cardiac antihypertension drugs Flashcards
Diuretics?
Thiazide
what drug falls under Thiazide
Metolazon
Metolazon…?
inhibits Sodium transports across renal tubular epithelium
Metolazon is good for?
pts with impaired renal functions
Beta-adrenergic receptor blockers…
reduce blood pressure due to decreased cardiac output
Beta receptors more effective in
young white patients
adverse effects of beta blockers
-bradycardia, fatigue, decrease labido, decrease impotence
- decreases HDL
- Increases tryglycerides
what are the two ACE inhibitors
Enalapril and Lisinopril
ACE inhibitors do what
reduce vascular resistance without increasing cardiac output, cardiac rate or contractility
explain the mechanism of ACE inhibitors
decreases angiotension 2 which causes:
- decrease sympathetic output
- increases vasodilation of vascular smooth muscle
- decrease aldosterone , na and h20 retention
- Increase levels of bradykinin
Therapeutic use of ACE inhibitors
slow progression of diabetic nephropathy and decrease albuminuria
adverse effects of Ace inhibitors
-dry cough , rash , fever, hypotension, hyperkalemia
- angioedema is rare but is life threatening
- contraindicated in pregnant women
what is an Angiotensin 2 receptors antagonist
Losartan
Losartan is similar to
ACE inhibitors
Losartan does not
increase bradykinin levels and has no dry cough or angioedema
