Cardiology Flashcards
Causes of angina
atheroma anaemia Aortic Stenosis tachyarrhythmias hypertrophic cardiomyopathy arteritis/small vessel disease (microvascular angina/cadiac syndrome X)
Types of angina
Stable- induced by effort, relieved by rest
Unstable - angina of increasing frequency or severity, occurs on minimal exertion. Associated with increased risk of MI
Decubitus angina precipitated by lying flat
Variant (Prinzmetal’s) angina - coronary artery spasm, pain during rest
Variant Angina (prinzmetal’s)
coronary artery spasm pain during rest ECG during pain shows ST elevation that resolves as pain subsides Rx- CCB ± long acting nitrates avoid B-blockers
ECG in angina
usually normal
may show ST depression
exclude precipitating factors - anaemia, DM, hyperlipidaemia, thyrotoxicosis, temporal arteritis
Management of Angina
Modify risk factors- smoking, exercise, HTN, DM
aspirin
B-Blockers- atenolol
Nitrates - GTN or isosorbide mononitrate
long acting calcium agonists - amlodipine
K+ channel activator- nicorandil
Definitions of ACS
unstable and evolving MI
ACS with ST segment elevation or new onset LBBB
ACS without ST segment elevation
Risk Factors for ACS
Non-modifiable- age, male, FHx of IHD
Modifiable- smoking, HTN, DM, hyperlipidaemia, obesity, sedentary lifestyle, cocaine use
Controversial - stress, type A personality, LVH, raised fibrinogen, hyperinsulinaemia, homocystiene
Diagnosis of ACE
Raise and then fall in cardiac biomarkers (troponin) and:
- symptoms of ischaemia, ECG changes of new ischaemia, development of pathological Q waves or loss of myocardium on imaging
Symptoms of ACS
Acute central chest pain lasting more than 20mins
Nausea, sweatiness, dyspnoea, palpitations
May be silent or present atypically
- syncope, pulmonary oedema, epigastric pain and vomiting, post-operative hypotension, oliguria, acute confusional state, stoke, diabetic hyperglycaemic states
Signs of ACS
Distress, anxiety, pallor, sweatiness, raised or low pulse or BP, 4th heart sound
May be signs of heart failure (raised JVP, 3rd heart sound)
pansystolic murmur- papillary muscle dysfunction/ rupture, `VSD
Later- pericardial friction rub or peripheral oedema
ECG changes in ACS
Hyperacute tall T waves
ST elevation or new LBBB
T wave inversion + pathological Q waves over hours-days
ST depression, T wave inversion , non-specific changes
CXR in ACS
cardiomegaly
pulmonary oedema
widened mediastinum (aortic rupture)
Differential diagnosis in ACS
Angina Pericarditis Myocarditis Aortic dissection Pulmonary embolism Oesophageal reflux/ spasm
Pre-hospital managment of ACS
300mg aspirin chewed
GTN sublingual
analgesia- 5-10mg morphine iV + metoclopramide 10mg IV
In hospital management of ACS
- ST segment elevation
O2, IVI, morphine, aspirin
- primary angioplasty/thrombolysis if not CI
- B-blocker (atenolol)
- ACE-i if normotensive
- consider clopidogrel 300mg loading dose, 75mg/day for 30 days
In hospital management of ACS
ACS without ST segment elevation
O2, IVI, morphine, aspirin -B-Blocker - antithrombotic (fondaparinux or LMWH) - Assess risk e.g. GRACE score -High risk pts- GPIIb/IIIa agonist (tirofiban) or bivalirudin angiography within 96hrs clopidogrel
Subsequent management of ACS
Bed rest Daily examination Prophylaxis against thromboembolism until fully mobile Aspirin Long term B-Blockade Continue ACE-i Start a statin Address modifiable risk factors Assess LV function Return to work 2/12 avoid sex for 1/12 exercise daily