Cardio pharm Flashcards

1
Q

what is considered elevated BP

A

systolic 120-129 AND diastolic <80

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2
Q

what is normal BP

A

<120/80

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3
Q

what are the two stages of Hypertension

A

Stage 1: S-130-139 or D: 80-89
Stage 2: S >140 or D >90

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4
Q

What are the ACC/AHA goals

A

decrease systolic pressure <130

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5
Q
A
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6
Q

Tx for Elevated BP

A
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7
Q
A

3-6 months

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8
Q
A
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9
Q

First tier HTN medications

A

ACEI/ARB
DHP CCB
Thiazide-like diuretics

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10
Q

What does Aldosterone do in the urine

A

Na reabsorption and K excretion as well as H2O retention

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11
Q

ACEI mechanism

A

inhibit conversion of ANg I to II
blocks ACE
and decrease afterload

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12
Q

endings of ACEI and the most common drug here

A

“pril”
Lasonopril

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13
Q

endings for ARBs and the main drug here

A

“sartan”
Losartan

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14
Q

ACEI/ARBS main adverse drug effects

A

Dry COUGH and Angioedema (most comon on first week, AfroAmerican ppl at riskk here)
Hypotention (1st dose)
HYPERKALEMIA

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15
Q

Contraindication of ACEI/ARBS

A

Pregnancy X
renal artery stenosis

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16
Q

Ccalcium channel blockers DHP ending and the main drug

A

dipines
-Amlodipine

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17
Q

CCB non-DHP are better compared to CCB-DHP for the heart, yes or no ?
who are they ?
*hint this is what dad takes

A

yes b/c it works on the heart specifically
VERAPIMIL and Diltiazem

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18
Q

what is the ending of a alpa 1 blocker that is second line for HTN?

A

sozin
Doxazosin , Prazosn

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19
Q

alpha 1 blocker (2nd line HTN) MOA

A

-antagonize alpha 1 receptor on vasculature of SM
-vasodoalate peripheral sm
-DECREASE afterload

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20
Q

alpha 1 blocker (2nd line HTN) ADR

A

postural hypotension (drops when you stand up)
Dizziness

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21
Q

what is an alpha 2 non selective agonist

A

clonidine

22
Q

beta block main MOA

A

reduce cardiac contractility and increase preload (ammt of blood ejected)

23
Q

beta blocker ADR

A

BRADYcardia, heart block , fatigue, depression, bronchospasm

24
Q

what are two mixed Beta with alpha-blocking medicines mostly used for HTN
“Leba el carvet” aka wash the corvet in Spanish

A

Lebatolol and carvedilol

25
Q

Direct-acting vasodialators MOA

A

-direcly realx vascular smooth muscle
- ↓ afterload

26
Q

what two medications decrease afterload

A

alpha 1 blockers and direct vasodialators

27
Q

Name a vasopressin antagonist (ADH antagonist)
*collect the last toll” - works at the end of collecting tube

A

Tolvaptan

28
Q

between Thiazide diuretics and Loop, who looses the most K+

A

Loop

29
Q

ARDS of Thiazides and channel they block

A

hypoK, hypoNa, Hyperglycemiam Hyperuremia
-block Na/Cl channel

30
Q

Which channel does the Loop diuretic block and ARDS

A

Na/2CL/K channel
-HYPOKALEMIA, cramping and hearing decrements
(pssst this is mainly used for CHF)

31
Q

Name the most common loop diuretic
“ides”

A

Furosemide

32
Q

primary manifestation of Heart failure

A

Dyspnea, fatigue, and fluid retention

33
Q

HErEF (heart failure w reduced ejection fraction) LVEF

A

LVEF <40 %
previously systolic HF

34
Q

HFpEF what is the LVEF

A

> 50%
-reviously diastolc HF

35
Q

most common cause of HFpEF

A

HTN

36
Q

1 horpitalizationipn in people >65

A

Heart failure

37
Q

Is HTN asymtomatic?

A

yes hence why its called the silent killer

38
Q

current guidelines for HTN

A

JNC 8

39
Q

can fish oil and garlic increase bleeding risk ?”

A

yes

40
Q

Can you use ACEI and ARBS togther?

A

never!! can cause Angioedema (emergency) due to ACEI

41
Q

ACEI main side effect

A

dry cough, if so change to ARBs

42
Q

pt seeing yellow green after taking his medicatins

A

think Digoxin toxicity

43
Q

vasodialators BBW

A

BBW: pericardial effusion, angina exacerbation , drug induced lupus erythmatous

44
Q

WHat to avoid with Statins

A

Grapefuid=t
Protease inhb
Aazoles
Cyclosporins
Macrlides
Amiodarone
Non DHP CCB

45
Q

Ranolazine MOA

A

anti-ischemic and anti-angina effects

46
Q

non selective alpha 2 that comes in a patch

A

clonidine

47
Q

ACEI hepatically cleared

A

Fisonopril

48
Q

ACEI/ ARBS CI

A

dont use with Aleskerin in diabetes
-Dont use together
-Pregnanc

49
Q

where do MRAs work on (location on the nephron)

A

distal tubule and collecting duct

50
Q
A