cardio drugs Flashcards
Anti- cholesterol drugs?
Statins
Fibrates
PCSK 9 inhibitors
Anti- hypertensive drugs?
Thiazide diuretics
Beta blockers
Vasodilators (CCB, alpha blockers, ACEI, ARB, spironolactone)
Anti- anginal drugs?
Vasodilators (nitrates, nicorandil, calcium antagonists)
Slow heart rate (BB, CCB)
Metabolic modulator (ranolazine)
Anti- thrombotic drugs?
Antiplatelets (aspirin, clopidogrel, prasugrel, ticagrelor)
Anticoagulants (heparin & fondaparinux, warfarin)
Fibrinolytics (streptokinase)
Anti- arrhythmic drugs?
AF - rate control with BB, digoxin, rate limiting CCB
chemically cardiovert with amiodarone
Heart failure drugs?
ACEI ARBs BBs Mineralocorticoid antagonists (spironolactone) Neprilysin inhibitors Diuretics Digoxin
Statins?
E.g. simvastatin
Blocks HMG CoA reductase
which blocks pathways for synthesising cholesterol in the liver
What are stations used in?
Hypercholesterolaemia Diabetes Angina/ MI CVA TIA If high risk of MI and CVA
Side effects of statins?
Myopathy
Rhabdomyolysis
Fibrates?
E.g. bezafibrate
Stimulate LDL receptor dependent clearance mechanisms and reduce LDL available for oxidation
When are fibrates used?
Hypertryglycerideaemia
Low HDL cholesterol
PCSK 9 inhibitors?
E.g. alirocumab, evolocumab
Inhibits binding of PCSK 9 to LDLR
Increases number of LDLRs available to clear LDL
Powers LCL-C levels
When are PCSK 9 inhibitors used?
Famillial hypercholesterolaemia
