Cardio, Pulmonary, Endocrine & Renal Flashcards

1
Q

___% of kids have a benign murmur

A

30

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2
Q

Two types of benign murmurs

A

stills murmur and venous hum

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3
Q

Stills murmur

A

SYSTOLIC,

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4
Q

Venous hum

A

best heard in anterior neck, disappears when jugular vein is compressed

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5
Q

Murmurs that are NEVER normal; tx

A

DIASTOLIC, anything >II/VI; get an echo

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6
Q

Dx–Newborn is cyanotic @

birth, O2 does not improve; most common in ____; [NO MURMUR]

A

transposition of great arteries; infants of diabetic mothers

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7
Q

Transposition of great arteries–tx

A

PGE1 to keep PDA patent

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8
Q

Dx–2y/o child who gets cyanotic and hyperpnea while playing, squats down; tx

A

TOF [pulm stenosis, RA hypertrophy, overriding aorta, VSD]; O2 and knees to chest, sx

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9
Q

TOF–murmur type

A

harsh SEM + single S2

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10
Q

Dx–Bipolar woman gives birth to a child w/ holosystolic murmur worse on inspiration

A

Ebstein anomaly

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11
Q

Ebstein anomaly

A

Tricuspid insuficciency 2/2 TV displacement into RV

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12
Q

Ebstein anomaly–arrhythmia

A

Wolff-Parkinson-White

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13
Q

Dx–Cyanosis @ birth with holosystolic murmur, depends on VSD or ASD for life. EKG shows LVH

A

Tricuspid atresia

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14
Q

Tricuspid atresia–tx

A

PGE1 until sx

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15
Q

Dx–Heart defect associated with DiGeorge syndrome. CXR shows ↑pulm blood flow and bi-ventricular hypertrophy

A

Truncus arteriosis

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16
Q

In truncus arteriosis, _____ develops early. Tx w/ sx in first few weeks of life

A

Eisenmenger

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17
Q

Describe Eisenmenger syndrome

A

increased blood flow to lungs instead of body causing extreme pulm HTN–>instead blood goes through shunt from RV to LV and gives O2-poor blood to body

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18
Q

MC congenital heart murmur; describe murmur

A

VSD; harsh holosystolic over LL sternal border, loud P2

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19
Q

If harsh holosystolic over LL sternal border at II/VI in 2mo w/ no sxs, next step

A

continue to monitor [VSD must close by 1-2yrs]

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20
Q

Gold standard test for murmurs

A

echo

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21
Q

VSD–surgery is indicated if____

A

FTT, 6-12mo w/ pHTN, >2yr w/ Qp/Qs >2:1

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22
Q

VSD–is louder murmurs better or worse? why?

A

Better. It means the defect is small. Most often membranous. More likely to spontaneously
close

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23
Q

Dx–Loud S1 w/ fixed and split S2. Older child w/ exercise intolerance

A

ASD

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24
Q

Dx–Most common defect in Down Syndrome baby

A

Endocardial cushion defect

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25
Q

Endocardial cushion defect–describe murmur

A

Fixed & split S2 + SEM w/ diastolic rumble

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26
Q

Endocardial cushion defect—-tx

A

sx before pHTN at 6-12mo [at risk for early Eisenmengers]

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27
Q

Dx–Continuous machine-like murmur w/ bounding pulses and wide pulse pressure

A

PDA

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28
Q

PDA–associated pathologies

A

prematurity, congenital rubella syndrome

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29
Q

PDA–tx

A

if not closed by 1wk, give indomethacin or sx

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30
Q

Dx–Most common defect in Turner’s baby

A

Coarctation of aorta

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31
Q

Dx–Decreased femoral pulses, “reverse 3 sign”, “notching” @ inf rib border 2/2 incr collateral

A

Coarctation of aorta

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32
Q

Dx–15yo athlete w/ occasional palpations, angina, dizziness. Last week, fainted during baseball game

A

Hypertrophic CM

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33
Q

Hypertrophic CM–murmur type; better with ____ preload, ___ w/ valsalva/standing/exercise

A

SEM; increased; louder

34
Q

Hypertrophic CM–tx

A

ß-blockers or CCB, alcohol ablation or surgical myotomy

35
Q

Hypertrophic CM–restrictions

A

no sports/heavy exercise!

36
Q

Why can’t you use diuretics or digitalis in Hypertrophic CM?

A

Dig–glycosides contraindicated except in pts a/ uncontrolled afib; Diuretics–potential adverse effect on the LV outflow gradient and ventricular volume

37
Q

Dx–7yo w/ vague chest pain, pain in different joints over the past few days, and a rash. ESR is elevated. EKG shows prolongation of the PR interval

A

Acute rheumatic fever

38
Q

Acute rheumatic fever–Tx

A

oral PCN (or erythromycin) for 10 days then prophylactically until 20yo

39
Q

Acute rheumatic fever–cardiac complications

A

mitral stenosis (M > aorta > tricuspid)

40
Q

CF–signs at birth; dx and tx

A

meconium ileus (dilated loops), “ground glass”, +/- rectal prolapse from chronic diarrhea; gastrograffin enema

41
Q

Early childhood, expect CF when see ____

A

FTT (

42
Q

CF–genetics and inheritance

A

AR, mut chr7, CFTR protein

43
Q

CF–dx

A

sweat test [>60mEq/L chloride]

44
Q

CF–tx (A) thick resp secretions (B) pneumonia (C) pancreatic insuff (D) electrolyte loss thru skin

A

(A) DNAse (mucolytic), albuterol/saline nebs (B) piperacillin + tobramycin or ceftazidime (C) enz replace w/ meals + ADEK supplement (D) fluid replacement

45
Q

CF–MC type pneumonia

A

pseudomonas or b. cepacia

46
Q

Asthma tx–pt has sxs twice a week and PFTs are normal

A

albuterol only

47
Q

Asthma tx–pt has sxs 4x a week, night cough 2x a month and

PFTs are normal

A

albuterol + inhaled CS

48
Q

Asthma tx–pt has sxs daily, night cough 2x a week and FEV1 is
60-80%

A

albuterol + inhaled CS + long-acting ß-ag (salmeterol)

49
Q

Asthma tx–pt has sxs daily, night cough 4x a week and FEV1 is

A

Albuterol + inhaled CS + salmeterol + montelukast and oral steroids

50
Q

Asthma exacerbation–tx w/ _____.

A

albuterol and PO/IV steroids

51
Q

Asthma exacerbation–watch __ and ___. PCO2 should be ____

A

peak flow rates; blood gas; low [if normalizing PCO2, means impending resp failure–must INTUBATE]

52
Q

Asthma can cause severe complications during this case _____

A

allergic bronchopulmonary aspergillus [hyper-reactivity of immune system]

53
Q

Type 1 DM–sxs when present to ER in DKA; labs–__ Na/Cl, ___HCO3, __ glucose

A

emesis, wt loss, polyphagia, polydipsia, polyuria; low; low/nl; high

54
Q

Child w/ DKA–next best steps

A

Start insulin drip + IVF, monitor BGL and anion gap, start K, bridge w/ glargine once tolerating PO

55
Q

Type 1 DM–pathophys

A

T-cell destruction of islet cells in pancreas, insulin autoAb, glutamic acid decarboxylase autoAb

56
Q

Diagnostic criteria for DM?

A

fasting glc >125 (x2) OR 2hr OGTT (75g) >200, random glc >200 + sxs

57
Q

Kid peeing blood–best first test

A

UA

58
Q

Kid peeing blood–dysmorphic RBCs or RBC casts

A

glomerular source

59
Q

Kid peeing blood–1-2 days after runny nose, sore throat and cough

A

Berger’s Dz (IgA nephropathy) = MCC

60
Q

Nephritic syndrome

A

proteinuria (

61
Q

Kid peeing blood–1-2 wks after sore throat of skin infx

A

Post-strep GN

62
Q

Post-strep glomerulonephritis characteristics

A

smoky/cola urine, best 1st test is ASO titer. Subepithelial IgG humps

63
Q

Hematuria + hemoptysis

A

Goodpasture syndrome (Abs to collagen IV)

64
Q

Hematuria + deafness

A

Alport syndrome (XLR mut in collagen IV)

65
Q

Dx–Flank pain radiating to groin + hematuria

A

kidney stone

66
Q

Kidney stone–best test

A

CT

67
Q

Kidney stone–MC type; tx

A

calcium oxalate; HCTZ

68
Q

Kidney stone–kid w/ family hx stones–MC type

A

cysteine (can’t resorb certain AA)

69
Q

Kidney stone–chronic indwelling foley and alkaline pee–MC type

A

struvite = Mg/Al/PO4

70
Q

What pathogens cause struvite kidney stones?

A

proteus, staph, pseudomonas, klebsiella

71
Q

Kidney stone–leukemia being tx w/ chemo–MC type

A

uric acid [tx by alkalinizing urine + hydration]

72
Q

Kidney stone–s/p bowel resection for volvulus–MC type

A

pure oxylate stone (CA not reabsorbed by gut and so pooped out)

73
Q

Kidney stone–tx of stones

A

will pass, hydrate

74
Q

Kidney stone–tx of stones >2cm

A

open or endoscopic sx

75
Q

Kidney stone–tx stones 5mm-2cm

A

extracorporal shock wave lithotropsy

76
Q

Kid peeing protein–best first test

A

repeat in 2 wks then quantify w/ 24hr urine

77
Q

Kid peeing protein–MC

A

minimal change disease (fusion foot processes)

78
Q

Minimal change disease–tx; MC complication

A

prednisone 4-6wks; infection (make sure immunized for pneumo and varicella)

79
Q

Nephrotic syndrome

A

> 3.5g protein/24hrs, hypoalbuminemia, edema, hyperlipidemia (fatty/waxy casts)

80
Q

Kid peeing protein–random cause

A

orthostatic =MC in school-aged kids; normal while supine

81
Q

Dx–nephrotic pt suddenly w/ flank pain

A

renal vein thrombosis (EMERGENCY), 2/2 peeing out ATIII, protein C/S; do CT/US!!