Cardiac Anti-Arrhythmic agents Flashcards
what happens when there is increased potassium permeability?
Vm close to Ek
strong repolarization
increased threshold
what happens when there is decreased potassium permeability?
Vm depolarized (toward ENa, ECa) decreased threshold
characteristics of a typical Fast AP
conduction velocity determined by phase ) slope
Fast Na channels cause the depolarization
slow ca channels are responsible for the plateau
characteristics of a typical slow AP
SA and AV nodal tissue
No fast Na channels (phase 0)
More Ca dependent
Spontaneous phase 4 depolarization due to funny Na and Ca channels
Action of Na channel blockers
decrease conduction velocity (phase 0)
suppress ventricular and atrial muscle firing
Action of K channel blocker
increase time for repolarization (phases 2 and 3)
prolongs AP duration , slows down
increases time to “reset” excitability (refractoriness)
Action of K channel stimulator
increases repolarizing influence (Ek)
decreases slope of phase 4
slows HR (Ach/PNS)
Action of Ca channel blocker
nodal cells: decreases slope of phase 4
decrease excitability of nodal cells
not as effective in Na-dependent cells
Spontaneous activity (phase 4) is under …
autonomic control
what prevents tetanus in cardiac muscle?
Refractory period
Absolute refractory period - another AP cannot fire, Na channels are inactive
Relative refractory period - late phase 3, Na channels are reactivated and another AP could fire
How are inactived Na channels reset?
by repolarization
What affinity contributes to Na channel efficacy?
blockers have a high affinity for O state (open) or inactive state of the Na channel
faster HR means more time in O or I, so more effective in a heart that is tachycardiac vs normal sinus rhythm
Cardiac ATP
75% of cardiac ATP is for the Na/K ATP pump
How does ischemia affect depolarization?
lowers ATP and increases intracellular NA so the cells are slightly depolarized because gradient not being closely maintained. There is less “reactivation” of fast Na channels, slower phase 0 upstroke and impulse conduction and may contribute to re-entry of impulses.
Need a negative potential to reactivate Na channels.
What is a strategy to decrease arrhythmias?
by increasing ERP
makes the cell less sensitive to stimulation
can slow the development/propagation of abnormal rhythms
K channel blocker
slows phase 3 repolarization
increases AP duration
delays “recovery” of Na channels
prolongs Effective repolarizing Potential and R (relative) RP
Na channel blocker
binds to and blocks inactive channels
reduces number of “recovered” channels
extends the ERP of atrial/ ventricular myocytes
Ca channel blocker
increase ERP and depress phase 4 slope in nodal tissue
bradyarrhythmias
SA node dysfunction
electronic pacemakers are t.o.c
atropine or isoproterenol
tachyarrhythmias
increased impulse generation (automaticity)
increased impulse conduction (propagation)
tx: primarily channel blockers
Triggered Activity
after depolarizations
occur “after” the normal AP depolarization
can trigger abnormal beat if threshold is reached and sufficient # of Na channels have recovered from inactivation
abnormal beat occurs before optimal diastolic filling
Delayed afterdepolarization (DAD)
often produced by too much calcium
occurs during phase 4
Early afterdepolarization (EAD)
can occur with excessive prolongation of AP
occurs during phase 3
3 simultaneous conditions for Premature excitation before next normal impulse
- area of depressed conduction/block
- block must be unidirectional
- impulse speed “around the block” must be slow enough to reenter healthy area AFTER the refractory period (sufficient Na channels have recovered and can be opened) this insures abnormal “retrograde” propagation