Cardio Flashcards
What are the cardiac disorders?
Hypertension
Cardiac dysrhythmia
Coronary artery disease
Heart failure
What is hypertension
When SBP > 130
When DBP > 80
What are consequences of HTN
Cardiac disease
Stroke
Renal disease
Peripheral artery disease
Blindness
What is coronary artery disease (CAD)
CAD is caused by plaque buildup in the wall of the arteries
What are symptoms of CAD
angina/chest pain
Shortness of breath
GI symptoms
Myocardial infarction
What are cardiac dysrhythmias/arrhythmias?
Abnormal heart rate and/or rhythm
What are signs and symptoms of cardiac dysrhythmias/arrhythmias
Low CO
heart failure
What is heart failure?
Heart failure occurs when the heart can no longer pump effectively and cannot supply adequate blood to the body
What are the signs and symptoms of left sided heart failure?
Low blood delivered to periphery
Low renal function
Low GI function
Chest pain
Fatigue
Lung congestion
What are the signs and symptoms of right sided heart failure?
Hypoxia
Peripheral edema
Jugular venous distention (JVD)
Hepatic congestion
Hepatomegaly
Ascites
What are the HTN drugs?
ACE inhibitors
A2RBs
Calcium blockers
Alpha 1 and 2 blockers
Beta blockers
MOA for ace inhibitors
Blocks the enzyme (ACE) that converts angiotensin 1 to angiotensin 2. This action promotes vasodilation and excretion of sodium and water from the kidneys
From graph:
Produces vasodilation.. decreases blood pressure.. Lowers hearts workload.. increased blood flow.. increases O2 supply
What is angiotensin 2
A potent vasoconstrictor and also stimulates the release of aldosterone from the adrenal cortex and antidiuretic hormone (ADH).
What is aldosterone
It’s a hormone that causes retention of sodium by the kidneys and ADH acts on the hypothalamus to stimulate thirst and on the kidneys to retain water. These actions attempt to increase blood volume and BP
How do ace inhibitors increase UO?
It blocks aldosterone. The kidneys will no longer hold sodium and retain water, therefore decreasing blood volume which will decrease BP
Prototype for ACEI
Lisinopril
Adverse effects of ACEI
Hypotension- dizziness, light headedness, syncope
Arrhythmias, angina, HF
sexual dysfunction
Hyperkalemia
Angioedema
Persistent dry cough
What is the MOA of angiotensin 2 receptor blockers?
Blocks angiotensin 2 to produce vasodilation
Adverse effects for A2RBs
Hypotension- dizziness, light headedness, syncope
Arrhythmias, angina, HF
sexual dysfunction
Hyperkalemia
Angioedema
Cough (less)
What are teachings for ACE and ARBs?
Monitor electrolytes especially K
Monitor renal function: BUN, creatine, EGFR
Avoid salt substitutes and foods with high potassium
What are specific teachings for all HTN drugs?
Same time and stagger if > 1
Don’t abruptly stop
No hot weather
No excess alcohol
MOA for calcium channel blockers
Blocks Ca+ channels in vascular smooth muscle walls which increases vasodilation
Generic names for calcium blockers
Nifedipine
Diltiazem
Verapamil
Amlodipine
Adverse effects for calcium blockers
Bradycardia or reflex tachycardia
Orthostatic hypotension
Constipation (with Verapamil)
Edema