Cardiovascular Flashcards
What is atherosclerosis?
The build up of plaque (made up of fats, cholesterol, cellular waste products, calcium and fibrin) in and on the artery walls which results in thickening or hardening of the arteries.
What are 7 major risk factors for atherosclerosis?
- Age
- Tobacco smoking
- High serum cholesterol
- Obesity
- Diabetes
- Hypertension
- Family history
What is a neointima?
A new or thickened layer of arterial intima formed in atherosclerosis by migration and proliferation of cells from the media.
What are 6 inflammatory cytokines found in plaques?
IL-1, IL-6, IL-8, IFN-y, TGF-b, MCP-1
What is the structure of an atherosclerotic plaque?
- Lipids (incl. cholesterol)
- Necrotic core (dead cells)
- Connective tissue
- Fibrous cap
What are the steps of atherosclerosis?
- Endothelial dysfunction
- Formation of lipid layer or fatty streak within the intima.
- Migration of leukocytes and smooth muscle cells into the vessel wall
- Foam cell formation and degradation of the extracellular matrix
What is a fatty streak?
The earliest lesion of atherosclerosis which consists of aggregations of lipid-laden macrophages and T-lymphocytes within the intimal layer of the vessel wall.
What are the constituents of intermdiate atherosclerotic lesions?
- Lipid laden macrophages (foam cells)
- Vascular smooth muscle cells
- T lymphocytes
- Adhesion and aggregation of platelets to vessel wall
- Isolated pools of extracellular lipid
What are the characteristics of fibrous plaques or advanced lesions?
- Impedes blood flow
- Prone to rupture
- Covered by dense fibrous cap made of extracellular matrix
proteins including collagen (strength) and
elastin (flexibility) laid down by smooth muscle cells that
overly lipid core and necrotic debris - May be calcified
- Contains: smooth muscle cells,
macrophages and foam cells and T
lymphocytes
What occurs when the atherotic plaque ruptures?
Plaques constantly grow and recede and if there is increased enzyme activity it can reach the fibrous cap and cause rupture so the basement membrane, collagen, and necrotic tissue are exposed to blood and a thrombus forms resulting in partial or complete vessel occlusion.
What is plaque erosion?
Second most prevalent cause of coronary thrombosis.
- Usually occurs in early lesions with a small lipid core and thickened fibrous cap
- Results in a ‘white thrombus’ formed of platelets and fibrinogen rather than a red thrombus of RBCs and fibrin
What is the difference between plaque erosion and rupture?
Plaque rupture is the disruption of a fibrous cap over a lipid core, erosion is the superficial disruption of a fibromuscular plaque without a core.
Where does atherosclerosis occur?
Within peripheral and coronary arteries with focal distribution along the length of the artery.
What is acute coronary syndrome?
A spectrum of acute myocardial ischaemia and/or infarction (unstable angina, STEMI, NSTEMI)
Define unstable angina
Myocardial ischaemia at rest or on minimal exertion in the absence of acute cardiomyocyte injury/necrosis.
What are 5 risk factors for acute coronary syndrome?
- Diabetes mellitus
- Hyperlipidaemia
- Hypertension
- Metabolic syndrome (abdominal obesity, hypertension, impaired fasting glucose, high triglyceride levels, and low HDL cholesterol levels)
- Renal impairment
What are 5 key symptoms of unstable angina?
- chest pain
- excessive sweating
- epigastric pain
- dyspnoea
- syncope (fainting)
What is the first line investigation for acute coronary syndrome?
ECG
What is the first line treatment for ACS?
Aspirin 300mg
What is the key presentation for STEMI?
New or increased and persistent ST-segment elevation in at least 2 contiguous leads (leads connecting to adjoining areas of tissue)
What is the acute management for STEMI?
MONA
Morphine
Oxygen (if sats <94%)
Nitrates
Aspirin
What is the key presentation for NSTEMI?
elevated troponin levels
What are the possible mechanisms leading to a NSTEMI?
- Plaque rupture with superimposed non-occlusive thrombus or embolic events leading to coronary vascular obstruction
- Dynamic obstruction, such as in vasospasm
- Progressive luminal narrowing (i.e., chronic arterial narrowing from restenosis)
- Inflammatory mechanisms (i.e., vasculitis)
- Extrinsic factors leading to poor coronary perfusion (such as hypotension, hypovolaemia, or hypoxia).
What are myocardial infarction complications?
Death
Arrhythmia
Rupture
Tamponade
Heart failure
Valve disease
Aneurysm
Dressler syndrome (autoimmune pericarditis)
Embolism
Recurrence regurgitation