Cardiac Drug Profiles Flashcards
Acetylsalicyclic Acid Names/Class
Acetylsaicylic Acid, ASA, Aspririn
Class: Analgesic, anti inflammatory, antipyretic
ASA Indications
CP or s/s suggestive of MI
Unstable Angina
Pain, Discomfort, Fever (adult only)
ASA contraindications
Hypersensitivity
Bleeding ulcer, hemorrhagic state, Hemophilia
Children or adolescents
ASA MOA
Blocks Thromboxane A2 (platelet aggregate and vasoconstrictor)
Decreases platelet aggregation
ASA adverse reactions
Caution with asthma, anaphylaxis in sensitive PT have occurred, Skin eruptions
ASA Dose (adult)
Cardiac: 160-325 PO (2-4 pediatric tablets)
Pain/discomfort/fever: 325 mg PO
Adenosine Names/Class
Adenosine
Brand: Adenocard
Class: Antiarrythmic, Endogenous nucleoside
Adenosine MOA
Slows conduction through AV node
Slows sinus rate
Larger doses decrease BP by decreasing peripheral resistance
Adenosine Indications
SVT with no known AFib or Aflutter
Undifferentiated regular monomorphic wide complex tachycardia
Adenosine Contraindications
Sick sinus syndrome, 2nd or 3rd degree block (except PT with functioning pacemaker)
Theophylline and related Methylxanthines
Dipyramidole (persantine) and carbamazepine (tegretol)
Known Afib/Aflutter
Pregnancy
Caution: asthma and cardiac tranplant PTs (more sensitive)
Adenosine Adverse Effects
CV: Systole bradycardia, and PVCs occur in 55% of PTs, palpitations, chest pressure, chest pain
Resp: Dyspnea, hyperventilation, facial flushing, sweating
CNS: Lightheadedness, headache, dizziness, parathesia apprehension, blurred vision, neck/back pain
GI: N/V, mettalic taste
Adenosine incompatability/interactions
Adenosine is not blocked by atropine
Theophylline and methylxanthines decrease effectiveness
Dipyradimole (persantine/blood thinner) and carbamazepine (tegretol/seizure med)) block uptake and potentiate effects
Adenosine Dosage (ad and ped)
Adult: 6mg rapid push W/20 ml NS flush, can repeat in 1-2 minutes with 12mg
Ped: 0.1 mg/kg rapid push with 2-3 ml NS flush, may double one time (0.2 mg/kg) MAX DOSE: 12mg
Amiodarone Names/Class
Amiodarone
Brand: pacerone, nexterone
Class: Antiarrythmic
Amiodarone MOA
Multiple effects on Na, Ca, and K channels
Prolongs action potential, refractory peros
K channel blockade increases ventricular automaticity
Na Channel blockade slows membrane depolirization and impulse conduction
Ca channel and Beta blockade has a negative chronotropic effect
Dilates coronary arteries due to Ca channel and Alpha-adrenergic blocking action
Amiodarone Indications
Defib refractory VF/Pulseless VT
Polymorphic VT
Wide complex tachycardia of uncertain origin
Control hemodynamically stable VT with cardoversion is not successful
Adjunct to cardioversion of SVT and PSVT
Rate control in AF/Aflutter
Amiodarone Contraindications
Bradycardia 2nd or 3rd degree heart blocks without functioning pacemaker Cardiogenic shock Hypotension Pulmonary congestion
Caution: temperature control is needed (77 F)
Amiodarone Adverse reactions
CV: Bradycardia, hypotension, asystole/cardiac arrest, AV block, Torsades, CHF
GI/Hepatic: N/V, abnormal liver function test
Skin: Slate blue pigmentation
Other: Fever, Headache, dizziness, fever, flushing, abnormal salivation, photophobia
Amiodarone Incompatibilities/interactions
Beta Blockers, Ca channel blockers, and other antiarrythmics are additive and can be proarrhythmic (BP Meds)
Precipates at Y site with Na Bicarb, Furosemide, and heparin
Amiodarone Dose (ad and Ped)
Adult
VF/Pulseless VT: 300 mg IV push over 30-60 seconds, may repeat in 3-5 minutes with 150 mg
Wide complex Tachycardia. Aflut, Afib, SVT with cardioversion: 150 mg Iv over 10 mins, may repeat every 10 mins. (in 50 mL bag of D5W)
Maint infusion post arrest/conversion: 1 mg/min infusion over 6 hours, then 0.5 mg infusion over 18 hours (max daily of 2.2 mg)
mix 450 mg in 250 mL D5W makes 1.8 mg/mL, run at 33.3 mL/hr for 1 mg/min or 16.7 mL for 0.5 mg infusion
Peds:
VF/Pulseless VT: 5 mg/kg (max 300 mg) may repeat every 5 minutes twice to a max of 15 mg/kg/day
Probable VT w/pulse: 5 mg/kg over 20 minutes, can be repeated twice for max of 15 mg/kg/day
Needs to be mixed in D5W bag because it is polyolefin
Atropine Sulfate Names/Class
Atropine Sulfate
Class: Anticholinergic, antimuscarinic, antidote, antispasmodic, antiarrhythmic
Atropine Sulfate MOA
Blocks ACH as a competitive antagonist at muscarinic receptor sites in smooth muscle, secretory glands and CNS.
Blocks parasympathetic response, allowing sympathetic to take over.
Reverses muscarinic effects of cholinergic poisoning by reversing bronchorea and bronchodilation
At higher doses, may affect the nicotinic receptors
Atropine Sulfate Indications
Symptomatic bradycardia (Sinus, Junctional, or AV block causing hypotension, ventriculat ectopy, CP, or ALOC) ACH poisoning (organophsophate)
Atropine Sulfate Contraindications
Hypersensitivity or Belladonna alkaloid allergy
Acute narrow angle glaucoma
Tachycardia
Obstuctive GI , Renal, or hepatic disease
Myasthenia Gravis (unless using as ACH inhibitor)
Asthma
Thyrotoxicosis
Mobitz Type II and 3rd degree block
Atropine Sulfate Adverse reactions
Major: Tachydysrhythmias, flushing, ventricular irritability, angina, acute narrow angle glaucoma, blurred vision, pupil dilation (mydriasis), agitation to delirium, bloating, constipation, decrease GI activity
Minor: Dry mouth/mucous membranes, loss of taste, N/V, Urinary retention, nueromuscular weakness, decreased sweating/increase body temp
Atropine Sulfate Incompatibilities/reactions
Thiopental, cimetidine, pentobarbital, floxacillin, metaraminol, methohexital, NE, NA bicarb
Increases effects of anticholinergics, cannaboids, and KCl.
Decreases effects of phenothiazines, ACHesterase inhibitors, and secretin
Atropine and psychotropics may have additive anticholinergic effects (dry mouth, blurry vision, etc)
Pramintide may increase effectiveness
ACHesterase inhibitors may decrease effect of atropine
Atropine Sulfate Dose (ad and Ped)
Adult:
Symptomatic Bradycardia: 0.5 mg every 5 minutes MAX of 3mg or 0.04 mg/kg
Organophosphate poisoning: initial 1-5 mg IV/IO every 5 minutes until signs abate, IV infusion of 0.5 - 1 mg or 10-20% loading dose/hr. Repeat every 10 mins.
IM Atropen: 2mg as soon as exposure is known, if severe symptoms develop, give 2 more doses (MAX of 3) Severe symptoms immediately admin (3) 2mg doses
Peds:
Symptomatic bradycardia: 0.02 mg/kg IV/IO every 5 mins (MAX of 1mg in children/2mg in adolescents.
Organophosphate poisoning: 0.03-0.05 mg/kg every 10-20 mins until signs abate, then every 1-4 hrs for 24 hrs
IM: Same guidelines as adult
<15 lbs (6.8 kg): not recommended, admin atropine .05mg/kg
15-40 lbs (6.8kg-18kg): 0.5 mg/dose
40-90 lbs (18-41kg): 1mg/dose
>90lbs (41kg): 2mg/dose
Calcium Chloride Names/Class
Calcium Chloride
Class: Electrolyte
Calcium Chloride MOA
Positive inotropic effect
Inhibits effects of adenosine on mast cells
Stimulate release of Catelcholamines
May enhance ventricular automaticity
Calcium Chloride Indications
Hypocalcemia Ca channel blocker OD (Amlodipine, diltiazem, verapamil) Acute HyperK Hypermagnesemia (OD) Pretreat for Ca Channel blockers
Calcium Chloride Contraindications
Hypercalcemia Digoxin therapy (relative)
Calcium Chloride Adverse reaction
Brady-asystolic arrest
Tissue necrosis with extravasation
Calcium Chloride Incompatabilities/Interactions
ALL DRUGS, flush line before and after admin
Calcium Chloride Doses (ad and ped)
Adult:
Hypocalcemia, Ca Channel OD, HyperK, and HyperMag: 5-10 mL (0.5-1gm) may repeat in 10 mins
Pretreatment for Ca Channel blockers: 3 mL, may repeat once
Peds:
Hypocalcemia, Ca Channel OD, HyperK, and HyperMag: 0.2-0.25 mL/kg slow infusion, do not repeat w/o documented Ca deficiency
Diltiazem Names/Class
Diltiazem
Brand: Cardizem
Class: Ca Channel blocker, Calcium antagonic
Diltiazem MOA
Pharmacological: Decreases SA/AV conduction and dilates coronary and peripheral arteries and arterioles by inhibiting Ca ion influx across cell membranes during cardiac depolarization
Clinical effects: Slows rapid ventricular rate associated with Afib/Aflutter, reduces coronary and peripheral resistance