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My pathology III > Cardio III - Q2,1 > Flashcards

Cardio III - Q2,1 Flashcards

1
Q

What is cardiomyopathy?

A

Disease of the heart where the cause is intrinsic to the myocardium itself, such as inflmmatory disorders, autoimmune, and metabolic diseases

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2
Q

What is cardiomyopathy used to describe

A

heart disease resulting from a primary abnormality in the myocardium

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3
Q

What are the 3 major categories of cardiomypathy?

A

Dilated - 90%, hypertrophic and restrictive

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4
Q

How would dilated cardiomyopathy be described

A

Ejection fraction of less than 40% in the presence of increased left ventricular demension (end size >115%)

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5
Q

how is dialated cardiomyopathy different from hypertrophic and restrictive.

A

dilated- the heart is bigger and the chambers are bigger, Hypertrophic-the heart may be bigger, but the Left ventricle or chamber is smaller. Restrictive- the walls just aren?t flexable like they should be.

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6
Q

In dialated cardiomyopathy, what chambers are dilated?

A

all 4 champers are enlarged and dilated.

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7
Q

What is the cause of dialated cardiomyopathy?

A

Idiopathic dialated cardiomyopathy.

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8
Q

What is the most common cause of non-ischemic dialated cardiomyopahty in the us?

A

chronic alcholism

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9
Q

What does DCM dialated cardiomyopathy look like

A

nonspecific abnormalities, monocyte size variation, vacuolation , loss of myofibrillar material and fibrosis.

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10
Q

why would a heart have a globoid shape

A

because all the chambers are dilated

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11
Q

What is HCM, hypertrophic cardiomyopathy characterized by?

A

characterized by myocardial hypertrophy, abnormal diastolic filling,

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12
Q

wht is present in about 1/3 of HCM cases in addition to the myocardial hypertrophy and abnormal diastolic filling

A

intermittent ventricular outflow obstruction

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13
Q

what does HCM look like microscopically

A

Hypertrophy of myocardial fibers that have a prominent dark nuclei along with interstitial fibrosis

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14
Q

what is the cause of HCM

A

Inherited- autosomal dominant trate. It?s a problem of some genes that code for sarcomeres.

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15
Q

compare the contracttion of DCM to HCM

A

HCM is thick walled and hypercontracting while DCM is flabby and hypo-contracting

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16
Q

essential feature of HCM?

A

massive myocardial hypertrophy without ventricular dilation

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17
Q

which parts of HCM are hypertrophic?

A

Its ususally only the one ventricle

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18
Q

classic appearance of HCM grossly is what?

A

disproportinate thickening of the ventricular septum as compred with the free wall of the ventricle.

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19
Q

what are the 2 most common causes of restrictive cardiomyopathy

A

amyloidosis and hemochromatosis

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20
Q

what happens in restrictive cardiomyopathy

A

the myocardium is infiltrated with abnormal tissue that impairs wall motion and abnormal contratcion/relaxation

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21
Q

What stain can show hemochromatosis?

A

prussian blue.

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22
Q

what does excessive depositon of iron in heart lead to?

A

Heart enlargement and failure. It?s a form of restrictive cardiomyopathy

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23
Q

what does amylodosis look like on slide in heart?

A

amorphus deposits of pale point material between myocardial fibers.

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24
Q

what does endocarditis refer to?

A

Inflammation on the valve leaflets. Endocardial lining of heart may also be involved

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25
Q

where does endocarditis ususally begin

A

lines of closure where the pressure is greatest

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26
Q

What organism causes the majority of community aquired endocarditis?

A

Staph aureus, but not the MRSA type.

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27
Q

After staph aureus, what causes Community aquired endo?

A

Strep veridans, 10-35, enterococcus 5-10%, culture neg 5-10%, Fungi <5%,

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28
Q

Infectious endocarditis vegetations are what?

A

bulky masses on valves colonized by bacteria and thrombic debris.

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29
Q

what valves are most commonly infected ?

A

Left sided valves, probably because there is more pressure on that side, Its also about equal between mitrial and aortic valves

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30
Q

what is friable vegitation?

A

how portions of vegetation breaks off and can embolize throughout the body.

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31
Q

what does infectious endocarditis lead to?

A

destruction of underlying valves and tissue, and the vegetations can embolize and carry infectious agents anywhere.

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32
Q

endocarditis generally refers to what?

A

bacterial endocarditis because generally its bacterial in nature.

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33
Q

how often can the culter of the endocarditis turn up negative?

A

5-30% of the time.

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34
Q

What organism is the most common nosocomial cause of endo?

A

Staph Aureus, 60-80%, and unlike community aquired its mostly MRSA

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35
Q

In community aquired strep veridians is 5-35%, what is it in nosocomial?

A

Less than 5%, strep veridians seems to be rare in the hospital setting.

36
Q

How often is nosocomial culture negative

A

about 5 %, in community aquired it can be up to 30%.

37
Q

what are some other things that can cause endocarditis?

A

E.coli, klebsiella and corneybacterium

38
Q

Why is culture negative increased in community aquired?

A

Because there is often antibiotic treatment prior to diagnosis.

39
Q

IF a PCR and full work up is done, what % finds an etiology?

A

75%.

40
Q

is there an association between culture negativity and risk factors or etiology

A

nope

41
Q

If a culture is negative, what are the most commonly found culperets

A

Fungi 10%, entercoccus 5%, A-hemolytic strep <5, then the miscelaneous butgs

42
Q

what can allow bugs into system?

A

Poor dental health/dental procedures- gentourinary infections, skin infections, IV drugs, pulmonary infections

43
Q

Clinically, how is endocarditis often classifiec?

A

acute or subacute

44
Q

acute endocarditis?

A

rapidly developing, destructive infection, of an previously normal valve (usually)

45
Q

what would cause acute endocarditis?

A

highly virulent organism that can lead to death withing days to weeks in 50% of patients even with vigorous treatment.

46
Q

Subacute endocarditis

A

slower less severe course that usually involves and already damaged valve and often a less virulent organism.

47
Q

what does onset of acute endo look like?

A

rapidly developing fever, chills, weakness and fatigue with new murmers, and absess development is common

48
Q

what is the most consistent sign of endocarditis?

A

fever

49
Q

why is fever not a reliable finding in subacute endocarditis?

A

because elderly patients may be unable to generate an appropriate febrile response.

50
Q

what can be a sign of subacute endocarditis found in a PE?

A

Petechaiae in mouth, under the tongue and the finger nail beds and in the retina (roths spots)

51
Q

what are the microemboli under the finger nails called?

A

splinter hemorrhages

52
Q

what doe a roth spot look like.

A

sort of like a flame. Or a rain drop shaped with white or pale centers.

53
Q

What are roth spots made of?

A

coagulated fibrin, often caused by immune comples mediated vasculitis resulting from bacterial endocarditis.

54
Q

In the past, what was the major risk factor for endocarditis?

A

Rheumtic heart disease

55
Q

Now that Rheumatic heart disease is more rare, what causes endocarditis.

A

artificial valves, immunocompromised, IV drug users, alcoholics. Indwelling catheters and those with vascular grafts.

56
Q

what bacteria is most likely to infect a native valve that has already been damaged?

A

strep veridans - aka, alpha hemolytic strep.

57
Q

how often is strep veridens found

A

its found in 50% of all cases of infectious endocarditis and is the main cause of subacute endocarditis.

58
Q

Iv drug users are at risk for what bug?

A

staph aureus

59
Q

prosthetic valves what bug

A

staph epidermitis

60
Q

alcoholics what bugs?

A

anaerobes and oral cavity bugs

61
Q

when are gram negative bact like E coli more likely?

A

after procedrues like cytoscopy or prostatectomy or with indwelling cathaters.

62
Q

what bacteria is mostl likely seen if you have carcinoma of the colon

A

Strep bovis - that is why a colonoscopy is indicated whenever you find this bug to rule out colon cancer

63
Q

why are negative blood cultures so common, 5-20%

A

antibiotic therapy instituited prior to blood raw, or the organism just not being in the blood at the time of draw. There are also limitations on what the lab can grow.

64
Q

What is another reason for negative blood cultures?

A

the endocarditis may be an inflamatory issue rather that caused by a bug.

65
Q

When can inflammatory vegetations occur

A

with certain collagen vascular disease like systemic lupus endocarditis.

66
Q

what can SLE , lupis of the endocarditis also be called

A

libman-sacks endocarditis**

67
Q

Flat spreading vegetations may be an indication of what if the person has systemic lupus erythematosus

A

libman-sacks endocarditis**

68
Q

What is marantic endocarditis?

A

Term for endocarditis that results from hypercoaguable state that is known as troussear’s syndrome.

69
Q

What is trousseau’s syndrome (has a hypercoaguable state) associated with?

A

Trosseau’s syncrome is a paraneoplastic syndrome that is associated with malignancies

70
Q

What would a marantic endocardits look like and in who?

A

with certain collagen vascular disease like systemic lupus endocarditis.

71
Q

Although merantic vegetations are small, ususally under .5cm why are they still very dangerous.

A

They are very prone to enbolize

72
Q

What happens to the valve after the antibiotics sterilize it?

A

it becomes more fibrotic and scarred, sometimes its damaged enough to cause CHF and then it must be replaced.

73
Q

Where can the vegetations be found?

A

they can spread from the valve surface to the endocardial surfice of the myocardium

74
Q

what is merantic endocarditis

A

sterile non infectious endocarditis hypercuaugable state.

75
Q

when do fever and infection not go together

A

in old people or really immune supressed**

76
Q

what should be done if strep bovis shows up

A

check for bowel cancer** colonoscopy is indicated

77
Q

what is the number 1 reason to have an initial negative culture

A

fungus ***

78
Q

what bug is at the top of community and nosocomial endocarditis

A

staph aurus,***

79
Q

what bug is the number one reason for a damaged valve

A

strep viridens from strep throat

80
Q

what bus is the most common over all*

A

staff aurus

81
Q

Bug for prosthetic valves*

A

staph epidermitis

82
Q

bug for iv drug users*

A

staph aureus

83
Q

bugs for alcholoics*

A

anerobes and oral cavity bugs

84
Q

bugs after cystoscopy, prostatectomy, or indwelling catheters*

A

Gram negative like E coli

85
Q

sound of endocarditis vegetations

A

holosystolic murmurs

My pathology III (3 decks)

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