CARDIO 269 Flashcards

1
Q

What causes a positive ionotrophy

A

catecholamines, digoxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what causes a negative ionotrophy

A

Uncompensated HF, narcotic overdose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what causes an increases venous return

A

Fluid Infusion, sympathetic activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what causes a dec in venous return

A

Acute Hemorrhage, Spinal anesthesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what increases TPR

A

Vasopressors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what causes a dec in TPR

A

AV shunt, exercise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is isovolumetric contraction

A

period btw mitral valve closure an aortic valve opening

Period of highest oxygen consumption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

period btw the time the aortic valve opens and closes is called

A

systolic éjection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

period btw the aortic valve closure and the mitral valve opening is called

A

isovolumetric relaxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

period just after mitral valve open is called

A

rapid filling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is reduced filling

A

period just BEFORE mitral valve closes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

when do u see an S3 sounds

A

when mitral valve opens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

when do you see s4 sound

A

just before mitral valve closes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

when do you hear the s1 sound and where is it loudest ?

A

mitral and tricuspid valve closure, loudest mitral area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what drug worsens lithium toxicity (Tremors, confusion, Ataxia )

A

NSAIDS, Thiazides and ACE inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the side effects of methotrexate

A

mouth ulcers, nausea, hepatotoxicity (inc AST & ALT), bone marrow suppression (take Folinic acid for reversal) Pulmonary fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is metalloproteinease and what it his function

A

a zinc containing enzyme that degrades collagen, laminin and fibronectin.
it is essential for proper tissue remodeling during wound healing.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what disease do you use Hydroxychloroquine to treat

A

RA & SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

S.E of minocycline

A

a tetracycline (photosensitivity & dermatitis)

20
Q

Naproxen S.E

A

an NSAIDS (gastic ulcers and acute kidney injury)

21
Q

what is the virulent factor for Acute rheumatic fever

A

M protein & anti-n-acetyl-beta- D glucosamine cross react with CNS and Cardiac cells

22
Q

what type of hypersensitivity is acute rheumatic fever?

A

Type 2

23
Q

soap bubble lesion in the brain refers to what pathology

A

cryptococcus neorformins (latex agglutination test is more specific than india ink)

24
Q

headache , facial pain and black necrotic eschar on face what diseaze

A

rhizopus and mucor

25
Q

pressure equation

A

p= Q*R

26
Q

viscosity depends mostly on that?

A

Hematocrit

27
Q

3 things that increase viscosity

A

Polycythemia, Hereditary spherocystosis, hyperproteinemic state ( multiple myeloma)

28
Q

cause of dec viscosity

A

anemia

29
Q

resistance is directly proportional to

A

viscosity and vessel length and inversely proportional to radius to 4th power

30
Q

What vessel has the most TPR

A

Arterioles regulate capillary flow

31
Q

what group of people should you reduce the dose of digoxin or avoid it

A

Elderly due to decrease kidney functions (poor renal clearance)

32
Q

what s2 sound

A

aortic and pulmonary

33
Q

what sound is heard in early diastole

A

s3

34
Q

S3 is associated with what?

A

Dilated cardiomyopathy, CHF, normal in pregnant women nd children

35
Q

what heart sound is heard in late diastole

A

s4

36
Q

a wave

A

atrial contraction

37
Q

C wave

A

RV contraction

38
Q

x descent

A

atrial relaxation and downward displacement of closed tricuspid valve during ventricular contraction

39
Q

absent x decent is seen

A

tricuspid regurg

40
Q

v wave

A

inc RA pressure due to filling against a close tricuspid valve

41
Q

y descent

A

blood flow frm RA to RV

42
Q

what is the physiological reason for a split

A

anything that causes pulmonary valve to close later leads to a split

43
Q

in a normal split what valve closes first

A

aortic valve then pulmonary valve in S1

44
Q

where do you see wide splitting

A

seen in condition that delay RV emptying

Pulmonary stenosis and Right bundle branch block

45
Q

fixed spliting

A

ASD

46
Q

paradoxical splitting

A

anything that delay the left ventricle from emptying

aortic stenosis and left bundle branch block