Cardiomyopathy Flashcards
What are the 3 main types of cardiomyopathy
dilated, hypertrophic and restrictive
What is dilated CM associated w
Alcohol raised BP Haemochromatosis biral infection autoimmune peri-postpartum congenital (x linked)
How can dilated CM present?
fatigue, SOB, pulm oedema, RVF, emboli, AF, VT
What are the signs of dilated CM?
tachycardia low BP Raised JVP displaced diffuse apex beat S3 Gallop MR/TR Pleural effusion Oedema
What imaging would you do for dilated CM and what would they show?
- CXR - cardiomegaly, pulm. oedema
- ECG - tachy, non-specific T wave changes, poor R wave progression
- Echo - globally dilated hyperkinetic heart w low EF
What is the management of dilated cM?
bed rest diuretics digoxin ACEi, anticoagulation, biventricular pacing ICDs transplant
What inheritance pattern does hypertrophic obstructive cardiomyopathy follow? what genes are mutated?
autosomal dominant
mutation in genes encoding beta myosin, alpha tropomyosin and troponin T
Why is hypertrophic obstructive cardiomyopathy important?
leading cause of sudden cardiac death in the young
What are the sx of HOCM?
- sudden death
- asymptomatic
- angina
- syncope
What are the signs of HOCM?
- jerky pulse
- large ‘a’ waves
- double apex beat
- ejection systolic murmur - increases w valsalva + reduced on squating
What is HOCM associated w
WPW
Friedreichs ataxia
What investigations would you do for HOCM?
- ECHO: MR SAM ASH
MR - mitral regurgitation
SAM - systolic anterior motion
ASH - asymmetric hypertrophy - ECG - LV hypertrophy, non-specific ST segment + T wave abnormalities, progressive T wave inversion, deep Q wave,AF occasionally
- Cardiac catheterisation to measure pressure diff between aorta and LV
- Cardiac MRI
What is the management of HOCM?
Amiodarone Beta blockers Cardioverter defibrillator Dual chamber pace-maker Endocarditis prophylaxis
What drugs should be avoided in HOCM?
Nitrates
ACEi
Inotropes
What are the causes of restrictive CM
Idiopathic Amyloidosis Haemochromatosis Sarcoidosis Scleroderma Lofflers endocarditis