Cardiac Autonomic Pharmacology

Question 1

What are the targets of muscarinic antagonists?

Answer 1

M receptors, M2 in the heart

Question 2

What are some muscarinic antagonists?

Answer 2

atropine, hyoscine

Question 3

what is the action of muscarinic antagonists?

Answer 3

inhibition of tachycardia

Question 4

what is the clinical application of muscarinic antagonists?

Answer 4

treatment of sinus bradycardia

Question 5

What are some beta-adrenoreceptor agonists?

Answer 5

adrenaline, dobutamine

Question 6

what are the targets of beta-adrenoreceptor agonists?

Answer 6

non-selective beta receptors

Question 7

what are the actions of beta-adrenoreceptor agonists?

Answer 7

affect heart rate, conduction and contractility

Question 8

what are the clinical applications of beta-adrenoreceptor agonists?

Answer 8

treatment of cardiac arrest and cardiogenic shock (i.e. heart can’t pump enough blood)

Question 9

what are some beta-adrenoreceptor antagonists and which targets do they bind to?

Answer 9

propranolol: non-selective
atenolol: beta 1
carvedilol: alpha and beta

Question 10

what are the actions of beta-adrenoreceptor antagonists?

Answer 10

affect heart rate, conduction and contractility

Question 11

what are the clinical applications of beta-adrenoreceptor antagonists?

Answer 11

treatment of angina, myocardial infarction, arrhythmias, heart failure and hypertension

Question 12

what are the clinical applications of muscarinic agonists?

Answer 12

none: cause bradycardia and vasodilation

Question 13

what does isoproterenol/isoprenaline do?

Answer 13

1 micromolar
long selective beta agonist
increase beta adrenergic signalling, increase rate

Question 14

what does ACh do?

Answer 14

0.01 micromolar
increases length of AP, i.e. decreases heart rate