropene or isoproterenol
What’s this all about?

Right bundle branch block
How bout this one?

Left bundle branch block
List some causes for bundle branch blocks (5ish)
Acute MI
Cardiomyopathy
Big PE
Aortic stenosis
being a dork
If a bundle branch block gets conduction across an accessory pathway, it’s called ___________ and it can put the patient at risk of __________
Wolff-Parkinson-White Syndrome
Other cardiac arrhythmias
What EKG finding will suggest WPW?
Delta waves

What duration defines a wide QRS
Greater than 120 milliseconds
A wide QRS without other signs of BBB is called
Intraventricular conduction delay
These 2 medications are contraindicated in WPW
Digoxin and CCB’s
Possible presenting symptoms of paroxysmal supraventricular tachycardia
palpitations or anxiety
another name for paroxysmal supraventricular tachycardia
AV nodal reentry tachycardia
PSVT EKG findings
Rate between 150 and 250
Regular rhythm
Typically no atrial activity seen
PSVT treatment (3-6)
Vagal maneuver
Antianxiety meds
Drug of choice is adenosine
Other rate slowing meds like CCB, beta-blockers, digoxin, may be helpful
Normal rhythm, then interrupted by a narrow QRS, out-of-rhythm beat
Premature atrial contraction
Normal rhythm interrupted by wide-complex QRS
premature ventricular contraction
PVC treatment
Treat underlying caue
may use antiarrhythmics
use of beta-blockers is common
Class Ia antiarrhytmics (3)
Sodium channel blockers like
Quinidine
Procainamide
disopyramide
Class Ib antiarrhythmics (2)
Sodium channel blockers like
Lidocaine
mexiletine
Class Ic antiarrhythmics (2)
Sodium channel blockers like
Flecainide
propafenone
Class II antiarrhythmics (2)
Beta blockers like
Propanolol
Metoprolol
Class III antiarrhythmics (2)
Prolonged action potential duration drugs like
Amiodarone
sotalol
Class IV antiarrhythmics (2)
Calcium channel blockers like
Verapamil
diltiazem
Class Ia antiarrhytmic side effects
Nausea, vomiting
Quinidine: hemolytic anemia, thrombocytopenia, tinnitus
Procainamide: drug induced lupus
Class Ib antiarrhythmic side effects
Lidocaine: dizziness, confusion, seizures, coma
Mexiletine: tremor, ataxia, rash
Class Ic antiarrhythmic side effects
Flecainide: nausea, dizziness
Class II antiarrhytmic side effects
CHF, bronchospasm, bradycardia, hypotension
Class III antiarhythmic side effects
Amiodarone: hepatitis, pulmonary toxicity, thyroid disease, peripheral neuropathy
Sotalol: bronchospasm
Class IV antiarrhythmic side effects
AV block, hypotension, bradycardia, constipation
Precipitating causes of V-tach (5)
electrolyte imbalance
acid-base problems
hypoxemia
MI
drugs
Long QT can lead to this dangerous rhythm
Torsades de pointes
Drugs associated with torsades de pointes (9)
Tricyclic antidepressants
Erythromycin
Ketoconazole
haloperidol
cisapride
disopyramide
pentamidine
sotalol
Class I antiarrhythmics
Some things that can lead to heart failure (6)
Valvular heart disease
Coronary artery disease
arrhythmia
hypothyroidism
High cardiac output syndromes
hypertension
Conditions that can precipitate heart failure (6)
Reduction of medication
discontinuing medication
increased sodium intake
anemia
infection
PE
Presenting symptoms of heart failure (6)
dyspnea
orthopnea
paroxysmal nocturnal dyspnea
fatigue
exercise intolerance
edema
Physical exam in heart failure (9)
restless
dyspnea
JVD
Rales
tachycardia
S3 / S4 heart sounds
displaced PMI
RUQ tenderness / ascites
Peripheral edema
Labs in heart failure
Elevated LFT’s
Elevated BNP
Check CBC and thyroid to rule out anemia and thyroid disease
Imaging in heart failure
CXR: cardiomegaly, increase in pulmonary vasculature, pleural effusion, Kerley B lines
Echocardiogram is diagnostic, signs of systolic or diastolic dysfunction, decreased ejection fraction
What’s weird here

Kerley B lines, suggestive of heart failure
EKG in heart failure
LVH
Class I heart failure
No cardiac symptoms with ordinary activity
Class II heart failure
Cardiac symptoms with marked activity, but asymptomatic at rest
Class III heart failure
Cardiac symptoms with mild activity, but asymptomatic at rest
Class IV heart failure
Cardiac symptoms at rest
Non-druggy therapy for heart failure
Low sodium diet
Quit smoking, idiot
other obvious things for heart: exercise and weight loss, controlling other comorbidities
Drugs that should be avoided in heart failure
Aspirin, NSAID’s, CCB’s
Goals of druggy therapy for heart failure
control fluid retention
control neurohormonal activation
control symptoms
Big 2 drugs for heart failure (especially with left ventricular dysfunction and if not contraindicated)
ACE and Beta
This drug can improve symptoms and exercise tolerance in heart failure by increasing cardiac contractility
Digitalis
If a patient can’t use an ACE in heart failure, what are some other options
Vasodilators, like hydralazine and nitrates
Some possible end organ damage from hypertension (7)
LVH
Angina
Heart failure
Stroke
Chronic Kidney Disease
Peripheral artery disease
Retinopathy
6 lifestyle modifications for hypertension
Weight loss
Limit alcohol intake
Regular aerobic exercise
Quit smoking, dummy
Reduce sodium intake
Reduce saturated fat and cholesterol intake
Drug choices for hypertension with angina
Beta blockers and CCBs
Drug choices for hypertension with diabeetus or hyperlipidemia
ACE inhibitors
CCBs
Drug choices for hypertension with CHF
Diuretics and ACE inhibitors
Drug choice for hypertension with previous MI
ACE and Beta
Drug choice for hypertension with chronic renal failure, or asthma/COPD
Diuretics and CCB’s, maybe also ACEi
7 common causes for secondary hypertension
Renovascular disease
Coarctation of the aorta
Primary aldosteronism
Cushing’s Syndrome
Pheochromocytoma
Obstructive Sleep Apnea
Renal parenchymal hypertension
Diagnosing renovascular disease
Elevated Cr
MRI of renal arteries
Renogram
Diagnosing coarctation of aorta
Unequal pulses
Rib notching
Claudication
MRI
Diagnosing primary aldosteronism
Hypokalemia
Metabolic acidosis
Renin / aldosterone
Diagnosing Cushing’s syndrome
truncal obesity
cortisol
dexamethasone suppression test
Diagnosing pheochromocytoma
Tachycardia
Polyuria
Headache
Diaphoresis
Plasma metanephrine and normetanephrine
Diagnosing sleep apnea
Snoring
Obesity
Sleep study
Diagnosing renal parenchymal hypertension
Elevated Cr
abnormal UA
24 hour urine for protein
Renal ultrasound
Avoid this drug in patients with bilateral renal artery stenosis
ACE inhibitors
7 etiologies for malignant hypertension
Aortic dissection
Post CABG
Acute MI
unstable angina
Eclampsia
Head trauma
Severe burns
Some defining symptoms of malignant hypertension (other than elevated blood pressure)
headache
confusion
blurry vision
nausea and vomiting
seizures
oliguria
Target blood pressure in malignant hypertension
170/110 over first 12 or so hours
Normal after that
3 meds in malignant hypertension
nitroprusside in hypertensive encephalopathy, intracranial bleeding and heart failure
Use nitroprusside with propanolol for dissecting aneurysm
Oral clonidine for hypertensive urgency
3 causes of hypovolemic shock
Hemorrhage
Volume depletion
Extravascular spacing
2 causes of cardiogenic shock
Myocardial dysfunction
Valvular defects
4 causes of obstructive noncardiogenic shock
Pericardial tamponade
Tension pneumothorax
Severe pulmonary embolism
Left ventricular outflow obstruction
Symptoms of cardiogenic shock
Altered mental status
cyanosis
oliguria
cool clammy extremities
Vasopressor agents used in cardiogenic shock
Dopamine can increase systemic pressure and cardiac output
Dobutamine can increase cardiac output, but not systemic blood pressure
Definition of orthostatic hypotension
Fall in systolic of 30 mm Hg or more
Fall in diastolic of 10 mm Hg or more
between recumbent and upright
10 causes of orthostatic hypotension
Antipsychotics
Diuretics
Alpha blockers
ACE inhibitors
Alcohol
Tranquilizers
Vasodilators
Methyldopa
Neuropathies
Parkinson’s
Most MI deaths occur within ________ of onset of symptoms
1 hour
10 Risk factors for coronary atherosclerosis
Hyperlipidemia
Hypertension
Oldness
Fatness
Family history
Stress
Diabeetus
Having a penis
Being lazy
Smoking like a goddamn idiot
Who tends to have painless MI’s?
Old folk
Diabeetuses
In addition to chest pain, list some other associated symptoms of MI
Nausea
Vomiting
Diaphoresis
Dyspnea
Weakness
How long does troponin stay elevated after an MI?
How about CKMb?
Myoglobin?
troponin 5-10 days
CKMb 2-4 days
Myoglobin less than 1 day
How long after the start of an MI is Troponin elevated?
CKMb?
Myoglobin?
Troponin 2-6 hours
CKMb 3-6 hours
Myoglobin 1-2 hours
ST elevation in II, III, aVF
Location?
Artery?
Inferior
RCA
STE in I, aVL, V5, V6
Location?
Artery?
Lateral
Circumflex
STE in V1-V4, I, aVL
Location?
Artery?
Anterior
LCA
ST Depression v1, v2
Location
Artery
Posterior
RCA circumflex
STE v3-v6
Location
Artery
Apical
LAD / RCA
STE I, aVL, v4-v6
Location
Artery
Anterolateral
LAD / circumflex
STE V1-V3
Location
Artery
Anteroseptal
LAD
4 absolute contraindications to thrombolytic therapy in MI
Active bleeding / bleeding disorder
Prior hemorrhagic stroke / other stroke within 1 year
Intracranial or spinal cord cancer
Suspected / known aortic dissection
4 relative contraindications to thrombolysis in MI
Severe / uncontrolled hypertension
Anticoagulation: therapeutic or elevated INR
Old ischemic stroke
Recent major surgery / trauma / pregnancy
Only way to exclude coronary artery disease with certainty. (used in angina)
Coronary angiography
4 general treatment considerations for angina
Quit smoking
control BP
control diabeetus
exercise
3 major meds for angina
ACE
Beta
Nitrates
3 things that would make angina unstable
New onset
Worsening
Occurs at rest
Treatment of unstable angina (5)
ACE
Beta
Aspirin / heparin / clopidogrel
Nitro
Revascularization (CABG / angioplasty)
2 other conditions that may be associated with Prinzmetal angina
Raynaud
Migraines
Treatment of Prinzmetal angina
nitrates
CCB’s
NO Beta Blockers!
5 Major Jones Criteria of acute Rheumatic Fever
Carditis
Polyarthritis
Chorea
Erythema Marginatum
Subcutaneous nodules
4 minor Jones Criteria for Rheumatic Fever
Arthralgia
Fever
Long PR
Lab (ESR, CRP)
Rheumatic fever treatment
Bed rest
Antibiotics to prevent, but they don’t help once you have RF
Anti-inflammatories can help (aspirin up to steroids)
AAA screening, how and who
Ultrasound, males 65-75 who have ever smoked
AAA treatment
Beta blockers
Imaging q6mo
surgery if greater than 5.5cm or rapidly changing
Definitive treatment for aortic dissection
surgery, duh
Embolus / thrombus physical exam
5 P’s
Pain
Pallor
Pulselessness
Paresthesia
Paralysis
What’s the awesome name for temporary loss of vision in one eye, frequently due to ophthalmic artery occlusion
amaurosis fugax
3 methods for diagnosis of peripheral arterial occlusion
Ankle/brachial index
Ultrasound doppler
Arteriography
5 treatments for peripheral arterial occlusion
Pentoxifylline (decreases blood viscosity)
Aspirin
Ticlopidine (inhibits platelet aggregation)
Thromboendarterectomy
Stop Fucking Smoking
Most common symptom of giant cell arteritis
New onset of temporal headache
Definitive diagnosis of giant cell arteritis
biopsy
Giant cell arteritis treatment
Corticosteroids
Phlebitis treatment
Warm moist compresses
NSAIDS
Abx to cover staph if septic thrombophlebitis
9 risk factors for DVT
Prolonged immobilization
Postoperative
Pelvic or extremity trauma
Birth control pills
Cancer
Hypercoagulable state
Preggers
Obesity
Smoking
DVT diagnosis
ultrasound
D-dimer may be useful to rule out in low probability patients
DVT treatment
Bridge heparin to warfarin
Warfarin, INR 2-3
IVC filter
Aortic stenosis symptoms
angina, syncope, CHF
Physical exam in Aortic stenosis
Delayed carotid upstroke
Strong apical impulse
Narrowing pulse pressure
Loud, rough, diamond-shaped systolic murmur with ejection click (best heard at base of heart, with radiation to neck)
Imaging in aortic stenosis
CXR: dilatation of ascending aorta, pulmonary congestion, boot shaped heart
Echo shows thickening of LV wall, valvular calcifications
Aortic stenosis treatment
Avoid strenuous activity
Treat CHF with diuretics and sodium restriction
Valve replacement
This awesome drug is contraindicated in aortic stenosis
ACEi
6 causes of aortic regurgitation
Rheumatic fever
Infectious endocarditis
Hypertension
Syphilis
Collagen vascular disease
Marfan
Symptoms of aortic regurgitation (4)
Dyspnea on exertion
syncope
chest pain
CHF
Physical exam in aortic regurgitation (6)
Wide pulse pressure
Bounding pulses
S3 heart sound
Displaced apical impulse
Decrescendo, blowing diastolic murmur on left sternal border
Low-pitched apical diastolic murmur (austin-flint murmur)
Imaging in aortic regurgitation
CXR: LVH
Echo: left ventricular enlargement
Druggy treatment for aortic regurgitation
Cover CHF sith digoxin, diuretics, ACEi, salt restriction
Definitive treatment for aortic regurgitation
surgical valve replacement should be performed before ejection fraction is less than 55%
Symptoms of mitral stenosis (3)
exertional dyspnea
orthopnea
paroxysmal nocturnal dyspnea
Mitral stenosis is most common in this population
Women between 25 and 45
Mitral stenosis physical exam
Prominent jugular A wave (sure)
Opening snap in early diastole
Soft, low pitched diastolic rumble heard best at apex in left decubitus postition
Palpable right ventricular heave at left sternal border
EKG in mitral stenosis
left atrial enlargement, atrial fib
CXR in mitral stenosis
left atrial enlargement, prominent pulmonary arteries
2 major diagnostic tests for mitral stenosis
echocardiogram
cardiac cath
Mitral stenosis treatment
Control a fib and CHF
Valve replacement or percutaneous transvenous mitral valvotomy
6 causes of mitral regurgitation
Rheumatic fever
Papillary muscle rupture
Chordae tendineae rupture
Calcification
Mitral valve prolapse
Lupus
Mitral regurgitation symptoms
fatigue
dyspnea
orthopnea
CHF
Mitral regurgitation physical exam (4)
Left ventricular lift or apical thrill
Holosystolic murmur at apex with radiation to base or left axilla
s3 heart sound
laterally displaced apical impulse
EKG with mitral regurgitation
LVH
Diagnostic test for mitral regurgitation
echocardiogram
Mitral regurgitation treatments
Treat CHF with digoxin, diuretics, ACEi and salt restriction
Valve replacement must be performed early and is the only definite treatment
Symptoms of mitral valve prolapse
chest pain
palpitations
Physical exam in mitral valve prolapse
mid to late click at apex
crescendo, mid to late systolic murmur
diagnostic test for mitral valve prolapse
echocardiogram shows valve leaflets bulging backwards in systole
mitral valve prolapse treatment
Avoid stimulants
Maybe some beta blockers
2 causes for tricuspid regurg
Pulmonary hypertension
Endocarditis
Symptoms of tricuspid regurgitation (3)
Ascites
Edema
RUQ pain
Physical exam in tricuspid regurgitation (4)
Hepatic enlargement
JVD
Parasternal lift
Holosystolic murmur, left sternal border
Treatment for tricuspid regurg
treat underlying cause (endocarditis, pulmonary hypertension)
Pulmonary stenosis physical exam
early systolic opening ejection click
systolic ejection murmur, radiates to base
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5 predisposing factors for endocarditis
Mitral valve prolapse
Degenerative valvular disease
IV drug abuse
Prosthetic valve
Congenital abnormalities
3 bugs for community acquired endocarditis
Staph aureus
Strep viridans
Enterococcus
4 bugs for nosocomial endocarditis
Staph aureus
Staph epidermidis
Enterococcus
Funguses
3 bugs for prosthetic valve endocarditis
Staph epidermidis
Staph aureus
Enterococcus
6 symptoms for endocarditis
Fever
Fatigue
Malaise
Weight loss
Arthritis
Myalgias
7 physical exam findings in endocarditis
Petechiae
Osler’s nodes (palmar surface of fingers and toes)
Janeway lesions (palms and soles)
Splinter hemorrhages
Roth’s spots (retinal hemorrhage)
Murmur
Splenomegaly
Labs in endocarditis
Leukocytosis
ESR elevation
Hematuria
2 major and 4 minor Duke criteria for endocarditis
Major: positive blood culture, murmur or echo showing a thing
Minor: predisposing condition, fever, vascular pneumonia, immunologic stuff
Empiric abx, community acquired endocarditis
nafcillin, penicillin, gentamicin
Empiric abx, hospital acquired endocarditis (or pcn allergy)
vanco, gentamycin
Empiric abx, endocarditis with prosthetic valve
vanco, genta, rifampin
may need to replace valve
symptoms of pericarditis
chest pain worsens with deep breathing or lying down
pain improved by sitting and leaning forward
pericarditis physical exam
friction rub
EKG in pericarditis
STE in all precordial leads, with no reciprocal depression
cardiac tamponade symptoms
Hypotenson
tachycardia
dyspnea on exertion
physical exam in cardiac tamponade (4)
JVD
indistinct heart sounds
narrow pulse pressure
pulsus paradoxus
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pericardial effusion CXR
large water bottle shaped heart