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M2 > Cardio Drugs > Flashcards

Cardio Drugs Flashcards

1
Q

alirocumab

A

PCSK9 inhibitor

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2
Q

evolocumab

A

pcsk9 inhibitor

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3
Q

-coloes-

A

resin-decrease hepatic cholesterol and increase LDL-R on liver

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4
Q

-fibro

A

activate PPARalpha-decrase TAGS

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5
Q

Epi

A

B1/B2>a1/2, @ high doses get a1

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6
Q

Ne

A

B1, a1, and a2

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7
Q

D

A

D1-R=diruse>B2>a1

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8
Q

phenylephrine

A

a1 agonist

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9
Q

clonidine

A

a2 agonist-inhibit SNS (NE release)-on presynaptic

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10
Q

Isoproterenol

A

nonselective B agonist

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11
Q

Dobutmine

A

B1 with some a1 effects

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12
Q

Phenoxybenzamine

A

ANT a1, a2-irreversible

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13
Q

Prazosin

+2 (root is okay)

A

ANT a1

-zosin=terazosin and doxazosin

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14
Q

Tamsulosin

A

ANT a1 and D1-BPH trx

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15
Q

3 normal ANT B1 selective drugs

A

atenolol, metroprolo, acebutolol (partial)

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16
Q

Esmolol

A

ultra short acting

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17
Q

Neviolol

A

ANT B1, some B3 vasodilatory effects

- no negative lipid/DM effects

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18
Q

Carvediol

A

ANT a1, b1, b2

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19
Q

labetalol

A

ANT a1,b1, b2

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20
Q

-afil (3)

A

PDE5 inhibitors
-cGMP increase

Sildenifil, vadenafil, taladafil

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21
Q

verapamill

A

bind to open L type Ca2+ (close)

-more relax heart and less relax VSM

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22
Q

Diltiazem

A

bind to open L type Ca2+ (close)

-relaxes both heart and VSM

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23
Q

Nefedipine

A

DHP
bind to closed L-type Ca2+ channels and keep closed
-bettter than other 2 (name)
-more vasodilation less heart relax

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24
Q

Ranolozine

A

inhibit inward Na+ channel in heart-decease Ca2+ level (Na Channel, Ca blocker)

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25
Digitalis
Block Na/K+ ATPase, Na increases cuz not bumped out, increases Ca2+ in cell
26
Milrinone
PDE3 inhibitor, increases cAMP increase contractility and vasodilation fatal arryhtmias
27
Enoximone | +1
PDE3 inhibitor, increases cAMP increase contractility and vasodilation -heart failure iamrinone
28
Enestro
ANP degradation + ARB activation
29
BiDil
Nitrate and hydraliziine (vasodilator)
30
hydralizine
vasodilator-gives you a lupus like syndrome
31
mioxidil
K+ channel opener=vasodilator hypertrichosifs and water retention -rogaine -need diuretic
32
Acetazolamide
prox tubule Ca inhibitor-less Na reabsorption hyperchloremic metabolic acidosis
33
Mannitol
prox tubule and descending LOH at bad hypertension/ICP
34
Furosemide
inhibits NKCC2-Na, K, Cl into cell | ottos, k wasting, hypo Mg
35
bumetanide
inhibits NKCC2-Na, K, Cl into cell | ottos, k wasting, hypo Mg
36
torsemide
inhibits NKCC2-Na, K, Cl into cell | ottos, k wasting, hypo Mg
37
ethacrynic acid
only non sulfonamide LOH diuretic all LOH are ascending loop
38
Thiazides
DCT NCC transport blocker-N and C into cell DECRASE URINE Ca2+
39
Spironolactone +1
DCT and collecting duct eplernone ALD inhibitor, decrease Na retention and K loss slow onset (1-2day duration)
40
Amiloride
DCT and collecting duct Block ENaC (Na+ in) K wasting
41
Triamterine
Block ENaC but more toxic
42
-vaptans
late DCt and collecting duct antagonize v1a and v2 reduce water absorption and increase plasma Na
43
thiazides and LOH and ALD antagnoistsand ENac antagonists common thing
all inhibited by NSAIDS
44
Heparin
activates antithrombin (F2) to inhibit F10 teratogenic Heperatin induced thrombocytopenia-trx with praline sulfate
45
Enoxaprin Fondaparinux
low molecular weight hepeorain-better pentasaccharide-100% bioaviail
46
-Prils
ACE inhibitors worked about bradykinene and substance P=cough and angioedema better than ARBs tereatogenic
47
-sartans
A2RBs | TERATOGENIC
48
Desirudin +2
Bivalirudin-30 min t1/2 Argatroban-bnds only in active (others do both)-30 minute t1/2 direct thrombin inhibitor-2 hour half life
49
warfarin
oral anticoag-vit K reductase antagonist | hit 7,9,10 protein c and s
50
dabigatran
direct thrombin inhibitor-expensive, oral
51
-xabans
novel Xa inhibitors-oral
52
altepase
tpa, 5 min t1/2
53
ASSA
irreversibly inhibit COX-decreased TXA2 (pro-thromb) and need to remake PGI2 (anti thromb)
54
Clopidogrel
irreversible ADP receptor antagnoist-decrase platelet aggregation
55
Prasugrel
irreversible ADP receptor antagnoist-decrase platelet aggregation
56
Ticarelor
reversible ADP receptor antagnoist-decrase platelet aggregation
57
Abciximab
Platelet GP11b/111a receptor blockers-decease platelet plug formation
58
Tirofiban and eptifibutide
Platelet GP11b/111a receptor blockers-decease platelet plug formation
59
Eptifibutide
Platelet GP11b/111a receptor blockers-decease platelet plug formation
60
Class 1a - names - effect
DQP disopyramide-longer duration of action and anti-musc. quiinidine-tinnitis, HA, thrombocytopenia procainamide Prolong AP duration, moderate Na block (moderately decrease phase 4 upstroke (depolarization time)), and increase refractory period
61
Class 1b - names - effect
Lettuce and Mayo lidocaine Mexiletine-oral acting and longer duration of action rapid kinetics shorten AP duration, weak Na block (small decrease in phase 4 upstroke), decrease refractory period
62
Class 1c - names - effect
Fries Please Flecainamide and Propafenone slower unblocking kinetics minimal effect on AP duration, strong Na block (greatly decrease phase 4 upstroke, no effect on refractory
63
CCB vs BB
BB prolong time till next beat CCB prolong repol and upstroke?
64
class 2 (3)
b1 and b2=propanolol, b1 selective=metropolol and atenolol
65
class 3 main + bootleg
amiodarone and Dronedarone (no Thyroid but other problems-N, V, D) Strong potassium block and Ca block prolong AP duration, slow HR/AV node, rarely cause arryhtmias THYROID, PULM FIBROSIS, deposits in skin and cornea
66
class 3 (2 excess)
Ibutilide and Dofetilide oral-fib prophylaxis worrried about QT prolongation and Torsades
67
Adenosine
Opens K channels-hyperpolarizes cell conduction block and reduce Ica-AV node -less on SA flushing, brochospasms, and chest pain

M2 (3 decks)

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