Cardiac Drug Profiles Flashcards

1
Q

Acetylsalicyclic Acid Names/Class

A

Acetylsaicylic Acid, ASA, Aspririn

Class: Analgesic, anti inflammatory, antipyretic

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2
Q

ASA Indications

A

CP or s/s suggestive of MI
Unstable Angina
Pain, Discomfort, Fever (adult only)

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3
Q

ASA contraindications

A

Hypersensitivity
Bleeding ulcer, hemorrhagic state, Hemophilia
Children or adolescents

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4
Q

ASA MOA

A

Blocks Thromboxane A2 (platelet aggregate and vasoconstrictor)
Decreases platelet aggregation

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5
Q

ASA adverse reactions

A

Caution with asthma, anaphylaxis in sensitive PT have occurred, Skin eruptions

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6
Q

ASA Dose (adult)

A

Cardiac: 160-325 PO (2-4 pediatric tablets)

Pain/discomfort/fever: 325 mg PO

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7
Q

Adenosine Names/Class

A

Adenosine

Brand: Adenocard

Class: Antiarrythmic, Endogenous nucleoside

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8
Q

Adenosine MOA

A

Slows conduction through AV node
Slows sinus rate
Larger doses decrease BP by decreasing peripheral resistance

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9
Q

Adenosine Indications

A

SVT with no known AFib or Aflutter

Undifferentiated regular monomorphic wide complex tachycardia

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10
Q

Adenosine Contraindications

A

Sick sinus syndrome, 2nd or 3rd degree block (except PT with functioning pacemaker)
Theophylline and related Methylxanthines
Dipyramidole (persantine) and carbamazepine (tegretol)
Known Afib/Aflutter
Pregnancy

Caution: asthma and cardiac tranplant PTs (more sensitive)

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11
Q

Adenosine Adverse Effects

A

CV: Systole bradycardia, and PVCs occur in 55% of PTs, palpitations, chest pressure, chest pain
Resp: Dyspnea, hyperventilation, facial flushing, sweating
CNS: Lightheadedness, headache, dizziness, parathesia apprehension, blurred vision, neck/back pain
GI: N/V, mettalic taste

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12
Q

Adenosine incompatability/interactions

A

Adenosine is not blocked by atropine
Theophylline and methylxanthines decrease effectiveness
Dipyradimole (persantine/blood thinner) and carbamazepine (tegretol/seizure med)) block uptake and potentiate effects

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13
Q

Adenosine Dosage (ad and ped)

A

Adult: 6mg rapid push W/20 ml NS flush, can repeat in 1-2 minutes with 12mg

Ped: 0.1 mg/kg rapid push with 2-3 ml NS flush, may double one time (0.2 mg/kg) MAX DOSE: 12mg

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14
Q

Amiodarone Names/Class

A

Amiodarone

Brand: pacerone, nexterone

Class: Antiarrythmic

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15
Q

Amiodarone MOA

A

Multiple effects on Na, Ca, and K channels
Prolongs action potential, refractory peros
K channel blockade increases ventricular automaticity
Na Channel blockade slows membrane depolirization and impulse conduction
Ca channel and Beta blockade has a negative chronotropic effect
Dilates coronary arteries due to Ca channel and Alpha-adrenergic blocking action

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16
Q

Amiodarone Indications

A

Defib refractory VF/Pulseless VT
Polymorphic VT
Wide complex tachycardia of uncertain origin
Control hemodynamically stable VT with cardoversion is not successful
Adjunct to cardioversion of SVT and PSVT
Rate control in AF/Aflutter

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17
Q

Amiodarone Contraindications

A
Bradycardia
2nd or 3rd degree heart blocks without  functioning pacemaker
Cardiogenic shock
Hypotension
Pulmonary congestion

Caution: temperature control is needed (77 F)

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18
Q

Amiodarone Adverse reactions

A

CV: Bradycardia, hypotension, asystole/cardiac arrest, AV block, Torsades, CHF
GI/Hepatic: N/V, abnormal liver function test
Skin: Slate blue pigmentation
Other: Fever, Headache, dizziness, fever, flushing, abnormal salivation, photophobia

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19
Q

Amiodarone Incompatibilities/interactions

A

Beta Blockers, Ca channel blockers, and other antiarrythmics are additive and can be proarrhythmic (BP Meds)
Precipates at Y site with Na Bicarb, Furosemide, and heparin

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20
Q

Amiodarone Dose (ad and Ped)

A

Adult
VF/Pulseless VT: 300 mg IV push over 30-60 seconds, may repeat in 3-5 minutes with 150 mg
Wide complex Tachycardia. Aflut, Afib, SVT with cardioversion: 150 mg Iv over 10 mins, may repeat every 10 mins. (in 50 mL bag of D5W)
Maint infusion post arrest/conversion: 1 mg/min infusion over 6 hours, then 0.5 mg infusion over 18 hours (max daily of 2.2 mg)

mix 450 mg in 250 mL D5W makes 1.8 mg/mL, run at 33.3 mL/hr for 1 mg/min or 16.7 mL for 0.5 mg infusion

Peds:
VF/Pulseless VT: 5 mg/kg (max 300 mg) may repeat every 5 minutes twice to a max of 15 mg/kg/day
Probable VT w/pulse: 5 mg/kg over 20 minutes, can be repeated twice for max of 15 mg/kg/day

Needs to be mixed in D5W bag because it is polyolefin

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21
Q

Atropine Sulfate Names/Class

A

Atropine Sulfate

Class: Anticholinergic, antimuscarinic, antidote, antispasmodic, antiarrhythmic

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22
Q

Atropine Sulfate MOA

A

Blocks ACH as a competitive antagonist at muscarinic receptor sites in smooth muscle, secretory glands and CNS.
Blocks parasympathetic response, allowing sympathetic to take over.
Reverses muscarinic effects of cholinergic poisoning by reversing bronchorea and bronchodilation
At higher doses, may affect the nicotinic receptors

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23
Q

Atropine Sulfate Indications

A
Symptomatic bradycardia (Sinus, Junctional, or AV block causing hypotension, ventriculat ectopy, CP, or ALOC)
ACH poisoning (organophsophate)
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24
Q

Atropine Sulfate Contraindications

A

Hypersensitivity or Belladonna alkaloid allergy
Acute narrow angle glaucoma
Tachycardia
Obstuctive GI , Renal, or hepatic disease
Myasthenia Gravis (unless using as ACH inhibitor)
Asthma
Thyrotoxicosis
Mobitz Type II and 3rd degree block

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25
Q

Atropine Sulfate Adverse reactions

A

Major: Tachydysrhythmias, flushing, ventricular irritability, angina, acute narrow angle glaucoma, blurred vision, pupil dilation (mydriasis), agitation to delirium, bloating, constipation, decrease GI activity
Minor: Dry mouth/mucous membranes, loss of taste, N/V, Urinary retention, nueromuscular weakness, decreased sweating/increase body temp

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26
Q

Atropine Sulfate Incompatibilities/reactions

A

Thiopental, cimetidine, pentobarbital, floxacillin, metaraminol, methohexital, NE, NA bicarb
Increases effects of anticholinergics, cannaboids, and KCl.
Decreases effects of phenothiazines, ACHesterase inhibitors, and secretin
Atropine and psychotropics may have additive anticholinergic effects (dry mouth, blurry vision, etc)
Pramintide may increase effectiveness
ACHesterase inhibitors may decrease effect of atropine

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27
Q

Atropine Sulfate Dose (ad and Ped)

A

Adult:
Symptomatic Bradycardia: 0.5 mg every 5 minutes MAX of 3mg or 0.04 mg/kg
Organophosphate poisoning: initial 1-5 mg IV/IO every 5 minutes until signs abate, IV infusion of 0.5 - 1 mg or 10-20% loading dose/hr. Repeat every 10 mins.
IM Atropen: 2mg as soon as exposure is known, if severe symptoms develop, give 2 more doses (MAX of 3) Severe symptoms immediately admin (3) 2mg doses

Peds:
Symptomatic bradycardia: 0.02 mg/kg IV/IO every 5 mins (MAX of 1mg in children/2mg in adolescents.
Organophosphate poisoning: 0.03-0.05 mg/kg every 10-20 mins until signs abate, then every 1-4 hrs for 24 hrs
IM: Same guidelines as adult
<15 lbs (6.8 kg): not recommended, admin atropine .05mg/kg
15-40 lbs (6.8kg-18kg): 0.5 mg/dose
40-90 lbs (18-41kg): 1mg/dose
>90lbs (41kg): 2mg/dose

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28
Q

Calcium Chloride Names/Class

A

Calcium Chloride

Class: Electrolyte

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29
Q

Calcium Chloride MOA

A

Positive inotropic effect
Inhibits effects of adenosine on mast cells
Stimulate release of Catelcholamines
May enhance ventricular automaticity

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30
Q

Calcium Chloride Indications

A
Hypocalcemia
Ca channel blocker OD (Amlodipine, diltiazem, verapamil)
Acute HyperK
Hypermagnesemia (OD)
Pretreat for Ca Channel blockers
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31
Q

Calcium Chloride Contraindications

A
Hypercalcemia
Digoxin therapy (relative)
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32
Q

Calcium Chloride Adverse reaction

A

Brady-asystolic arrest

Tissue necrosis with extravasation

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33
Q

Calcium Chloride Incompatabilities/Interactions

A

ALL DRUGS, flush line before and after admin

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34
Q

Calcium Chloride Doses (ad and ped)

A

Adult:
Hypocalcemia, Ca Channel OD, HyperK, and HyperMag: 5-10 mL (0.5-1gm) may repeat in 10 mins
Pretreatment for Ca Channel blockers: 3 mL, may repeat once

Peds:
Hypocalcemia, Ca Channel OD, HyperK, and HyperMag: 0.2-0.25 mL/kg slow infusion, do not repeat w/o documented Ca deficiency

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35
Q

Diltiazem Names/Class

A

Diltiazem

Brand: Cardizem

Class: Ca Channel blocker, Calcium antagonic

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36
Q

Diltiazem MOA

A

Pharmacological: Decreases SA/AV conduction and dilates coronary and peripheral arteries and arterioles by inhibiting Ca ion influx across cell membranes during cardiac depolarization

Clinical effects: Slows rapid ventricular rate associated with Afib/Aflutter, reduces coronary and peripheral resistance

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37
Q

Diltiazem indications

A

Rapid Ventricular Rates with Afib/Aflut

Paroxysmal SVT refractory to adenosine

38
Q

Diltiazem Contraindications

A
Hypotension below 90mm/Hg
AMI
Cardiogenic shock
VTach or wide complex VT of unknown origin
2nd or 3rd degree AV block
WPW
Sick sinus syndrome
Beta blocker use
39
Q

Diltiazem Adverse reactions

A

CV: Hypotension, bradycardia, heart block, chest pain, asystole
GI: N/V
CNS: Headache, fatigue, drowsiness

40
Q

Diltiazem Incompatibilties/reactions

A

Avoid in PTs with suspected poison/drug induced tachycardia

CaCl can be used to prevent hypotensive effects and treat CaCl blocker poisoning

41
Q

Diltiazem Dose (ad)

A

Adult: 0.25 mg/kg over 2 minutes, if no response, repeat in 15 minutes at 0.35 mg/kg over 2 mins
Maintenance infusion of 5-15 mg/hr

42
Q

Dopamine Names/Class

A

Dopamine

Brand: Inotropin

Class: Sympathomimetic

43
Q

Dopamine MOA

A

1-2 mcg/min: acts on dopaminergic receptors to stimulate cerebral, renal, and mesenteric vasculature to dilate. HR and BP are usually unchanged, may increase urine output
2-10 mcg/min: Beta 2 stimulant, antagonizes A-Adrenergic mediated vasoconstriction. Results in Increased cardiac output, and modest increase in systemic vascular resistance
10-20 mcg/min: A Adrenergic effects resulting in renal, mesenteric, and venous vasoconstriction. marked increase in SVR, pulmonary vascular resistance, and further increased preload
>20 mcg/min: Hemodynamic effects similar to NE, may increase in HR and O2 demand to undesirable limits.

44
Q

Dopamine indications

A

Symptomatic bradycardias

Hemdoynamically significant hypotension in absence of hypovolemia

45
Q

Dopamine Contraindications

A
Pheochromocytoma
MAO inhibitors (causes HTN crisis)

Relative: hypovolemic shock

46
Q

Dopamine Adverse reactions

A

CV: Arrythmias from increased O2 demand, HTN, hypotension at lower doses
GI: N/V
GU: Renal shutdown at higher doses

Extravasation causes necrosis

47
Q

Dopamine Incompatabilities/interatctions

A

ANY ALKALINE SOLUTION

48
Q

Dopamine Dose (ad and ped)

A

Adult: 2-20 mcg/min (400mg/250 mL NS or DX makes 1600 mcg/mL.
Bradycardia starts at 5 mcg/min
Cardiogenic/Non hypovolemic septic shock : BP <70 systolic start at 5mcg/min. BP >70 start at 2.5 mcg/min

Peds: 2-20 mcg/min for circulatory shock or shock unresponsive to fluid admin.
6 x kg = mg to add to NS to make 100 mL (1mL/hr delivers 1 mcg/kg/min, titrate)

49
Q

Epinephrine Names/CLass

A

Epinephrine HCL

May be called adrenaline

Class: Sympathomimetic

50
Q

Epinephrine MOA

A

Pharm: Alpha and Beta agonist, increase SVR with visceral arterial constricton. Beta1: positive ino/chronotoropic effects (increase Myocardial workload and O2 demand, increased automaticity and irritability. Beta 2: bronchial smooth muscle relaxation and dilation of skeletal vasculature. (blocks histamine release)
Clinical effect: Cardiac arrest use increases cerebral and Myocardial perfusion pressures, systolic and diastolic BP, electrical activity in the heart. Can stimulate contractions in asystole. Bradycardia: increases HR/BP. Reverses S/S of anaphylaxis and bronchospasm

51
Q

Epinephrine Indications

A

Cardiac arrest: VF/PVtach, asystole, PEA
Severe bronchospasm
Anaphylaxis
Bradycardia, refractory w/profound hypotension (monitored)
Hypotension unresponsive to other therapy (monitored)
Croup

52
Q

Epinephrine Contraindications

A

Non in cardiac arrest

Hypothermia is relative

53
Q

Epinephrine adverse reactions

A

CV: HTN, Ventricular dysrythmias, tachycardia, angina
CNS: Anxiety and agitation
GI: N/V

54
Q

Epinephrine incompatibilities/interactions

A

Potentiates other sympathomimetics

Reacts with alkaline solutions

55
Q

Epinephrine Adult Dose

A

Pulseless arrest: 1mg 1:10000 every 3-5 mins
ET: 2-2.5 mg 1:10000
Hypotension/symptomatic bradycardia: 1 mg/500mL NS @ 1 mcg/min titrated (2-10 mcg/min and not frontline)
Anaphylaxis: 0.3-0.5 mg 1:1000 every 10-15 mins. May be asked to give 1:10000 @ 0.1 mg every 5 mins or continuous infusion of 1-4 mg/min

56
Q

Epinephrine Ped dose

A

Pulseless arrest/refractory bradycardia: 0.01 mg/kg 1:10000 every 3-5 mins, max of 1mg dose
ET: .01 mg/kg of 1:1000 diluted or flushed with 3-5mL NS, max dose 10mg
Asthma/anaphylaxis: 0.01 mg/kg 1:1000 max dose of 0.5
IV infusion: 0.1-1 mcg/kg/min
Croup: 3mg 1:1000 in 3mL NS via SVN

Neonatal (1st 12 hours of life):
Cardiac arrest/refractory bradycardia: 0.01-0.03 mg/kg 1:10000 every 3-5 mns
ET: 0.1 mg/kg of 1:10000 every 3-5 mins if vascular access unavailable or failure to respond to positive pressure ventilation.

57
Q

Lidocaine Name/class

A

Lidocaine

Brand: lidopen

Class: anti-arrhythmic, local anesthetic

(Class I drug)

58
Q

Lidocaine MOA

A

Na Channel Blocker, decreases automatcity by slowing rate of phase 4 depolarization
Decreases conductions in reentrant pathways
Increases VF threshold

59
Q

Lidocaine Indications

A

Vtach, VF, PVCs
Prophylaxis against Vtach/VF after conversion
Pain management after IO insertion in conscious patients

60
Q

Lidocaine Contraindications

A

Extreme caution with 2nd or 3rd degree blocks

Not for ectopic beats if HR is <60, treat bradycardia instead

61
Q

Lidocaine Adverse reaction

A

CV: may cause SA nodal depression/conduction problems and hypotension in lower doses or if given too rapidly.
CNS: larger doses cause drowsiness, disorientation, parathesias, decreased hearing, muscle twitching, agitation, focal/generalized seziures

62
Q

Lidocaine Incompatibility/reactions

A

NONE

63
Q

Lidocaine Dose (ad and ped)

A

Adult:
PVfib/VT: initial bolus of 1-1.5 mg/kg IV push every 3-5 mins to a total of 3mg/kg. Initial bolus of 1.5 should be given in cardiac arrest situations.

Antidyshrythmic/ rhythm w/o pulse: initial bolus of 0.5-0.75 mg/kg up to 1-1.5 mg/kg. Additional bolus of 0.5-0.75 mg/kg given every 5-10 mins to max of 3mg/kg.

Maintenance dose: 1-2 gm in 250 mL NS/D5W admin drip at 2-4 mg/min. Reduce dose by half in PTs older than 70, or with hepatic/renal disease, or poor perfusion state

IO pain management: 20-40 mg VERY SLOW IO push

Peds:
VF/PVtach: initial bolus of 1 mg/kg repeated 1 time in 3-5 mins/15 mins for refractory dysrythmias with a pulse.

Maintenance: add 120 mg (3mL) of 1gm/25mL (40mg/mL) to 97mL NS for 1200 mcg/min administered at 20-50 mcg/kg/min. 1ml/kg/hr delivers 20mcg/kg/min. 2.5ml/kg/hr delivers 50 mcg/kg/min. Reduce to <20mcg/kg/min for those with low cardiac output, severe CHF, or compormised hepatic perfusion. Avoid unless infusion pump is used.

IO pain managment: 0.1 mg/kg not to exceed adult dose

64
Q

Nitroglycerin Name/Class

A

Nitroglycerin

Brand: Nitrostat

Class: vasodilator, organic nitrate, antianginal

65
Q

Nitroglycerin MOA

A

Smooth muscle relaxant on vascular, uterine, bronchial, and intestinal smooth muscle
Decreases preload by reducing workload on the heat causing blood pooling
Arteriolar vasodilation (decrease afterload)
Coronary artery vasodilation
Increase bloodflow to myocardium, descrease O2 Demand

66
Q

Nitroglycerin Indication

A

Angina
MI
CHF with pulmonary edema

67
Q

Nitroglycerin contraindications

A

Hypovolemia/hypotension (above 90-100 systolic)

Sexual enhancement drugs

68
Q

Nitroglycerin adverse reactions

A

CV: hypotension, reflex tachycardia, bradycardia, headache, decrease coronary perfusion at higher doses

69
Q

Nitroglycerin Incompatabilities/reactions

A

Other vasodilators

Pulmonary HTN

70
Q

Nitroglycerin Dose (ad)

A

SL for chest pain: 1/150gr (0.4mg tab) or one full spray repeated 3 times
SL for pulmonary edema: 1-2 0.4 mg tablets every 5-10 minutes (monitor BP)

IV infusion (inter-facility on infusion pump): start at 5ug/min and increase by 5ug increments, titrate

71
Q

Norepinephrine (interfacilty only) Name/class

A

Norepinephrine (interfacilty only)

Brand: Noradrenaline

Class: sympathomimetic, Alpha/beta adrenergic agonist, inotropic cardiac stimulant, vasopressor

72
Q

Norepinephrine (interfacilty only) MOA

A

Stimulates A1 and B1 receproes in sympathetic system causing vasoconstriction, increase BP, enhance contractility, and decrease HR.

73
Q

Norepinephrine (interfacilty only) Indications

A

Severe hypotension from cardiogenic, septic, or nuerogenic shock refractory to fluid bolus or when bolus is contraindicated

74
Q

Norepinephrine (interfacilty only) Contraindications

A

Hypotension caused by blood volume deficit, profound hypoxia/hypercarbia
Mesenteric or peripheral vascular thrombosis

75
Q

Norepinephrine (interfacilty only) Adverse reactions

A
CNS: headache, anxiety
CV: bradycardia, severe HTN, arrythmias
Respiratory difficulty
Skin: irritation/necrosis w/extravasation
Ischemic injury
76
Q

Norepinephrine (interfacilty only) Incompatibility/interactions

A

Alpha-adrenergic blockers (antagonizes NE effect)
Antihistamines, ergot alkaloids, guanethidine, MAO inhibitors, oxytocin, TCAs, severe HTN
Bretylium, inhalation anesthetics, increased risk of arrythmias

77
Q

Norepinephrine (interfacilty only) Dose (ad and ped)

A

Adult: initial dose of 2-4 mcg/min

Maint: adjust rate to a normal BP of 80-100 systolic, average is 1-12 mcg/min, max of 30mcg/min

Ped: 0.1-2 mcg/kg/min (2 is max)

78
Q

Vasopressin Name/Class

A

Vasopressin

Brand: vasostrict

Class: Pituitary hormone (antidiuertic)

79
Q

Vasopressin MOA

A

Vasoconstriction of peripheral, cerebral, pulmonary and coronary vessels

80
Q

Vasopressin Indications

A

adult shock refractory VF/PVtach

81
Q

Vasopressin Contraindications

A

Responsive PT with CAD

HTN

82
Q

Vasopressin Adverse Reactions

A
Provoking of cardiac ischemia and angine
Abdominal distress
N/V
Tremors
Necrosis with extravasation
83
Q

Vasopressin Incompatability/interactions

A

NONE in pre-hospital setting

84
Q

Vasopressin Dose (ad)

A

VF/PVtach : 40 U may replace the FIRST or SECOND dose of epi

85
Q

Verapamil Name/Class

A

Verapamil HCL

Brand: Calan

Class: Ca Channel blocker

86
Q

Verapamil MOA

A

Blocks Ca influx causing depressant on contractile mechanism (negative inotropy)
Reduced vascular smooth muscle tone resulting in coronary and peripheral vasodilation
Slows SA node discharge
DECREASES MYOCARDIAL CONTRACTILE FORCE AND SLOWS AV CONDUCTION

87
Q

Verapamil Indications

A

SVT

AFib/Aflutter with RVR (>100 BPM)

88
Q

Verapamil contraindications

A
AV block
SIck sinus
ANY wide complex tachycardia
WPW
Shock
Severe CHF
IV beta blocker
Hypotension
89
Q

Verapamil Adverse reactions

A
Extreme bradycardia
Asystole
AV block
Hypotension
CHF
90
Q

Verapamil Incompatability/interation

A

IV beta blocker

91
Q

Verapamil Dose (ad)

A

2.5-5 mg SLOW IV push over 2-3 mins. May rebolus in 15-30 mins w/5-10mg until max dose of 30 mg