Cardiology Flashcards
What does meant by low Pretest probability of CAD?
Low (<10%)
Asymptomatic people of all ages
Atypical chest pain in women age <50
What does meant by Intermediate Pretest probability of CAD?
Intermediate
(20%-80%)
Atypical angina in men of all ages
Atypical Angina in women age >50
Typical angina in women age 30-50
What does meant by high Pretest probability of CAD?
High
(>90%)
Typical angina in men age >40
Typical angina in women age >60
Important point of Aspirin
Aspirin is given before heparin in ACA as it reduces the rate of MI, stroke and overall mortality in ACS
How to approach chest Pain In Emergency dept?
Take history & do Examination
Check stability—> if unstable then stabilise hemodynamics and find the cause
If stable then do ECG/CXR
If ECG consistent with ACS then give anticoagulants if NSTEMI /// if STEMI then t/m with ER CATH & thrombolysis
If ECG normal—> do CXR—> if diagnostic then t/m the cause Or if non-dx then check underlying other cause of chest pain / check cardiac markers
What medication to hold prior to cardiac stress testing?
BB / CCB / Nitrates = hold for 48 hours
Dipyridamole = Hold for 48 hours prior to vasodilator stress test
Caffeine containing food Or Drinks = hold for 12 hours prior to vasodilator stress test
What medication can be continued before doing cardiac stress testing?
AIDS
A = ARBs/ACEI ID = Digoxin / diuretics S = statins
How chest wall/ musculoskeletal chest pain presents?
Persistent and prolong pain with palpation
Worse with movement Or change in position
Often follows repetitive activity
How pulmonary/pleuritic (pleurisy, pneumonia, pericarditis, PE) chest pain present?
Sharp/stabbing pain
Worse with inspiration
Pericarditis:: Worse when lying flat
PE / Pneuomthorax:: Respiratory distress / hypoxia
How GIT/Esophageal chest pain present?
Non exertional prolong chest pain lasting>1 hour
Nocturnal pain
Postprandial symptoms
What is the first line agent for stable chronic angina?
Beta blocker
But CCB can be combine with BB of angina persist Or as alternate therapy
When to used short acting form and long acting form of nitrates in stable chronic angina?
Short acting form is used in the acute setting
Long acting form is an add on therapy for persistent angina
How variant angina different from ACS on the basis of ECG?
In variant angina, Transient ST elevation and then return to baseline
Whereas ST depression in unstable angina and longer duration of ST elevation in MI.
Which vessels and what are the ECG findings of Right ventricle MI?
RCA
ST elevation in leads V4-V6R
***Right ventricle MI occurs in 50% of inferior MI
Important point of Inferior wall MI
Transient bradycardia Or AC block occurs due to enhanced cabal time so give IV fluid unless pulmonary congestion
Important point of RVMI
RV MI (Heat failure) leads to decrease preload and resultant hypotension
So avoid all those medications which decreases preload viz nitroglycerin / Diuretics / Opioids)
Also be cautious when using BB and CCB
Which artery and what are the findings of Posterior MI?
LCX or RCA
ST depression in leads V1-V3
ST elevation in leads I & aVL (LCX)
ST depression in leads I & aVL (RCA)
Which artery and what are the ECG findings of lateral wall MI?
LCX diagonal
ST elevation in leads I, aVL, V5 & V6
ST depression in leads II, III & aVF
Important point
Occlusion of LAD can cause 2nd degrees AV block as it perfumed anterior 2/3rd of septum
What is the MC arrhythmia will be seen in setting of acute MI?
Ventricular fibrillation
What is the mechanism of arrhythmias within 10 mins of coronary occlusion?
Arrhythmia occurring within 10 mins of coronary occlusion—immediate or phase 1a ventricular arrhythmia
MOA:: reentrant arrhythmia
What is the mechanism of arrhythmias within 10-60 mins after acute infarction?
Arrhythmia occurring within 10-60 min after acute infarction—delayed or phase 1b arrhythmia—
MOA: abnormal automaticity
How ventricular aneurysm different from MI on ECG?
Ventricular aneurysm has persistent ST elevation after recent MI and deep Q waves in same leads
Whereas ST elevation resolve within a few weeks of an MI
What are CXR and Echo findings of ventricular aneurysm?
CXR = Prominence Or Bulge among left heart border
ECHO = showing dyskinetic wall motion of a portion of left ventricle
How to t/m dressler syndrome?
NSAIDs is mainstay of therapy
Steroids can be used in refractory cases Or when NSAIDs are contraindicated
Avoid to use anticoagulant to prevent development of hemorrhagic pericardial effusion
How to avoid coronary stent thrombosis?
Give long term dual anti-platelet therapy with aspirin and platelet P2Y12 receptor blocker
What is the most important intervention to improve long term prognosis of MI esp STEMI?
PCI
or Fibrinolytic therapy
Name the discharge medication of MI
- Dual anti-platelet therapy
- BB
- ACEI or ARB
- STATINS
- Aldosterone antagonist if EF <40% with HF symptoms Or DM
Important point
ACEi should be started in all pts with MI within 24 hours to prevent remodeling of heart
i.e. dilation of left ventricle with thinning of ventricular wall which takes wks to months
What are the causes of heart failure with preserved left ventricular function?
- Diastolic heart failure (HOCM / Restrictive cardiomyopathy / HTN / Occult CAD)
- Valvular Heart disease (AR AS / MR MS)
- Pericardial disease (Constrictive pericarditis / Cardiac tamponade)
- High Output cardiac conditions ( Thyrotoxicosis / Severe anaemia / Wet beri / Paget’s disease/ AV Fistula)
How to t/m acute decompensated HF with normal Or Elevated BP with adequate end organ damage?
Supplemental O2
IV loop diuretics
Consider IV vasodilator Viz nitroglycerin
How to t/m acute decompensated HF with hypotension Or signs of shock?
Supplemental O2
IV loop diuretics
IV vasodilator Viz nitroglycerin
What are the laboratory findings suggest poor prognostic factors in systolic HF?
Low Serum Sodium
Elevated Pro-BNP level
Renal insufficiency
What are the clinical findings suggest poor prognostic factors in systolic HF?
Resting tachycardia with higher NYHA functional class
Elevated JVP with presence of S3 gallop
Low BP and maximal O2 consumption
Moderate to severe MR
What are the ECG and ECHO finding suggests poor prognostic factors in systolic HF?
ECG:::
LBBB and QRS>120msec
ECHO:::
Severe LV dysfunction
Concomitant diastolic dysfunction
Reduced Right ventricular function
Pulmonary HTN
What is the initial therapy in hyponatremia in CHF patient?
Restrict water intake
ACEi
and loop diuretics
What are the features of Cocaine Induced STEMI?
Chest pain due to coronary vasoconstriction
Increase Sympathetic activity Viz pupil dilation /HTN / tachycardia
Blood crusted nose
What are medication not to used in Cocaine Induced STEMI?
Beta blockers
Fibrinolytics due to increased risk of intracranial hemorrhage
Where the sound of murmur localized if Aortic regurgitation occurs due to valvular disease?
murmur heard along left sternal border (3rd and 4th Intercostal space)
Where the sound of murmur localized if Aortic regurgitation occurs due to aortic root dilation?
murmur best heard at right sternal border
Important point
If new AV block is present in case of IV drug user alongwith AR murmur, suspect perivalvular abscess extending into adjacent cardiac conduction pathway (conduction defects not common in tricuspid endocarditis)
What are the causes of Dilated Cardiomyopathy?
ABCDe
A= alcohol abuse B= beri beri (wet) / Coxsackie B virus C= cocaine / Chagas D= Doxorubicin toxicity E= elsewhere (hemochromatosis / sarcoidosis /peripartum cardiomyopathy
What are the laboratory findings of Dilated Cardiomyopathy?
ECHO:::
Dilated heart / systolic regurgitant murmur
CXR:::
Balloon appearance of heart
Miscellaneous:::
Eccentric hypertrophy
How takotsubo cardiomyopathy occurs?
Ventricular apical ballooning likely due to increased sympathetic stimulation
What is the histological finding of HOCM?
Marked ventricular concentric hypertrophy
(Sarcomere added in parallel)
Myofibrillar disarray and fibrosis
Name the protein get mutated in HOCM?
Genes encoding sarcomere protein such as myosin binding protein C and B-myosin heavy chain
Name the condition which cause isolated Right HF
Cor pulmonale
What will be detected in physical finding in HOCM?
carotid pulse with dual upstroke due to mid-systolic obstruction during cardiac contraction
What are the major causes of sudden cardiac death?
CAD
HOCM
Arrhythmia Viz long QT Syndrome
Congenital heart disease
What is Cornell Criteria?
It is criteria for HOCM
Tall “R” wave in aVL plus deep “S” wave in V3
What is the difference b/w HOCM and restrictive cardiomyopathy?
HOCM:::
Wall is asymmetrical thick
Restrictive cardiomyopathy:::
Wall is symmetrical thick
What is the ECHO findings of amyloidosis?
Increased ventricular wall thickness with normal ventricular cavity dimensions (esp in ots without HTN)
What will be ECHO finding of Dilated Cardiomyopathy?
echo shows dilated ventricles with diffuse hypokinesia resulting in a low ejection fraction (i.e. systolic dysfunction)
What will be laboratory findings of Cardiac tamponade?
CXR:::
Enlarged globular cardiac silhouette (water bottle heart shape)
ECG:::
Electrical alternans with sinus tachycardia is highly specific for large pericardial effusion
When to consider S3 sound normal?
Children
Young adult
Pregnancy
Important point of S4
S4 is heard in acute MI because of ischemia induced myocardial dysfunction
What is the key distinguished feature of benign and pathological murmur?
benign Vs pathological murmur is change in instensity with change in position. Position that dec. venous return to heart, dec intensity of innocent murmur.
In which condition Hepatojuglar reflux seen?
Common in constrictive pericarditis, right ventricular infarction and restrictive cardiomyopathy
What is Kussmaul’s sign?
lack of ↓ or an ↑ in JVP on inspiration
What are the causes of Constrictive pericarditis?
Viral pericarditis
Cardiac surgery
Tb
Radiation therapy
Which is the ECHO and CXR finding of Constrictive pericarditis?
ECHO:::
Increase pericardial thickness
Abnormal Septal motion
Bi atrial enlargement
CXR:::
Pericardial calcification
What is the JVP finding of Constrictive pericarditis?
Prominent X and Y descent
Difference between Pericardial knock and S3
Pericardial knock::
Occurs earlier than S3 gallop
Louder and higher pitched than the S3
Heard with the diaphragm over a larger area
S3:::
Best heard with a lightly
How to t/m Constrictive pericarditis?
Temporary:::
Diuretics
Definitive:::
Pericardiectomy (also in refractory cases)
Important point of Uremic pericarditis
Does not present with classic ECG findings of pericarditis as inflammatory cells do not penetrate the myocardium and lack of involvement of epicardium
What is the effective t/m of Uremic pericarditis?
Dialysis is the most effective treatment for UP and can resolve symptoms and decrease the size of any pericardial effusion
How to t/m first degree heart block with normal QRS?
No further evaluation needed
What to do if patient has first degree heart block with wide QRS?
It should have electrophysiologic testing to determine the site of conduction delay
Difference between first degree heart block with Normal and wide QRS complex?
Normal QRS::
due to conduction delay in AV node
Wide QRS::
conduction delay below AV node, mostly bundle branches
What is pacemaker syndrome?
uncomfortable sensation of awareness of heart beat due to atrial contraction against close mitral valve during ventricular systole.
At what level there is block in 2nd degree heart block?
Type 1::
Usually AV node
Type 2::
Below the level of AV node
How exercise(Or atropine) and vagal maneuvers?
Atropine (Or Exercise)::
Improves type 1 block whereas worsen type 2 block
Vagal Maneuvers::
Improves type 2 block whereas worsen type 1 block
What will be the ECG findings type 1 block?
Constant P-P interval
Increasing PR interval
Decreasing R-R interval
Difference between first degree and other heart block
First degree always have conducted P waves with Qrs , unlike other AV blocks
What are the ECG findings of type 2B block?
Normal PR interval
Constant RR interval
Non conducting P waves
Area of drop QRS complex
What are the ECG findings of third degree third block?
PP and RR interval constant
Escape rhythm
Important point of third degree heart block
Unless an escape rhythm is initiated, ventricle a-systole will occur
Name the drugs contraindicated in third degree heart block
Beta blocker and Digoxin
What is the most frequent location of ectopic foci that cause AF?
Pulmonary vein
What are the causes of tachycardia mediated cardiomyopathy?
AF / atrial flutter
ventricular tachycardia / incessant atrial/junctional tachycardia
and
atrioventricular nodal reentrant tachycardia.
How tachyarrhythmias induced cardiomyopathy occurs?
tachyarrhythmias with prolonged periods of rapid ventricular rates can lead to this cardiomyopathy
How to t/m tachyarrhythmias induced cardiomyopathy?
AV nodal block agents
Anti arrhythmics agent
Catheter ablation of arrhythmias
Name the pulmonary origin condition associated with A fib
Obstructive sleep apnea
Pulmonary embolism
COPD
Acute hypoxia
Name the cardiac origin condition associated with A FIB
Hypertensive heart disease
CAD
MR/MS
CHF / HOCM
ASD
Post cardiac surgery
How to control the rate in A fib?
.
Rate control is achieved by beta blockers (metoprolol), calcium channel blockers (diltiazem) or digoxin to control ventricular rates.
What are the indications of rhythm control in A fib?
Hemodynamic unstable patient with rapid A fib
Not responding to rate controlling drugs
recurrent symptomatic episodes (eg, palpitations, lightheadedness, dyspnea, angina) or
heart failure symptoms in setting of underlying left ventricular systolic dysfunction
Important point of A FIB
Attempting cardioversion for an unknown duration or >48 hours without adequate anticoagulation inc. risk of systemic thromboembolism