Cardiac and Tissue Intrinsic regulation

Question 1

The balance between the rate of supply of O2 (or any nutrient) to a tissue and its rate of consumption determines the local ____________.

Answer 1

Tissue O2 concentration or PTO2

Question 2

The total vascular resistance seen by the heart (TPR) will _______________ if any local tissue resistance increases.

Answer 2

increase

Question 3

If all else were to be held equal, a decrease in the metabolic rate of a tissue would cause the local PO2 to ____________ and TPR would ____________.

Answer 3

increase, increase

Question 4

The preload seen by cardiac muscle in the wall of the pumping ventricle is determined by ventricular volume at _____________________.

Answer 4

EDV

Question 5

The afterload seen by cardiac muscle in the wall of the pumping ventricle during ejection is determined by ventricular ___________ and aortic ____________.

Answer 5

radius or size, pressure

Question 6

The effect of slowing the heart rate in an isolated, electrically paced heart would be to _________________ contractility due to a ____________ in the peak intracellular _________ concentration.

Answer 6

decrease, decrease, Ca++