Cardiac Disease Flashcards
What type of mechanical abnormality is present in congenital heart disease?
Faulty pump construction.
What 2 structures divert blood from the lungs in the developing fetus?
Ductus arteriosus and foramen ovale.
What two structures does the ductus arteriosus connect?
The aorta and pulmonary artery.
What does the ductus arteriosus become after birth?
The fibrous cord called ligamentum arteriosum.
What two structures does the foramen ovale connect, and in which direction does blood flow through it?
A 1-way flap between the right and left artia makes blood flow from right to left.
What are the 2 defects related to the fetal shunts of the heart? What is the impact of these defects?
Patent Foramen Ovale/ Ductus Arteriosus. Deoxygenated and oxygenated blood mixes. If a large amount is shunted, pulmonary blood pressure raises, damaging the lungs by thickening the vessels and right ventricle.
What is pulmonary or aortic valve stenosis?
Abnormal development of valve leaflets narrows the valve opening.
Pulmonary stenosis obstructs outflow from which structure?
The right ventricle.
Aortic stenosis obstructs outflow from which structure?
The left ventricle.
How is pulmonary/ aortic stenosis treated?
A ballon like device increases the size of the opening.
What 4 factors make up the tetalogy of fallot?
- Ventricular septal defect
- Pulmonary stenosis
- Enlarged aorta
- Right ventricular hypertrophy
What are 2 clinical indications of tetralogy of fallot?
- Cyanosis
- Clubbing of digits
In tetralogy of fallot, from where does the enlarged aorta receive blood?
From both ventricles. (less oxygenated blood)
What is the 2 step treatment of tetralogy of fallot?
- Ventricular septum closed surgically
- Pulmonary valve/ artery enlarged.
What are the 2 main structural changes in transposition of the great arteries?
- Left ventricle pumps oxygenated blood into pulmonary artery (O2 in pulmonary circulation)
- Right ventricle pumps poorly oxygenated blood to systemic circulation.
What is the treatment for transposition of the great arteries?
Emergency surgery to connect vessels.
What is coarctation of the aorta?
Aorta narrows and restricts blood flow to the distal aorta.
How is the obstruction of the aorta bypassed in coarctation of the aorta?
Collateral circulation develops and shunts blood into the distal aorta.
How will blood pressure be affected by coarctation of the aorta?
High BP in brachial artery, and low BP in LEs.
What is the mechanism of atherosclerotic disease?
Dirty or plugged fuel lines.
What are the 3 layers of the artery wall, and what is found in each layer?
- Intima: Endothelial cells
- Media: Smooth muscle
- Adventitia: Nerves, Lymphatics, Vascularture
What are the 4 functions of the intima?
- Resists clot formation
- Prevents blood and large molecules from entering media and adventitia
- Chemotaxis
- Controls smooth muscle contraction/ dilation
What is the 5 step mechanism of the plaque formation?
- Endothelium becomes damaged
- Endothelium becomes inflamed
- Fibrous plaque forms that is filled with cell debris, foam cells, and lipids
- Smooth muscles migrate into intima, and surround fatty streak
- Mass covered with a fibrous cap
Describe the 2 methods of artery walls narrowing due to atherosclerosis.
Plaque rupture
- Inflammation weakens fibrous cap
- Cap ruptures
- Clot may form or cap reattaches narrowing aterial walls
Plaque w/o rupture
- Calcification of the plaque causes the wall to become rigid
- Artery cannot loses some ability to dilate