cardiovascular Flashcards
Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study 2021 JVIM Schober et al
In this study of cats with HCM and recent CHF, no benefit of pimobendan on 180-day outcome was identified.
nonobstructive cats, the success rate was 32% in pimobendan-treated cats versus 18.2% in the placebo group
Obstructive
success rate was 28.6% and 60% in the pimobendan and placebo groups, respectively
Efficacy of oral torasemide in dogs with degenerative mitral valve disease and new onset congestive heart failure: The CARPODIEM study
2020 JVIM beshce et al
Torasemide was noninferior to furosemide as first line PO treatment for new onset CHF caused by DMVD
Retrospective study of dilated cardiomyopathy in dogs JVIM 2021 Freid et al
investigating possible diet-associated dilated cardiomyopathy (DCM) in dogs and cats.
Dogs with DCM eating nontraditional diets can experience improvement in cardiac function after diet change but additional research is needed to examine possible associations between diet and DCM
The gut microbiome in dogs with congestive heart failure: a pilot study 2020 Sci Rep
dogs with congestive heart failure have dysbiosis, and we show additional trends in our data suggesting that dogs may have a similar pattern to that described in people.
The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
JVIM multicentre 2021 Vezzosi et al - MINE score
The proposed Mitral INsufficiency Echocardiographic (MINE) score was based on 4 echocardiographic variables: left atrium-to-aorta ratio, left ventricular end-diastolic diameter normalized for body weight, fractional shortening, and E-wave transmitral peak velocity.
severity scores were assigned as follows: mild (score: 4-5), moderate (score: 6-7), severe (score: 8-12), late stage (score: 13-14).
MINE score >8 was predictive of cardiac death
DELay of Appearance of sYmptoms of Canine Degenerative Mitral Valve Disease Treated with Spironolactone and Benazepril: the DELAY Study
Jvetcardiol 2020 Borgarelli
failed in demonstrating that combined administration of spironolactone and benazepril delays onset of HF in dogs with preclinical MMVD. However, such treatment induces beneficial effects on cardiac remodeling and these results could be of clinical relevance.
Cardiac cachexia in cats with congestive heart failure: Prevalence and clinical, laboratory, and survival findings 2020 JVIM Santiago et al
he association between cachexia and reduced survival time emphasizes the importance of identifying and addressing this common problem in cats with CHF.
Focused ultrasound of the caudal vena cava in dogs with cavitary effusions or congestive heart failure: A prospective, observational study PLoS One 2021 Chou et al
Variables demonstrating the highest diagnostic accuracy for discriminating R-CHF versus NC were CVC-CI (collapsibility index) <33% in 2D and presence of hepatic venous distension
L-CHF dogs had higher CVC:Ao and lower CVC-CI compared to NC dogs, but increased CVC-CI compared to the R-CHF group.
The predictive value of clinical, radiographic, echocardiographic variables and cardiac biomarkers for assessing risk of the onset of heart failure or cardiac death in dogs with preclinical myxomatous mitral valve disease enrolled in the DELAY study JVCardio 2021 BOrgarelli
echocardiographic variables and NT-proBNP can be used to identify dogs with preclinical MMVD at higher risk to develop HF or cardiac death
Left atrial to aortic root ratio >2.1, normalized left ventricular end-diastolic diameter > 1.9 , early transmitral peak velocity (E peak) > 1 m/sec, and NT-proBNP > 1500 ρmol/L were associated with increased risk of HF or cardiac death.
Left atrial decompression as a palliative minimally invasive treatment for congestive heart failure caused by myxomatous mitral valve disease in dogs: 17 cases (2018-2019) JVIM 2021 Allen et al
For dogs with advanced MMVD and left-sided CHF, LAdecompression resulted in an immediate and substantial reduction in LA pressure
Minimally invasive creation of an atrial septal defect for the purpose of LAD was successful in all dogs
Tolerance of torasemide in cats with congestive heart failure: a retrospective study on 21 cases (2016-2019)
BMC vet res 2020 Poissonnier et al
case series demonstrates that torasemide can be used in cats with spontaneous CHF
Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure BMC vet Res 2020 Rubio et al
Advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF.
Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
Frontiers 2021 Araki et al
Intestinal mucosal injury risk was significantly higher in Chihuahuas with heart failure due to MMVD
Prediction and measurement of diuretic responsiveness after oral administration of furosemide to healthy dogs and dogs with congestive heart failure JVIM 2020 Loughran
Urinary Na excretion and uVol are complementary but distinct aspects of diuretic responsiveness in dogs
Ultrasonographic evaluation of the caudal vena cava in dogs with right-sided heart disease Jvet Cardio 2021 Fujioka
In addition to the echocardiographic assessment of right-sided cardiac function, the CVC variables in this study, especially ShortestDiameter(min)/Ao diameter and SD/LD(min), would be useful diagnostic indices for identifying R-CHF in dogs with RHD.
