Cardiology Flashcards
What is angina?
Chest pain on exertion caused by myocardial ischaemia from coronary heart disease, usually atherothrombosis
What is the difference between stable and unstable angina?
Stable angina is induced by effort and relieved by rest/GTN spray
Unstable angina is an acute coronary syndrome with pain at rest/not relieved by GTN
List aetiology/risk factors for angina
Atherosclerosis Males Smoking, excess alcohol Poor diet, obesity Arteritis Low exercise Hypertension Diabetes
List clinical features of angina
Central chest tightness on exertion Pain may radiate to jaw/arm Dyspnoea Nausea Sweating Syncope
What investigations would you order for angina?
ECG may be normal
Exercise ECG, 24h ECG
CT catheter angiography
Outline medical treatment for angina
GTN spray when required
Secondary prevention (aspirin, statin, ACEi)
B-blockers unless contraindicated
Ivabradine/nicorandil if others not tolerated
Outline surgical treatment for angina
Coronary revascularisation (PCI, CABG) using balloon stent or graft bypass from internal mammary artery and greater saphenous vein
What are the acute coronary syndromes (ACS)?
Unstable angina
NSTEMI
STEMI
What is the pathophysiology of ACS?
Atherothrombotic plaque rupture leads to thrombosis and complete occlusion of coronary artery, causing ischaemia and potential necrosis
List risk factors/aetiology for ACS
Males Family history Smoking, excess alcohol Hypertension Diabetes High cholesterol Obesity Sedentary lifestyle
List clinical features of ACS
New onset severe crushing chest pain, radiating to arm and/or jaw Nausea, vomiting Not relieve by rest or GTN Breathlessness Syncope Confusion Pallor, sweating Palpitations, tachycardia SENSE OF IMPENDING DOOM
What investigations would you do for ACS?
Bloods: cardiac enzymes (CK, troponin), electrolytes, glucose, lipids
ECG
CXR
What is the criteria for STEMI on ECG?
ST elevation of 1mm or more in 2 adjacent limb leads
or
ST elevation of 2mm or more in 2 contiguous chest leads
List ischaemic changes on ECG
T wave inversion Q waves Tall T waves ST depression ST elevation
When do levels of troponin and CK peak in ACS?
Troponin: 3-12 h
CK: 24 h
Outline medical treatment for acute MI
Aspirin 300 mg
GTN sublingual
IV morphine
O2 if hypoxic
Outline definitive treatment for acute NSTEMI
B-blocker IV
LMW heparin
IV nitrate
Angiography if high risk
Outline definitive treatment for acute STEMI
PCI within 120 mins
Otherwise thrombolysis with streptokinase + aspirin, then reassess after 90 mins for need for PCI
What are the different stages of hypertension? (stage 1, stage 2 etc.)
Stage 1: 140-159/90-99
Stage 2: 160-179/100-109
Stage 3: 180/110 or higher
List risk factors/aetiology for hypertension
Renal disease (GN, polyarteritis, renal artery stenosis)
Endocrine disease (Cushing’s, Conn’s, phaeochromocytoma)
Pregnancy
Drugs
Alcohol excess
High salt intake
Essential hypertension (idiopathic)
List clinical features of hypertension
Asymptomatic Headache Palpitations Breathlessness Advanced disease: blurred vision, palpable kidney, RF delay
What investigations would you do for hypertension?
ECG, echo Bloods: electrolytes, endocrine markers Funduscopy Urinalysis Home/ambulatory BP monitoring
How is hypertensive retinopathy graded?
I: tortuous arteries, narrowing/sclerosis
II: AV nipping, marked sclerosis
III: haemorrhages, cotton wool spots, hard exudates
IV: III + papilloedema
Outline medical management of hypertension
If under 55yo, start with ACEi If over 55yo or black, start with Ca ch blocker If uncontrolled on these, ACEi + Ca ch blocker then add thiazide diuretic then add alpha/beta blocker
What is the BP target for diabetic patients with hypertension?
Less than 130/80
What is an arrhythmia?
Disturbance in the cardiac rhythm generated by abnormal conduction
List risk factors/aetiology for arrhythmias
Heart conditions Congenital heart disease Smoking, alcohol High caffeine intake Pneumonia Thyrotoxicosis Metabolic imbalance Drugs (amiodarone, B agonists, digoxin, levodopa, illicit drugs)
List clinical features of arrhythmias
Palpitations Abnormal pulse Chest pain Syncope Dizziness Dyspnoea Altered consciousness
What investigations would you order for arrhythmias?
ECG, 24 h ECG, event recording
Electrophysiology
FBC, U+E, glucose, Ca, Mg, thyroid function
Echocardiogram
Which drug can be used to treat bradycardia?
Atropine
Outline treatment of supraventricular tachycardias
Vagal maneuvres (breath-hold, Valsalva, ice, carotid massage)
IV adenosine/verapamil
DC shock
List class I anti-arrhythmic drugs and whether they are rhythm or rate controlling
Na channel blockers (rhythm control)
Lignocaine
Disopyramide
Flecanaide
List class II anti-arrhythmic drugs and whether they are rhythm or rate controlling
B blockers (rate control)
Atenolol
Propranolol
List class III anti-arrhythmic drugs and whether they are rhythm or rate controlling
K channel blockers (rhythm control)
Amiodarone
Sotalol
List class IV anti-arrhythmic drugs and whether they are rhythm or rate controlling
Ca ch blockers (rate control)
Verapamil
Diltiazem
List the main narrow-complex tachycardias
Sinus tachycardia Supra-ventricular tachycardia Atrial fibrillation/flutter Atrial tachycardia Junctional tachycardia (AVNRT, AVRT, BBB)
List the main broad-complex tachycardias
Ventricular tachycardia
Torsades de Pointes
SVT with aberrancy
Ventricular fibrillation
Outline treatment of narrow-complex tachycardias (except AF)
SVT: vagal maneuvres, IV adenosine/verapamil, DC shock
Junctional: ablation of accessory pathways, rhythm control
Outline treatment of ventricular tachycardia
Amiodarone/lignocaine + dextrose if stable
Correct K with calcium chloride
DC shock if pulseless or unstable
Outline treatment of ventricular fibrillation
DC shock
Mg chloride
Implantable defibrillator
Outline treatment of torsades de Pointes
Mg sulfate IV
Overdrive pacing
List aetiology/risk factors for AF
Heart failure Ischaemia, MI Hypertension Mitral valve disease Pneumonia Hyperthyroidism Caffeine, alcohol Hypokalaemia Cardiomyopathy Pericarditis Sick sinus syndrome
Outline treatment of acute AF
O2 + emergency cardioversion/amiodarone if unstable
Anticoagulation with LMW heparin
Rate control: diltiazem/verapamol/metoprolol/digoxin
AV node ablation or pacing
What is the aim for INR with warfarin on AF?
2-3
Describe 1’ heart block
Prolonged PR interval (greater than 0.22s)
Describe 2’ type 1 heart block
Progressive prolonging of PR interval with dropped QRS complex
Describe 2’ type 2 heart block
Normal PR interval with some dropped QRS complexes
Describe 3’ heart block
Dissociation of P-wave and QRS complexes
What would an ECG show in right bundle branch block?
M-wave in V1, W-wave in V6
What would an ECG show in left bundle branch block?
W-wave in V1, M-wave in V6
List risk factors/aetiology for heart blockWhat is
Normal variants Athletes Sick sinus syndrome Ischaemic heart disease Drugs (digoxin, B blockers) Congenital heart disease Calcified valves Trauma Surgery
Outline treatment of heart block
IV atropine
Pacing
How does the body try to compensate for low cardiac output in heart failure?
Retains fluid which increases preload and causes further stress on the heart, causing congestive heart failure
What is “systolic” heart failure? Give causes
Ventricles unable to contract normally, causing reduced cardiac output (ejection fraction less than 40%)
Causes: IHD, MI, cardiomyopathy
What is “diastolic” heart failure? Give causes
Ventricles unable to relax normally, causing increased preload (ejection fraction greater than 50%)
Causes: constrictive pericarditis, restrictive CM, tamponade, hypertension
List causes of right heart failure
Left ventricular failure
Pulmonary stenosis
Lung disease, cor pulmonale
List causes of left heart failure
Valve disease
Arrhythmia
Hypertension
Congenital defects
List clinical features of right heart failure
Raised JVP Peripheral oedema Epistaxis Organomegaly Ascites Nausea Anorexia
List clinical features of left heart failure
Dyspnoea Fatigue, poor exercise tolerance Pulmonary oedema Orthopnoea PND Pink frothy sputum Cold peropheries
What are major symptoms/signs of heart failure according to Framingham criteria?
PND Crepitations S3 Cardiomegaly Raised JVP Pulmonary oedema Weight loss
What are minor symptoms/signs of heart failure according to Framingham criteria?
Ankle oedema Dyspnoea Tachycardia Nocturnal cough Pleural effusion
What would you see on an XR in heart failure?
Alveolar shadowing (bat's wings) Kerley B lines Cardiomegaly Dilated upper vessels Effusion
Outline treatment of acute heart failure
Sit up High flow O2 IV diamorphine IV furosemide GTN/nitrate
Outline medical treatment of heart failure
Diuretics (furosemide, spironolactone)
ACEi if LV dysfunction
Digoxin if LV impairment
B-blocker reduces mortality long-term
What is a cardiac murmur?
Sound made due to turbulent blood flow against diseased/damaged heart valves
Systolic murmurs are in time with the carotid pulse. True/False?
True
List aetiology of mitral stenosis
Rheumatic fever
Congenital anomaly
Prosthesis
Carcinoid tumour
List notable clinical features of mitral stenosis
Mid-diastolic "rumbling" with loud opening snap Tapping apex Malar flush Low-volume pulse Atrial fibrillation
List aetiology of mitral regurgitation
Rheumatic fever LV dilation Calcification Endocarditis Connective tissues disease Chordae rupture
List notable clinical features of mitral regurgitation
Pansystolic with radiation to axillar
RV heave
Atrial fibrillation
Ankle swelling
List aetiology of mitral valve prolapse
WPW Atrial septal defect Patent ductus Cardiomyopath Connective tissue disease
List notable clinical features of mitral valve prolapse
Mid-systolic click +/- late systolic murmur
Autonomic dysfunction
Outline general treatment of mitral valve disease
Control AF, anticoagulation
Balloon valvoplasty in stenosis
Valve replacement
B blocker may help symptoms
List aetiology of atrial stenosis
Calcification
Congenital bicuspid valve
Kidney disease
Hypertrophic cardiomyopathy
List notable clinical features of aortic stenosis
Ejection systolic with radiation to carotids
Slow-rising pulse
Heaving apex
Exertional dyspnoea
List aetiology of aortic regurgitation
Connective tissue disease
Rheumatic fever
Endocarditis
Vasculitis
List notable clinical features of aortic regurgitation
Early-diastolic Displaced apex Collapsing pulse Corrigan's sign (carotid pulsation) De Musset sign (head nod with beat)
Outline general treatment for aortic valve disease
Valve replacement (valvotomy, TAVI) ACEi, diuretics
List aetiology of tricuspid regurgitation
RV dilation Pulmonary hypertension Rheumatic fever Endocarditis IV drug use Carcinoid tumour Ebstein's anomaly
List notable clinical features of tricuspid regurgitation
Pansystolic RV heave Hugely raised JVP Pulsatile hepatomegaly Hepatic pain on exertion Ascites
List aetiology of pulmonary stenosis
Congenital
Turner’s, Noonan’s, Falot’s
Rheumatic fever
Carcinoid tumour
List notable clinical features of pulmonary stenosis
Ejection systolic with radiation to left shoulder
Split S2
Dyspnoa
Ascites
If someone presents with a fever and new cardiac murmur, what’s the diagnosis until proven otherwise?
Infective endocarditis
List non-bacterial aetiology/risk factors for endocarditis
IVDU Diabetes Valve disease Congenital heart conditions Low dental hygiene, dental procedures
List bacterial aetiology for endocarditis
Strep viridans
Staph aureus, Enterococci, Staph epidermidis (prosthesis)
Rare: Haemophilus, Actinobacillus, Cardiobacter, Eikenella, Kingella (HACEK)
List clinical features of endocarditis
Signs of sepsis - fever, rigors, night sweats, malaise, weight loss New murmur Breathless Fatigue Clubbing Roth spots (retinal haemorrhage) Splinter haemorrhages Janeway lesions (painless palmar nodes) Osler nodes (painful pulps on fingers/toes)
What investigations would you do for endocarditis?
3 sets of blood cultures at peak of fever PRIOR to antibiotics Bloods Urinalysis CXR ECG Echocardiograph
Outline Duke’s major criteria for endocarditis
\+ve blood culture Endocardium involvement (+ve echo, new valve regurg)
Outline Duke’s minor criteria for endocarditis
Risk factor present Fever above 38'C Immune/vascular signs \+ve blood culture \+ve echocardiograph
What is required from Duke’s criteria to diagnose endocarditis?
2 majors
1 major + 3 minors
5 minors
What empirical therapy is used for endocarditis?
Benzylpenicillin + gentamicin
+/- flucloxacillin
What antibiotics would you give for Staph endocarditis?
Flucloxacillin
Gentamicin
Vancomycin if MRSA +/- rifampicin
What antibiotics would you give for Strep endocarditis?
Benzylpenicillin
Gentamicin
What antibiotics would you give for Enterococcus endocarditis?
Amoxicillin
Gentamicin
What antibiotics would you give for atypical endocarditis?
Doxycycline
Cotrimoxazole
Fluconazole/amphoterecin
List aetiology/risk factors for myocarditis
Viral infection (Coxsackie, CMV, adenovirus, HIV)
Drugs (cyclophosphamide, penicillin, chloramphenicol, phenyotin, radiation)
Idiopathic
List clinical features of myocarditis
Fatigue Dyspnoea Palpitations Chest pain Fever Tachycardia Soft S1, S4 gallop rhythm
What investigations would you do for myocarditis?
ECG (STE/STD, T inversion, arrhythmia, AV block)
Tropnonin I or T confirms diagnosis
CK
Outline treatment of myocarditis
Supportive, rest, treat cause
Avoid sports
ACEi/B-blocker/spironolactone where heart failure
List aetiology/risk factors for pericarditis
Viruses (EBV, Coxsackie, flu, mumps, varicella, HIV)
Bacteria (pneumonia, rheumatic fever, TB)
Post-MI (Dressler’s syndrome)
Drugs
Inflammatory/chronic disease
List clinical features of pericarditis
Chest pain, worse on inspiration/lying flat, relieved sitting forward
Friction rub
Evidence of effusion/tamponade
What investigations would you order for pericarditis?
ECG shows widespread saddle-shaped STE CXR Echo Cardiac enzymes (troponin may be raised) Blood cultures/serology
Outline treatment of pericarditis
Rest, analgesia
Treat cause
Steroid or immunosuppression
What are cardiomyopathies?
Diseases that affect the mechanical/electrical function of the heart
What is hypertrophic cardiomyopathy?
LV outflow obstruction from asymmetrical septal hypetrophy
What is the genetic abnormality in hypertrophic cardiomyopathy?
Autosomal dominant mutation in sarcomeric genes, resulting in reduced myosin and troponin
List clinical features of hypertrophic cardiomyopathy
Asymptomatic or sudden death Syncope Chest pain Dyspnoea Jerky pulse Double apex pulsation Systolic thrill, ejection murmur
What investigations would you order for hypertrophic cardiomyopathy?
ECG shows LVH, inferolateral Q waves
May be in AF/WPW
Echo shoes asymmetrical septal hypertrophy, midsystolic aortic valve closure
Outline treatment of hypertrophic cardiomyopathy
B-blocker/verapamil for symptoms
Amiodarone control arrhythmia
Septal myomectomy if severe
Implantable defib
What is dilated cardiomyopathy?
Dilated ventricles with systolic dysfunction but preserved wall thickness
Essentially a flabby heart
What genetic abnormality causes dilated cardiomyopathy?
Mutation in cytoskeletal/myocyte genes causing contractile insufficiency
What risk factors is dilated cardiomyopathy associated with?
Alcohol Hypertension Haemochromatosis Viral infections Autoimmunity
List clinical features of dilated cardiomyopathy
Fatigue Dyspnoea Po oedema RV failure, emboli Raised JVP Arrhythmia, tachycardia Hypotension Displaced apex Jaundice, ascites, hepatomegaly
What investigations would you do for dilated cardiomyopathy?
CXR shows cardiomegaly, po oedema
ECG
Echo shows dilated chambers, low ejection fraction
Outline treatment of dilated cardiomyopathy
Manage heart failure (digoxin, furosemide, ACEi)
Pacing
Heart transplant
What is restrictive cardiomyopathy?
Reduced volume of both ventricles with atrial enlargement and impaired filling
What conditions are associated with restrictive cardiomyopathy?
Amyloidosis
Haemochromatosis
Sarcoidosis
Scleroderma
List clinical features of restrictive cardiomyopathy
Similar to pericarditis
RHF signs
Hepatomegaly, ascites
What investigations would you do for restrictive cardiomyopathy?
CXR shoes po venous congestion
ECG low-voltage QRS
Echo shows impaired filling
Cardiac catheterisation
What is arrhythmogenic right ventricular cardiomyopathy (ARVC)?
Fibro-fatty replacement of myocytes, causing RV dilation
What is the genetic abnormality that causes ARVC?
Mutation in desmosomal genes affecting the ryanodine receptor
What is atrial myxoma?
Rare benign cardiac tumour, usually found in right atrium
List clinical features of atrial myxoma
May mimic endocarditis
Mitral stenosis
Tumour plop on auscultation
What is the difference between ostium secundum and primum atrial septal defect?
Secundum: high in septum, presents in adulthood
Primum: opposite endocardial cushions, presents early
List clinical features of atrial septal defect
Cyanosis Po hypertension Arrhythmia Haemoptysis Chest pain Raised JVP Wide split S2 heart sound Ejection systolic murmur Migraines
What investigations would you do for atrial septal defect?
Echo shows left-right shunt
ECG shows RBBB with LAD and prolonged PR interval
CXR shows small aortic knuckle, po plethora
Outline treatment of atrial septal defect
Usually closes before age of 10
Transcatheter closure
What is the most common congenital cardiac anomaly?
Ventricular septal defect
List clinical features of ventricular septal defect
Severe heart failure
Loud murmur, thrill
Harsh pansystolic murmur at left sternal edge
What investigations would you do for ventricular septal defect?
Echo shows left-right shunt
Eisenmenger complex (right-left shunt)
ECG shows LAD and LVH or PVH
CXR shows normal or cardiomegaly
Outline treatment of ventricular septal defect
May close spontaneously
Endovascular or medical closure
Treat heart failure
What is patent ductus arteriosus?
Persistent communication between po. artery and desc. aorta
List clinical features of patent ductus arteriosus
Bounding pulse
Machine-gun murmur
What is coarctation of aorta?
Narrowing of desc. aorta just distal to insertion of ductus arteriosus
List risk factors/aetiology of coarctation of aorta
Boys Bicuspid aortic valve Ventricular septal defect Mitral valve disease CTD's
List clinical features of coarctation of aorta
Headaches
Nosebleeds
Radio-femoral delay
Scapular bruit
What would a CXR of coarctation of aorta show?
Rib-notching
Outline treatment of coarctation of aorta
Surgery
Balloon dilation +/- stent
What makes up tetralogy of Fallot?
Ventricular septal defect
Pulmonary stenosis
RV hypertrophy
Overriding aorta
List clinical features of tetralogy of Fallot
Cyanosis (right-left shunt) Restless, agitated Toddler squat to increase peripheral resistance Difficulty feeding Failure to thrive Clubbing Exertional dyspnoea Palpitations RV failure Syncope
What investigations would you do for tetralogy of Fallot?
CXR boot-shaped heart
Echo assesses degree of stenosis
Outline treatment of tetralogy of Fallot
Oxygen Positioning Morphine if irritated Long-term B-blocker Endocarditis prophylaxis Surgery to close VSD, correct po stenosis
What is intermittent claudication?
Chronic lower limb ischaemia relieved by rest
List aetiology/risk factors for intermitted claudication
Smoking
Diabetes
High cholesterol
Hypertension
List clinical features of intermittent claudication
Exertional/cramping pain usually in calves relieved by rest Ulceration Dry skin Hair loss Diminished/absent pulses Cold legs Atrophy Cap refill less than 2s
What investigations would you do for intermittent claudication?
Bloods ECG Catheterisation Duplex US scan ABPI of 0.4-0.9
Outline treatment of intermittent claudication
Lifestyle improvement (smoking, exercise, weight)
Antiplatelets (aspirin)
Surgery (angioplasty +/- stent, bypass graft)
Amputation
Acute limb ischaemia is a surgical emergency. True/False?
True
Requires revascularisation within 4-6 hours
List aetiology/risk factors for acute limb ischaemia
Thrombosis in situ
Emboli
Graft, angioplasty occlusion
Trauma
List clinical features of acute limb ischaemia
Pale Pulseless Painful Paralysis Paraesthesiae Perishing cold
Outline treatment of acute limb ischaemia
Urgent arteriography Surgical embolectomy Local thrombolysis (tPA) Anticoagulate (heparin) Angioplasty
What are varicose veins?
Incompetent valves prevent blood progressing from deep to superficial veins, causing long tortuous dilated veins
List aetiology/risk factors for varicose veins
Obstruction DVT Ovarian tumour Valve disease AV malformation Prolonged standing Pregnancy OCP use
List clinical features of varicose veins
Pain Crampy legs Tingling Ugly legs Oedema Varicose eczema Ulcers Haemosiderin staining Atrophie blanche Lipidodermatosclerosis Phlebitis
What investigations would you do for varicose veins?
Doppler USS
Trendelenberg test
Buerger test
Outline treatment for varicose veins
Treat cause, education Elevation, stock, lose weight Injection sclerotherapy Laser coagulation Endovenous ablation
List aetiology/risk factors for DVT
Post-surgery Immobility Increasing age Pregnancy Oestrogen therapy Trauma Malignancy Thrombophilia Previous DVT
List clinical features of DVT
Calf warmth Tenderness Swelling Erythema Mild fever Pitting oedema PE-like features
What investigations would you do for DVT?
Bloods: d-dimers, thrombophilia tests
Compression Doppler USS
PTP score
Well’s score
Outline treatment of DVT
Stop OCP Mobilisation TED stockings Anticoagulate (LMWH, warfarin) IVC filters if active bleeding
What is an aneurysm?
Greater than 50% dilation of an artery’s original diameter involving all layers of the vessel
What are the common sites for an aneurysm?
Aorta
Iliac artery
Femoral artery
Popliteal artery
List aetiology/risk factors abdominal aortic aneurysm
Defect in collagen-elastase regulation Atherosclerosis Trauma Infection CTD's Vasculitis Genetics
List clinical features of abdominal aortic aneurysm
May be asymptomatic until rupture Intermittent/continuous abdo pain radiating to back Collapse Hypotension Expansile abdo mass Discoloured peripheries Tachycardia Pallor
What investigations would you do for abdominal aortic aneurysm?
Regular USS monitoring for men over 65
Outline treatment of abdominal aortic aneurysm
Less than 5.5 cm - monitoring
Reserve surgery unless expanding more than 1cm a year
Lifestyle advice, exercise tests
Surgery (EVAR, open)
Outline acute treatment of rupture of abdominal aortic aneurysm?
Blood amylase, ECG, crossmatch blood
Catheterise
Large IV access, give O Rh blood
Prompt surgery and antibiotic
What is aortic dissection?
Splitting of aortic tunica media
Either type A (involving ascending aorta) and type B (not involving ascending aorta)
List clinical features of aortic dissection
Sudden tearing chest pain radiating to back
Hemiplegia
Radio-radio delay
Hypotension
What investigations would you do for aortic dissection?
Crossmatch blood ECG CXR CT/MRI Trans-oesophageal echo
Outline treatment of aortic dissection
Hypotensives (keep systolic 100-110) (labetolol)
Urgent surgery