Cardio Flashcards
What is Angina?
Mismatch of oxygen demand and supply to heart muscle. Leas to chest pain or discomfort due to reversible ischaemia. Exacerbated by exertion.
What are some types of angina?
Stable angina – the most common type, pain on exertion
Prinzmetal’s angina/Variant angina (coronary artery spasm) – shut down of arteries means increased resistance and decreased flow
Microvascular angina (Syndrome X) – increase in downstream resistance but main arteries are okay
Crescendo angina – occurs at rest with minimal exertion
Decubitus angina – caused by lying flat
Unstable angina – chest pain at rest, can occur at any time. Difficult to distinguish from MI, need to be treated in hospital
Most common cause of stable angina?
Ischaemic heart disease. Narrowing of coronary arteries due to atherosclerosis.
Environmental factors exacerbating angina?
- Cold weather
- Heavy meals
- Emotional stress
Medical conditions that exacerbate angina due to reduced blood supply?
- Anaemia
- Hypoxaemia
- Polycythaemia
- Hypothermia
- Hypovolaemia (shock)
- Hypervolaemia
Medical conditions that exacerbate angina due to increased blood demand?
- Hypertension
- Tachyarrhythmia
- Valvular heart disease
- Hyperthyroidism
- Hypertrophic cardiomyopathy
Risk factors for angina?
- Increasing age
- Cigarette smoking
- Fam Hx
- Diabetes Mellitus
- Hyperlipidaemia
- Hypertension
- Kidney disease
- Obesity
- Physical inactivity
- Stress
Clinical features of angina?
- Crushing central chest pain
- May radiate to arms, neck and jaw
- May have SOB
- Provoked by physical exertion
- Relieved by rest or GTN spray
Investigations for angina?
- 12 lead ECG
- Exercise testing w/ ECG
- Myoview scan - looks at perfusion on exercise
- Stress echo - USS when given inotropic drug
- CT scan calcium scoring
- Coronary angiography
Management of angina?
- Lifestyle: smoking cessation, w loss, diet, exercise
- GTN spray for sx relief
- Statins
- Aspirin
- BB’s - negatively inotropic and chronotropic so reduce O2 demand
- ACE-i
- K+ channel openers
- Ivabradine
Surgical management of angina?
- Percutaneous coronary intervention - including stenting and balloon dilatation
- CABG
Effects of beta blockers on heart?
- Decrease HR
- Decrease LV contractilitity
- Decrease cardiac output
- Decrease oxygen demand
Main s/e of beta blockers?
- Tiredness, nightmares
- Bradycardia
- Cold hands and feet
- Erectile dysfunction – always ask because patients may not volunteer this information
- Depression
C/i for beta blockers?-
- Asthma
- Prinzmetals angina
- Severe heart block
- Excessive bradycardia
Effects of nitrates?
- Predominantly venodilators
- Decrease venous return by increasing venous capacity
- Decreaes preload due to less venous return
- Decreases afterload by causing arterial dilatation
S/e of nitrates?
- Headaches
- Dizziness
- Light headedness
- Nausea
- Flushing
- Burning and tingling under the tongue (GTN)
- Low BP
Effects of CCB’s?
- Decreases blood pressure
- Decreases afterload
- Decreases cardiac oxygen demand
- Coronary artery dilation
- Negatively chronotropic so decreases HR
- Negatively inotropic so decreases LV contraction –decreases cardiac workload
S/e of CCBs?
Arterial dilatation which causes:
- Hot flushes
- Postural hypotension
- Swollen ankles
3 classes of ACS?
1) STEMI - Q wave infarction
2) NTSTEMI - Non Q wave infarction, ST depression/T wave inversion
3) Unstable angina - no ecg changes
How to diagnose each ACS?
STEMI : ECG features at presentation
NSTEMI: Retrospective diagnosis made after troponin results available.
Unstable angina: Use pattern of the pain. No significant troponin rise.
What are the types of MI?
Type 1 – spontaneous MI with ischaemia due to a primary coronary event (e.g. plaque erosion/rupture)
Type 2 – MI secondary to ischaemia due to increased oxygen demand or decreased supply (e.g. coronary spasm, coronary embolism, anaemia, arrhythmias, hypertension, hypotension)
Type 3, 4, 5 – Diagnosis of MI in sudden cardiac death, after PC and after CABG respectively
Causes of ACS?
- Rupture of an atherosclerotic plaque and consequential arterial thrombosis (MOST COMMON)
- Coronary vasopsasm w/o plaque rupture
- Drug abuse (amphetamines, cocaine)
- Dissection of coronary artery due to CTD (eg marfans)
- Thoracic aortic dissection
Risk factors for ACS?
- Male gender
- Increased age
- Renal failure
- LVSD
- Elevated NT-proBNP level
- Fam Hx
- Smoking, diabetes, htn, hyperlipidaemia
- Obesity + Physical inactivity
- Premature menopause
Signs and symptoms of ACS?
- Unremitting cardiac chest pain
- Usually severe but may be mild or absent in a silent MI (be aware that less pain does not mean it’s a ‘better’ MI)
- Occurs at rest
- New onset angina with limitation of ADL’s
- Associated with: Sweating, SOB, nausea and/or vomiting, dyspnoea, fatigue and palpitations
- 1/3 occur in bed at night