Cardinal Presentations Flashcards
This deck covers Chapters 9-32 in Rosens, compromising all of the cardinal presentations.
List 2 outpatient and 2 inpatient antibiotic regimens for PID
Outpatient
- Doxycycline + Ceftriaxone + Flagyl
- Levofloxacin + Flagyl
Inpatient
- Clindamycin + Gentamycin
- Cefoxitin + Doxycycline
List 4 risk factors for C. difficile
- Recent hospitalization
- Recent antibiotics
- LTC facility
- Antacid use
List 5 reasons why you may not be able to visualize the optic fundus on fundoscopy
- Hyphemia
- Cornea scar
- Cataract
- Miotic pupil
- Vitreous hemorrhage
- Retinal detachment
What is the definition of massive hemoptysis? What is the usual source?
>500 cc/24h or >100 cc/hr
- Bronchial artery (90%)
- Pulmonary artery
List 6 risk factors for renal colic
- Male
- FHx
- Previous stone
- Dehydrated
- Hot climates
- Metabolic disturbance
List 8 causes of neuromuscular weakness that are life-threatening
- Stroke
- GBS
- MG
- LES
- Tick
- Botulism
- Tetanus
- Organophosphates
- ALS
- Pufferfish
- SEH
- SEA
- Transverse myelitis
What enzyme reduces met-HgB?
NADH MetHgB reductase
List 5 risk factors for serious abdominal pathology
- Age >60
- Previous OR
- Recent OR
- Fever/Rigors
- IBD
- Cancer
- Chemotherapy
- Immunocompromised
- Child-bearing age
- Recent immigrants
- Language barrier
List 5 causes of cervical motion tenderness
- PID
- Ovarian torsion
- Ovarian cyst
- TOA
- Ectopic
- Endometriosis
- Appendicitis
- Peritonitis
List 3 BPPV variants and their provocative and curative maneuver
-
Posterior (MCC)
* Dx: Dix-Hallpike
* Tx: Epley -
Horizontal
* Dx: Supine roll
* Tx: BBQ roll -
Anterior
* Dx: Dix-Hallpike
* Tx: Deep Head Hanging
List 5 risk factors for PUD/Gastritis
- H. pylori
- NSAIDs
- Alcohol
- Steroids
- Smoking
- Critical Illness
List 6 complications of vomiting
- UGIB (Mallory-Weiss)
- Aspiration
- Esophageal perforation (Boerhaave’s)
- Electrolyte abnormalities (HypoCl-/K+)
- Metabolic Alkalosis
- Dehdyration
List the 5 common causes of any ocular nerve palsy
- Aneurysm
- Diabetes
- CVST
- Tumour
- Trauma
- MS = CN3
- MG = CN4 (longest/thinnest and most prone to trauma)
- ICP = CN6
Describe 6 classic findings when performing the Dix-Hallpike maneuver in someone with posterior canal BPPV
- Symptomatic when head down
- Latency of nystagmus
- Geotropic nystagmus (up/rotatory ground)
- Nystagmus resolves within 30s
- Fatiguable on repeated testing
- Direction-changing when sitting up
List 10 causes of hemoptysis
Airway
- FB
- Bronchitis
- Bronchiectasis
- Cancer
- Trauma
Parenchymal
- Pneumonia
- TB
- Cancer
Vascular
- PE
- AVM
- Pulmonary HTN
- Vasculitis
Hematologic
- OAC
- Coagulopathy
- DIC
- Thrombocytopenia
Cardiac
- Endocarditis
- Valvular heart disease
- CHD
Miscellaneous
- Cocaine
- SLE
- Tracheal-arterial fistula (trach)
- Post-procedural
List 5 red flags with headache
- Sudden onset
- Syncope
- Focal deficits
- Trauma
- Fever
- Immunocompromised
- Weight loss
- Cancer history
- Elderly
- No history of headaches
List 6 causes of methemoglobinemia
- Nitrites
- Nitrates
- Topical anesthetics (lidocaine, benzocaine)
- Antibiotics (dapsone, sulfa)
- Anti-malarials (quinones)
- Antineoplastics (cyclophosphamide)
- NADH Met-HgB reductase deficiency
- G6PD deficiency
- Mothballs
Give 6 categories for causes of central cyanosis
- Shunt
- V/Q mismatch
- Diffusion
- Low FiO2
- Hypoventilation
- Hemoglobinopathy
Define orthostatic hypotension
5 min supine, stand, measure BP within 2-5 min
>20 mmHg drop in sBP
>10 mmHg drop in dBP
List 3 antibiotics that are 1st line for GAS sore throat and 2 if PCN-allergic.
No allergies
- Pen G IM
- Pen V PO
- Amoxicillin PO
PCN Allergic
- Azithromycin
- Clindamycin
Give a DDx of 8 items that cause hyperthermia (not fever)
- Stroke
- Seizure
- DVT
- CHF
- MI
- Pulmonary edema
- Pancreatitis
- Crohn’s/UC
- Gout
- Cancer
- Hyperthyroidism
- SS/NMS/MH
- Transfusion reaction
- Drugs
List 4 admission criteria for PID
- Unable to tolerate PO antibiotics
- Failure of PO antibiotics
- Pregnant
- Toxic
- TOA
List 5 critical diagnoses that cause pelvic pain in women
- Ovarian torsion
- PID
- Ectopic pregnancy
- Placental abruption
- Uterine rupture
- TOA
List 7 critical diagnoses that present with vomiting
- ICH/Stroke
- ACS
- Boerhaave’s
- Bowel Ischemia
- Ovarian/Testicular torsion
- DKA
- Sepsis
- Pregnancy
- Organophosphate
Define weakness
Lacking physical strength, energy, or vigor (feeble)
List 4 things that shift the oxy-HgB curve to the left
(higher affinity for oxygen)
- Decreased temp
- Decreased H+
- Decreased 2,3-DPG
- Carboxy-HgB
- Met-HgB
- Fetal-HgB
List 8 causes of binocular diplopia
Orbital
- Grave’s, Hematoma, Abscess, Entrapment
Oculomotor
- CN3/4/6 palsy
Neuro-muscular
- GBS, Tick, LES, MG
Brain
- MS, Migraine, Tumour
Vascular
- Aneurysm, Dissection, CVST
List the 4 components of the MacIsaac-Centor score
- Fever
- Exudative tonsils
- No cough
- Anterior lymphadenopathy
- Age
What are 6 requirements for the use of methotrexate for therapeutic abortion?
- Small (<3.5cm)
- BhCG <5000
- No fetal heart beat
- Hemodynamically stable
- Not ruptured
- Good follow-up
After what week in pregnancy is a pelvic exam contraindicated without an ultrasound to rule out previa?
20 weeks
List 6 factors that increase mortality in LGIB
- Age >70
- Male
- Transfused
- Intestinal ischemia
- OAC use
- Comorbid
What are the three main categories for causes of jaundice? Give a DDx for 5 for each.
Overproduction
- Hemolysis
- Hemoglobinopathy
- Membranopathy
- Enzymopathy
- Sepsis
- ABO incompatibility
- Breast milk jaundice
- Breastfeeding jaundice
- HEELP syndrome
Hepatocellular
- Infectious (Hepatitis)
- Ischemic
- Drugs (Tylenol, EtOH, etc.)
- Autoimmune
- Metabolic (Gilbert, Wilson)
- Budd-Chiari
Obstructive
- Cholangitis
- Choledocholithiasis
- Choledochal cyst
- Biliary atresia
- Biliary stricture
- Cancer
- CF
- Sepsis
List 4 treatment options for stable abnormal uterine bleeding
- OCP
- Progestin-only OCP
- Estrogen IV
- NSAIDs
- TXA
- Lupron
How much do HR and RR increase with fever?
HR = 10 bpm/degree
RR = 5 bpm/degree
List 6 ‘can’t miss’ diagnoses for sore throat
- PTA w/ airway compromise
- RPA w/ airway compromise
- Epiglottitis w/ airway compromise
- Croup w/ stridor at rest
- Lemierre’s
- Ludwig’s
- Angioedema
- Anaphylaxis
- ACS with referred pain
Give a DDx of 8 for altered mental status
DIMES
- Drugs (BZD, opiates, sedatives, EtOH, toxin)
- Infection (sepsis, CNS infection)
- Metabolic (hypoglycemia, hypoxia, hepatic/renal failure)
- Endocrine (adrenal insufficiency, hypo/hyperthyroid)
- Structural (mass, bleed, stroke)
List 5 critical causes of hemoptysis
- PE
- Tracheoinominate fistula
- Aortotracheal fistula
- DIC
- Post-procedural
List 4 inclusion criteria for the Ottawa SAH Rule.
Inclusion
- Age >15
- Max intensity with 1hr
- Non-traumatic
- GCS 15
Rule:
ANT LEaF
- Age >40
- Neck stiffness
- Thunderclap
- LOC
- Exertional
- Flexion limited
List 5 categories of Type 1 and Type 2 respiratory failure
Type 1 (Hypoxemic)
- V/Q mismatch
- Shunt
- Low FiO2
- Diffusion
- Hypoventilation
- Hemoglobinopathy
Type 2 (Hypercarbic)
- Hypoventilation
- Neuromuscular
- Obstructive
- Chest wall disorder
- Decreased gas exchange area
List 4 indications for OR with a GI bleed
- Hemorrhage despite endoscopic therapy
- 4 units pRBCs within 1 hr
- Indication for surgery as the cause of bleed (perf)
- Life-threatening hemorrhage despite resuscitation
List 5 indications to get a CT scan after a seizure
- First seizure
- Age >65
- >15 minutes
- Focal neuro deficits
- Persistently altered
- Immunocompromised
- Trauma history
- Cancer history
Give 4 causes of invasive and non-invasive infectious diarrhea
Invasive
- E. coli H157:07
- Yersinia
- Campylobacter
- Shigella
- Salmonella
Non-Invasive
- ETEC
- Vibrio vulnificus
- Vibrio cholera
- C. diff
- C. perfringes
List 6 red flag symptoms for constipation
- Fever
- Anorexia
- Weight loss
- Blood in stool
- Anemia
- Nausea/Vomiting
- Onset >50yo
- FHx of colon cancer
List 5 causes of persistent altered mental status after seizure
- NCSE
- Bleed
- Meningitis
- Hypoglycemia
- Drug toxicity
- Psychogenic
- Migraine
- Transient global amnesia
- Metabolic encephalopathy
List 8 risk factors for short term risk of serious adverse outcome following syncope
- No prodrome
- Palpitations
- Long duration
- Exertional
- Seated at onset
- Age >65
- Male
- Hx of arrhythmia
- Hx of structural heart disease
- FHx of sudden cardiac death
San Francisco Rule (CHESS)
- CHF
- HCT <30%
- ECG changes
- SOB
- SBP <90 mmHg
What is the triad of fulminant hepatic failure?
- Jaundice
- Encephalopathy
- Coagulopathy
List 3 causes of seizure in a patient with HIV
- Toxoplasmosis
- Cryptococcus
- CNS Lymphoma
- PML
- HIV Encephalopathy
- CMV Encephalitis
- Brain abscess
- TB
Provide the DSM-5 criteria for delirium (5)
- Acute and fluctuating
- Alterations in attention/awareness
- Alterations in cognition
- Due to GMC or substance
- Not due to dementia
What is the San Francisco Syncope rule?
CHESS
- CHF
- HCT <30%
- ECG changes
- SOB
- SBP <90
Any of the above predicts adverse outcome at 7 days
Sensitivity in derivation = 96%; in validation = 90%
List 5 first-line agents for migraine treatment
- Triptans
- NSAIDs
- Metoclopramide
- Prochlorperazine
- Dexamethasone
List 5 causes of non-neurologic weakness
- Dehydration
- Electrolyte/Glucose abnormalities
- Anemia
- MI
- Shock
- Infection
- Mitochondrial dysfunction (sepsis/toxin)
- Sedation (toxins)
When would you consider starting someone on an anticonvulsant after their first seizure?
High likelihood of recurrence:
- Todd’s paralysis
- Partial seizures
- Status epilepticus
- HIV
- Previous CNS surgery
Keppra 250 mg PO BID
What is the Canadian Syncope Risk Score?
Clinical
- Vasovagal predisposition
- sBP <90 or >180 (2)
- Heart disease
Investigations
- QRS >130 ms
- Axis deviation
- QTc >480 ms
- Troponin AbN (2)
Diagnosis
- Vasovagal (-2)
- Cardiac (2)
Define syncope
A sudden, transient LOC with spontaneous recovery
What are 2 indications to treat Met-Hgb?
How do you treat Met-HgB?
What is the mechanism of action of methylene blue?
Indications:
- Symptomatic
- >30%
Dose & Mechanism:
- Methylene Blue 1-2 mg/kg
- via NADPH to leukomethylene blue (LMB)
- LMB reduces MetHgB to HgB
List 5 ototoxic drugs
- Aminoglycosides
- Lasix
- Alcohol
- ASA
- Deferoxamine
- Anticonvulsants
- Quinine
- Chemotherapy
List 4 suppurative and 4 non-suppurative complications of GAS sore throat
Suppurative
- PTA
- RPA
- Lemierre’s
- Mastoiditis
- Cervical lymphadenitis
Non-suppurative
- Scarlet fever
- Rheumatic fever
- Glomerulonephritis
- PANDAS
What is a normal A-a gradient?
< 15 mmHg
List 4 indications to admit someone following syncope
- Chest pain
- Dyspnea
- CHF
- Valvular disease
- AbN ECG
List 7 critical diagnoses that present with back pain
- Aortic dissection
- ACS
- Pneumothorax
- AAA
- Spinal fracture with cord involvement
- Cauda equina
- SEA
- SEH
List 5 causes of an adnexal mass
- Ovarian tumour
- Ovarian cyst
- Ovarian torsion
- TOA
- Ectopic pregnancy
List 3 ways to stop bleeding in a tracheoinominate fistula
- Trach balloon
- Foley
- Finger
Give 8 critical diagnoses causing coma
DIMES
Drugs
- Opioids
- Hypoglycemic agents
Infection
- Sepsis
Metabolic
- CO
- MetHgB
- Asphyxiants
Endocrine
- Hypoglycemia
- Hyperglycemia
- Adrenal insufficiency
Structural
- Stroke
- Bleed
List 7 precipitants of hepatic encephalopathy
BEDRAIL-C
- Bleeding
- Electrolyte AbN
- Drugs (Opiates/Sedation)
- Renal failure
- Alcohol withdrawal
- Infection
- Large protein meals
- Constipation
List 5 critical diagnoses for infectious fever
- Pneumosepsis
- Peritonitis
- Meningitis
- Lemierre’s syndrome
- CVST
- Septic shock
List 5 triggers for migraine
- Caffeine
- Chocolate
- Stress
- Lack of sleep
- Menses
- Weather changes
- Alcohol
List 5 causes of peripheral neuropathy
- Diabetes
- Compression
- Heavy metals
- Trauma
- Malignancy
- Vasculitis
- B12 deficiency
- Alcohol
- HIV
- Critical illness
List the components of triple therapy for H. pylori
- Amoxicillin
- Clarithromycin
- PPI
List 6 principles of neuroprotective resuscitation
- HOB 30
- Remove constricting items from neck
- Avoid hypoxia/hyperoxia
- Avoid hypo/hypercarbia
- Avoid hypo/hyperglycemia
- Avoid hyperthermia
- Avoid hypotension
- Prevent and treat seizure
List 6 indications for intubating a patient with weakness and ventilatory insufficiency
- Hypoxia
- Decreased LOC
- Unable to handle secretions
- Increasing CO2
- FVC <20 cc/kg
- MIP <30 cmH2O
- MEP <40 cmH2O
What are the components of the CAM score for delirium?
Acute/Fluctuating AND Inattentive
AND
Disorganized OR Altered
List 7 tests to order in pediatric jaundice
- CBC
- Smear
- Bilirubin
- Coombs
- G6PD
- TSH
- Ultrasound
- +/- septic workup
List 7 risk factors for a ‘high-risk’ GI bleed
- Advanced age
- ASA, NSAIDs, Steroid, OAC use
- EtOH abuse
- Smoker
- Cirrhosis
- PUD
- AAA repair
- Comorbid
List 6 syncope mimics
- Seizure
- Hypoxia
- Hypoglycemia
- Narcolepsy
- Toxin
- Psychogenic
List 4 conditions that increase the risk of neurotoxicity from unconjugated bilirubinemia
- Hemolysis
- Hypoalbuminemia
- Acidosis
- Drugs that compete for albumin binding
What is the definition of status epilepticus? Refractory status? Super-refractory status?
Status Epilepticus
- >5 min or 2 seizures without full recovery between
Refractory Status
- Seizing despite BZD + 1 AED (often Dilantin)
Super-refractory Status
- Seizing 24h+ despite anesthetic therapy
- Propofol, Midaz, Barbituates
What is a contraindication to methylene blue? How would you treat someone with the contraindication?
Contraindicated in G6PD
If Met-HgB + G6PD: ascorbic acid, exchange transfusion/HBO
What are the components of the MMSE?
ORArLL 23 RWD
- Orientation
- Registration
- Attention
- RecalL
- Language
- Identify 2 objects
- Follow 3-step command
- Reading
- Writing
- Drawing
List 4 treatment strategies for hepatic encephalopathy
- Fix reversible causes
- Lactulose
- Flagyl
- Rifaxamin
- Low protein diet
List the 4 stages of hepatic encephalopathy
- MCI/Tremor
- Confusion/Asterixis
- Stuporous/Clonus
- Coma/Posturing
Provide a DDx of 6 for seizure
- Syncope
- PNES
- Panic attack
- Cataplexy
- Tics
- Migraine
- Rigors
- Hypoglycemia
- Intoxication
- Thyrotoxicosis
- Delirium Tremens
- Tetanus
- CNS infection
List 4 complications of PUD.
- Perforation
- Penetration
- Hemorrhage
- Obstruction
For detecting an IUP, what is the discriminatory BhCG for TAUS and TVUS? What are the U/S findings that confirm an IUP?
Discriminatory Zone
- TAUS = 6,000
- TVUS = 1,500
U/S Findings
- Gestational sac
- Yolk sac/fetal pole
- >8mm myometrial mantle
- Bladder juxtaposition
List the top 3 causes of post-menopausal bleeding
- Endometrial cancer/hyperplasia
- Exogenous hormone use
- Atrophic vaginitis
List 6 findings that are associated with serious eye diagnoses
- Severe pain
- Loss of vision
- Contact lenses
- Unreactive pupil
- Corneal opacification
- Ciliary flush
- Exophthalmos
- Immunocompromised
- Neonate
- Worsening on treatment
What defines a negative LP for SAH?
- No xanthochromia
- RBCs < 2000
List 4 mechanisms that can explain diarrhea
- Osmotic
- Secretory
- Inflammatory
- Motility
List 4 characteristics that differentiate peripheral from central nystagmus
Central
- Vertical
- Direction changing
- Non-fatiguable
- Spontaneous
- Downbeating (toward nose)
List 4 causes of cauda equina syndrome
- Trauma
- Herniation
- Tumour
- Hematoma
- Abscess
List 5 types of seizure with special treatment
- Eclampsia
- Hypoglycemia
- Hyponatremia
- Drugs (INH, TCA, ASA)
- ICP
List 4 cytokines involved in fever production.
- IL-1
- IL-6
- TNF-a
- Interferon
List 8 risk factors for ectopic pregnancy
- IVF
- PID
- IUD
- Previous ectopic
- Previous Tubal surgery
- Previous D&C
- Smoking
- Age
List 8 critical diagnoses to consider in a patient with syncope.
- Stroke
- SAH
- Arrhythmia
- MI
- Severe AS
- HOCM
- Tamponade
- Dissection
- AAA
- PE
- Ectopic
- Hemorrhage
List 5 causes of peripheral vertigo and 5 causes of central vertigo
Peripheral
- BPPV
- Labyrinthitis
- Vestibular neuritis
- Meniere’s
- AOM
- Acoustic neuroma
Central
- Stroke
- Tumour
- Vestibular migraine
- MS
- Meningitis
- Toxin (EtOH, Ketamine)
List 5 contraindications to OCP
- Smoking
- Age >35
- Migraine with focal symptoms
- VTE
- HTN
- Ischemic heart disease
- Stroke
- Liver disease
- Breast cancer
- Pregnancy
List 5 reasons to get stool cultures in someone with diarrhea
- Symptoms >2 weeks
- Fever
- Severe symptoms
- Immunocompromised
- Recent antibiotics
- Recent hospitalization
- Bloody stool
What are the minimum criteria to diagnose PID?
Minimum
- Sexually active female
- Pelvic pain
- Adnexal tenderness/CMT
Additional Criteria
- Mucopurulent cervical discharge
- Gonorrhea/Chlamydia cultured
- WBCs on microscopy
- Fever
- Elevated ESR/CRP
List 3 populations who should receive Thiamine 100 mg IV on spec
- Malnourished
- Alcohol dependence
- Hyperemesis
List 8 critical diagnoses causing dyspnea
- Anaphylaxis
- Obstruction
- Epiglottis
- Tension PTX
- Pulmonary edema
- PE
- Pneumosepsis
- ACS
- Tamponade
- DKA
- Toxin (CO, ASA)
List 5 causes of monocular diplopia
- Iridodialysis
- Refractive error
- Lens dislocation
- Cataracts
- Corneal scar
- Conversion disorder
List the results from the HINTS exam that would point to peripheral cause
- HI - catch up saccade
- N - unilateral, non-direction changing
- TS - no skew deviation
What is the PALM-COINE in relation to abnormal uterine bleeding?
PALM - Structural Causes
- Polyp
- Adenomyosis
- Leiomyoma
- Malignancy
COINE - Non-Structural Causes
- Coagulopathy
- Ovulatory dysfunction
- Iatrogenic
- Not yet classified
- Endometrial
Give 5 categories for causes of peripheral cyanosis
- Low CO
- Cold environment
- Venous occlusion
- Arterial occlusion
- Flow redistribution
List the 6 components of a slit-lamp exam
- Lashes/Lacrimals
- Sclera/Conjunctiva
- Cornea
- Iris
- AC
- Lens